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5KLT
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BU of 5klt by Molmil
Prototypical P4[M]cNLS
Descriptor: Importin subunit alpha-1, Prototypical P4[M]cNLS
Authors:Smith, K.M, Forwood, J.K.
Deposit date:2016-06-25
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting.
Biochim Biophys Acta Mol Cell Res, 1865, 2018
5KLR
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BU of 5klr by Molmil
Prototypical P4[R]cNLS
Descriptor: Importin subunit alpha-1, Prototypical P4[R]cNLS
Authors:Smith, K.M, Forwood, J.K.
Deposit date:2016-06-25
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting.
Biochim Biophys Acta Mol Cell Res, 1865, 2018
6BVZ
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BU of 6bvz by Molmil
Importin alpha 3 in cargo free state
Descriptor: Importin subunit alpha-3
Authors:Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BVT
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BU of 6bvt by Molmil
Importin alpha 1 in cargo free state
Descriptor: Importin subunit alpha-1
Authors:Smith, K.M, Tsimablyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
Deposit date:2017-12-13
Release date:2018-07-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BW0
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BU of 6bw0 by Molmil
Nipah virus W protein C-terminus in complex with Importin alpha 1
Descriptor: Importin subunit alpha-1, Protein W
Authors:Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BVV
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BU of 6bvv by Molmil
Nipah virus W protein C-terminus in complex with Importin alpha 3
Descriptor: Importin subunit alpha-3, Protein W
Authors:Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
Deposit date:2017-12-13
Release date:2018-07-04
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
5SVZ
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BU of 5svz by Molmil
HIV-1 Tat NLS in complex with importin alpha
Descriptor: Importin subunit alpha-1, Tat
Authors:Smith, K.M, Himiari, Z, Forwood, J.K.
Deposit date:2016-08-08
Release date:2016-08-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Importin-alpha Binding of the Human Immunodeficiency Virus Tat.
Sci Rep, 7, 2017
6BW9
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BU of 6bw9 by Molmil
Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1
Descriptor: Importin subunit alpha-3, Protein W
Authors:Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BWA
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BU of 6bwa by Molmil
Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 2
Descriptor: Importin subunit alpha-3, Protein W
Authors:Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BWB
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BU of 6bwb by Molmil
Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 3
Descriptor: Importin subunit alpha-3, Protein W
Authors:Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BW1
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BU of 6bw1 by Molmil
Hendra virus W protein C-terminus in complex with Importin alpha 1
Descriptor: Importin subunit alpha-1, Protein W
Authors:Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
7RG4
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BU of 7rg4 by Molmil
Importin alpha2 in complex with p50 NLS
Descriptor: Importin subunit alpha-1, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit
Authors:Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K.
Deposit date:2021-07-14
Release date:2021-08-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Nat Commun, 13, 2022
7RG5
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BU of 7rg5 by Molmil
Importin alpha3 in complex with p50 NLS
Descriptor: Importin subunit alpha-3, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit
Authors:Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K.
Deposit date:2021-07-14
Release date:2021-08-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Nat Commun, 13, 2022
5W41
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BU of 5w41 by Molmil
Zika MR766 NLS in complex with Importin alpha subunit-1
Descriptor: Importin subunit alpha-1, ZIKA MR766 NLS
Authors:Jeffress, S, Smith, K.M, Forwood, J.K.
Deposit date:2017-06-08
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Zika virus NS5 forms supramolecular nuclear bodies that sequester importin alpha and modulate the host immune and pro-inflammatory response in neuronal cells.
ACS Infect Dis, 2019
5HHG
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BU of 5hhg by Molmil
Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex
Descriptor: Importin subunit alpha-1, RNA-directed RNA polymerase NS5
Authors:Smith, K.M, Forwood, J.K.
Deposit date:2016-01-11
Release date:2016-05-18
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.
PLoS Pathog., 12, 2016
5FC8
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BU of 5fc8 by Molmil
Mouse importin alpha: Dengue 3 NS5 C-terminal NLS peptide complex
Descriptor: Importin subunit alpha-1, Nonstructural protein 5
Authors:Smith, K.M, Forwood, J.K.
