Author results

2WO0
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EDTA TREATED E. COLI COPPER AMINE OXIDASE
Descriptor:PRIMARY AMINE OXIDASE, COPPER (II) ION, SODIUM ION
Authors:Smith, M.A., Pirrat, P., Pearson, A.R., Knowles, P.F., Phillips, S.E.V., McPherson, M.J.
Deposit date:2009-07-21
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Exploring the Roles of the Metal Ions in Escherichia Coli Copper Amine Oxidase.
Biochemistry, 49, 2010
2WOF
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EDTA TREATED E. COLI COPPER AMINE OXIDASE
Descriptor:PRIMARY AMINE OXIDASE, COPPER (II) ION, SODIUM ION
Authors:Smith, M.A., Pirrat, P., Pearson, A.R., Knowles, P.F., Phillips, S.E.V., McPherson, M.J.
Deposit date:2009-07-23
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Exploring the Roles of the Metal Ions in Escherichia Coli Copper Amine Oxidase.
Biochemistry, 49, 2010
2WOH
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STRONTIUM SOAKED E. COLI COPPER AMINE OXIDASE
Descriptor:PRIMARY AMINE OXIDASE, COPPER (II) ION, CALCIUM ION, ...
Authors:Smith, M.A., Pirrat, P., Pearson, A.R., Knowles, P.F., Phillips, S.E.V., McPherson, M.J.
Deposit date:2009-07-23
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Exploring the Roles of the Metal Ions in Escherichia Coli Copper Amine Oxidase.
Biochemistry, 49, 2010
3HMK
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CRYSTAL STRUCTURE OF SERINE RACEMASE
Descriptor:Serine racemase, MANGANESE (II) ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Smith, M.A., Barker, J., Mack, V., Ebneth, A., Felicetti, B., Woods, M.
Deposit date:2009-05-29
Release date:2010-01-26
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.
J.Biol.Chem., 285, 2010
3L6B
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X-RAY CRYSTAL STRUCTURE OF HUMAN SERINE RACEMASE IN COMPLEX WITH MALONATE A POTENT INHIBITOR
Descriptor:Serine racemase, PYRIDOXAL-5'-PHOSPHATE, MANGANESE (II) ION, ...
Authors:Smith, M.A., Barker, J., Mack, V., Ebneth, A., Moraes, I., Felicetti, B., Cesura, A.
Deposit date:2009-12-23
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.
J.Biol.Chem., 285, 2010
3L6C
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X-RAY CRYSTAL STRUCTURE OF RAT SERINE RACEMASE IN COMPLEX WITH MALONATE A POTENT INHIBITOR
Descriptor:Serine racemase, PYRIDOXAL-5'-PHOSPHATE, MANGANESE (II) ION, ...
Authors:Smith, M.A., Mack, V., Ebneth, A., Moraes, I., Felicetti, B., Wood, M., Schonfeld, D., Mather, O., Cesura, A., Barker, J.
Deposit date:2009-12-23
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.
J.Biol.Chem., 285, 2010
3L6R
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THE STRUCTURE OF MAMMALIAN SERINE RACEMASE: EVIDENCE FOR CONFORMATIONAL CHANGES UPON INHIBITOR BINDING
Descriptor:Serine racemase, MALONATE ION, MANGANESE (II) ION
Authors:Smith, M.A., Mack, V., Ebneth, A., Cesura, A., Felicetti, B., Barker, J.
Deposit date:2009-12-24
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.
J.Biol.Chem., 285, 2010
4GXP
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CHIMERIC FAMILY 1 BETA-GLUCOSIDASE MADE WITH NON-CONTIGUOUS SCHEMA
Descriptor:Beta-glucosidase Chimeric protein
Authors:Smith, M.A., Romero, P.A., Wu, T., Brustad, E.M., Arnold, F.H.
Deposit date:2012-09-04
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Chimeragenesis of distantly-related proteins by noncontiguous recombination.
Protein Sci., 22, 2013
1YTQ
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STRUCTURE OF NATIVE HUMAN BETA B2 CRYSTALLIN
Descriptor:Beta crystallin B2
Authors:Slingsby, C., Smith, M.A., Bateman, O.A.
Deposit date:2005-02-10
Release date:2006-01-31
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mutation of interfaces in domain-swapped human betaB2-crystallin
Protein Sci., 16, 2007
4AKY
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CRYSTAL STRUCTURE OF VIRB8 FROM BRUCELLA SUIS IN COMPLEX WITH INTERACTION INHIBITOR 2-(BUTYLAMINO)-8-QUINOLINOL
Descriptor:TYPE IV SECRETION SYSTEM PROTEIN VIRB8, 2-(butylamino)quinolin-8-ol
Authors:Coincon, M., Smith, M.A., Sygusch, J., Baron, C.
Deposit date:2012-02-29
Release date:2012-09-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of the Binding Site of Brucella Virb8 Interaction Inhibitors.
