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1IAP
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BU of 1iap by Molmil
CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN
Descriptor: GUANINE NUCLEOTIDE EXCHANGE FACTOR P115RHOGEF
Authors:Sprang, S.R, Chen, Z.
Deposit date:2001-03-22
Release date:2001-09-05
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the rgRGS domain of p115RhoGEF.
Nat.Struct.Biol., 8, 2001
3CX8
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BU of 3cx8 by Molmil
Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GTP-gamma-S
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein alpha-13 subunit, MAGNESIUM ION, ...
Authors:Sprang, S.R, Chen, Z.
Deposit date:2008-04-23
Release date:2008-10-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF.
Structure, 16, 2008
3CX7
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BU of 3cx7 by Molmil
Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP-AlF4
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Glutamate Transporter Associated Protein 48, Guanine Nucleotide-Binding Protein Galpha 13, ...
Authors:Sprang, S.R, Chen, Z.
Deposit date:2008-04-23
Release date:2008-10-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF.
Structure, 16, 2008
3CX6
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BU of 3cx6 by Molmil
Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein alpha-13 subunit, MAGNESIUM ION, ...
Authors:Sprang, S.R, Chen, Z.
Deposit date:2008-04-23
Release date:2008-10-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF.
Structure, 16, 2008
1BOF
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BU of 1bof by Molmil
GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
Descriptor: GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Coleman, D.E, Sprang, S.R.
Deposit date:1998-08-04
Release date:1999-01-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment.
Biochemistry, 37, 1998
6OVE
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BU of 6ove by Molmil
Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-propylphenyl-ACEPC
Descriptor: (3R,5S)-5-[(2R)-2-amino-2-carboxyethyl]-1-(4-propylphenyl)pyrazolidine-3-carboxylic acid, GLYCINE, Glutamate receptor ionotropic, ...
Authors:Syrenne, J.T, Mou, T.C, Tamborini, L, Pinto, A, Sprang, S.R, Hansen, K.B.
Deposit date:2019-05-07
Release date:2020-05-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 3-ethylphenyl-ACEPC
To Be Published
6AU4
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BU of 6au4 by Molmil
Crystal structure of the major quadruplex formed in the human c-MYC promoter
Descriptor: DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION
Authors:Stump, S, Mou, T.C, Sprang, S.R, Natale, N.R, Beall, H.D.
Deposit date:2017-08-30
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene.
PLoS ONE, 13, 2018
1IK7
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BU of 1ik7 by Molmil
Crystal Structure of the Uncomplexed Pelle Death Domain
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PROBABLE SERINE/THREONINE-PROTEIN KINASE Pelle
Authors:Xiao, T, Gardner, K.H, Sprang, S.R.
Deposit date:2001-05-02
Release date:2002-07-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cosolvent-induced transformation of a death domain tertiary structure
Proc.Natl.Acad.Sci.USA, 99, 2002
1BH2
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BU of 1bh2 by Molmil
A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANINE NUCLEOTIDE-BINDING PROTEIN, MAGNESIUM ION
Authors:Mixon, M.B, Posner, B.A, Wall, M.A, Gilman, A.G, Sprang, S.R.
Deposit date:1998-06-12
Release date:1998-11-04
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The A326S mutant of Gialpha1 as an approximation of the receptor-bound state.
J.Biol.Chem., 273, 1998
1AS2
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BU of 1as2 by Molmil
GDP+PI BOUND G42V GIA1
Descriptor: GIA1, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION
Authors:Raw, A.S, Coleman, D.E, Gilman, A.G, Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS0
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BU of 1as0 by Molmil
GTP-GAMMA-S BOUND G42V GIA1
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GIA1, MAGNESIUM ION, ...
Authors:Raw, A.S, Coleman, D.E, Gilman, A.G, Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AZS
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BU of 1azs by Molmil
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, IIC2, ...
Authors:Tesmer, J.J.G, Sprang, S.R.
Deposit date:1997-11-20
Release date:1998-02-25
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
Science, 278, 1997
1AS3
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BU of 1as3 by Molmil
GDP BOUND G42V GIA1
Descriptor: GIA1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:Raw, A.S, Coleman, D.E, Gilman, A.G, Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1NCF
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BU of 1ncf by Molmil
A NEW PARADIGM FOR TUMOR NECROSIS FACTOR SIGNALLING
Descriptor: TUMOR NECROSIS FACTOR RECEPTOR
Authors:Naismith, J.H, Sprang, S.R.
