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2AZM
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BU of 2azm by Molmil
Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX
Descriptor: GAMMA-H2AX HISTONE, Mediator of DNA damage checkpoint protein 1
Authors:Clapperton, J.A, Stucki, M, Mohammad, D, Yaffe, M.B, Jackson, S.P, Smerdon, S.J.
Deposit date:2005-09-12
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
Cell(Cambridge,Mass.), 123, 2005
5NNE
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BU of 5nne by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated TOP2A peptide (K1201ac/K1204ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GKA(ALY)GK(ALY)TQMY
Authors:Filippakopoulos, P, Picaud, S, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
3UN0
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BU of 3un0 by Molmil
Crystal Structure of MDC1 FHA Domain
Descriptor: Mediator of DNA damage checkpoint protein 1, SULFATE ION
Authors:Clapperton, J.A, Lloyd, J, Haire, L.F, Li, J, Smerdon, S.J.
Deposit date:2011-11-15
Release date:2011-12-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.
Nucleic Acids Res., 40, 2012
3UOT
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BU of 3uot by Molmil
Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus
Descriptor: Mediator of DNA damage checkpoint protein 1
Authors:Clapperton, J.A, Lloyd, J, Haire, L.F, Li, J, Smerdon, S.J.
Deposit date:2011-11-17
Release date:2011-12-28
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.
Nucleic Acids Res., 40, 2012
5NNC
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BU of 5nnc by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)
Descriptor: Bromodomain-containing protein 4, Histone H3
Authors:Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5NNG
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BU of 5nng by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SRPK1 peptide (K585ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, VAG(ALY)YS(ALY)EFFY
Authors:Filippakopoulos, P, Picaud, S, Newman, J, Sorrell, F, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Structural Genomics Consortium (SGC)
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5NNF
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BU of 5nnf by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated BAZ1B peptide (K221ac)
Descriptor: Bromodomain-containing protein 4, FLPH(ALY)YDVKL
Authors:Filippakopoulos, P, Picaud, S, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5NND
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BU of 5nnd by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Histone H3
Authors:Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0S
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BU of 6g0s by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SIRT7 peptide (K272ac/K275ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, NAD-dependent protein deacetylase sirtuin-7
Authors:Filippakopoulos, P, Picaud, S, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0Q
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BU of 6g0q by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated GATA1 peptide (K312ac/K315ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Erythroid transcription factor
Authors:Filippakopoulos, P, Picaud, S, Newman, J, Sorrell, F, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0R
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BU of 6g0r by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated POLR2A peptide (K775ac/K778ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DNA-directed RNA polymerase II subunit RPB1
Authors:Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0O
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BU of 6g0o by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated ATRX peptide (K1030ac/K1033ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Transcriptional regulator ATRX
Authors:Filippakopoulos, P, Picaud, S, Newman, J, Sorrell, F, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0P
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BU of 6g0p by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated E2F1 peptide (K117ac/K120ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Transcription factor E2F1
Authors:Filippakopoulos, P, Picaud, S, Krojer, T, Sorrell, F, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019

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PDB entries from 2024-03-27

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