6Q3K
 
 | | Engineered Human HLA_A2 MHC Class I molecule in complex with NV9 peptide | | Descriptor: | ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, COBALT (II) ION, ... | | Authors: | Meijers, R, Anjanappa, R, Springer, S, Garcia-Alai, M. | | Deposit date: | 2018-12-04 | | Release date: | 2019-07-24 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Engineered Human HLA_A2MHC Class I molecule in complex with NV9 peptide
Sci Immunol, 2019
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6Q3S
 | | Engineered Human HLA_A2 MHC Class I molecule in complex with TCR and SV9 peptide | | Descriptor: | ACETATE ION, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Meijers, R, Anjanappa, R, Springer, S, Garcia-Alai, M. | | Deposit date: | 2018-12-04 | | Release date: | 2019-07-24 | | Last modified: | 2021-02-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules.
Sci Immunol, 4, 2019
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6TDP
 | | Crystal structure of the disulfide engineered HLA-A0201 molecule in complex with one GL dipeptide in the A pocket. | | Descriptor: | Beta-2-microglobulin, GLYCEROL, GLYCINE, ... | | Authors: | Anjanappa, R, Garcia Alai, M, Springer, S, Meijers, R. | | Deposit date: | 2019-11-10 | | Release date: | 2020-03-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection.
Nat Commun, 11, 2020
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6TDR
 | | Crystal structure of the disulfide engineered HLA-A0201 molecule devoid of peptide (annealed) | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, MHC class I antigen, ... | | Authors: | Anjanappa, R, Garcia Alai, M, Springer, S, Meijers, R. | | Deposit date: | 2019-11-10 | | Release date: | 2020-03-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection.
Nat Commun, 11, 2020
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6TDO
 | | Crystal structure of the disulfide engineered HLA-A0201 molecule in complex with one GM dipeptide in the A pocket. | | Descriptor: | Beta-2-microglobulin, GLYCEROL, GLYCINE, ... | | Authors: | Anjanappa, R, Garcia Alai, M, Springer, S, Meijers, R. | | Deposit date: | 2019-11-09 | | Release date: | 2020-03-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection.
Nat Commun, 11, 2020
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6TDQ
 | | Crystal structure of the disulfide engineered HLA-A0201 molecule in complex with one GM dipeptide in the A pocket and one GM dipeptide in the F pocket. | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ... | | Authors: | Anjanappa, R, Garcia Alai, M, Springer, S, Meijers, R. | | Deposit date: | 2019-11-10 | | Release date: | 2020-03-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection.
Nat Commun, 11, 2020
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6TDS
 | | Crystal structure of the disulfide engineered HLA-A0201 molecule without peptide bound after NaCl wash | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ... | | Authors: | Anjanappa, R, Garcia Alai, M, Springer, S, Meijers, R. | | Deposit date: | 2019-11-10 | | Release date: | 2020-03-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection.
Nat Commun, 11, 2020
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4HS3
 | | Crystal structure of H-2Kb with a disulfide stabilized F pocket in complex with the LCMV derived peptide GP34 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-2-microglobulin, Envelope glycoprotein, ... | | Authors: | Uchtenhagen, H, Boulanger, B, Hein, Z, Abualrous, E.T, Zacharias, M, Werner, J, Elliott, T, Springer, S, Achour, A. | | Deposit date: | 2012-10-29 | | Release date: | 2014-05-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Peptide-independent stabilization of MHC class I molecules breaches cellular quality control.
J.Cell.Sci., 127, 2014
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6GB5
 | | Structure of H-2Db with truncated SEV peptide and GL | | Descriptor: | Beta-2-microglobulin, GLY-LEU, GLYCEROL, ... | | Authors: | Hafstrand, I, Sandalova, T, Achour, A. | | Deposit date: | 2018-04-13 | | Release date: | 2019-03-06 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6GB7
 | | Structure of H-2Db with scoop loop from tapasin | | Descriptor: | Beta-2-microglobulin, GLY-GLY-LEU-SER, GLYCEROL, ... | | Authors: | Hafstrand, I, Sandalova, T, Achour, A. | | Deposit date: | 2018-04-13 | | Release date: | 2019-03-06 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6GB6
 | | Structure of H-2Kb with dipeptide GL | | Descriptor: | Beta-2-microglobulin, GLYCEROL, GLYCINE, ... | | Authors: | Hafstrand, I, Sandalova, T, Achour, A. | | Deposit date: | 2018-04-13 | | Release date: | 2019-03-06 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7P49
 | | HLA-E*01:03 in complex with Mtb14 | | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | | Authors: | Walters, L.C, Gillespie, G.M. | | Deposit date: | 2021-07-10 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.
Cell Rep, 39, 2022
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7P4B
 | | HLA-E*01:03 in complex with IL9 | | Descriptor: | Beta-2-microglobulin, ESAT-6-like protein EsxH, GLYCEROL, ... | | Authors: | Walters, L.C, Gillespie, G.M. | | Deposit date: | 2021-07-10 | | Release date: | 2022-07-27 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.
Cell Rep, 39, 2022
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1QLF
 | | MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, HUMAN BETA-2-MICROGLOBULIN, ... | | Authors: | Tormo, J, Jones, E.Y. | | Deposit date: | 1999-08-30 | | Release date: | 1999-09-01 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Crystal Structures of Two H-2Db/Glycopeptide Complexes Suggest a Molecular Basis for Ctl Cross-Reactivity
Immunity, 10, 1999
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1CE6
 | | MHC CLASS I H-2DB COMPLEXED WITH A SENDAI VIRUS NUCLEOPROTEIN PEPTIDE | | Descriptor: | PROTEIN (HUMAN BETA-2 MICROGLOBULIN), PROTEIN (MHC CLASS I H-2DB HEAVY CHAIN), PROTEIN (SENDAI VIRUS NUCLEOPROTEIN), ... | | Authors: | Tormo, J, Jones, E.Y. | | Deposit date: | 1999-03-17 | | Release date: | 1999-03-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.
Immunity, 10, 1999
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4IHO
 | | Crystal structure of H-2Db Y159F in complex with chimeric gp100 | | Descriptor: | Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... | | Authors: | Uchtenhagen, H, Stahl, E, Achour, A. | | Deposit date: | 2012-12-19 | | Release date: | 2013-09-11 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Proline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptides
Eur.J.Immunol., 43, 2013
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