Deposit date:1994-10-12
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor.
J.Biol.Chem., 270, 1995
1ANN
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BU of 1ann by Molmil
ANNEXIN IV
Descriptor: ANNEXIN IV, CALCIUM ION
Authors:Sutton, R.B, Sprang, S.R.
Deposit date:1995-09-21
Release date:1996-01-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three Dimensional Structure of Annexin IV
Annexins: Molecular Structure to Cellular Function, 1996
1A25
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BU of 1a25 by Molmil
C2 DOMAIN FROM PROTEIN KINASE C (BETA)
Descriptor: CALCIUM ION, O-PHOSPHOETHANOLAMINE, PROTEIN KINASE C (BETA)
Authors:Sutton, R.B, Sprang, S.R.
Deposit date:1998-01-16
Release date:1998-05-06
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
Structure, 6, 1998
1AGR
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BU of 1agr by Molmil
COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4
Descriptor: CITRIC ACID, GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tesmer, J.J.G, Sprang, S.R.
Deposit date:1997-03-25
Release date:1997-06-16
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
Cell(Cambridge,Mass.), 89, 1997
1AZT
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BU of 1azt by Molmil
GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, MAGNESIUM ION, ...
Authors:Tesmer, J.J.G, Sprang, S.R.
Deposit date:1997-11-20
Release date:1998-02-25
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
6TYL
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BU of 6tyl by Molmil
Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex
Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Nanobody A, Nanobody B, ...
Authors:Mou, T.C, McClelland, L, Yates-Hansen, C, Sprang, S.R.
Deposit date:2019-08-09
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to G alpha i1.
Nat Commun, 11, 2020
6UKT
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BU of 6ukt by Molmil
Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex
Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, NB8109, NB8117, ...
Authors:Mou, T.C, Zhang, K, Johnston, J.D, Chiu, W, Sprang, S.R.
Deposit date:2019-10-05
Release date:2020-03-11
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to G alpha i1.
Nat Commun, 11, 2020
5I56
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BU of 5i56 by Molmil
Agonist-bound GluN1/GluN2A agonist binding domains with TCN201
Descriptor: GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ...
Authors:Mou, T.-C, Sprang, S.R, Hansen, K.B.
Deposit date:2016-02-14
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
4MU8
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BU of 4mu8 by Molmil
Crystal structure of an oxidized form of yeast iso-1-cytochrome c at pH 8.8
Descriptor: Cytochrome c iso-1, GLYCEROL, HEME C, ...
Authors:McClelland, L.J, Mou, T.-C, Jeakins-Cooley, M.E, Sprang, S.R, Bowler, B.E.
Deposit date:2013-09-20
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of a mitochondrial cytochrome c conformer competent for peroxidase activity.
Proc.Natl.Acad.Sci.USA, 111, 2014
6D8X
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BU of 6d8x by Molmil
PPAR gamma LBD complexed with the agonist GW1929
Descriptor: (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, CITRATE ANION, GLYCEROL, ...
Authors:Mou, T.C, Chrisman, I.M, Hughes, T.S, Sprang, S.R.
Deposit date:2018-04-27
Release date:2019-05-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:PPAR gamma LBD complexed with the agonist GW1929
To Be Published
6DBH
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BU of 6dbh by Molmil
Crystal structure of PPAR gamma in complex with NMP422
Descriptor: 4-{2-[(2,3-dioxo-1-pentyl-2,3-dihydro-1H-indol-5-yl)sulfanyl]ethyl}benzoic acid, CHLORIDE ION, Peroxisome proliferator-activated receptor gamma
Authors:Mou, T.C, Chrisman, I.M, Hughes, T.S, Sprang, S.R.
Deposit date:2018-05-03
Release date:2019-05-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.597 Å)
Cite:Crystal structure of PPAR gamma in complex with NMP422
To Be Published
6DCU
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BU of 6dcu by Molmil
Crystal structure of PPAR gamma co-crystallized with nTZDpa
Descriptor: 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID, Peroxisome proliferator-activated receptor gamma
Authors:Mou, T.C, Chrisman, I.M, Hughes, T.S, Sprang, S.R.
Deposit date:2018-05-08
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of PPAR gamma in complex with NMP422
To Be Published

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