Chem.Biol., 19, 2012
4AKZ
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CRYSTAL STRUCTURE OF VIRB8 FROM BRUCELLA SUIS
Descriptor:TYPE IV SECRETION SYSTEM PROTEIN VIRB8
Authors:Coincon, M., Smith, M.A., Sygusch, J., Baron, C.
Deposit date:2012-02-29
Release date:2012-09-05
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Identification of the Binding Site of Brucella Virb8 Interaction Inhibitors.
Chem.Biol., 19, 2012
4N1B
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STRUCTURE OF KEAP1 KELCH DOMAIN WITH(1S,2R)-2-[(1S)-1-[(1-OXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)METHYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-2-CARBONYL]CYCLOHEXANE-1-CARBOXYLIC ACID
Descriptor:Kelch-like ECH-associated protein 1, (1S,2R)-2-{[(1S)-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid, ACETATE ION
Authors:Smith, M.A., Duclos, S., Beaumont, E., Kwong, J., Brooks, M., Barker, J., Jnoff, E., Brookfield, F., Courade, J.P., Barker, O., Fryatt, T., Albrecht, C., Bromidge, S.
Deposit date:2013-10-03
Release date:2014-02-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.
Chemmedchem, 9, 2014
2W0Q
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E. COLI COPPER AMINE OXIDASE IN COMPLEX WITH XENON
Descriptor:COPPER AMINE OXIDASE, COPPER (II) ION, CALCIUM ION, ...
Authors:Pirrat, P., Smith, M.A., Pearson, A.R., McPherson, M.J., Phillips, S.E.V.
Deposit date:2008-08-20
Release date:2008-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structure of a Xenon Derivative of Escherichia Coli Copper Amine Oxidase: Confirmation of the Proposed Oxygen-Entry Pathway.
Acta Crystallogr.,Sect.F, 64, 2008
3HVG
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STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH EV0
Descriptor:Beta-secretase 1, 2-amino-6-propylpyrimidin-4(3H)-one, GLYCEROL
Authors:Godemann, R., Madden, J., Kramer, J., Smith, M.A., Barker, J., Ebneth, A.
Deposit date:2009-06-16
Release date:2009-11-03
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays
Biochemistry, 48, 2009
3HW1
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STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH LIGAND EV2
Descriptor:Beta-secretase 1, 3-pyrrolidin-1-ylquinoxalin-2-amine, GLYCEROL
Authors:Godemann, R., Madden, J., Kramer, J., Smith, M.A., Barker, J., Ebneth, A.
Deposit date:2009-06-17
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays
Biochemistry, 48, 2009
4AUE
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CRYSTAL STRUCTURE, RECOMBINANT EXPRESSION AND MUTAGENESIS STUDIES OF THE BIFUNCTIONAL CATALASE-PHENOL OXIDASE FROM SCYTALIDIUM THERMOPHILUM
Descriptor:CATALASE-PHENOL OXIDASE, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Yuzugullu, Y., Trinh, C.H., Smith, M.A., Pearson, A.R., Phillips, S.E.V., Sutay Kocabas, D., Bakir, U., Ogel, Z.B., McPherson, M.J.
Deposit date:2012-05-17
Release date:2013-02-27
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure, Recombinant Expression and Mutagenesis Studies of the Catalase with Oxidase Activity from Scytalidium Thermophilum
Acta Crystallogr.,Sect.D, 69, 2013
4AUL
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CRYSTAL STRUCTURE, RECOMBINANT EXPRESSION AND MUTAGENESIS STUDIES OF THE BIFUNCTIONAL CATALASE-PHENOL OXIDASE FROM SCYTALIDIUM THERMOPHILUM
Descriptor:CATALASE-PHENOL OXIDASE, PROTOPORPHYRIN IX CONTAINING FE, CALCIUM ION
Authors:Yuzugullu, Y., Trinh, C.H., Smith, M.A., Pearson, A.R., Phillips, S.E.V., Sutay Kocabas, D., Bakir, U., Ogel, Z.B., McPherson, M.J.
Deposit date:2012-05-18
Release date:2013-02-27
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure, Recombinant Expression and Mutagenesis Studies of the Catalase with Oxidase Activity from Scytalidium Thermophilum
Acta Crystallogr.,Sect.D, 69, 2013
4AUM
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CRYSTAL STRUCTURE, RECOMBINANT EXPRESSION AND MUTAGENESIS STUDIES OF THE BIFUNCTIONAL CATALASE-PHENOL OXIDASE FROM SCYTALIDIUM THERMOPHILUM
Descriptor:CATALASE-PHENOL OXIDASE, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, CALCIUM ION, ...
Authors:Yuzugullu, Y., Trinh, C.H., Smith, M.A., Pearson, A.R., Phillips, S.E.V., Sutay Kocabas, D., Bakir, U., Ogel, Z.B., McPherson, M.J.
