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4W9W
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BU of 4w9w by Molmil
Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762
Descriptor: 1,2-ETHANEDIOL, 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, BMP-2-inducible protein kinase
Authors:Sorrell, F.J, Elkins, J.M, Krojer, T, Savitsky, P, Williams, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2014-08-28
Release date:2014-09-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
Structure, 24, 2016
4W9X
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BU of 4w9x by Molmil
Crystal Structure of BMP-2-inducible kinase in complex with baricitinib
Descriptor: 1,2-ETHANEDIOL, BMP-2-inducible protein kinase, Baricitinib
Authors:Sorrell, F.J, Elkins, J.M, Krojer, T, Williams, E, Savitsky, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2014-08-28
Release date:2014-09-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
Structure, 24, 2016
6EIM
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BU of 6eim by Molmil
Human STK10 bound to GW683134A
Descriptor: 1,2-ETHANEDIOL, Serine/threonine-protein kinase 10, ~{N}-[5-[4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1~{H}-benzimidazol-2-yl]furan-2-carboxamide
Authors:Sorrell, F.J, Berger, B.-T, Salah, E, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Elkins, J.M.
Deposit date:2017-09-19
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Human STK10 bound to GW683134
To Be Published
6FD3
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BU of 6fd3 by Molmil
Thiophosphorylated PAK3 kinase domain
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sorrell, F.J, Wang, D, von Delft, F, Bountra, C, Edwards, A.M, Elkins, J.M.
Deposit date:2017-12-21
Release date:2018-01-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited incis.
Biochem.J., 476, 2019
4WSQ
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BU of 4wsq by Molmil
Crystal Structure of Adaptor Protein 2 Associated Kinase (AAK1) in complex with small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, AP2-associated protein kinase 1, K-252A, ...
Authors:Sorrell, F.J, Elkins, J.M, Krojer, T, Williams, E, Abdul, K, Gileadi, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2014-10-28
Release date:2014-11-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
Structure, 24, 2016
6QP5
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BU of 6qp5 by Molmil
Apo Human Calcium/Calmodulin-dependent kinase type 1D
Descriptor: 1,2-ETHANEDIOL, Calcium/calmodulin-dependent protein kinase type 1D, SULFATE ION
Authors:Sorrell, F.J, Knapp, S.
Deposit date:2019-02-13
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Apo Human Calcium/Calmodulin-dependent kinase type 1D
To Be Published
6S1B
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BU of 6s1b by Molmil
Crystal Structure of DYRK1A with small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ...
Authors:Sorrell, F.J, Henderson, S.H, Redondo, C, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S1J
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BU of 6s1j by Molmil
Crystal Structure of DYRK1A with small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-[2-[(3~{S})-3-fluoranylpyrrolidin-1-yl]pyrimidin-4-yl]pyrazolo[1,5-b]pyridazine, DIMETHYL SULFOXIDE, ...
Authors:Sorrell, F.J, Henderson, S.H, Redondo, C, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.408 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S11
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BU of 6s11 by Molmil
Crystal Structure of DYRK1A with small molecule inhibitor
Descriptor: 6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Authors:Sorrell, F.J, Henderson, S.H, Redondo, C, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.445 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S14
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BU of 6s14 by Molmil
Crystal Structure of DYRK1A with small molecule inhibitor
Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ~{N}-cyclopropyl-~{N}-methyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine
Authors:Sorrell, F.J, Henderson, S.H, Redondo, C, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S17
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BU of 6s17 by Molmil
Crystal Structure of DYRK1A with small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ...
Authors:Sorrell, F.J, Henderson, S.H, Redondo, C, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S1H
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BU of 6s1h by Molmil
Crystal Structure of DYRK1A with small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ...
Authors:Sorrell, F.J, Henderson, S.H, Redondo, C, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6HVD
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BU of 6hvd by Molmil
Human SLK bound to a maleimide inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-(1,3-benzothiazol-2-ylamino)-4-(2-methoxyphenyl)pyrrole-2,5-dione, STE20-like serine/threonine-protein kinase, ...
Authors:Sorrell, F.J, Berger, B.T, Salah, E, Serafim, R.A.M, Savitsky, P.A, Krojer, T, Bailey, H.J, Pinkas, D, Burgess-Brown, N.A, von Delft, F, Knapp, S, Arrowsmith, C, Bountra, C, Edwards, A.M, Elkins, J.M.
Deposit date:2018-10-10
Release date:2018-10-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Human SLK bound to a maleimide inhibitor
To Be Published
6HXF
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BU of 6hxf by Molmil
Human STK10 bound to a maleimide inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-(2-methoxyphenyl)-4-[[4-(phenylcarbonyl)phenyl]amino]pyrrole-2,5-dione, CHLORIDE ION, ...
