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1DBH
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BU of 1dbh by Molmil
DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1
Descriptor: PROTEIN (HUMAN SOS 1)
Authors:Soisson, S.M, Kuriyan, J.
Deposit date:1998-12-17
Release date:1998-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.
Cell(Cambridge,Mass.), 95, 1998
2AAC
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BU of 2aac by Molmil
ESCHERCHIA COLI GENE REGULATORY PROTEIN ARAC COMPLEXED WITH D-FUCOSE
Descriptor: ACETIC ACID, ARAC, beta-D-fucopyranose
Authors:Soisson, S.M, Wolberger, C.
Deposit date:1996-10-31
Release date:1997-11-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The 1.6 A crystal structure of the AraC sugar-binding and dimerization domain complexed with D-fucose.
J.Mol.Biol., 273, 1997
3BEJ
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BU of 3bej by Molmil
Structure of human FXR in complex with MFA-1 and co-activator peptide
Descriptor: (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ...
Authors:Soisson, S.M, Parthasarathy, G, Becker, J.W.
Deposit date:2007-11-19
Release date:2008-03-18
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ARA
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BU of 2ara by Molmil
APO FORM OF ESCHERICHIA COLI REGULATORY PROTEIN ARAC
Descriptor: ARAC
Authors:Soisson, S.M, Wolberger, C.
Deposit date:1996-10-30
Release date:1997-05-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for ligand-regulated oligomerization of AraC.
Science, 276, 1997
2ARC
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BU of 2arc by Molmil
ESCHERICHIA COLI REGULATORY PROTEIN ARAC COMPLEXED WITH L-ARABINOSE
Descriptor: ARABINOSE OPERON REGULATORY PROTEIN, alpha-L-arabinopyranose
Authors:Soisson, S.M, Wolberger, C.
Deposit date:1996-10-29
Release date:1997-05-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for ligand-regulated oligomerization of AraC.
Science, 276, 1997
3N2Z
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BU of 3n2z by Molmil
The Structure of Human Prolylcarboxypeptidase at 2.80 Angstroms Resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lysosomal Pro-X carboxypeptidase, ...
Authors:Soisson, S.M, Patel, S.B, Lumb, K.J, Sharma, S.
Deposit date:2010-05-19
Release date:2010-07-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase.
Bmc Struct.Biol., 10, 2010
2RJT
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BU of 2rjt by Molmil
Crystal Structure Analysis of a Surface Entropy Reduction Mutant of S. pneumoniae FabF
Descriptor: Beta-ketoacyl-ACP synthase II
Authors:Soisson, S.M, Parthasarathy, G, Becker, J.
Deposit date:2007-10-15
Release date:2008-01-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Surface-entropy reduction approaches to manipulate crystal forms of beta-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae.
Acta Crystallogr.,Sect.D, 64, 2008
4IWD
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BU of 4iwd by Molmil
Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-8033 analog
Descriptor: 1-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-N-(pyridin-2-ylmethyl)methanesulfonamide, Hepatocyte growth factor receptor
Authors:Soisson, S.M, Northrup, A, Rickert, K, Patel, S, Allison, T.
Deposit date:2013-01-23
Release date:2013-12-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
J.Med.Chem., 56, 2013
3R7O
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BU of 3r7o by Molmil
Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-2461 analog
Descriptor: Hepatocyte growth factor receptor, N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N'-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}sulfuric diamide
Authors:Soisson, S.M, Rickert, K, Patel, S.B, Munshi, S, Lumb, K.J.
Deposit date:2011-03-22
Release date:2012-02-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for selective small molecule kinase inhibition of activated c-Met.
J.Biol.Chem., 286, 2011
3Q6W
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BU of 3q6w by Molmil
Structure of dually-phosphorylated MET receptor kinase in complex with an MK-2461 analog with specificity for the activated receptor
Descriptor: 3-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-N-(pyridin-2-ylmethyl)propanamide, Hepatocyte growth factor receptor
Authors:Soisson, S.M, Rickert, K.W, Patel, S.B, Lumb, K.J.
Deposit date:2011-01-03
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for selective small molecule kinase inhibition of activated c-Met.
J.Biol.Chem., 286, 2011
3Q6U
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BU of 3q6u by Molmil
Structure of the apo MET receptor kinase in the dually-phosphorylated, activated state
Descriptor: Hepatocyte growth factor receptor
Authors:Soisson, S.M, Rickert, K.W, Patel, S.B, Allison, T, Lumb, K.J.
