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1IAP
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CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN
Descriptor:GUANINE NUCLEOTIDE EXCHANGE FACTOR P115RHOGEF
Authors:Sprang, S.R., Chen, Z.
Deposit date:2001-03-22
Release date:2001-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the rgRGS domain of p115RhoGEF.
Nat.Struct.Biol., 8, 2001
3CX6
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CRYSTAL STRUCTURE OF PDZRHOGEF RGRGS DOMAIN IN A COMPLEX WITH GALPHA-13 BOUND TO GDP
Descriptor:Guanine nucleotide-binding protein alpha-13 subunit, Rho guanine nucleotide exchange factor 11, MAGNESIUM ION, ...
Authors:Sprang, S.R., Chen, Z.
Deposit date:2008-04-23
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF.
Structure, 16, 2008
3CX7
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CRYSTAL STRUCTURE OF PDZRHOGEF RGRGS DOMAIN IN A COMPLEX WITH GALPHA-13 BOUND TO GDP-ALF4
Descriptor:Guanine Nucleotide-Binding Protein Galpha 13, Glutamate Transporter Associated Protein 48, MAGNESIUM ION, ...
Authors:Sprang, S.R., Chen, Z.
Deposit date:2008-04-23
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF.
Structure, 16, 2008
3CX8
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CRYSTAL STRUCTURE OF PDZRHOGEF RGRGS DOMAIN IN A COMPLEX WITH GALPHA-13 BOUND TO GTP-GAMMA-S
Descriptor:Guanine nucleotide-binding protein alpha-13 subunit, Rho guanine nucleotide exchange factor 11, MAGNESIUM ION, ...
Authors:Sprang, S.R., Chen, Z.
Deposit date:2008-04-23
Release date:2008-10-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF.
Structure, 16, 2008
1BOF
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GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
Descriptor:GI ALPHA 1, SULFATE ION, MAGNESIUM ION, ...
Authors:Coleman, D.E., Sprang, S.R.
Deposit date:1998-08-04
Release date:1999-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment.
Biochemistry, 37, 1998
1GIT
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STRUCTURE OF GTP-BINDING PROTEIN
Descriptor:G PROTEIN GI ALPHA 1, PHOSPHATE ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Berghuis, A.M., Lee, E., Sprang, S.R.
Deposit date:1996-10-16
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis.
Structure, 4, 1996
1EXT
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EXTRACELLULAR DOMAIN OF THE 55KDA TUMOR NECROSIS FACTOR RECEPTOR. CRYSTALLIZED AT PH3.7 IN P 21 21 21.
Descriptor:TUMOR NECROSIS FACTOR RECEPTOR, SULFATE ION, MAGNESIUM ION
Authors:Naismith, J.H., Sprang, S.R.
Deposit date:1996-07-03
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of the extracellular domain of the type I tumor necrosis factor receptor.
Structure, 4, 1996
1GDD
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TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS
Descriptor:GI ALPHA 1, SULFATE ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Mixon, M.B., Sprang, S.R.
Deposit date:1995-07-25
Release date:1995-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis.
Science, 270, 1995
1CJK
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5'-(ALPHA THIO)-TRIPHOSPHATE (RP), MG, AND MN
Descriptor:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1999-04-16
Release date:1999-08-31
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJT
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG
Descriptor:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1999-04-16
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJU
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG
Descriptor:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1999-04-16
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJV
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MG, AND ZN
Descriptor:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1999-04-19
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CS4
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG
Descriptor:TYPE V ADENYLATE CYCLASE, TYPE II ADENYLATE CYCLASE, GUANINE NUCLEOTIDE-BINDING PROTEIN G(S), ...
Authors:Tesmer, J.J.G., Dessauer, C.A., Sunahara, R.K., Johnson, R.A., Gilman, A.G., Sprang, S.R.
Deposit date:1999-08-16
Release date:2001-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
1GFI
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STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G, MAGNESIUM ION, TETRAFLUOROALUMINATE ION, ...
Authors:Coleman, D.E., Berghuis, A.M., Sprang, S.R.
Deposit date:1994-11-11
Release date:1995-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIA
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STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:G PROTEIN GI ALPHA 1, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Berghuis, A.M., Coleman, D.E., Sprang, S.R.
Deposit date:1994-07-20
Release date:1994-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIL
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STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:G PROTEIN GI ALPHA 1, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Coleman, D.E., Berghuis, A.M., Sprang, S.R.
Deposit date:1995-01-02
Release date:1995-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1NCF
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A NEW PARADIGM FOR TUMOR NECROSIS FACTOR SIGNALLING
Descriptor:TUMOR NECROSIS FACTOR RECEPTOR
Authors:Naismith, J.H., Sprang, S.R.
Deposit date:1994-10-12
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor.
J.Biol.Chem., 270, 1995
1TNF
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THE STRUCTURE OF TUMOR NECROSIS FACTOR-ALPHA AT 2.6 ANGSTROMS RESOLUTION. IMPLICATIONS FOR RECEPTOR BINDING
Descriptor:TUMOR NECROSIS FACTOR-ALPHA
Authors:Eck, M.J., Sprang, S.R.
Deposit date:1989-08-25
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
J.Biol.Chem., 264, 1989
1XHM
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THE CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE PEPTIDE (SIGK) BOUND TO A G PROTEIN BETA:GAMMA HETERODIMER
Descriptor:Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, SIGK Peptide
Authors:Davis, T.L., Bonacci, T.M., Smrcka, A.V., Sprang, S.R.
Deposit date:2004-09-20
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Molecular Characterization of a Preferred Protein Interaction Surface on G Protein betagamma Subunits.
Biochemistry, 44, 2005
5I56
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AGONIST-BOUND GLUN1/GLUN2A AGONIST BINDING DOMAINS WITH TCN201
Descriptor:Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1, ...
Authors:Mou, T.-C., Sprang, S.R., Hansen, K.B.
Deposit date:2016-02-14
Release date:2016-09-07
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
1A25
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C2 DOMAIN FROM PROTEIN KINASE C (BETA)
Descriptor:PROTEIN KINASE C (BETA), CALCIUM ION, O-PHOSPHOETHANOLAMINE
Authors:Sutton, R.B., Sprang, S.R.
Deposit date:1998-01-16
Release date:1998-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
Structure, 6, 1998
1AGR
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COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), RGS4, MAGNESIUM ION, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1997-03-25
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
Cell(Cambridge,Mass.), 89, 1997
1ANN
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ANNEXIN IV
Descriptor:ANNEXIN IV, CALCIUM ION
Authors:Sutton, R.B., Sprang, S.R.
Deposit date:1995-09-21
Release date:1996-01-29
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three Dimensional Structure of Annexin IV
Annexins: Molecular Structure to Cellular Function, 1996
1AS0
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GTP-GAMMA-S BOUND G42V GIA1
Descriptor:GIA1, MAGNESIUM ION, SULFATE ION, ...
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS2
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GDP+PI BOUND G42V GIA1
Descriptor:GIA1, PHOSPHATE ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997