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4AW0
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BU of 4aw0 by Molmil
Human PDK1 Kinase Domain in Complex with Allosteric Compound PS182 Bound to the PIF-Pocket
Descriptor: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, DIMETHYL SULFOXIDE, ...
Authors:Schulze, J.O, Busschots, K, Lopez-Garcia, L.A, Lammi, C, Stroba, A, Zeuzem, S, Piiper, A, Alzari, P.M, Neimanis, S, Arencibia, J.M, Engel, M, Biondi, R.M.
Deposit date:2012-05-30
Release date:2012-10-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Substrate-Selective Inhibition of Protein Kinase Pdk1 by Small Compounds that Bind to the Pif-Pocket Allosteric Docking Site.
Chem.Biol., 19, 2012
4AW1
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BU of 4aw1 by Molmil
Human PDK1 Kinase Domain in Complex with Allosteric Compound PS210 Bound to the PIF-Pocket
Descriptor: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Schulze, J.O, Busschots, K, Lopez-Garcia, L.A, Lammi, C, Stroba, A, Zeuzem, S, Piiper, A, Alzari, P.M, Neimanis, S, Arencibia, J.M, Engel, M, Biondi, R.M.
Deposit date:2012-05-30
Release date:2012-10-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Substrate-Selective Inhibition of Protein Kinase Pdk1 by Small Compounds that Bind to the Pif-Pocket Allosteric Docking Site.
Chem.Biol., 19, 2012
3HRF
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BU of 3hrf by Molmil
Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the PIF-pocket
Descriptor: (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid, 3-phosphoinositide-dependent protein kinase 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Hindie, V, Alzari, P.M, Biondi, R.M.
Deposit date:2009-06-09
Release date:2009-09-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.
Nat.Chem.Biol., 5, 2009
3HRC
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BU of 3hrc by Molmil
Crystal structure of a mutant of human PDK1 Kinase domain in complex with ATP
Descriptor: 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE
Authors:Hindie, V, Alzari, P.M, Biondi, R.M.
Deposit date:2009-06-09
Release date:2009-09-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.
Nat.Chem.Biol., 5, 2009
4CT2
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BU of 4ct2 by Molmil
Human PDK1-PKCzeta Kinase Chimera
Descriptor: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, DITHIANE DIOL, ...
Authors:Schulze, J.O, Zhang, H, Lopez-Garcia, L.A, Biondi, R.M.
Deposit date:2014-03-11
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-Terminal Domains and an Allosteric Small Compound.
Chem.Biol., 21, 2014
4CT1
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BU of 4ct1 by Molmil
Human PDK1-PKCzeta Kinase Chimera in Complex with Allosteric Compound PS315 Bound to the PIF-Pocket
Descriptor: (2Z)-3-(biphenyl-4-yl)-5-(4-chlorophenyl)pent-2-enoic acid, 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Schulze, J.O, Zhang, H, Lopez-Garcia, L.A, Biondi, R.M.
Deposit date:2014-03-11
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-Terminal Domains and an Allosteric Small Compound.
Chem.Biol., 21, 2014

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