Deposit date:2011-01-03
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for selective small molecule kinase inhibition of activated c-Met.
J.Biol.Chem., 286, 2011
2GFW
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BU of 2gfw by Molmil
Structure of wild type E. coli FabF (KASII)
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2006-03-23
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature, 441, 2006
2GFX
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BU of 2gfx by Molmil
Structure of E. coli FabF(C163Q) in complex with Platensimycin
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, PLATENSIMYCIN
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2006-03-23
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature, 441, 2006
2GFY
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BU of 2gfy by Molmil
Structure of E. coli FabF(K335A) mutant with covalently linked dodecanoic acid
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, LAURIC ACID
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2006-03-23
Release date:2006-05-23
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature, 441, 2006
2GFV
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BU of 2gfv by Molmil
Structure of E. coli FabF (KASII) C163Q mutant
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2006-03-23
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature, 441, 2006
3G11
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BU of 3g11 by Molmil
Structure of E. coli FabF(C163Q) in complex with dihydrophenyl platensimycin
Descriptor: 3-({3-[(1S,4S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-4-phenyldecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2009-01-29
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and biological evaluation of platensimycin analogs.
Bioorg.Med.Chem.Lett., 19, 2009
3G0Y
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BU of 3g0y by Molmil
Structure of E. coli FabF(C163Q) in complex with dihydroplatensimycin
Descriptor: 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2009-01-29
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthesis and biological evaluation of platensimycin analogs.
Bioorg.Med.Chem.Lett., 19, 2009
3HO9
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BU of 3ho9 by Molmil
Structure of E.coli FabF(C163A) in complex with Platencin A1
Descriptor: 2,4-dihydroxy-3-({3-[(2R,4aR,8S,8aR,9R)-9-hydroxy-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonap hthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2009-06-01
Release date:2010-02-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.
Bioorg.Med.Chem.Lett., 19, 2009
3HNZ
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BU of 3hnz by Molmil
Structure of E. coli FabF(C163A) in Complex with Platensimycin
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, PLATENSIMYCIN
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2009-06-01
Release date:2010-02-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.
Bioorg.Med.Chem.Lett., 19, 2009
3HO2
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BU of 3ho2 by Molmil
Structure of E.coli FabF(C163A) in complex with Platencin
Descriptor: 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2009-06-01
Release date:2010-02-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.
Bioorg.Med.Chem.Lett., 19, 2009
3I8P
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BU of 3i8p by Molmil
Crystal structure of E. coli FabF(C163A) in complex with Platensimycin A1
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Platensimycin A1
Authors:Soisson, S.M, Parthsarathy, G.
Deposit date:2009-07-09
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.
Bioorg.Med.Chem.Lett., 19, 2009
4DXD
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BU of 4dxd by Molmil
Staphylococcal Aureus FtsZ in complex with 723
Descriptor: 3-[(6-chloro[1,3]thiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluorobenzamide, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE
Authors:Lu, J, Soisson, S.M.
Deposit date:2012-02-27
Release date:2012-05-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Restoring methicillin-resistant Staphylococcus aureus susceptibility to beta-lactam antibiotics.
Sci Transl Med, 4, 2012
4MDT
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BU of 4mdt by Molmil
Structure of LpxC bound to the reaction product UDP-(3-O-(R-3-hydroxymyristoyl))-glucosamine
Descriptor: PHOSPHATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, ...
Authors:Clayton, G.M, Klein, D.J, Rickert, K.W, Patel, S.B, Kornienko, M, Zugay-Murphy, J, Reid, J.C, Tummala, S, Sharma, S, Singh, S.B, Miesel, L, Lumb, K.J, Soisson, S.M.
Deposit date:2013-08-23
Release date:2013-10-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer.
J.Biol.Chem., 288, 2013
1XDV
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BU of 1xdv by Molmil
Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang.
Descriptor: Son of sevenless protein homolog 1
Authors:Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J.
Deposit date:2004-09-08
Release date:2004-11-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004
1XD4
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BU of 1xd4 by Molmil
Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)
Descriptor: Son of sevenless protein homolog 1
Authors:Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J.
Deposit date:2004-09-03
Release date:2004-11-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.64 Å)
Cite:Structural analysis of autoinhibition in the ras activator son of sevenless.
Cell(Cambridge,Mass.), 119, 2004

 

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