4TKN
 
 | | Structure of the SNX17 FERM domain bound to the second NPxF motif of KRIT1 | | Descriptor: | Krev interaction trapped protein 1, Sorting nexin-17 | | Authors: | Stiegler, A.L, Zhang, R, Liu, W, Boggon, T.J. | | Deposit date: | 2014-05-27 | | Release date: | 2014-07-30 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Determinants for Binding of Sorting Nexin 17 (SNX17) to the Cytoplasmic Adaptor Protein Krev Interaction Trapped 1 (KRIT1).
J.Biol.Chem., 289, 2014
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8DGQ
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6D4G
 | | N-GTPase domain of p190RhoGAP-A | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 35 | | Authors: | Stiegler, A.L, Boggon, T.J. | | Deposit date: | 2018-04-18 | | Release date: | 2018-09-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase.
Structure, 26, 2018
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2IEP
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5U4U
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5U4V
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3HKL
 | | Crystal Structure of the Frizzled-like Cysteine-rich Domain of MuSK | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Muscle, skeletal receptor tyrosine protein kinase | | Authors: | Stiegler, A.L, Hubbard, S.R. | | Deposit date: | 2009-05-24 | | Release date: | 2009-08-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK.
J.Mol.Biol., 393, 2009
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4EDM
 | | Crystal structure of beta-parvin CH2 domain | | Descriptor: | 1,2-ETHANEDIOL, Beta-parvin | | Authors: | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | | Deposit date: | 2012-03-27 | | Release date: | 2012-08-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
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4HI9
 | | 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974 | | Descriptor: | IODIDE ION, Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ... | | Authors: | Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J. | | Deposit date: | 2012-10-11 | | Release date: | 2013-12-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.203 Å) | | Cite: | 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974
To be Published
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4HI8
 | | Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800 | | Descriptor: | Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, PHOSPHATE ION, ... | | Authors: | Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J. | | Deposit date: | 2012-10-11 | | Release date: | 2013-12-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.203 Å) | | Cite: | Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
To be Published
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4EDL
 | | Crystal structure of beta-parvin CH2 domain | | Descriptor: | 1,2-ETHANEDIOL, Beta-parvin | | Authors: | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | | Deposit date: | 2012-03-27 | | Release date: | 2012-08-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
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4EDN
 | | Crystal structure of beta-parvin CH2 domain in complex with paxillin LD1 motif | | Descriptor: | Beta-parvin, Paxillin, SULFATE ION | | Authors: | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | | Deposit date: | 2012-03-27 | | Release date: | 2012-08-08 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
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7TPB
 | | p120RasGAP SH3 domain in complex with DLC1 RhoGAP domain | | Descriptor: | Ras GTPase-activating protein 1, Rho GTPase-activating protein 7 | | Authors: | Stiegler, A.L, Boggon, T.J, Chau, J.E, Vish, K.J. | | Deposit date: | 2022-01-25 | | Release date: | 2022-08-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP.
Nat Commun, 13, 2022
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4WJ7
 | | CCM2 PTB domain in complex with KRIT1 NPxY/F3 | | Descriptor: | KRIT1 NPxY/F3, Malcavernin | | Authors: | Fisher, O.S, Liu, W, Zhang, R, Stiegler, A.L, Boggon, T.J. | | Deposit date: | 2014-09-29 | | Release date: | 2014-12-24 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.753 Å) | | Cite: | Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations.
J.Biol.Chem., 290, 2015
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6PXC
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6PXB
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3IXE
 | | Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase | | Descriptor: | Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 2, ZINC ION | | Authors: | Chiswell, B.P, Stiegler, A.L, Boggon, T.J, Calderwood, D.A. | | Deposit date: | 2009-09-03 | | Release date: | 2009-12-15 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.
J.Struct.Biol., 170, 2010
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6WAY
 | | C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide | | Descriptor: | Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 | | Authors: | Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. | | Deposit date: | 2020-03-26 | | Release date: | 2020-06-17 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain.
J.Biol.Chem., 295, 2020
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6WAX
 | | C-terminal SH2 domain of p120RasGAP | | Descriptor: | 1,2-ETHANEDIOL, Ras GTPase-activating protein 1, SULFATE ION | | Authors: | Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. | | Deposit date: | 2020-03-26 | | Release date: | 2020-06-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain.
J.Biol.Chem., 295, 2020
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7UGB
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