Author results

5DTO
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DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH VIRAL CAP 0-RNA AND SAH
Descriptor:NS5, RNA (5'-R(P*AP*GP*UP*U)-3'), ZINC ION, ...
Authors:Zhao, Y., Soh, T.S., Lim, S.P., Chung, K.Y., Swaminathan, K., Vasudevan, S.G., Shi, P.-Y., Lescar, J., Luo, D.
Deposit date:2015-09-18
Release date:2015-11-25
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)
Proc.Natl.Acad.Sci.USA, 112, 2015
5ZQK
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DENGUE VIRUS NON STRUCTURAL PROTEIN 5
Descriptor:Non Structural Protein 5, S-ADENOSYLMETHIONINE, GLYCEROL, ...
Authors:El Sahili, A., Soh, T.S., Schiltz, J., Gharbi-Ayachi, A., Goh, B.C., Seh, C.C., Dedon, P.C., Shi, P.Y., Lim, S.P., Lescar, J.
Deposit date:2018-04-19
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A conformation of Dengue virus serotype 2 NS5 akin to its ZIKV and JEV homologues.
To Be Published
4V0Q
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DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH SAH
Descriptor:NS5 POLYMERASE, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Zhao, Y., Soh, S., Zheng, J., Phoo, W.W., Swaminathan, K., Cornvik, T.C., Lim, S.P., Shi, P.-Y., Lescar, J., Vasudevan, S.G., Luo, D.
Deposit date:2014-09-18
Release date:2015-01-28
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication.
Plos Pathog., 11, 2015
4V0R
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DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH GTP AND SAH
Descriptor:NS5 POLYMERASE, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Zhao, Y., Soh, S., Zheng, J., Phoo, W.W., Swaminathan, K., Cornvik, T.C., Lim, S.P., Shi, P.-Y., Lescar, J., Vasudevan, S.G., Luo, D.
Deposit date:2014-09-18
Release date:2015-01-28
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication.
Plos Pathog., 11, 2015
5I3P
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5I3Q
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5JJR
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Lescar, J., El Sahili, A.
Deposit date:2016-04-25
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5JJS
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 27
Descriptor:Genome polyprotein, ZINC ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Lescar, J., El Sahili, A.
Deposit date:2016-04-25
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5K5M
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CO-CRYSTAL STRUCTURE OF DENGUE VIRUS SEROTYPE 2 RNA DEPENDENT RNA POLYMERASE WITH COMPOUND 27
Descriptor:RNA Dependent RNA Polymerase, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, ...
Authors:Arora, R., Benson, T.E.
Deposit date:2016-05-23
Release date:2016-08-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
Plos Pathog., 12, 2016