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2EX5
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BU of 2ex5 by Molmil
Group I Intron-encoded Homing Endonuclease I-CeuI Complexed With DNA
Descriptor: CALCIUM ION, DNA endonuclease I-CeuI, I-CeuI DNA target site, ...
Authors:Spiegel, P.C, Stoddard, B.L.
Deposit date:2005-11-07
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold.
Structure, 14, 2006
4MO3
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BU of 4mo3 by Molmil
Crystal Structure of Porcine C2 Domain of Blood Coagulation Factor VIII
Descriptor: Coagulation factor VIII, GLYCEROL
Authors:Spiegel, P.C, Brison, C.
Deposit date:2013-09-11
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Crystal Structure of Porcine C2 Domain of Blood Coagulation Factor VIII (FoldIt Target)
To be Published
4XZU
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BU of 4xzu by Molmil
Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody
Descriptor: 3E6 antibody Fab heavy chain, 3E6 antibody Fab light chain, Coagulation factor VIII, ...
Authors:Spiegel, P.C, Wuerth, M.E.
Deposit date:2015-02-05
Release date:2015-12-09
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody.
Sci Rep, 5, 2015
8TY1
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BU of 8ty1 by Molmil
Cryo-EM structure of coagulation factor VIII bound to NB2E9
Descriptor: Coagulation factor VIII, NB2E9 heavy chain, NB2E9 light chain, ...
Authors:Childers, K.C, Spiegel, P.C.
Deposit date:2023-08-24
Release date:2023-09-13
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis for inhibition of coagulation factor VIII reveals a shared immunogenic hot-spot on the C1 domain
To Be Published
8G6I
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BU of 8g6i by Molmil
Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor VIII chimera from human and pig, NB33 heavy chain, ...
Authors:Childers, K.C, Davulcu, O, Haynes, R.M, Lollar, P, Doering, C.B, Coxon, C.H, Spiegel, P.C.
Deposit date:2023-02-15
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (4.23 Å)
Cite:Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor.
Blood, 142, 2023
7K66
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Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2A9 heavy chain, ...
Authors:Childers, K.C, Gish, J, Jarvis, L, Peters, S, Garrels, C, Smith, I.W, Spencer, H.T, Spiegel, P.C.
Deposit date:2020-09-18
Release date:2020-10-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.
Blood, 137, 2021
7KBT
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BU of 7kbt by Molmil
Factor VIII in complex with the anti-C2 domain antibody, G99
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Ronayne, E.K, Gish, J, Wilson, C, Peters, S, Spencer, H.T, Spiegel, P.C, Childers, K.C.
Deposit date:2020-10-02
Release date:2020-11-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.15 Å)
Cite:Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor
Front Immunol, 12, 2021
4KI5
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BU of 4ki5 by Molmil
Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99
Descriptor: Coagulation factor VIII, MURINE MONOCLONAL 3E6 FAB HEAVY CHAIN, MURINE MONOCLONAL 3E6 FAB LIGHT CHAIN, ...
Authors:Walter, J.D, Meeks, S.L, Healey, J.F, Lollar, P, Spiegel, P.C.
Deposit date:2013-05-01
Release date:2014-01-15
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes.
Blood, 122, 2013
3QA9
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BU of 3qa9 by Molmil
Crystal Structure of Prb (PH1109 protein redesigned for binding)
Descriptor: CoA binding domain protein
Authors:Spiegel, P.C.
Deposit date:2011-01-10
Release date:2011-04-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A de novo protein binding pair by computational design and directed evolution.
Mol.Cell, 42, 2011
7S0P
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BU of 7s0p by Molmil
Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine
Descriptor: Coagulation factor VIII, PHOSPHOSERINE
Authors:Peters, S.C, Childers, K.C, Wo, S.W, Brison, C.M, Swanson, C.D, Spiegel, P.C.
Deposit date:2021-08-30
Release date:2021-10-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII.
Front Mol Biosci, 9, 2022
6MF2
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BU of 6mf2 by Molmil
Improved Model of Human Coagulation Factor VIII
Descriptor: CALCIUM ION, COPPER (I) ION, Coagulation factor VIII, ...
Authors:Smith, I.W, Spiegel, P.C.
Deposit date:2018-09-08
Release date:2019-09-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.609364 Å)
Cite:The 3.2 angstrom structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.
J.Thromb.Haemost., 18, 2020
6MF0
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BU of 6mf0 by Molmil
Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (I) ION, ...
Authors:Smith, I.W, Spiegel, P.C.
Deposit date:2018-09-07
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.19999886 Å)
Cite:The 3.2 angstrom structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.
J.Thromb.Haemost., 18, 2020
1P8K
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BU of 1p8k by Molmil
The structure and DNA recognition of a bifunctional homing endonuclease and group I intron splicing factor
Descriptor: 5'-D(P*CP*CP*TP*CP*CP*TP*CP*AP*GP*CP*GP*CP*GP*CP*T)-3', 5'-D(P*GP*CP*GP*CP*GP*CP*TP*GP*AP*GP*GP*AP*GP*GP*TP*TP*TP*C)-3', 5'-D(P*GP*CP*GP*CP*TP*TP*TP*AP*CP*AP*GP*AP*GP*AP*AP*A)-3', ...
Authors:Stoddard, B.L, Bolduc, J.M.
Deposit date:2003-05-07
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor.
Genes Dev., 17, 2003
2R7E
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BU of 2r7e by Molmil
Crystal Structure Analysis of Coagulation Factor VIII
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ...
Authors:Stoddard, B.L, Shen, B.W.
Deposit date:2007-09-07
Release date:2008-04-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:The tertiary structure and domain organization of coagulation factor VIII.
Blood, 111, 2008

217705

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