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6N9F
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC ACCA-DPHE AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ...
Authors:Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S.
Deposit date:2018-12-03
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 47, 2019
6N9E
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC CC-PMN AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ...
Authors:Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S.
Deposit date:2018-12-03
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 47, 2019
5V6X
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CRYSTAL STRUCTURE OF THE TRNA BINDING DOMAIN OF PYRROLYSYL-TRNA SYNTHETASE MUTANT (32A NTD) BOUND TO TRNA(PYL)
Descriptor:Pyrrolysine--tRNA ligase, RNA (70-MER), ZINC ION
Authors:Suzuki, T., Soll, D.
Deposit date:2017-03-17
Release date:2017-10-11
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.
Nat. Chem. Biol., 13, 2017
5UD5
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CRYSTAL STRUCTURE OF THE TRNA BINDING DOMAIN OF PYRROLYSYL-TRNA SYNTHETASE BOUND TO TRNA(PYL)
Descriptor:Pyrrolysine--tRNA ligase, RNA (70-MER), ZINC ION
Authors:Suzuki, T., Soll, D.
Deposit date:2016-12-23
Release date:2017-10-11
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.347 Å)
Cite:Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.
Nat. Chem. Biol., 13, 2017
5J4C
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (SOAKED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
Deposit date:2016-03-31
Release date:2016-04-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5J4B
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (CO-CRYSTALLIZED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
Deposit date:2016-03-31
Release date:2016-04-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5IZM
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THE CRYSTAL STRUCTURE OF HUMAN EEFSEC IN COMPLEX WITH GDPNP
Descriptor:Selenocysteine-specific elongation factor, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Dobosz-Bartoszek, M., Otwinowski, Z., Simonovic, M.
Deposit date:2016-03-25
Release date:2016-10-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.
Nat Commun, 7, 2016
5IZL
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THE CRYSTAL STRUCTURE OF HUMAN EEFSEC IN COMPLEX WITH GDPCP
Descriptor:Selenocysteine-specific elongation factor, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Authors:Dobosz-Bartoszek, M., Simonovic, M.
Deposit date:2016-03-25
Release date:2016-10-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.
Nat Commun, 7, 2016
5IZK
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THE CRYSTAL STRUCTURE OF HUMAN EEFSEC IN COMPLEX WITH GDP
Descriptor:Selenocysteine-specific elongation factor, GUANOSINE-5'-DIPHOSPHATE
Authors:Dobosz-Bartoszek, M., Simonovic, M.
Deposit date:2016-03-25
Release date:2016-10-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.
Nat Commun, 7, 2016
4ZIB
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF PYLRS MUTANT BOUND WITH 3-BENZOTHIENYL-L-ALANINE AND ATP
Descriptor:Pyrrolysine--tRNA ligase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Nakamura, A., Guo, L.T., Wang, Y.S., Soll, D.
Deposit date:2015-04-28
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Probing the active site tryptophan of Staphylococcus aureus thioredoxin with an analog.
Nucleic Acids Res., 43, 2015
4Y4P
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.5A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
Deposit date:2015-02-10
Release date:2015-03-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
4Y4O
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO PROTEIN Y (YFIA) AT 2.3A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
Deposit date:2015-02-10
Release date:2015-03-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
4WJ4
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CRYSTAL STRUCTURE OF NON-DISCRIMINATING ASPARTYL-TRNA SYNTHETASE FROM PSEUDOMONAS AERUGINOSA COMPLEXED WITH TRNA(ASN) AND ASPARTIC ACID
Descriptor:Aspartate--tRNA(Asp/Asn) ligase, 76mer-tRNA, ASPARTIC ACID
Authors:Suzuki, T., Nakamura, A., Kato, K., Tanaka, I., Yao, M.
Deposit date:2014-09-29
Release date:2014-12-31
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (3.294 Å)
Cite:Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis
Proc.Natl.Acad.Sci.USA, 112, 2015
4WJ3
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CRYSTAL STRUCTURE OF THE ASPARAGINE TRANSAMIDOSOME FROM PSEUDOMONAS AERUGINOSA
Descriptor:Glutamyl-tRNA(Gln) amidotransferase subunit A, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Glutamyl-tRNA(Gln) amidotransferase subunit C, ...
Authors:Suzuki, T., Nakamura, A., Kato, K., Tanaka, I., Yao, M.
Deposit date:2014-09-29
Release date:2014-12-31
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (3.705 Å)
Cite:Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis
Proc.Natl.Acad.Sci.USA, 112, 2015
4TQF
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF IFRS BOUND WITH 2-(5-BROMOTHIENYL)-L-ALA AND ATP
Descriptor:Pyrrolysine--tRNA ligase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Nakamura, A., O'Donoghue, P., Soll, D.
Deposit date:2014-06-11
Release date:2014-11-12
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (2.7143 Å)
Cite:Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TQD
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF IFRS BOUND WITH 3-IODO-L-PHE AND ATP
Descriptor:Pyrrolysine--tRNA ligase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Nakamura, A., O'Donoghue, P., Soll, D.
