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3ZKR
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BU of 3zkr by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoform
Descriptor: CYS-LOOP LIGAND-GATED ION CHANNEL, TRIBROMOMETHANE
Authors:Spurny, R, Billen, B, Howard, R.J, Brams, M, Debaveye, S, Price, K.L, Weston, D.A, Strelkov, S.V, Tytgat, J, Bertrand, S, Bertrand, D, Lummis, S.C.R, Ulens, C.
Deposit date:2013-01-24
Release date:2013-02-06
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (3.649 Å)
Cite:Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia Chrysanthemi Ligand-Gated Ion Channel (Elic).
J.Biol.Chem., 288, 2013
5MQC
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BU of 5mqc by Molmil
Structure of black queen cell virus
Descriptor: VP1, VP2, VP3
Authors:Spurny, R, Kiem, H.H.T, Plevka, P.
Deposit date:2016-12-20
Release date:2017-01-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Virion Structure of Black Queen Cell Virus, a Common Honeybee Pathogen.
J. Virol., 91, 2017
2YOE
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BU of 2yoe by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with GABA and flurazepam
Descriptor: CYS-LOOP LIGAND-GATED ION CHANNEL, Flurazepam, GAMMA-AMINO-BUTANOIC ACID
Authors:Spurny, R, Brams, M, Nury, H, Legrand, P, Ulens, C.
Deposit date:2012-10-23
Release date:2012-10-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Pentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines.
Proc.Natl.Acad.Sci.USA, 109, 2012
5AFH
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BU of 5afh by Molmil
alpha7-AChBP in complex with lobeline
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7, ...
Authors:Spurny, R, Debaveye, S, Farinha, A, Veys, K, Gossas, T, Atack, J, Bertrand, D, Kemp, J, Vos, A, Danielson, U.H, Tresadern, G, Ulens, C.
Deposit date:2015-01-22
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.
Proc.Natl.Acad.Sci.USA, 112, 2015
5AFL
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BU of 5afl by Molmil
alpha7-AChBP in complex with lobeline and fragment 3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7, ...
Authors:Spurny, R, Debaveye, S, Farinha, A, Veys, K, Gossas, T, Atack, J, Bertrand, D, Kemp, J, Vos, A, Danielson, U.H, Tresadern, G, Ulens, C.
Deposit date:2015-01-22
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.385 Å)
Cite:Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.
Proc.Natl.Acad.Sci.USA, 112, 2015
5AFK
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BU of 5afk by Molmil
alpha7-AChBP in complex with lobeline and fragment 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7, ...
Authors:Spurny, R, Debaveye, S, Farinha, A, Veys, K, Gossas, T, Atack, J, Bertrand, D, Kemp, J, Vos, A, Danielson, U.H, Tresadern, G, Ulens, C.
Deposit date:2015-01-22
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.381 Å)
Cite:Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.
Proc.Natl.Acad.Sci.USA, 112, 2015
5AFN
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BU of 5afn by Molmil
alpha7-AChBP in complex with lobeline and fragment 5
Descriptor: (4R)-4-(2-phenylethyl)pyrrolidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE-BINDING PROTEIN, ...
Authors:Spurny, R, Debaveye, S, Farinha, A, Veys, K, Gossas, T, Atack, J, Bertrand, D, Kemp, J, Vos, A, Danielson, U.H, Tresadern, G, Ulens, C.
Deposit date:2015-01-22
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.149 Å)
Cite:Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.
Proc.Natl.Acad.Sci.USA, 112, 2015
5AFJ
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BU of 5afj by Molmil
alpha7-AChBP in complex with lobeline and fragment 1
Descriptor: (3S)-6-(4-bromophenyl)-3-hydroxy-1,3-dimethyl-2,3-dihydropyridin-4(1H)-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE-BINDING PROTEIN, ...
Authors:Spurny, R, Debaveye, S, Farinha, A, Veys, K, Gossas, T, Atack, J, Bertrand, D, Kemp, J, Vos, A, Danielson, U.H, Tresadern, G, Ulens, C.
Deposit date:2015-01-22
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.
Proc.Natl.Acad.Sci.USA, 112, 2015
5AFM
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BU of 5afm by Molmil
alpha7-AChBP in complex with lobeline and fragment 4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,5-dibromo-N-(3-hydroxypropyl)-1H-pyrrole-2-carboxamide, ACETYLCHOLINE-BINDING PROTEIN, ...
Authors:Spurny, R, Debaveye, S, Farinha, A, Veys, K, Gossas, T, Atack, J, Bertrand, D, Kemp, J, Vos, A, Danielson, U.H, Tresadern, G, Ulens, C.
Deposit date:2015-01-22
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.
Proc.Natl.Acad.Sci.USA, 112, 2015
4A98
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BU of 4a98 by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoflurazepam
Descriptor: 7-BROMO-1-[2-(DIETHYLAMINO)ETHYL]-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, CYS-LOOP LIGAND-GATED ION CHANNEL
Authors:Spurny, R, Brams, M, Nury, H, Legrand, P, Ulens, C.
Deposit date:2011-11-24
Release date:2012-10-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.61 Å)
Cite:Pentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines.
Proc.Natl.Acad.Sci.USA, 109, 2012
4A97
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BU of 4a97 by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with zopiclone
Descriptor: (5R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate, CYS-LOOP LIGAND-GATED ION CHANNEL
Authors:Spurny, R, Brams, M, Ulens, C.
Deposit date:2011-11-24
Release date:2012-10-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.343 Å)
Cite:Pentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines.
Proc.Natl.Acad.Sci.USA, 109, 2012
6HJX
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BU of 6hjx by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cys-loop ligand-gated ion channel, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C.
