Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
4PHU
DownloadVisualize
BU of 4phu by Molmil
Crystal structure of Human GPR40 bound to allosteric agonist TAK-875
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, DIMETHYL SULFOXIDE, Free fatty acid receptor 1,Lysozyme, ...
Authors:Srivastava, A, Yano, J.K, Hirozane, Y, Kefala, G, Snell, G, Lane, W, Gruswitz, F, Ivetac, A, Aertgeerts, K, Nguyen, J, Jennings, A, Okada, K.
Deposit date:2014-05-07
Release date:2014-07-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.332 Å)
Cite:High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
Nature, 513, 2014
6W3H
DownloadVisualize
BU of 6w3h by Molmil
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATV Fc, Transferrin receptor protein 1,Transferrin receptor protein 1
Authors:Srivastava, A, Kariolis, M, Wells, R.
Deposit date:2020-03-09
Release date:2020-06-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Sci Transl Med, 12, 2020
8DEG
DownloadVisualize
BU of 8deg by Molmil
Crystal structure of DLK in complex with inhibitor DN0011197
Descriptor: Mitogen-activated protein kinase kinase kinase 12, methyl (1S,4S)-5-{(4P)-4-[5-amino-6-(difluoromethoxy)pyrazin-2-yl]-6-[(1R,4R)-2-azabicyclo[2.1.1]hexan-2-yl]pyridin-2-yl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
Authors:Srivastava, A, Lexa, K, de Vicente, J.
Deposit date:2022-06-20
Release date:2022-12-14
Last modified:2023-01-04
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J.Med.Chem., 65, 2022
2VXY
DownloadVisualize
BU of 2vxy by Molmil
The structure of FTsZ from Bacillus subtilis at 1.7A resolution
Descriptor: CELL DIVISION PROTEIN FTSZ, CITRIC ACID, POTASSIUM ION
Authors:Barynin, V.V, Baker, P.J, Rice, D.W, Sedelnikova, S.E, Haydon, D.J, Stokes, N.R, Ure, R, Galbraith, G, Bennett, J.M, Brown, D.R, Heal, J.R, Sheridan, J.M, Aiwale, S.T, Chauhan, P.K, Srivastava, A, Taneja, A, Collins, I, Errington, J, Czaplewski, L.G.
Deposit date:2008-07-15
Release date:2008-09-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:An Inhibitor of Ftsz with Potent and Selective Anti-Staphylococcal Activity.
Science, 321, 2008
1SFY
DownloadVisualize
BU of 1sfy by Molmil
Crystal structure of recombinant Erythrina corallodandron Lectin
Descriptor: CALCIUM ION, Lectin, MANGANESE (II) ION, ...
Authors:Kulkarni, K.A, Srivastava, A, Mitra, N, Surolia, A, Vijayan, M, Suguna, K.
Deposit date:2004-02-21
Release date:2004-08-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Effect of glycosylation on the structure of Erythrina corallodendron lectin.
Proteins, 56, 2004
4DPM
DownloadVisualize
BU of 4dpm by Molmil
Structure of malonyl-coenzyme A reductase from crenarchaeota in complex with CoA
Descriptor: COENZYME A, MAGNESIUM ION, Malonyl-CoA/succinyl-CoA reductase
Authors:Demmer, U, Warkentin, E, Srivastava, A, Kockelkorn, D, Fuchs, G, Ermler, U.
Deposit date:2012-02-13
Release date:2012-12-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for a Bispecific NADP+ and CoA Binding Site in an Archaeal Malonyl-Coenzyme A Reductase.
J.Biol.Chem., 288, 2013
4DPK
DownloadVisualize
BU of 4dpk by Molmil
Structure of malonyl-coenzyme A reductase from crenarchaeota
Descriptor: Malonyl-CoA/succinyl-CoA reductase, PHOSPHATE ION
Authors:Demmer, U, Warkentin, E, Srivastava, A, Kockelkorn, D, Fuchs, G, Ermler, U.
Deposit date:2012-02-13
Release date:2012-12-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis for a Bispecific NADP+ and CoA Binding Site in an Archaeal Malonyl-Coenzyme A Reductase.
J.Biol.Chem., 288, 2013
4DPL
DownloadVisualize
BU of 4dpl by Molmil
Structure of malonyl-coenzyme A reductase from crenarchaeota in complex with NadP
Descriptor: Malonyl-CoA/succinyl-CoA reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, UNKNOWN LIGAND
Authors:Demmer, U, Warkentin, E, Srivastava, A, Kockelkorn, D, Fuchs, G, Ermler, U.
Deposit date:2012-02-13
Release date:2013-01-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for a Bispecific NADP+ and CoA Binding Site in an Archaeal Malonyl-Coenzyme A Reductase.
