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1KUN
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BU of 1kun by Molmil
SOLUTION STRUCTURE OF THE HUMAN ALPHA3-CHAIN TYPE VI COLLAGEN C-TERMINAL KUNITZ DOMAIN, NMR, 20 STRUCTURES
Descriptor: ALPHA3-CHAIN TYPE VI COLLAGEN
Authors:Sorensen, M.D, Bjorn, S, Norris, K, Olsen, O, Petersen, L, James, T.L, Led, J.J.
Deposit date:1997-03-04
Release date:1997-11-12
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of the human alpha3-chain type VI collagen C-terminal Kunitz domain,.
Biochemistry, 36, 1997
4W1O
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BU of 4w1o by Molmil
PDE4D complexed with inhibitor
Descriptor: N-(3,5-dichloropyridin-4-yl)-3-[(3-ethyl-1,2-oxazol-5-yl)methoxy]-4-methoxybenzamide, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Authors:Sorensen, M.D.
Deposit date:2014-08-14
Release date:2014-11-05
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis
J.Med.Chem, 57, 2014
4WCU
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PDE4 complexed with inhibitor
Descriptor: MAGNESIUM ION, N-benzyl-2-{6-[(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide, ZINC ION, ...
Authors:Sorensen, M.D.
Deposit date:2014-09-05
Release date:2014-10-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis.
J. Med. Chem., 57, 2014
6ZBA
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BU of 6zba by Molmil
Crystal structure of PDE4D2 in complex with inhibitor LEO39652
Descriptor: 1,2-ETHANEDIOL, 2-methylpropyl 1-[8-methoxy-5-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate, DIMETHYL SULFOXIDE, ...
Authors:Akutsu, M, Hakansson, M, Welin, M, Svensson, A, Logan, D.T, Sorensen, M.D.
Deposit date:2020-06-08
Release date:2020-09-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3 H -isobenzofuran-5-yl)-[1,2,4]triazolo[1,5- a ]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel "Dual-Soft" PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis.
J.Med.Chem., 63, 2020
2AWH
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BU of 2awh by Molmil
Human Nuclear Receptor-Ligand Complex 1
Descriptor: Peroxisome proliferator activated receptor delta, VACCENIC ACID, heptyl beta-D-glucopyranoside
Authors:Fyffe, S.A, Alphey, M.S, Buetow, L, Smith, T.K, Ferguson, M.A.J, Sorensen, M.D, Bjorkling, F, Hunter, W.N.
Deposit date:2005-09-01
Release date:2006-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids
J.Mol.Biol., 356, 2006
2B50
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BU of 2b50 by Molmil
Human Nuclear Receptor-Ligand Complex 2
Descriptor: CALCIUM ION, Peroxisome proliferator activated receptor delta, VACCENIC ACID, ...
Authors:Fyffe, S.A, Alphey, M.S, Buetow, L, Smith, T.K, Ferguson, M.A.J, Sorensen, M.D, Bjorkling, F, Hunter, W.N.
Deposit date:2005-09-27
Release date:2006-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids
J.Mol.Biol., 356, 2006
2BAW
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BU of 2baw by Molmil
Human Nuclear Receptor-Ligand Complex 1
Descriptor: Peroxisome proliferator activated receptor delta, VACCENIC ACID, heptyl beta-D-glucopyranoside
Authors:Fyffe, S.A, Alphey, M.S, Buetow, L, Smith, T.K, Ferguson, M.A.J, Sorensen, M.D, Bjorkling, F, Hunter, W.N.
Deposit date:2005-10-15
Release date:2006-01-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Reevaluation of the PPAR-beta/delta Ligand Binding Domain Model Reveals Why It Exhibits the Activated Form
Mol.Cell, 21, 2006
1MHI
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BU of 1mhi by Molmil
THREE-DIMENSIONAL SOLUTION STRUCTURE OF AN INSULIN DIMER. A STUDY OF THE B9(ASP) MUTANT OF HUMAN INSULIN USING NUCLEAR MAGNETIC RESONANCE DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS
Descriptor: INSULIN
Authors:Jorgensen, A.M.M, Kristensen, S.M, Led, J.J, Balschmidt, P.
Deposit date:1994-11-30
Release date:1995-10-15
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of an insulin dimer. A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics.
J.Mol.Biol., 227, 1992
1MHJ
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SOLUTION STRUCTURE OF THE SUPERACTIVE MONOMERIC DES-[PHE(B25)] HUMAN INSULIN MUTANT. ELUCIDATION OF THE STRUCTURAL BASIS FOR THE MONOMERIZATION OF THE DES-[PHE(B25)] INSULIN AND THE DIMERIZATION OF NATIVE INSULIN
Descriptor: INSULIN
Authors:Jorgensen, A.M.M, Olsen, H.B, Led, J.J, Balschmidt, P.
Deposit date:1994-11-30
Release date:1995-10-15
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the superactive monomeric des-[Phe(B25)] human insulin mutant: elucidation of the structural basis for the monomerization of des-[Phe(B25)] insulin and the dimerization of native insulin.
J.Mol.Biol., 257, 1996

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