Author results

3RTO
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ACOUSTICALLY MOUNTED PORCINE INSULIN MICROCRYSTALS YIELD AN X-RAY SAD STRUCTURE
Descriptor:Insulin, ZINC ION
Authors:Soares, A.S., Engel, M.A., Stearns, R., Datwani, S., Olechno, J., Ellson, R., Skinner, J.M., Allaire, M., Orville, A.M.
Deposit date:2011-05-03
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Acoustically Mounted Microcrystals Yield High-Resolution X-ray Structures.
Biochemistry, 50, 2011
5WHW
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USING SOUND PULSES TO SOLVE THE CRYSTAL HARVESTING BOTTLENECK
Descriptor:Proteinase K, CALCIUM ION, NITRATE ION, ...
Authors:Soares, A.S., Brennan, H.M., Natarajan, R., McCarthy, L., Leroy, L.
Deposit date:2017-07-18
Release date:2017-08-02
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Using sound pulses to solve the crystal-harvesting bottleneck.
Acta Crystallogr D Struct Biol, 74, 2018
5WJG
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USING SOUND PULSES TO SOLVE THE CRYSTAL HARVESTING BOTTLENECK
Descriptor:Proteinase K, CALCIUM ION, L(+)-TARTARIC ACID, ...
Authors:Soares, A.S., Brennan, H.M., McCarthy, L., Leroy, L.
Deposit date:2017-07-22
Release date:2017-08-02
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Using sound pulses to solve the crystal-harvesting bottleneck.
Acta Crystallogr D Struct Biol, 74, 2018
5WJH
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USING SOUND PULSES TO SOLVE THE CRYSTAL HARVESTING BOTTLENECK
Descriptor:Proteinase K, CALCIUM ION, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID
Authors:Soares, A.S., Brennan, H.M., McCarthy, L., Leroy, L.
Deposit date:2017-07-22
Release date:2017-08-02
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Using sound pulses to solve the crystal-harvesting bottleneck.
Acta Crystallogr D Struct Biol, 74, 2018
5F81
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ACOUSTIC INJECTORS FOR DROP-ON-DEMAND SERIAL FEMTOSECOND CRYSTALLOGRAPHY
Descriptor:Lysozyme C, SODIUM ION, CHLORIDE ION
Authors:Roessler, C.G., Agarwal, R., Allaire, M., Alonso-Mori, R., Andi, B., Bachega, J.F.R., Bommer, M., Brewster, A.S., Browne, M.C., Chatterjee, R., Cho, E., Cohen, A.E., Cowan, M., Datwani, S., Davidson, V.L., Defever, J., Eaton, B., Ellson, R., Feng, Y., Ghislain, L.P., Glownia, J.M., Han, G., Hattne, J., Hellmich, J., Heroux, A., Ibrahim, M., Kern, J., Kuczewski, A., Lemke, H.T., Liu, P., Majlof, L., McClintock, W.M., Myers, S., Nelsen, S., Olechno, J., Orville, A.M., Sauter, N.K., Soares, A.S., Soltis, M.S., Song, H., Stearns, R.G., Tran, R., Tsai, Y., Uervirojnangkoorn, M., Wilmot, C.M., Yachandra, V., Yano, J., Yukl, E.T., Zhu, D., Zouni, A.
Deposit date:2015-12-08
Release date:2016-02-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.
Structure, 24, 2016
5HL4
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ACOUSTIC INJECTORS FOR DROP-ON-DEMAND SERIAL FEMTOSECOND CRYSTALLOGRAPHY
Descriptor:Ring-hydroxylating dioxygenase, FE2/S2 (INORGANIC) CLUSTER, FE (III) ION, ...
Authors:Roessler, C.G., Agarwal, R., Allaire, M., Alonso-Mori, R., Andi, B., Bachega, J.F.R., Bommer, M., Brewster, A.S., Browne, M.C., Chatterjee, R., Cho, E., Cohen, A.E., Cowan, M., Datwani, S., Davidson, V.L., Defever, J., Eaton, B., Ellson, R., Feng, Y., Ghislain, L.P., Glownia, J.M., Han, G., Hattne, J., Hellmich, J., Heroux, A., Ibrahim, M., Kern, J., Kuczewski, A., Lemke, H.T., Liu, P., Majlof, L., McClintock, W.M., Myers, S., Nelsen, S., Olechno, J., Orville, A.M., Sauter, N.K., Soares, A.S., Soltis, M.S., Song, H., Stearns, R.G., Tran, R., Tsai, Y., Uervirojnangkoorn, M., Wilmot, C.M., Yachandra, V., Yano, J., Yukl, E.T., Zhu, D., Zouni, A.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.