J.Biol.Chem., 288, 2013
6K8Q
DownloadVisualize
BU of 6k8q by Molmil
Solution structure of the intermembrane space domain of the mitochondrial import protein Tim21 from S. cerevisiae
Descriptor: Mitochondrial import inner membrane translocase subunit TIM21
Authors:Bala, S, Shinya, S, Srivastava, A, Shimada, A, Kobayashi, N, Kojima, C, Tama, F, Miyashita, O, Kohda, D.
Deposit date:2019-06-13
Release date:2019-09-11
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study.
Biochim Biophys Acta Gen Subj, 1864, 2020
4P1T
DownloadVisualize
BU of 4p1t by Molmil
Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum
Descriptor: Erythrocyte membrane protein 1
Authors:Gangnard, S, Dechavanne, S, Srivastava, A, Amirat, F, Gamain, B, Lewit-Bentley, A, Bentley, G.A.
Deposit date:2014-02-27
Release date:2015-03-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the DBL3X-DBL4 epsilon region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions.
Sci Rep, 5, 2015
4UVE
DownloadVisualize
BU of 4uve by Molmil
Discovery of pyrimidine isoxazoles InhA in complex with compound 9
Descriptor: 2-(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFANYLETHANOL, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], MAGNESIUM ION, ...
Authors:Read, J.A, Gingell, H, Madhavapeddi, P, Ghorpade, S, Cowan, S.
Deposit date:2014-08-05
Release date:2015-09-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Hitting the Target in More Than One Way: Novel, Direct Inhibitors of Mycobacterium Tuberculosis Enoyl Acp Reductase
To be Published
4UVH
DownloadVisualize
BU of 4uvh by Molmil
Discovery of pyrimidine isoxazoles InhA in complex with compound 10
Descriptor: ACETATE ION, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], N-(1,3-BENZOTHIAZOL-2-YL)ACETAMIDE, ...
Authors:Read, J.A, Gingell, H, Madhavapeddi, P, Ghorpade, S, Cowan, S.
Deposit date:2014-08-05
Release date:2015-09-30
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Hitting the Target in More Than One Way: Novel, Direct Inhibitors of Mycobacterium Tuberculosis Enoyl Acp Reductase
To be Published
4UVG
DownloadVisualize
BU of 4uvg by Molmil
Discovery of pyrimidine isoxazoles InhA in complex with compound 15
Descriptor: 5-[(4,6-dimethylpyrimidin-2-yl)sulfanylmethyl]isoxazole-3-carboxamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], MAGNESIUM ION, ...
Authors:Read, J.A, Gingell, H, Madhavapeddi, P, Ghorpade, S, Cowan, S.
Deposit date:2014-08-05
Release date:2015-09-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Hitting the Target in More Than One Way: Novel, Direct Inhibitors of Mycobacterium Tuberculosis Enoyl Acp Reductase
To be Published
4UVI
DownloadVisualize
BU of 4uvi by Molmil
Discovery of pyrimidine isoxazoles InhA in complex with compound 23
Descriptor: 5-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]methyl}-N-[(2-methylpyridin-4-yl)methyl]-1,2-oxazole-3-carboxamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Read, J.A, Gingell, H, Madhavapeddi, P, Ghorpade, S, Cowan, S.
Deposit date:2014-08-05
Release date:2015-09-30
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Hitting the Target in More Than One Way: Novel, Direct Inhibitors of Mycobacterium Tuberculosis Enoyl Acp Reductase
To be Published
4UVD
DownloadVisualize
BU of 4uvd by Molmil
Discovery of pyrimidine isoxazoles InhA in complex with compound 6
Descriptor: 2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-N-[(2Z)-5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2(3H)-ylidene]acetamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], MAGNESIUM ION, ...
Authors:Read, J.A, Gingell, H, Madhavapeddi, P, Ghorpade, S, Cowan, S.
Deposit date:2014-08-05
Release date:2015-09-30
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Hitting the Target in More Than One Way: Novel, Direct Inhibitors of Mycobacterium Tuberculosis Enoyl Acp Reductase
To be Published
4RA6
DownloadVisualize
BU of 4ra6 by Molmil
Crystal structure of linker less Pyrococcus furiosus L-asparaginase
Descriptor: GLYCEROL, L-asparaginase
