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1R62
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE TWO-COMPONENT SYSTEM TRANSMITTER PROTEIN NRII (NTRB)
分子名称:Nitrogen regulation protein NR(II)
著者Song, Y., Peisach, D., Pioszak, A.A., Xu, Z., Ninfa, A.J.
登録日2003-10-14
公開日2004-06-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of the C-terminal Domain of the Two-Component System Transmitter Protein Nitrogen Regulator II (NRII; NtrB), Regulator of Nitrogen Assimilation in Escherichia coli.
Biochemistry, 43, 2004
5HDM
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA GLUTAMATE-1-SEMIALDEHYDE-2,1-AMINOMUTASE
分子名称:Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ...
著者Song, Y., Pu, H., Liu, L.
登録日2016-01-05
公開日2016-06-15
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Crystal structure of glutamate-1-semialdehyde-2,1-aminomutase from Arabidopsis thaliana
Acta Crystallogr.,Sect.F, 72, 2016
5X7L
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STRUCTURE OF TSRD FROM STREPTOMYCES LAURENTII
分子名称:TsrD, ISOPROPYL ALCOHOL
著者Song, Y., Lin, Z., Deng, W., Liu, W.
登録日2017-02-27
公開日2018-03-07
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Structure of TsrD from Streptomyces laurentii
To Be Published
5YH1
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MEMBER OF S1P FAMILY OF RIBOSOMAL PROTEINS PF0399 DHH DOMAIN
分子名称:Member of s1p family of ribosomal proteins, GLYCEROL, MANGANESE (II) ION
著者Song, Y., Liu, X.P.
登録日2017-09-27
公開日2018-08-01
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Member of s1p family of ribosomal proteins PF0399 DHH domain
To Be Published
5YHX
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STRUCTURE OF LACTOCOCCUS LACTIS ZITR, WILD TYPE
分子名称:Zinc transport transcriptional regulator, ZINC ION
著者Song, Y., Liu, H., Zhu, R., Yi, C., Chen, P.
登録日2017-10-01
公開日2017-12-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of Lactococcus lactis ZitR
Proc.Natl.Acad.Sci.Usa, 2017
5YHY
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STRUCTURE OF LACTOCOCCUS LACTIS ZITR, C30S MUTANT
分子名称:Zinc transport transcriptional regulator, ZINC ION
著者Song, Y., Liu, H., Zhu, R., Yi, C., Chen, P.
登録日2017-10-01
公開日2017-12-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure of Lactococcus lactis ZitR
Proc.Natl.Acad.Sci.Usa, 2017
5YHZ
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STRUCTURE OF LACTOCOCCUS LACTIS ZITR, E41A MUTANT
分子名称:Zinc transport transcriptional regulator, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Song, Y., Liu, H., Zhu, R., Yi, C., Chen, P.
登録日2017-10-01
公開日2017-12-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of Lactococcus lactis ZitR
Proc.Natl.Acad.Sci.Usa, 2017
5YI0
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STRUCTURE OF LACTOCOCCUS LACTIS ZITR, C30AH42A MUTANT
分子名称:Zinc transport transcriptional regulator, ZINC ION
著者Song, Y., Liu, H., Zhu, R., Yi, C., Chen, P.
登録日2017-10-01
公開日2017-12-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of Lactococcus lactis ZitR
Proc.Natl.Acad.Sci.Usa, 2017
5YI1
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STRUCTURE OF LACTOCOCCUS LACTIS ZITR, C30AH42A MUTANT IN APO FORM
分子名称:Zinc transport transcriptional regulator
著者Song, Y., Liu, H., Zhu, R., Yi, C., Chen, P.
登録日2017-10-01
公開日2017-12-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Lactococcus lactis ZitR
Proc.Natl.Acad.Sci.Usa, 2017
5YI2
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STRUCTURE OF LACTOCOCCUS LACTIS ZITR, WILD TYPE IN COMPLEX WITH DNA
分子名称:Zinc transport transcriptional regulator, DNA (5'-D(*TP*GP*TP*TP*AP*AP*CP*TP*AP*GP*TP*TP*AP*AP*CP*A)-3'), ZINC ION
著者Song, Y., Liu, H., Zhu, R., Yi, C., Chen, P.