Deposit date:2012-05-18
Release date:2013-02-27
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure, Recombinant Expression and Mutagenesis Studies of the Catalase with Oxidase Activity from Scytalidium Thermophilum
Acta Crystallogr.,Sect.D, 69, 2013
4AUN
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CRYSTAL STRUCTURE, RECOMBINANT EXPRESSION AND MUTAGENESIS STUDIES OF THE BIFUNCTIONAL CATALASE-PHENOL OXIDASE FROM SCYTALIDIUM THERMOPHILUM
Descriptor:CATALASE-PHENOL OXIDASE, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, CALCIUM ION
Authors:Yuzugullu, Y., Trinh, C.H., Smith, M.A., Pearson, A.R., Phillips, S.E.V., Sutay Kocabas, D., Bakir, U., Ogel, Z.B., McPherson, M.J.
Deposit date:2012-05-18
Release date:2013-02-27
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure, Recombinant Expression and Mutagenesis Studies of the Catalase with Oxidase Activity from Scytalidium Thermophilum
Acta Crystallogr.,Sect.D, 69, 2013
4L7B
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STRUCTURE OF KEAP1 KELCH DOMAIN WITH (1S,2R)-2-{[(1S)-1-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}CYCLOHEXANECARBOXYLIC ACID
Descriptor:Kelch-like ECH-associated protein 1, ACETATE ION, (1S,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid, ...
Authors:Jnoff, E., Brookfield, F., Albrecht, C., Barker, J.J., Barker, O., Beaumont, E., Bromidge, S., Brooks, M., Ceska, T., Courade, J.P., Crabbe, T., Duclos, S., Fryatt, T., Jigorel, E., Kwong, J., Sands, Z., Smith, M.A.
Deposit date:2013-06-13
Release date:2014-02-19
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.
Chemmedchem, 9, 2014
4L7C
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STRUCTURE OF KEAP1 KELCH DOMAIN WITH 2-{[(1S)-2-{[(1R,2S)-2-(1H-TETRAZOL-5-YL)CYCLOHEXYL]CARBONYL}-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE
Descriptor:Kelch-like ECH-associated protein 1, 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione, ACETATE ION
Authors:Jnoff, E., Brookfield, F., Albrecht, C., Barker, J.J., Barker, O., Beaumont, E., Bromidge, S., Brooks, M., Ceska, T., Courade, J.P., Crabbe, T., Duclos, S., Fryatt, T., Jigorel, E., Kwong, J., Sands, Z., Smith, M.A.
Deposit date:2013-06-13
Release date:2014-02-19
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.
Chemmedchem, 9, 2014
4L7D
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STRUCTURE OF KEAP1 KELCH DOMAIN WITH (1S,2R)-2-{[(1S)-5-METHYL-1-[(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]CARBONYL}CYCLOHEXANECARBOXYLIC ACID
Descriptor:Kelch-like ECH-associated protein 1, (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid, ACETATE ION
Authors:Jnoff, E., Brookfield, F., Albrecht, C., Barker, J.J., Barker, O., Beaumont, E., Bromidge, S., Brooks, M., Ceska, T., Courade, J.P., Crabbe, T., Duclos, S., Fryatt, T., Jigorel, E., Kwong, J., Sands, Z., Smith, M.A.
Deposit date:2013-06-13
Release date:2014-02-19
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.
Chemmedchem, 9, 2014
4RG8
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STRUCTURAL AND BIOCHEMICAL STUDIES OF A MODERATELY THERMOPHILIC EXONUCLEASE I FROM METHYLOCALDUM SZEGEDIENSE
Descriptor:Exonuclease I, MAGNESIUM ION
Authors:Fei, L., Tian, S., Moysey, R., Misca, M., Barker, J.J., Smith, M.A., McEwan, P.A., Pilka, E.S., Crawley, L., Evans, T., Sun, D.
Deposit date:2014-09-29
Release date:2015-02-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural and Biochemical Studies of a Moderately Thermophilic Exonuclease I from Methylocaldum szegediense.
Plos One, 10, 2015
6EZZ
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI AMINE OXIDASE MUTANT E573Q
Descriptor:Primary amine oxidase, COPPER (II) ION, CALCIUM ION, ...
Authors:Gaule, T.G., Smith, M.A., Tych, K.M., Pirrat, P., Trinh, C.H., Pearson, A.R., Knowles, P.F., McPherson, M.J.
Deposit date:2017-11-16
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli.
Biochemistry, 57, 2018
6GRR
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI AMINE OXIDASE MUTANT I342F/E573Q
Descriptor:Amine oxidase, COPPER (II) ION, CALCIUM ION, ...
Authors:Gaule, T.G., Smith, M.A., Tych, K.M., Pirrat, P., Trinh, C.H., Pearson, A.R., Knowles, P.F., McPherson, M.J.
Deposit date:2018-06-12
Release date:2018-09-05
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli.
Biochemistry, 57, 2018
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