Structure, 24, 2016
5HQD
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ACOUSTIC INJECTORS FOR DROP-ON-DEMAND SERIAL FEMTOSECOND CRYSTALLOGRAPHY
Descriptor:Thermolysin, CALCIUM ION, ZINC ION
Authors:Roesser, C.G., Agarwal, R., Allaire, M., Alonso-Mori, R., Andi, B., Bachega, J.F.R., Bommer, M., Brewster, A.S., Browne, M.C., Chatterjee, R., Cho, E., Cohen, A.E., Cowan, M., Datwani, S., Davidson, V.L., Defever, J., Eaton, B., Ellson, R., Feng, Y., Ghislain, L.P., Glownia, J.M., Han, G., Hattne, J., Hellmich, J., Heroux, A., Ibrahim, M., Kern, J., Kuczewski, A., Lemke, H.T., Liu, P., Majlof, L., McClintock, W.M., Myers, S., Nelsen, S., Olechno, J., Orville, A.M., Sauter, N.K., Soares, A.S., Soltis, M.S., Song, H., Stearns, R.G., Tran, R., Tsai, Y., Uervirojnangkoorn, M., Wilmot, C.M., Yachandra, V., Yano, J., Yukl, E.T., Zhu, D., Zouni, A.
Deposit date:2016-01-21
Release date:2016-02-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.
Structure, 24, 2016
4TPY
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HIGH THROUGHPUT SCREENING USING ACOUSTIC DROPLET EJECTION TO COMBINE PROTEIN CRYSTALS AND CHEMICAL LIBRARIES ON CRYSTALLIZATION PLATES AT HIGH DENSITY
Descriptor:Cationic trypsin, CALCIUM ION, SODIUM ION, ...
Authors:Teplitsky, E., Joshi, K., Mullen, J.D., Soares, A.S.
Deposit date:2014-06-10
Release date:2014-10-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density.
J.Struct.Biol., 191, 2015
2FRF
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HORSE HEART MYOGLOBIN, NITRITE ADDUCT, CRYSTAL SOAK
Descriptor:Myoglobin, SULFATE ION, NITRITE ION, ...
Authors:Copeland, D.M., Soares, A.S., West, A.H., Richter-Addo, G.B.
Deposit date:2006-01-19
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin.
J.Inorg.Biochem., 100, 2006
2FRI
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HORSE HEART MYOGLOBIN, NITRITE ADDUCT, CO-CRYSTALLIZED
Descriptor:Myoglobin, NITRITE ION, SULFATE ION, ...
Authors:Copeland, D.M., Soares, A.S., West, A.H., Richter-Addo, G.B.
Deposit date:2006-01-19
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin.
J.Inorg.Biochem., 100, 2006
2FRJ
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NITROSYL HORSE HEART MYOGLOBIN, NITRITE/DITHIONITE METHOD
Descriptor:Myoglobin, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Copeland, D.M., Soares, A.S., West, A.H., Richter-Addo, G.B.
Deposit date:2006-01-19
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin.
J.Inorg.Biochem., 100, 2006
2FRK
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NITROSYL HORSE HEART MYOGLOBIN, NITRIC OXIDE GAS METHOD
Descriptor:Myoglobin, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Copeland, D.M., Soares, A.S., West, A.H., Richter-Addo, G.B.
Deposit date:2006-01-19
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin.
J.Inorg.Biochem., 100, 2006
2R25
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COMPLEX OF YPD1 AND SLN1-R1 WITH BOUND MG2+ AND BEF3-
Descriptor:Phosphorelay intermediate protein YPD1, Osmosensing histidine protein kinase SLN1, MAGNESIUM ION, ...
Authors:Copeland, D.M., Zhao, X., Soares, A.S., West, A.H.
Deposit date:2007-08-24
Release date:2008-01-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of a complex between the phosphorelay protein YPD1 and the response regulator domain of SLN1 bound to a phosphoryl analog
J.Mol.Biol., 375, 2008
2R2X
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RICIN A-CHAIN (RECOMBINANT) COMPLEX WITH UREA
Descriptor:Ricin A chain, SULFATE ION, UREA
Authors:Carra, J.H., McHugh, C.A., Mulligan, S., Machiesky, L.M., Soares, A.S., Millard, C.B.
Deposit date:2007-08-28
Release date:2007-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site.
