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4J8S
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CRYSTAL STRUCTURE OF HUMAN CNOT1 MIF4G DOMAIN IN COMPLEX WITH A TTP PEPTIDE
Descriptor:CCR4-NOT transcription complex subunit 1, Tristetraprolin
Authors:Frank, F., Fabian, M.R., Rouya, C., Siddiqui, N., Lai, W.S., Karetnikov, A., Blackshear, P.J., Sonenberg, N., Nagar, B.
Deposit date:2013-02-14
Release date:2013-05-08
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin.
Nat.Struct.Mol.Biol., 20, 2013
1AP8
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TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES
Descriptor:TRANSLATION INITIATION FACTOR EIF4E, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Matsuo, H., Li, H., Mcguire, A.M., Fletcher, M., Gingras, A.C., Sonenberg, N., Wagner, G.
Deposit date:1997-07-25
Release date:1998-01-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.
Nat.Struct.Biol., 4, 1997
1CVJ
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X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA
Descriptor:5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3', POLYADENYLATE BINDING PROTEIN 1, ADENOSINE-5'-MONOPHOSPHATE
Authors:Deo, R.C., Bonanno, J.B., Sonenberg, N., Burley, S.K.
Deposit date:1999-08-23
Release date:1999-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Recognition of polyadenylate RNA by the poly(A)-binding protein.
Cell(Cambridge,Mass.), 98, 1999
1EJ1
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COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Marcotrigiano, J., Gingras, A.-C., Sonenberg, N., Burley, S.K.
Deposit date:2000-02-29
Release date:2000-03-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.
Cell(Cambridge,Mass.), 89, 1997
1EJ4
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COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE
Descriptor:EUKARYOTIC INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E BINDING PROTEIN 1, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Marcotrigiano, J., Gingras, A.-C., Sonenberg, N., Burley, S.K.
Deposit date:2000-02-28
Release date:2000-03-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.
Mol.Cell, 3, 1999
1EJH
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EIF4E/EIF4G PEPTIDE/7-METHYL-GDP
Descriptor:EUKARYOTIC INITIATION FACTOR 4E, EUKARYOTIC INITIATION FACTOR 4GII, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Marcotrigiano, J., Gingras, A.-C., Sonenberg, N., Burley, S.K.
Deposit date:2000-03-02
Release date:2000-03-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.
Mol.Cell, 3, 1999
1HU3
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MIDDLE DOMAIN OF HUMAN EIF4GII
Descriptor:EIF4GII
Authors:Marcotrigiano, J., Lomakin, I., Pestova, T.V., Hellen, C.U.T., Sonenberg, N., Burley, S.K.
Deposit date:2001-01-03
Release date:2001-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery.
Mol.Cell, 7, 2001
1I2T
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X-RAY STRUCTURE OF THE HUMAN HYPERPLASTIC DISCS PROTEIN: AN ORTHOLOG OF THE C-TERMINAL DOMAIN OF POLY(A)-BINDING PROTEIN
Descriptor:HYD PROTEIN
Authors:Deo, R.C., Sonenberg, N., Burley, S.K.
Deposit date:2001-02-12
Release date:2001-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein.
Proc.Natl.Acad.Sci.USA, 98, 2001
1L8B
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COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYLGPPPG
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
Authors:Niedzwiecka, A., Marcotrigiano, J., Stepinski, J., Jankowska-Anyszka, M., Wyslouch-Cieszynska, A., Dadlez, M., Gingras, A.-C., Mak, P., Darzynkiewicz, E., Sonenberg, N.
Deposit date:2002-03-19
Release date:2002-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins.
J.Mol.Biol., 319, 2002
1UG3
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C-TERMINAL PORTION OF HUMAN EIF4GI
Descriptor:eukaryotic protein synthesis initiation factor 4G
Authors:Bellsolell, L., Cho-Park, P.F., Poulin, F., Sonenberg, N., Burley, S.K.
Deposit date:2003-06-11
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1
Structure, 14, 2006
2MX4
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NMR STRUCTURE OF PHOSPHORYLATED 4E-BP2
Descriptor:Eukaryotic translation initiation factor 4E-binding protein 2
Authors:Bah, A., Forman-Kay, J., Vernon, R., Siddiqui, Z., Krzeminski, M., Muhandiram, R., Zhao, C., Sonenberg, N., Kay, L.
Deposit date:2014-12-10
Release date:2015-01-07
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.
