Author results

1TOF
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THIOREDOXIN H (OXIDIZED FORM), NMR, 23 STRUCTURES
Descriptor:THIOREDOXIN H
Authors:Mittard, V., Blackledge, M.J., Stein, M., Jacquot, J.-P., Marion, D., Lancelin, J.-M.
Deposit date:1996-05-30
Release date:1996-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR solution structure of an oxidised thioredoxin h from the eukaryotic green alga Chlamydomonas reinhardtii.
Eur.J.Biochem., 243, 1997
3OKJ
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ALPHA-KETO-ALDEHYDE BINDING MECHANISM REVEALS A NOVEL LEAD STRUCTURE MOTIF FOR PROTEASOME INHIBITION
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Poynor, M., Gallastegui, P., Stein, M., Schmidt, B., Kloetzel, P.M., Huber, R.
Deposit date:2010-08-25
Release date:2011-06-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition
Angew.Chem.Int.Ed.Engl., 50, 2011
3CWX
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CRYSTAL STRUCTURE OF CAGD FROM HELICOBACTER PYLORI PATHOGENICITY ISLAND
Descriptor:protein CagD
Authors:Cendron, L., Zanotti, G., Angelini, A., Barison, N., Couturier, M., Stein, M.
Deposit date:2008-04-23
Release date:2008-12-30
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Helicobacter pylori CagD (HP0545, Cag24) protein is essential for CagA translocation and maximal induction of interleukin-8 secretion.
J.Mol.Biol., 386, 2009
3CWY
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STRUCTURE OF CAGD FROM H. PYLORI PATHOGENICITY ISLAND CRYSTALLIZED IN THE PRESENCE OF CU(II) IONS
Descriptor:protein CagD, COPPER (II) ION
Authors:Cendron, L., Zanotti, G., Angelini, A., Barison, N., Couturier, M., Stein, M.
Deposit date:2008-04-23
Release date:2008-12-30
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Helicobacter pylori CagD (HP0545, Cag24) protein is essential for CagA translocation and maximal induction of interleukin-8 secretion.
J.Mol.Biol., 386, 2009
4FZC
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20S YEAST PROTEASOME IN COMPLEX WITH CEPAFUNGIN I
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Stein, M., Beck, P., Kaiser, M., Dudler, R., Becker, C.F.W., Groll, M.
Deposit date:2012-07-06
Release date:2012-10-24
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FZG
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20S YEAST PROTEASOME IN COMPLEX WITH GLIDOBACTIN
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Stein, M., Beck, P., Kaiser, M., Dudler, R., Becker, C.F.W., Groll, M.
Deposit date:2012-07-06
Release date:2012-10-24
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor.
Proc.Natl.Acad.Sci.USA, 109, 2012
4LTC
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH ENONE CARMAPHYCIN ANALOGUE 6
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M., Trivella, D.B.B., Groll, M.
Deposit date:2013-07-23
Release date:2014-07-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor.
Chem.Biol., 21, 2014
4HNP
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH VINYLKETONE CARMAPHYCIN ANALOGUE VNK1
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Trivella, D.B.B., Stein, M., Groll, M.
Deposit date:2012-10-20
Release date:2014-01-29
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor.
Chem.Biol., 21, 2014
4HRC
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH EPOXYKETONE CARMAPHYCIN ANALOGUE 3
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Trivella, D.B.B., Stein, M., Groll, M.
Deposit date:2012-10-27
Release date:2014-01-29
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor.
Chem.Biol., 21, 2014
4HRD
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH THE NATURAL PRODUCT CARMAPHYCIN A
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Trivella, D.B.B., Stein, M., Groll, M.
Deposit date:2012-10-27
Release date:2014-01-29
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor.
Chem.Biol., 21, 2014
4R02
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YCP IN COMPLEX WITH BSC4999 (ALPHA-KETO PHENYLAMIDE)
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Voss, C., Scholz, C., Knorr, S., Beck, P., Stein, M., Zall, A., Kuckelkorn, U., Kloetzel, P.-M., Groll, M., Hamacher, K., Schmidt, B.
Deposit date:2014-07-29
Release date:2014-08-13
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:alpha-Keto Phenylamides as P1'-Extended Proteasome Inhibitors.
Chemmedchem, 9, 2014
1DBY
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NMR STRUCTURES OF CHLOROPLAST THIOREDOXIN M CH2 FROM THE GREEN ALGA CHLAMYDOMONAS REINHARDTII
Descriptor:CHLOROPLAST THIOREDOXIN M CH2
Authors:Lancelin, J.-M., Guilhaudis, L., Krimm, I., Blackledge, M.J., Marion, D.
Deposit date:1999-11-03
Release date:1999-11-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structures of thioredoxin m from the green alga Chlamydomonas reinhardtii.
Proteins, 41, 2000
1FCT
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NMR STRUCTURES OF FERREDOXIN CHLOROPLASTIC TRANSIT PEPTIDE FROM CHLAMYDOMONAS REINHARDTII PROMOTED BY TRIFLUOROETHANOL IN AQUEOUS SOLUTION
Descriptor:FERREDOXIN CHLOROPLASTIC TRANSIT PEPTIDE SEQUENCE FROM THE GREEN ALGA
Authors:Lancelin, J.-M., Blackledge, M.
Deposit date:1994-03-30
Release date:1994-06-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structures of ferredoxin chloroplastic transit peptide from Chlamydomonas reinhardtii promoted by trifluoroethanol in aqueous solution.
FEBS Lett., 343, 1994
3IEC
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HELICOBACTER PYLORI CAGA INHIBITS PAR1/MARK FAMILY KINASES BY MIMICKING HOST SUBSTRATES
Descriptor:Serine/threonine-protein kinase MARK2, Cytotoxicity-associated immunodominant antigen
Authors:Stebbins, C.E., Nesic, D., Miller, M.
Deposit date:2009-07-22
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.
Nat.Struct.Mol.Biol., 17, 2010
1EP7
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CRYSTAL STRUCTURE OF WT THIOREDOXIN H FROM CHLAMYDOMONAS REINHARDTII
Descriptor:THIOREDOXIN CH1, H-TYPE
Authors:Menchise, V., Corbier, C., Didierjean, C., Saviano, M., Benedetti, E., Jacquot, J.P., Aubry, A.
Deposit date:2000-03-28
Release date:2001-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism.
Biochem.J., 359, 2001
1EP8
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CRYSTAL STRUCTURE OF A MUTATED THIOREDOXIN, D30A, FROM CHLAMYDOMONAS REINHARDTII
Descriptor:THIOREDOXIN CH1, H-TYPE
Authors:Menchise, V., Corbier, C., Didierjean, C., Saviano, M., Benedetti, E., Jacquot, J.P., Aubry, A.
Deposit date:2000-03-28
Release date:2001-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism.
Biochem.J., 359, 2001
1EAS
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NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OF ORALLY ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES
Descriptor:PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ...
Authors:Ceccarelli, C.
Deposit date:1994-11-22
Release date:1995-02-07
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
J.Med.Chem., 37, 1994
1EAT
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NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5-AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES
Descriptor:PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ...
Authors:Ceccarelli, C.
Deposit date:1994-11-22
Release date:1995-02-07
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.
J.Med.Chem., 38, 1995
1EAU
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NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 6. DESIGN OF A POTENT, INTRATRACHEALLY ACTIVE, PYRIDONE-BASED TRIFLUOROMETHYL KETONE
Descriptor:PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ...
Authors:Ceccarelli, C.
Deposit date:1994-11-22
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone.
J.Med.Chem., 38, 1995