Deposit date:2014-06-11
Release date:2014-11-12
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (2.1429 Å)
Cite:Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.
Proc.Natl.Acad.Sci.USA, 111, 2014
4Q6G
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF ACKRS-1 BOUND WITH N-ACETYL-LYSINE AND ADPNP
Descriptor:Pyrrolysine--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 1,2-ETHANEDIOL, ...
Authors:Eiler, D.R., Kavran, J., Steitz, T.A.
Deposit date:2014-04-22
Release date:2014-11-12
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.
Proc.Natl.Acad.Sci.USA, 111, 2014
4EO4
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CRYSTAL STRUCTURE OF THE YEAST MITOCHONDRIAL THREONYL-TRNA SYNTHETASE (MST1) IN COMPLEX WITH SERYL SULFAMOYL ADENYLATE
Descriptor:Threonine--tRNA ligase, mitochondrial, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, ...
Authors:Peterson, K.M., Ling, J., Simonovic, I., Soll, D., Simonovic, M.
Deposit date:2012-04-13
Release date:2012-07-11
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:The mechanism of pre-transfer editing in yeast mitochondrial threonyl-tRNA synthetase.
J.Biol.Chem., 287, 2012
4DWR
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RNA LIGASE RTCB/MN2+ COMPLEX
Descriptor:tRNA-splicing ligase RtcB, SUCROSE, MANGANESE (II) ION, ...
Authors:Xia, S., Englert, M., Soll, D., Wang, J.
Deposit date:2012-02-26
Release date:2012-09-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH.
Proc.Natl.Acad.Sci.USA, 109, 2012
4DWQ
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RNA LIGASE RTCB-GMP/MN(2+) COMPLEX
Descriptor:tRNA-splicing ligase RtcB, GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ...
Authors:Okada, C., Xia, S., Englert, M., Yao, M., Soll, D., Wang, J.
Deposit date:2012-02-26
Release date:2012-09-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH.
Proc.Natl.Acad.Sci.USA, 109, 2012
3WKS
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CRYSTAL STRUCTURE OF THE SEPCYSS-SEPCYSE N-TERMINAL DOMAIN COMPLEX FROM
Descriptor:O-phospho-L-seryl-tRNA:Cys-tRNA synthase, Uncharacterized protein MJ1481
Authors:Nakazawa, Y., Asano, N., Nakamura, A., Yao, M.
Deposit date:2013-10-30
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.029 Å)
Cite:Ancient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaea
Proc.Natl.Acad.Sci.USA, 2014
3WKR
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CRYSTAL STRUCTURE OF THE SEPCYSS-SEPCYSE COMPLEX FROM METHANOCALDOCOCCUS JANNASCHII
Descriptor:O-phospho-L-seryl-tRNA:Cys-tRNA synthase, Uncharacterized protein MJ1481
Authors:Nakazawa, Y., Asano, N., Nakamura, A., Yao, M.
Deposit date:2013-10-30
Release date:2014-07-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Ancient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaea
Proc.Natl.Acad.Sci.USA, 2014
3WCO
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CRYSTAL STRUCTURE OF THE DEPENTAMERIZED MUTANT OF N-TERMINAL TRUNCATED SELENOCYSTEINE SYNTHASE SELA
Descriptor:L-seryl-tRNA(Sec) selenium transferase, THIOSULFATE
Authors:Itoh, Y., Sekine, S., Yokoyama, S.
Deposit date:2013-05-29
Release date:2014-01-22
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dimer-Dimer Interaction of the Bacterial Selenocysteine Synthase SelA Promotes Functional Active-Site Formation and Catalytic Specificity
J.Mol.Biol., 426, 2014
3WCN
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CRYSTAL STRUCTURE OF THE DEPENTAMERIZED MUTANT OF SELENOCYSTEINE SYNTHASE SELA
Descriptor:L-seryl-tRNA(Sec) selenium transferase, THIOSULFATE
Authors:Itoh, Y., Sekine, S., Yokoyama, S.
Deposit date:2013-05-29
Release date:2014-01-22
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Dimer-Dimer Interaction of the Bacterial Selenocysteine Synthase SelA Promotes Functional Active-Site Formation and Catalytic Specificity
J.Mol.Biol., 426, 2014
3WC2
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CRYSTAL STRUCTURE OF C. ALBICANS TRNA(HIS) GUANYLYLTRANSFERASE (THG1) WITH A TRNA(PHE)(GUG)
Descriptor:Likely histidyl tRNA-specific guanylyltransferase, 76mer-tRNA
Authors:Nakamura, A., Nemoto, T., Sonoda, T., Yamashita, K., Tanaka, I., Yao, M.
Deposit date:2013-05-24
Release date:2013-12-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.641 Å)
Cite:Structural basis of reverse nucleotide polymerization
Proc.Natl.Acad.Sci.USA, 110, 2013
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