Bmc Struct.Biol., 7, 2007
2R3D
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RICIN A-CHAIN (RECOMBINANT) COMPLEX WITH ACETAMIDE
Descriptor:Ricin A chain (EC 3.2.2.22), SULFATE ION, ACETAMIDE
Authors:Carra, J.H., McHugh, C.A., Mulligan, S., Machiesky, L.M., Soares, A.S., Millard, C.B.
Deposit date:2007-08-29
Release date:2007-11-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site
BMC Struct.Biol., 7, 2007
2R9P
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HUMAN MESOTRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR(BPTI)
Descriptor:Trypsin-3, Pancreatic trypsin inhibitor, SULFATE ION
Authors:Salameh, M.A., Soares, A.S., Radisky, E.S.
Deposit date:2007-09-13
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin.
J.Biol.Chem., 283, 2008
2RA3
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HUMAN CATIONIC TRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI)
Descriptor:Trypsin-1, Pancreatic trypsin inhibitor, CALCIUM ION, ...
Authors:Salameh, M.A., Soares, A.S., Radisky, E.S.
Deposit date:2007-09-14
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin.
J.Biol.Chem., 283, 2008
3L33
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HUMAN MESOTRYPSIN COMPLEXED WITH AMYLOID PRECURSOR PROTEIN INHIBITOR(APPI)
Descriptor:Trypsin-3, Amyloid beta A4 protein, FORMIC ACID, ...
Authors:Salameh, M.A., Soares, A.S., Radisky, E.S.
Deposit date:2009-12-16
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
J.Biol.Chem., 285, 2010
3L3T
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HUMAN MESOTRYPSIN COMPLEXED WITH AMYLOID PRECURSOR PROTEIN INHIBITOR VARIANT (APPIR15K)
Descriptor:PRSS3 protein, Protein APP, FORMIC ACID, ...
Authors:Salameh, M.A., Soares, A.S., Radisky, E.S.
Deposit date:2009-12-17
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.378 Å)
Cite:Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
J.Biol.Chem., 285, 2010
3P92
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HUMAN MESOTRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR VARIANT (BPTI-K15R/R17G)
Descriptor:PRSS3 protein, Pancreatic trypsin inhibitor, CALCIUM ION
Authors:Salameh, M.A., Soares, A.S., Radisky, E.S.
Deposit date:2010-10-15
Release date:2011-08-31
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (1.5992 Å)
Cite:The P2' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity.
Biochem.J., 440, 2011
3P95
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HUMAN MESOTRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR VARIANT (BPTI-K15R/R17D)
Descriptor:PRSS3 protein, Pancreatic trypsin inhibitor, CALCIUM ION
Authors:Salameh, M.A., Soares, A.S., Radisky, E.S.
Deposit date:2010-10-15
Release date:2011-08-31
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (1.2991 Å)
Cite:The P2' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity.
Biochem.J., 440, 2011
3V96
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COMPLEX OF MATRIX METALLOPROTEINASE-10 CATALYTIC DOMAIN (MMP-10CD) WITH TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1)
Descriptor:Metalloproteinase inhibitor 1, Stromelysin-2, PHOSPHATE ION, ...
Authors:Batra, J., Soares, A.S., Radisky, E.S.
Deposit date:2011-12-23
Release date:2012-03-28
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.
J.Biol.Chem., 287, 2012
4DG4
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HUMAN MESOTRYPSIN-S39Y COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI)
Descriptor:PRSS3 protein, Pancreatic trypsin inhibitor, SULFATE ION, ...
Authors:Salameh, M.A., Soares, A.S., Radisky, E.S.
Deposit date:2012-01-24
Release date:2012-09-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors.
Protein Sci., 21, 2012
4DSI
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CRYSTAL STRUCTURE OF FRAGMENT DNA POLYMERASE I FROM BACILLUS STEAROTHERMOPHILUS WITH DUPLEX DNA, SE-DGTP AND CALCIUM
Descriptor:DNA polymerase, DNA, Se-dGTP, ...
Authors:Gan, J.H., Abdur, R., Liu, H.H., Sheng, J., Caton-Willians, J., Soares, A.S., Huang, Z.
Deposit date:2012-02-19
Release date:2013-03-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase
To be Published
4DSJ
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CRYSTAL STRUCTURE OF FRAGMENT DNA POLYMERASE I FROM BACILLUS STEAROTHERMOPHILUS WITH DUPLEX DNA, DGTP AND CALCIUM
Descriptor:DNA polymerase, DNA, dGTP, ...
Authors:Gan, J.H., Abdur, R., Liu, H.H., Sheng, J., Caton-Willians, J., Soares, A.S., Huang, Z.
Deposit date:2012-02-19
Release date:2013-03-27
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase
To be Published
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