Deposit date:2015-12-15
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.
PLoS Pathog., 12, 2016
4FCF
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BU of 4fcf by Molmil
K234R: apo structure of inhibitor resistant beta-lactamase
Descriptor: 2-AMINOETHANESULFONIC ACID, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
Authors:Rodkey, E.A, van den Akker, F.
Deposit date:2012-05-24
Release date:2012-12-26
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) beta-lactamase.
J.Med.Chem., 56, 2013
6HMK
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BU of 6hmk by Molmil
POLYADPRIBOSYL GLYCOHYDROLASE IN COMPLEX WITH PDD00016690
Descriptor: 1-methyl-~{N}-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-bis(oxidanylidene)quinazoline-6-sulfonamide, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Tucker, J.A, Barkauskaite, E.
Deposit date:2018-09-12
Release date:2018-11-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J.Med.Chem., 61, 2018
6HMM
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BU of 6hmm by Molmil
POLYADPRIBOSYL GLYCOHYDROLASE IN COMPLEX WITH PDD00013907
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Poly(ADP-ribose) glycohydrolase, ...
Authors:Tucker, J.A, Brassington, C, Hassall, G.
Deposit date:2018-09-12
Release date:2018-11-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J.Med.Chem., 61, 2018
6HML
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BU of 6hml by Molmil
POLYADPRIBOSYL GLYCOSIDASE IN COMPLEX WITH PDD00017299
Descriptor: 1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-6-[[(1-methylcyclopropyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-3-[(1-methylpyrazol-4-yl)methyl]quinazoline-2,4-dione, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Tucker, J.A, Barkauskaite, E.
Deposit date:2018-09-12
Release date:2018-11-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J.Med.Chem., 61, 2018
6HMN
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BU of 6hmn by Molmil
POLYADPRIBOSYL GLYCOSIDASE IN COMPLEX WITH PDD00014909
Descriptor: 3-methyl-6-[[(1-methylcyclopropyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-1-(phenylmethyl)quinazoline-2,4-dione, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Tucker, J.A, Brassington, C, Hassall, G.
Deposit date:2018-09-12
Release date:2018-11-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J.Med.Chem., 61, 2018
5EP5
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BU of 5ep5 by Molmil
The crystal structure of the hypothetical protein SAV0944 mutant (Glu47Ala) from Staphylococcus aureus.
Descriptor: thioesterase
Authors:Khandokar, Y.B, Srivastava, P, Forwood, J.K.
Deposit date:2015-11-11
Release date:2015-11-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The crystal structure of the hypothetical protein SAV0944 mutant (Glu47Ala) from Staphylococcus aureus
TO BE PUBLISHED
5LHB
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BU of 5lhb by Molmil
POLYADPRIBOSYL GLYCOSIDASE IN COMPLEX WITH PDD00017262
Descriptor: 1-(cyclopropylmethyl)-6-[[(1-methylcyclopropyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-3-[(2-methyl-1,3-thiazol-5-yl)methyl]quinazoline-2,4-dione, DIMETHYL SULFOXIDE, Poly(ADP-ribose) glycohydrolase, ...
Authors:Tucker, J, Barkauskaite, E.
Deposit date:2016-07-10
Release date:2016-10-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
ACS Chem. Biol., 11, 2016
7RXY
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BU of 7rxy by Molmil
Hen egg-white lysozyme with ionic liquid ethylammonium nitrate 5 mol%
Descriptor: Lysozyme C, NITRATE ION
Authors:Han, Q, Darmanin, C, Smith, K, Drummond, C, Greaves, T.
Deposit date:2021-08-24
Release date:2023-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids.
J Colloid Interface Sci, 650, 2023
7RYK
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BU of 7ryk by Molmil
Hen egg-white lysozyme with ionic liquid ethanolammonium nitrate 1 mol%
Descriptor: Lysozyme C, NITRATE ION
Authors:Han, Q, Darmanin, C, Smith, K, Drummond, C, Greaves, T.
Deposit date:2021-08-25
Release date:2023-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids.
J Colloid Interface Sci, 650, 2023

 

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