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4NB3
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CRYSTAL STRUCTURE OF RPA70N IN COMPLEX WITH A 3,4 DICHLOROPHENYLALANINE ATRIP DERIVED PEPTIDE
Descriptor:Replication protein A 70 kDa DNA-binding subunit, 3,4 dichlorophenylalanine ATRIP derived peptide
Authors:Feldkamp, M.D., Frank, A.O., Vangamudi, B., Souza-Fagundes, E.M., Luzwik, J.W., Cortez, D., Olejniczak, O.T., Waterson, A.G., Rossanese, O.W., Fesik, S.W., Chazin, W.J.
Deposit date:2013-10-22
Release date:2014-02-26
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A.
J.Med.Chem., 57, 2014
5E7N
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CRYSTAL STRUCTURE OF RPA70N IN COMPLEX WITH VU0085636
Descriptor:Replication protein A 70 kDa DNA-binding subunit, 2-({3-[(4-bromophenyl)sulfamoyl]-4-methylbenzoyl}amino)benzoic acid
Authors:Gilston, B.A., Patrone, J.D., Pelz, N.F., Bates, B.S., Souza-Fagundes, E.M., Vangamudi, B., Camper, D., Kuznetsov, A., Browning, C.F., Feldkamp, M.D., Olejniczak, E.T., Rossanese, O.W., Waterson, A.G., Fesik, S.W., Chazin, W.J.
Deposit date:2015-10-12
Release date:2016-01-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A.
Chemmedchem, 11, 2016
4R4C
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STRUCTURE OF RPA70N IN COMPLEX WITH 5-(4-((4-(5-CARBOXYFURAN-2-YL)-2-CHLOROBENZAMIDO)METHYL)PHENYL)-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
Descriptor:Replication protein A 70 kDa DNA-binding subunit, 5-[4-({[4-(5-carboxyfuran-2-yl)-2-chlorobenzoyl]amino}methyl)phenyl]-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
Authors:Feldkamp, M.D., Waterson, A.G., Kennedy, J.P., Patrone, J.D., Pelz, N.F., Frank, A.O., Vangamudi, B., Sousa-Fagundes, E.M., Rossanese, O.W., Fesik, S.W., Chazin, W.J.
Deposit date:2014-08-19
Release date:2014-11-19
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4R4I
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STRUCTURE OF RPA70N IN COMPLEX WITH 5-(4-((6-(5-CARBOXYFURAN-2-YL)-1-THIOXO-3,4-DIHYDROISOQUINOLIN-2(1H)-YL)METHYL)PHENYL)-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
Descriptor:Replication protein A 70 kDa DNA-binding subunit, 5-(4-{[6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydroisoquinolin-2(1H)-yl]methyl}phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
Authors:Feldkamp, M.D., Waterson, A.G., Kennedy, J.P., Patrone, J.D., Pelz, N.F., Frank, A.O., Vangamudi, B., Sousa-Fagundes, E.M., Rossanese, O.W., Fesik, S.W., Chazin, W.J.
Deposit date:2014-08-19
Release date:2014-11-19
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4R4O
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CRYSTAL STRUCTURE OF RPA70N IN COMPLEX WITH 5-(4-((4-(5-CARBOXYFURAN-2-YL)BENZYL)CARBAMOTHIOYL)PHENYL)-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
Descriptor:Replication protein A 70 kDa DNA-binding subunit, 5-(4-{[4-(5-carboxyfuran-2-yl)benzyl]carbamothioyl}phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
Authors:Feldkamp, M.D., Waterson, A.G., Kennedy, J.P., Patrone, J.D., Pelz, N.F., Frank, A.O., Vangamudi, B., Sousa-Fagundes, E.M., Rossanese, O.W., Fesik, S.W., Chazin, W.J.
Deposit date:2014-08-19
Release date:2014-11-19
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4R4Q
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CRYSTAL STRUCTURE OF RPA70N IN COMPLEX WITH 5-(3-((N-(4-(5-CARBOXYFURAN-2-YL)BENZYL)ACETAMIDO)METHYL)PHENYL)-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
Descriptor:Replication protein A 70 kDa DNA-binding subunit, 5-[4-({acetyl[4-(5-carboxyfuran-2-yl)benzyl]amino}methyl)phenyl]-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
Authors:Feldkamp, M.D., Waterson, A.G., Kennedy, J.P., Patrone, J.D., Pelz, N.F., Frank, A.O., Vangamudi, B., Sousa-Fagundes, E.M., Rossanese, O.W., Fesik, S.W., Chazin, W.J.
Deposit date:2014-08-19
Release date:2014-11-19
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4R4T
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CRYSTAL STRUCTURE OF RPA70N IN COMPLEX WITH 5-(4-((4-(5-CARBOXYFURAN-2-YL)PHENYLTHIOAMIDO)METHYL)PHENYL)-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
Descriptor:Replication protein A 70 kDa DNA-binding subunit, 5-{4-[({[4-(5-carboxyfuran-2-yl)phenyl]carbonothioyl}amino)methyl]phenyl}-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
Authors:Feldkamp, M.D., Waterson, A.G., Kennedy, J.P., Patrone, J.D., Pelz, N.F., Frank, A.O., Vangamudi, B., Sousa-Fagundes, E.M., Rossanese, O.W., Fesik, S.W., Chazin, W.J.
Deposit date:2014-08-19
Release date:2014-11-19
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015