Deposit date:2018-09-04
Release date:2019-10-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6HJY
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BU of 6hjy by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72
Descriptor: Cys-loop ligand-gated ion channel, nanobody 72
Authors:Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C.
Deposit date:2018-09-04
Release date:2019-10-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6SSP
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BU of 6ssp by Molmil
Structure of the pentameric ligand-gated ion channel ELIC in complex with a NAM nanobody
Descriptor: CALCIUM ION, Cys-loop ligand-gated ion channel, NANOBODY 21, ...
Authors:Ulens, C, Brams, M, Evans, G.L, Spurny, R, Govaerts, C, Pardon, E, Steyaert, J.
Deposit date:2019-09-09
Release date:2020-02-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT 3 receptor via a common vestibule site.
Elife, 9, 2020
6SSI
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BU of 6ssi by Molmil
Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, CALCIUM ION, ...
Authors:Ulens, C, Brams, M, Evans, G.L, Spurny, R, Govaerts, C, Pardon, E, Steyaert, J.
Deposit date:2019-09-07
Release date:2020-02-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT 3 receptor via a common vestibule site.
Elife, 9, 2020
2YME
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BU of 2yme by Molmil
Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with granisetron
Descriptor: 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, ...
Authors:Kesters, D, Thompson, A.J, Brams, M, Elk, R.v, Spurny, R, Geitmann, M, Villalgordo, J.M, Guskov, A, Danielson, U.H, Lummis, S.C.R, Smit, A.B, Ulens, C.
Deposit date:2012-10-09
Release date:2012-12-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Ligand Recognition in 5-Ht3 Receptors.
Embo Rep., 14, 2013
2YMD
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BU of 2ymd by Molmil
Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with serotonin (5-hydroxytryptamine)
Descriptor: GLYCEROL, PHOSPHATE ION, SEROTONIN, ...
Authors:Kesters, D, Thompson, A.J, Brams, M, Elk, R.v, Spurny, R, Geitmann, M, Villalgordo, J.M, Guskov, A, Danielson, U.H, Lummis, S.C.R, Smit, A.B, Ulens, C.
Deposit date:2012-10-09
Release date:2012-12-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural Basis of Ligand Recognition in 5-Ht(3) Receptors.
Embo Rep., 14, 2013
4TWH
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BU of 4twh by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) mutant F16'S
Descriptor: Cys-loop ligand-gated ion channel
Authors:Ulens, C, Spurny, R, Thompson, A.J, Alqazzaz, M, Debaveye, S, Lu, H, Price, K, Villalgordo, J.M, Tresadern, G, Lynch, J.W, Lummis, S.C.R.
Deposit date:2014-06-30
Release date:2014-09-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine.
Structure, 22, 2014
4TWD
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BU of 4twd by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with memantine
Descriptor: Cys-loop ligand-gated ion channel, Memantine
Authors:Ulens, C, Spurny, R, Thompson, A.J, Alqazzaz, M, Debaveye, S, Lu, H, Price, K, Villalgordo, J.M, Tresadern, G, Lynch, J.W, Lummis, S.C.R.
Deposit date:2014-06-30
Release date:2014-09-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine.
Structure, 22, 2014
4TWF
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BU of 4twf by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromomemantine
Descriptor: Bromomemantine, Cys-loop ligand-gated ion channel
Authors:Ulens, C, Spurny, R, Thompson, A.J, Alqazzaz, M, Debaveye, S, Lu, H, Price, K, Villalgordo, J.M, Tresadern, G, Lynch, J.W, Lummis, S.C.R.
Deposit date:2014-06-30
Release date:2014-09-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.901 Å)
Cite:The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine.
Structure, 22, 2014
5LG3
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BU of 5lg3 by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with chlorpromazine
Descriptor: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, Gamma-aminobutyric-acid receptor subunit beta-1
Authors:Nys, M, Wijckmans, E, Farinha, A, Brams, M, Spurny, R, Ulens, C.
Deposit date:2016-07-05
Release date:2016-10-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.567 Å)
Cite:Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.
Proc.Natl.Acad.Sci.USA, 113, 2016
5LID
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BU of 5lid by Molmil
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromopromazine
Descriptor: Cys-loop ligand-gated ion channel, bromopromazine
Authors:Nys, M, Wijckmans, E, Farinha, A, Brams, M, Spurny, R, Ulens, C.
Deposit date:2016-07-14
Release date:2016-10-26
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.
Proc.Natl.Acad.Sci.USA, 113, 2016
7QVY
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BU of 7qvy by Molmil
Cryo-EM structure of coxsackievirus A6 empty particle
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Buttner, C.R, Spurny, R, Fuzik, T, Plevka, P.
Deposit date:2022-01-24
Release date:2022-09-07
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Cryo-electron microscopy and image classification reveal the existence and structure of the coxsackievirus A6 virion.
Commun Biol, 5, 2022
7QW9
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BU of 7qw9 by Molmil
Cryo-EM structure of coxsackievirus A6 mature virion
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ...
Authors:Buttner, C.R, Spurny, R, Fuzik, T, Plevka, P.
Deposit date:2022-01-25
Release date:2022-09-07
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-electron microscopy and image classification reveal the existence and structure of the coxsackievirus A6 virion.
Commun Biol, 5, 2022
7QVX
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BU of 7qvx by Molmil
Cryo-EM structure of coxsackievirus A6 altered particle
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Buttner, C.R, Spurny, R, Fuzik, T, Plevka, P.
Deposit date:2022-01-24
Release date:2022-09-07
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-electron microscopy and image classification reveal the existence and structure of the coxsackievirus A6 virion.
Commun Biol, 5, 2022

 

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