Authors:Sorrell, F.J, Salah, E, Serafim, R.A.M, Savitsky, P.A, Krojer, T, Bailey, H.J, Pinkas, D, Burgess-Brown, N.A, von Delft, F, Knapp, S, Arrowsmith, C, Bountra, C, Edwards, A.M, Elkins, J.M.
Deposit date:2018-10-17
Release date:2018-10-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Human STK10 bound to a maleimide inhibitor
To Be Published
6I2Y
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BU of 6i2y by Molmil
Human STK10 bound to Foretinib
Descriptor: N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, Serine/threonine-protein kinase 10
Authors:Sorrell, F.J, Berger, B.-T, Oerum, S, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Elkins, J.M.
Deposit date:2018-11-02
Release date:2018-12-12
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Human STK10 bound to GW683134
To Be Published
4H2A
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BU of 4h2a by Molmil
Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Protective antigen
Authors:Baker, P.J, Sorrell, F.J.
Deposit date:2012-09-12
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)
TO BE PUBLISHED
4TXC
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BU of 4txc by Molmil
Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 4-(3-{3-[(R)-{[2-(dimethylamino)ethyl]amino}(hydroxy)methyl]phenyl}imidazo[1,2-b]pyridazin-6-yl)-2-methoxyphenol, Death-associated protein kinase 1
Authors:Sorrell, F.J, Krojer, T, Wilbek, T.S, Skovgaard, T, Berthelsen, J, Dixon-Clarke, S, Chalk, R, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Stromgaard, K, Knapp, S.
Deposit date:2014-07-03
Release date:2014-07-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.
Chembiochem, 16, 2015
5L4Q
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BU of 5l4q by Molmil
Crystal Structure of Adaptor Protein 2 Associated Kinase 1 (AAK1) in Complex with LKB1 (AAK1 Dual Inhibitor)
Descriptor: 1,2-ETHANEDIOL, AP2-associated protein kinase 1, ~{N}-[5-(4-cyanophenyl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide
Authors:Sorrell, F.J, Williams, E, Fox, N, Abdul Azeez, K.R, Gileadi, O, von Delft, F, Edwards, A.M, Bountra, C, Elkins, J.M, Knapp, S.
Deposit date:2016-05-26
Release date:2016-06-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
J.Med.Chem., 2019
8BDS
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BU of 8bds by Molmil
Ternary complex between VCB, BRD4-BD1 and PROTAC 48
Descriptor: (2S,4R)-N-[(1S)-1-(4-chlorophenyl)-3-[2-[2-[2-[2-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8$l^{5},11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxidanylidene-propyl]-1-[(2R)-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ...
Authors:Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
Deposit date:2022-10-20
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDN
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BU of 8bdn by Molmil
VCB in complex with compound 23
Descriptor: (2~{R})-3-methyl-1-[(2~{S},4~{R})-2-[(5~{R})-5-methyl-5-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-4~{H}-1,2,4-oxadiazol-3-yl]-4-oxidanyl-pyrrolidin-1-yl]-2-(3-methyl-1,2-oxazol-5-yl)butan-1-one, Elongin-B, Elongin-C, ...
Authors:Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
Deposit date:2022-10-19
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDJ
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BU of 8bdj by Molmil
VCB in complex with compound 30
Descriptor: (2~{S},4~{R})-~{N}-[(1~{S})-1-[4-chloranyl-2-(2-methoxyethoxy)phenyl]ethyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
Deposit date:2022-10-19
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDT
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BU of 8bdt by Molmil
Ternary complex between VCB, BRD4-BD2 and PROTAC 51
Descriptor: (2~{S},4~{R})-~{N}-[(1~{S})-3-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethylamino]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxidanylidene-propyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Elongin-B, ...
Authors:Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.A.
Deposit date:2022-10-20
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDO
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BU of 8bdo by Molmil
VCB in complex with compound 21
Descriptor: (2~{S},4~{R})-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-~{N}-[4-(4-methyl-1,3-thiazol-5-yl)phenoxy]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
Deposit date:2022-10-19
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDM
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BU of 8bdm by Molmil
VCB in complex with compound 26
Descriptor: (2~{S},4~{R})-~{N}-[[2-(2-methoxyethoxy)-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
Deposit date:2022-10-19
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.021 Å)
Cite:Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDI
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BU of 8bdi by Molmil
VCB in complex with compound 32
Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[(1~{S})-3-(methylamino)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxidanylidene-propyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
Deposit date:2022-10-19
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.108 Å)
Cite:Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023

 

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