Authors:Sharma, P, Tomar, R, Ashish, Kundu, B.
Deposit date:2014-09-09
Release date:2014-12-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains.
Acta Crystallogr.,Sect.D, 70, 2014
6FBV
DownloadVisualize
BU of 6fbv by Molmil
Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Das, K, Lin, W, Ebright, E.
Deposit date:2017-12-19
Release date:2018-02-28
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Mol. Cell, 70, 2018
3EOZ
DownloadVisualize
BU of 3eoz by Molmil
Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w
Descriptor: GLYCEROL, PHOSPHATE ION, putative Phosphoglycerate mutase
Authors:Wernimont, A.K, Tempel, W, Lam, A, Zhao, Y, Lew, J, Lin, Y.H, Wasney, G, Vedadi, M, Kozieradzki, I, Cossar, D, Schapira, M, Weigelt, J, Arrowsmith, C.H, Bochkarev, A, Edwards, A.M, Hui, R, Pizarro, J, Hills, T, Structural Genomics Consortium (SGC)
Deposit date:2008-09-29
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Characterization of a new phosphatase from Plasmodium.
Mol.Biochem.Parasitol., 179, 2011
3D8H
DownloadVisualize
BU of 3d8h by Molmil
Crystal structure of phosphoglycerate mutase from Cryptosporidium parvum, cgd7_4270
Descriptor: Glycolytic phosphoglycerate mutase
Authors:Wernimont, A.K, Lew, J, Wasney, G, Alam, Z, Kozieradzki, I, Cossar, D, Schapiro, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Wilkstrom, M, Edwards, A.M, Hui, R, Artz, J.D, Hills, T, Structural Genomics Consortium (SGC)
Deposit date:2008-05-23
Release date:2008-07-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Characterization of a new phosphatase from Plasmodium.
Mol.Biochem.Parasitol., 179, 2011
6VQF
DownloadVisualize
BU of 6vqf by Molmil
CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244- 487)-L6-SRC1(678-692)) IN COMPLEX WITH AN INVERSE AGONIST
Descriptor: (1R,3S,4R)-4-[(3aR,9bR)-9b-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonyl]-3-methylcyclohexane-1-carboxylic acid, GLYCEROL, Nuclear receptor ROR-gamma
Authors:Sack, J.S.
Deposit date:2020-02-05
Release date:2020-04-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR gamma t Inverse Agonist.
Acs Med.Chem.Lett., 11, 2020
7D1C
DownloadVisualize
BU of 7d1c by Molmil
Crystal structure of mouse Cryptochrome 1 in complex with compound TH303
Descriptor: Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide
Authors:Miller, S.A, Hirota, T.
Deposit date:2020-09-14
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock.
J.Am.Chem.Soc., 143, 2021
7D19
DownloadVisualize
BU of 7d19 by Molmil
Crystal structure of mouse Cryptochrome 1 in complex with compound TH129
Descriptor: Cryptochrome-1, N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide
Authors:Miller, S.A, Hirota, T.
Deposit date:2020-09-14
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock.
J.Am.Chem.Soc., 143, 2021
6OF7
DownloadVisualize
BU of 6of7 by Molmil
Crystal structure of the CRY1-PER2 complex
Descriptor: Cryptochrome-1, Period circadian protein homolog 2
Authors:Michael, A.K, Fribourgh, J.L, Tripathi, S.M, Partch, C.L.
Deposit date:2019-03-28
Release date:2020-03-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing.
Elife, 9, 2020
6KX8
DownloadVisualize
BU of 6kx8 by Molmil
Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound
Descriptor: 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-2
Authors:Miller, S.A, Aikawa, Y, Hirota, T.
Deposit date:2019-09-10
Release date:2020-04-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Isoform-selective regulation of mammalian cryptochromes.
Nat.Chem.Biol., 16, 2020
6KX7
DownloadVisualize
BU of 6kx7 by Molmil
Crystal structure of mouse Cryptochrome 1 in complex with TH301 compound
Descriptor: 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-1
Authors:Miller, S.A, Aikawa, Y, Hirota, T.
Deposit date:2019-09-10
Release date:2020-04-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Isoform-selective regulation of mammalian cryptochromes.
Nat.Chem.Biol., 16, 2020

 

12>

217157

PDB entries from 2024-03-13

PDB statisticsPDBj update infoContact PDBjnumon