Author results

1DM9
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HEAT SHOCK PROTEIN 15 KD
Descriptor:HYPOTHETICAL 15.5 KD PROTEIN IN MRCA-PCKA INTERGENIC REGION, SULFATE ION
Authors:Staker, B.L., Korber, P., Bardwell, J.C.A., Saper, M.A.
Deposit date:1999-12-14
Release date:2000-02-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Hsp15 reveals a novel RNA-binding motif.
EMBO J., 19, 2000
1K4S
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HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*(5IU)P*(5IU))-3', 5'-D(*(SPT)P*GP*AP*AP*AP*AP*AP*(5IU)P*(5IU)P*(5IU)P*(5IU)P*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*CP*AP*AP*AP*GP*(IDO)UP*CP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*T)-3', ...
Authors:Staker, B.L., Hjerrild, K., Feese, M.D., Behnke, C.A., Burgin Jr., A.B., Stewart, L.J.
Deposit date:2001-10-08
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99, 2002
1K4T
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
Authors:Staker, B.L., Hjerrild, K., Feese, M.D., Behnke, C.A., Burgin Jr., A.B., Stewart, L.J.
Deposit date:2001-10-08
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99, 2002
1SC7
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDENOISOQUINOLINE MJ-II-38 AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
Authors:Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Deposit date:2004-02-11
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
1SEU
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDOLOCARBAZOLE SA315F AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
Authors:Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Deposit date:2004-02-18
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
1T8I
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON CAMPTOTHECIN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
Authors:Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Deposit date:2004-05-12
Release date:2005-05-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
3I4E
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CRYSTAL STRUCTURE OF ISOCITRATE LYASE FROM BURKHOLDERIA PSEUDOMALLEI
Descriptor:Isocitrate lyase
Authors:Staker, B.L., Arakaki, T., Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-07-01
Release date:2009-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Crystal structure of Isocitrate Lyase from Burkholderia pseudomallei
To be Published
3IEW
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE FROM BURKHOLDERIA PSEUDOMALLEI WITH BOUND CTP AND CDP
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, CYTIDINE-5'-DIPHOSPHATE, ...
Authors:Staker, B.L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-07-23
Release date:2009-08-18
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
J Struct Funct Genomics, 12, 2011
3BL7
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG156844
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BL9
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG157493
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BLA
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG153249
Descriptor:Scavenger mRNA-decapping enzyme DcpS, 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
Authors:Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-12-10
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3G45
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4B WITH REGULATORY DOMAIN AND D155988
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4G
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH REGULATORY DOMAIN AND D155871
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4I
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4K
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4L
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-03
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G58
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155988/PMNPQ
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Staker, B.L.
Deposit date:2009-02-04
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3HZG
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE SYNTHASE X BOUND WITH FAD
Descriptor:Thymidylate synthase thyX, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Staker, B.L., Rathod, P., Hunter, J., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-06-23
Release date:2009-07-07
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
3IAD
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH BOUND ALLOSTERIC MODULATOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-{4-[(2-fluoro-6-methoxy-3'-nitrobiphenyl-3-yl)methyl]phenyl}urea, ZINC ION, ...
Authors:Staker, B.L., Burgin Jr., A.B.
Deposit date:2009-07-13
Release date:2010-01-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3IML
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE FROM BURKHOLDERIA PSEUDOMALLEI
Descriptor:S-adenosylmethionine synthetase
Authors:Staker, B.L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-08-10
Release date:2009-09-22
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
3L56
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CRYSTAL STRUCTURE OF THE LARGE C-TERMINAL DOMAIN OF POLYMERASE BASIC PROTEIN 2 FROM INFLUENZA VIRUS A/VIET NAM/1203/2004 (H5N1)
Descriptor:Polymerase PB2
Authors:Staker, B.L., Edwards, T., Eric, S., Raymond, A., Stewart, L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-12-21
Release date:2010-03-09
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
3GMT
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CRYSTAL STRUCTURE OF ADENYLATE KINASE FROM BURKHOLDERIA PSEUDOMALLEI
Descriptor:Adenylate kinase, SULFATE ION
Authors:Abendroth, J., Staker, B.L., Robinson, H., Buchko, G.W., Hewitt, S.N., Napuli, A.J., Van Voorhis, W., Stacy, R., Myler, P.J., Stewart, L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-03-15
Release date:2009-06-02
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state.
Biochem.Biophys.Res.Commun., 394, 2010
1EIZ
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FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE
Descriptor:FTSJ, S-ADENOSYLMETHIONINE
Authors:Bugl, H., Fauman, E.B., Staker, B.L., Zheng, F., Kushner, S.R., Saper, M.A., Bardwell, J.C.A., Jakob, U.
Deposit date:2000-02-29
Release date:2000-08-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:RNA methylation under heat shock control.
Mol.Cell, 6, 2000
1EJ0
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FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE, MERCURY DERIVATIVE
Descriptor:FTSJ, MERCURY (II) ION, S-ADENOSYLMETHIONINE
Authors:Bugl, H., Fauman, E.B., Staker, B.L., Zheng, F., Kushner, S.R., Saper, M.A., Bardwell, J.C.A., Jakob, U.
Deposit date:2000-02-29
Release date:2000-08-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:RNA methylation under heat shock control.
Mol.Cell, 6, 2000
1RR8
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STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ...
Authors:Chrencik, J.E., Staker, B.L., Burgin, A.B., Stewart, L., Redinbo, M.R.
Deposit date:2003-12-08
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004