登録日2017-10-01
公開日2017-12-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Lactococcus lactis ZitR
Proc.Natl.Acad.Sci.Usa, 2017
5YI3
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STRUCTURE OF LACTOCOCCUS LACTIS ZITR, C30S MUTANT IN COMPLEX WITH DNA
分子名称:Zinc transport transcriptional regulator, DNA (5'-D(*TP*GP*TP*TP*AP*AP*CP*TP*AP*GP*TP*TP*AP*AP*CP*A)-3'), ZINC ION
著者Song, Y., Liu, H., Zhu, R., Yi, C., Chen, P.
登録日2017-10-01
公開日2017-12-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of Lactococcus lactis ZitR
Proc.Natl.Acad.Sci.Usa, 2017
5V58
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CRYSTAL STRUCTURE OF HUMAN PROLYL-TRNA SYNTHETASE IN COMPLEX WITH AZE-SA
分子名称:Bifunctional glutamate/proline--tRNA ligase, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine, ZINC ION
著者Zhou, H., Song, Y., Schimmel, P.
登録日2017-03-13
公開日2018-01-10
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
5V59
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF HUMAN ALARS IN COMPLEX WITH AZE-SA
分子名称:Alanine--tRNA ligase, cytoplasmic, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine
著者Zhou, H., Song, Y., Schimmel, P.
登録日2017-03-13
公開日2018-01-10
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
5XOR
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CRYSTAL STRUCTURE OF N-TERMINAL REPLICASE PROTEIN OF PORCINE CIRCOVIRUS TYPE 2
分子名称:Rep protein
著者Song, Y., Peng, G.
登録日2017-05-30
公開日2018-07-04
最終更新日2018-09-19
実験手法X-RAY DIFFRACTION (2.699 Å)
主引用文献Crystal Structure of the Dimerized N Terminus of Porcine Circovirus Type 2 Replicase Protein Reveals a Novel Antiviral Interface
J. Virol., 92, 2018
5CVC
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STRUCTURE OF MAIZE SERINE RACEMASE
分子名称:Serine racemase, MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE
著者Song, Y., Zou, L., Fan, J.
登録日2015-07-26
公開日2016-03-16
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystal structure of maize serine racemase with pyridoxal 5'-phosphate.
Acta Crystallogr.,Sect.F, 72, 2016
5VBL
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STRUCTURE OF APELIN RECEPTOR IN COMPLEX WITH AGONIST PEPTIDE
分子名称:agonist peptide, Apelin receptor,Rubredoxin,Apelin receptor Chimera, ZINC ION, ...
著者Ma, Y., Yue, Y., Ma, Y., Zhang, Q., Zhou, Q., Song, Y., Shen, Y., Li, X., Ma, X., Li, C., Hanson, M.A., Han, G.W., Sickmier, E.A., Swaminath, G., Zhao, S., Stevems, R.C., Hu, L.A., Zhong, W., Zhang, M., Xu, F.
登録日2017-03-29
公開日2017-05-31
最終更新日2017-07-19
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Basis for Apelin Control of the Human Apelin Receptor
Structure, 25, 2017
6MO0
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STRUCTURE OF DENGUE VIRUS PROTEASE WITH AN ALLOSTERIC INHIBITOR THAT BLOCKS REPLICATION
分子名称:FLAVIVIRUS_NS2B/Peptidase S7, 1-(4-{3-[4-(furan-3-yl)phenyl]-5-[(piperidin-4-yl)methoxy]pyrazin-2-yl}phenyl)methanamine
著者Lin, Y.-L., Nie, S., Hua, Y., Wu, J., Wu, F., Huo, T., Yao, Y., Song, Y.
登録日2018-10-03
公開日2019-05-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.
J. Am. Chem. Soc., 141, 2019
6MO1
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STRUCTURE OF DENGUE VIRUS PROTEASE WITH AN ALLOSTERIC INHIBITOR THAT BLOCKS REPLICATION
分子名称:FLAVIVIRUS_NS2B/Peptidase S7, 5-[4-(aminomethyl)phenyl]-6-[4-(furan-3-yl)phenyl]-N-[(piperidin-4-yl)methyl]pyrazin-2-amine
著者Lin, Y.-L., Hua, Y., Nie, S., Wu, J., Wu, F., Huo, T., Yao, Y., Song, Y.
