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4AT1
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STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Stevens, R.C., Gouaux, J.E., Lipscomb, W.N.
Deposit date:1990-04-26
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry, 29, 1990
5AT1
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STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Stevens, R.C., Gouaux, J.E., Lipscomb, W.N.
Deposit date:1990-04-26
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry, 29, 1990
6AT1
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STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Stevens, R.C., Gouaux, J.E., Lipscomb, W.N.
Deposit date:1990-04-26
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry, 29, 1990
2AT2
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MOLECULAR STRUCTURE OF BACILLUS SUBTILIS ASPARTATE TRANSCARBAMOYLASE AT 3.0 ANGSTROMS RESOLUTION
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE
Authors:Stevens, R.C., Reinisch, K.M., Lipscomb, W.N.
Deposit date:1992-07-20
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular structure of Bacillus subtilis aspartate transcarbamoylase at 3.0 A resolution.
Proc.Natl.Acad.Sci.USA, 88, 1991
1ACM
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ARGININE 54 IN THE ACTIVE SITE OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE IS CRITICAL FOR CATALYSIS: A SITE-SPECIFIC MUTAGENESIS, NMR AND X-RAY CRYSTALLOGRAPHY STUDY
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Stevens, R.C., Kantrowitz, E.R., Lipscomb, W.N.
Deposit date:1992-07-08
Release date:1992-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Arginine 54 in the active site of Escherichia coli aspartate transcarbamoylase is critical for catalysis: a site-specific mutagenesis, NMR, and X-ray crystallographic study.
Protein Sci., 1, 1992
1FL3
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CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K
Descriptor:BLUE FLUORESCENT ANTIBODY (19G2)-HEAVY CHAIN, BLUE FLUORESCENT ANTIBODY (19G2)-LIGHT CHAIN, 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
Authors:Stevens, R.C., Beuscher IV, A.E.
Deposit date:2000-08-11
Release date:2000-11-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Blue-fluorescent antibodies.
Science, 290, 2000
1HTZ
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CRYSTAL STRUCTURE OF TEM52 BETA-LACTAMASE
Descriptor:BETA-LACTAMASE MUTANT TEM52
Authors:Stevens, R.C., Orencia, M.C.
Deposit date:2001-01-03
Release date:2001-03-21
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Predicting the emergence of antibiotic resistance by directed evolution and structural analysis.
Nat.Struct.Biol., 8, 2001
1PAH
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HUMAN PHENYLALANINE HYDROXYLASE DIMER, RESIDUES 117-424
Descriptor:PHENYLALANINE HYDROXYLASE, FE (III) ION
Authors:Stevens, R.C., Erlandsen, H.
Deposit date:1997-10-25
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria.
Nat.Struct.Biol., 4, 1997
2NYY
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN TYPE A COMPLEXED WITH MONOCLONAL ANTIBODY CR1
Descriptor:Botulinum neurotoxin type A, CR1 monoclonal antibody, ZINC ION, ...
Authors:Stevens, R.C., Arndt, J.W.
Deposit date:2006-11-21
Release date:2006-12-26
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.
Nat.Biotechnol., 25, 2007
2NZ9
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN TYPE A COMPLEXED WITH MONOCLONAL ANTIBODY AR2
Descriptor:Botulinum neurotoxin type A, AR2 monoclonal antibody, ZINC ION, ...
Authors:Stevens, R.C., Arndt, J.W.
Deposit date:2006-11-22
Release date:2006-12-26
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (3.79 Å)
Cite:Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.
Nat.Biotechnol., 25, 2007
2PAH
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TETRAMERIC HUMAN PHENYLALANINE HYDROXYLASE
Descriptor:PROTEIN (PHENYLALANINE HYDROXYLASE), FE (III) ION
Authors:Stevens, R.C., Fusetti, F., Erlandsen, H.
Deposit date:1998-05-26
Release date:1999-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria.
J.Biol.Chem., 273, 1998
3BTA
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A
Descriptor:PROTEIN (BOTULINUM NEUROTOXIN TYPE A), ZINC ION
Authors:Stevens, R.C., Lacy, D.B.
Deposit date:1998-08-12
Release date:1999-10-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of botulinum neurotoxin type A and implications for toxicity.