Nature, 519, 2015
2X04
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CRYSTAL STRUCTURE OF THE PABC-TNRC6C COMPLEX
Descriptor:POLYADENYLATE-BINDING PROTEIN 1, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN, SULFATE ION
Authors:Jinek, M., Fabian, M.R., Coyle, S.M., Sonenberg, N., Doudna, J.A.
Deposit date:2009-12-04
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation
Nat.Struct.Mol.Biol., 17, 2010
3LUC
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CRYSTAL STRUCTURE OF MID DOMAIN FROM HAGO2
Descriptor:Protein argonaute-2, PHOSPHATE ION
Authors:Frank, F., Sonenberg, N., Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.691 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUD
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CRYSTAL STRUCTURE OF MID DOMAIN FROM HAGO2 IN COMPLEX WITH AMP
Descriptor:Protein argonaute-2, ADENOSINE MONOPHOSPHATE, PHOSPHATE ION
Authors:Frank, F., Sonenberg, N., Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUG
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CRYSTAL STRUCTURE OF MID DOMAIN FROM HAGO2 IN COMPLEX WITH CMP
Descriptor:Protein argonaute-2, PHOSPHATE ION, CYTIDINE-5'-MONOPHOSPHATE
Authors:Frank, F., Sonenberg, N., Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUH
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CRYSTAL STRUCTURE OF MID DOMAIN FROM HAGO2 IN COMPLEX WITH GMP
Descriptor:Protein argonaute-2, GUANOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION
Authors:Frank, F., Sonenberg, N., Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUJ
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CRYSTAL STRUCTURE OF MID DOMAIN FROM HAGO2 IN COMPLEX WITH UMP
Descriptor:Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE
Authors:Frank, F., Sonenberg, N., Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUK
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CRYSTAL STRUCTURE OF MID DOMAIN FROM HAGO2
Descriptor:Protein argonaute-2, PHOSPHATE ION, GLYCEROL
Authors:Frank, F., Sonenberg, N., Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3QX8
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CRYSTAL STRUCTURE OF MID DOMAIN FROM HAGO2 IN COMPLEX WITH M7GPPPG
Descriptor:Protein argonaute-2, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE
Authors:Frank, F., Fabian, M.R., Stepinski, J., Jemielity, J., Darzynkiewicz, E., Sonenberg, N., Nagar, B.
Deposit date:2011-03-01
Release date:2011-04-20
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
Embo Rep., 12, 2011
3QX9
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CRYSTAL STRUCTURE OF MID DOMAIN FROM HAGO2 IN COMPLEX WITH ATP
Descriptor:Protein argonaute-2, ADENOSINE-5'-TRIPHOSPHATE
Authors:Frank, F., Fabian, M.R., Stepinski, J., Jemielity, J., Darzynkiewicz, E., Sonenberg, N., Nagar, B.
Deposit date:2011-03-01
Release date:2011-04-20
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
Embo Rep., 12, 2011
4G0M
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGO2 MID DOMAIN
Descriptor:Protein argonaute 2, SULFATE ION
Authors:Frank, F., Hauver, J., Sonenberg, N., Nagar, B.
Deposit date:2012-07-09
Release date:2012-07-25
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs.
Embo J., 31, 2012
4G0O
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGO5 MID DOMAIN
Descriptor:Protein argonaute 5, SULFATE ION
Authors:Frank, F., Hauver, J., Sonenberg, N., Nagar, B.
Deposit date:2012-07-09
Release date:2012-07-25
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (2.186 Å)
Cite:Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs.
Embo J., 31, 2012
4G0P
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGO1 MID DOMAIN IN COMPLEX WITH UMP
Descriptor:Protein argonaute 1, URIDINE-5'-MONOPHOSPHATE
Authors:Frank, F., Hauver, J., Sonenberg, N., Nagar, B.
Deposit date:2012-07-09
Release date:2012-07-25
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs.
Embo J., 31, 2012
4G0Q
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGO1 MID DOMAIN IN COMPLEX WITH CMP
Descriptor:Protein argonaute 1, CYTIDINE-5'-MONOPHOSPHATE
Authors:Frank, F., Hauver, J., Sonenberg, N., Nagar, B.
Deposit date:2012-07-09
Release date:2012-07-25
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs.
Embo J., 31, 2012
4G0X
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGO1 MID DOMAIN
Descriptor:Protein argonaute 1, SULFATE ION
Authors:Frank, F., Hauver, J., Sonenberg, N., Nagar, B.
Deposit date:2012-07-10
Release date:2012-07-25
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs.
Embo J., 31, 2012
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