登録日2018-10-03
公開日2019-05-15
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.
J.Am.Chem.Soc., 141, 2019
6MO2
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STRUCTURE OF DENGUE VIRUS PROTEASE WITH AN ALLOSTERIC INHIBITOR THAT BLOCKS REPLICATION
分子名称:FLAVIVIRUS_NS2B/Peptidase S7, 1-(4-{5-[(piperidin-4-yl)methoxy]-3-[4-(1H-pyrazol-4-yl)phenyl]pyrazin-2-yl}phenyl)methanamine
著者Lin, Y.-L., Nie, S., Hua, Y., Wu, J., Wu, F., Huo, T., Yao, Y., Song, Y.
登録日2018-10-03
公開日2019-05-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.
J.Am.Chem.Soc., 141, 2019
3SR4
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CRYSTAL STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH A SELECTIVE INHIBITOR
分子名称:Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ...
著者Diao, J., Chen, P., Yao, Y., Prasad, B.V.V., Song, Y.
登録日2011-07-06
公開日2011-10-05
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies.
J.Am.Chem.Soc., 133, 2011
4I3K
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CRYSTAL STRUCTURE OF A METABOLIC REDUCTASE WITH 1-HYDROXY-6-(4-HYDROXYBENZYL)-4-METHYLPYRIDIN-2(1H)-ONE
分子名称:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ...
著者Zheng, B., Yao, Y., Liu, Z., Deng, L., Anglin, J.L., Jiang, H., Prasad, B.V.V., Song, Y.
登録日2012-11-26
公開日2013-05-22
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (3.3056 Å)
主引用文献Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.
ACS Med Chem Lett, 4, 2013
4I3L
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CRYSTAL STRUCTURE OF A METABOLIC REDUCTASE WITH 6-BENZYL-1-HYDROXY-4-METHYLPYRIDIN-2(1H)-ONE
分子名称:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ...
著者Zheng, B., Yao, Y., Liu, Z., Deng, L., Anglin, J.L., Jiang, H., Prasad, B.V.V., Song, Y.
登録日2012-11-26
公開日2013-05-22
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (3.292 Å)
主引用文献Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.
ACS Med Chem Lett, 4, 2013
4XRX
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CRYSTAL STRUCTURE OF A METABOLIC REDUCTASE WITH (E)-5-((1-METHYL-5-OXO-2-THIOXOIMIDAZOLIDIN-4-YLIDENE)METHYL)PYRIDIN-2(1H)-ONE
分子名称:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(E)-(1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl]pyridin-2(1H)-one
著者Zheng, B., Wu, F., Jiang, H., Kogiso, M., Yao, Y., Zhou, C., Li, X., Song, Y.
登録日2015-01-21
公開日2015-12-09
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds.
J.Med.Chem., 58, 2015
4XS3
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CRYSTAL STRUCTURE OF A METABOLIC REDUCTASE WITH (E)-1-BENZYL-5-((1-METHYL-5-OXO-2-THIOXOIMIDAZOLIDIN-4-YLIDENE)METHYL)PYRIDIN-2(1H)-ONE
分子名称:Isocitrate dehydrogenase [NADP] cytoplasmic, (E)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zheng, B., Wu, F., Jiang, H., Kogiso, M., Yao, Y., Zhou, C., Li, X., Song, Y.
登録日2015-01-21
公開日2016-07-27
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (3.291 Å)
主引用文献Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds.
J.Med.Chem., 58, 2015
3RAS
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CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH A LIPOPHILIC PHOSPHONATE INHIBITOR
分子名称:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(N-HYDROXYACETAMIDO)-1-(3,4-DICHLOROPHENYL)PROPYLPHOSPHONIC ACID, ...
著者Diao, J., Deng, L., Prasad, B.V.V., Song, Y.
登録日2011-03-28
公開日2011-05-25
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.
J.Med.Chem., 54, 2011