Nat.Struct.Biol., 5, 1998
3CZO
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CRYSTAL STRUCTURE OF DOUBLE MUTANT PHENYLALANINE AMMONIA-LYASE FROM ANABAENA VARIABILIS
Descriptor:Histidine ammonia-lyase
Authors:Stevens, R.C., Wang, L.
Deposit date:2008-04-29
Release date:2008-05-20
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and biochemical characterization of the therapeutic Anabaena variabilis phenylalanine ammonia lyase.
J.Mol.Biol., 380, 2008
1AJ7
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IMMUNOGLOBULIN 48G7 GERMLINE FAB ANTIBODY COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY
Descriptor:IMMUNOGLOBULIN 48G7 FAB (LIGHT CHAIN), IMMUNOGLOBULIN 48G7 FAB (HEAVY CHAIN), 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID
Authors:Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C.
Deposit date:1997-05-15
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into the evolution of an antibody combining site.
Science, 276, 1997
2RCS
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IMMUNOGLOBULIN 48G7 GERMLINE FAB-AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY
Descriptor:IMMUNOGLOBULIN 48G7 GERMLINE FAB
Authors:Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C.
Deposit date:1997-05-14
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into the evolution of an antibody combining site.
Science, 276, 1997
7AT1
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CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Gouaux, J.E., Stevens, R.C., Lipscomb, W.N.
Deposit date:1989-09-22
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
8AT1
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CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Gouaux, J.E., Stevens, R.C., Lipscomb, W.N.
Deposit date:1989-09-22
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
1E74
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NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R11E
Descriptor:ALPHA-CONOTOXIN IM1(R11E)
Authors:Rogers, J.P., Luginbuhl, P., Pemberton, K., Harty, P., Wemmer, D.E., Stevens, R.C.
Deposit date:2000-08-24
Release date:2000-12-27
Last modified:2017-06-14
Method:SOLUTION NMR
Cite:Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist
J.Mol.Biol., 304, 2000
1E75
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NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R7L
Descriptor:ALPHA-CONOTOXIN IM1(R7L)
Authors:Rogers, J.P., Luginbuhl, P., Pemberton, K., Harty, P., Wemmer, D.E., Stevens, R.C.
Deposit date:2000-08-24
Release date:2000-12-27
Last modified:2017-06-14
Method:SOLUTION NMR
Cite:Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist
J.Mol.Biol., 304, 2000
1E76
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NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT D5N
Descriptor:ALPHA-CONOTOXIN IM1(D5N)
Authors:Rogers, J.P., Luginbuhl, P., Pemberton, K., Harty, P., Wemmer, D.E., Stevens, R.C.
Deposit date:2000-08-24
Release date:2000-12-27
Last modified:2017-06-14
Method:SOLUTION NMR
Cite:Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist
J.Mol.Biol., 304, 2000
1HKL
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FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY
Descriptor:48G7 FAB
Authors:Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C.
Deposit date:1996-12-20
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal structures of the free and liganded form of an esterolytic catalytic antibody.
J.Mol.Biol., 268, 1997
2RH1
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN B2-ADRENERGIC G PROTEIN-COUPLED RECEPTOR.
Descriptor:beta-2-adrenergic receptor/T4-lysozyme chimera, MALTOSE, SULFATE ION, ...
Authors:Cherezov, V., Rosenbaum, D.M., Hanson, M.A., Rasmussen, S.G.F., Thian, F.S., Kobilka, T.S., Choi, H.J., Kuhn, P., Weis, W.I., Kobilka, B.K., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2007-10-05
Release date:2007-10-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Science, 318, 2007
1A4J
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DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR
Descriptor:IMMUNOGLOBULIN, DIELS ALDER CATALYTIC ANTIBODY (LIGHT CHAIN), DIELS ALDER CATALYTIC ANTIBODY (HEAVY CHAIN)
Authors:Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C.
Deposit date:1998-01-30
Release date:1998-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science, 279, 1998
1A4K
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DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE
Descriptor:ANTIBODY FAB, CADMIUM ION, [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID
Authors:Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C.
Deposit date:1998-01-30
Release date:1998-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science, 279, 1998
1AXS
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MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN
Descriptor:OXY-COPE CATALYTIC ANTIBODY, CADMIUM ION, (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL
Authors:Mundorff, E.C., Ulrich, H.D., Stevens, R.C.
Deposit date:1997-10-20
Release date:1998-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The interplay between binding energy and catalysis in the evolution of a catalytic antibody.
Nature, 389, 1997