Author results

1B1C
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CRYSTAL STRUCTURE OF THE FMN-BINDING DOMAIN OF HUMAN CYTOCHROME P450 REDUCTASE AT 1.93A RESOLUTION
分子名称:PROTEIN (NADPH-CYTOCHROME P450 REDUCTASE), CALCIUM ION, FLAVIN MONONUCLEOTIDE
著者Zhao, Q., Modi, S., Smith, G., Paine, M., Mcdonagh, P.D., Wolf, C.R., Tew, D., Lian, L.-Y., Roberts, G.C.K., Driessen, H.P.C.
登録日1998-11-19
公開日1999-11-24
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution.
Protein Sci., 8, 1999
3EOC
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CDK2/CYCLINA COMPLEXED WITH A IMIDAZO TRIAZIN-2-AMINE
分子名称:Cell division protein kinase 2, Cyclin-A2, 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine
著者Cheung, M., Kuntz, K., Pobanz, M., Salovich, J., Wilson, B., Andrews, W., Shewchuk, L., Epperly, A., Hassler, D., Leesnitzer, M., Smith, J., Smith, G., Lansing, T., Mook, R.
登録日2008-09-26
公開日2008-11-04
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
Bioorg.Med.Chem.Lett., 18, 2008
4A0D
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STRUCTURE OF UNLIGANDED HUMAN PARG CATALYTIC DOMAIN
分子名称:POLY(ADP-RIBOSE) GLYCOHYDROLASE, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, ...
著者Brassington, C., Ellston, J., Hassall, G., Holdgate, G., McAlister, M., Overman, R., Smith, G., Tucker, J.A., Watson, M.
登録日2011-09-08
公開日2012-10-17
最終更新日2013-01-16
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1G
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STRUCTURE OF UNLIGANDED HUMAN PARG CATALYTIC DOMAIN
分子名称:POLY(ADP-RIBOSE) GLYCOHYDROLASE, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, SULFATE ION
著者Brassington, C., Ellston, J., Hassall, G., Holdgate, G., McAlister, M., Overman, R., Smith, G., Tucker, J.A., Watson, M.
登録日2012-07-10
公開日2012-12-19
最終更新日2013-01-16
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1H
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STRUCTURE OF HUMAN PARG CATALYTIC DOMAIN IN COMPLEX WITH ADP-RIBOSE
分子名称:POLY(ADP-RIBOSE) GLYCOHYDROLASE, BETA-MERCAPTOETHANOL, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ...
著者Brassington, C., Ellston, J., Hassall, G., Holdgate, G., McAlister, M., Smith, G., Tucker, J.A., Watson, M.
登録日2012-07-10
公開日2012-12-19
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1I
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STRUCTURE OF HUMAN PARG CATALYTIC DOMAIN IN COMPLEX WITH OA-ADP-HPD
分子名称:POLY(ADP-RIBOSE) GLYCOHYDROLASE, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, ...
著者Brassington, C., Ellston, J., Hassall, G., Holdgate, G., Johnson, T., McAlister, M., Smith, G., Tucker, J.A., Watson, M.
登録日2012-07-10
公開日2012-12-19
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1J
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STRUCTURE OF HUMAN PARG CATALYTIC DOMAIN IN COMPLEX WITH ADP-HPD
分子名称:POLY(ADP-RIBOSE) GLYCOHYDROLASE, GLYCEROL, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, ...
著者Brassington, C., Ellston, J., Hassall, G., Holdgate, G., McAlister, M., Overman, R., Smith, G., Tucker, J.A., Watson, M.
登録日2012-07-10
公開日2012-12-19
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
6CXC
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3.9A CRYO-EM STRUCTURE OF MURINE ANTIBODY BOUND AT A NOVEL EPITOPE OF RESPIRATORY SYNCYTIAL VIRUS FUSION PROTEIN
分子名称:R4.C6 Fab Heavy Chain, R4.C6 Fab Light Chain, Fusion glycoprotein F0, ...
著者Xie, Q., Wang, Z., Chen, X., Ni, F., Ma, J., Wang, Q.
登録日2018-04-02
公開日2019-07-31
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Near-atomic structure of a novel site II/IV antigenic epitope on respiratory syncytial virus fusion glycoprotein determined by cryo-EM
To be Published
3BXQ
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THE STRUCTURE OF A MUTANT INSULIN UNCOUPLES RECEPTOR BINDING FROM PROTEIN ALLOSTERY. AN ELECTROSTATIC BLOCK TO THE TR TRANSITION
分子名称:insulin A chain, insulin B chain, ZINC ION
著者Wan, Z.L., Huang, K., Hu, S.Q., Whittaker, J., Weiss, M.A.
登録日2008-01-14
公開日2008-05-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
3FQ9
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DESIGN OF AN INSULIN ANALOG WITH ENHANCED RECEPTOR-BINDING SELECTIVITY. RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
分子名称:Insulin, ZINC ION
著者Zhao, M., Wan, Z.L., Whittaker, L., Xu, B., Phillips, N., Katsoyannis, P., Whittaker, J., Weiss, M.A.
登録日2009-01-07
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
3GKY
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THE STRUCTURAL BASIS OF AN ER STRESS-ASSOCIATED BOTTLENECK IN A PROTEIN FOLDING LANDSCAPE
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Liu, M., Wan, Z.L., Chu, Y.C., Alddin, H., Klaproth, B., Weiss, M.A.
登録日2009-03-11
公開日2009-03-24
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
3KQ6
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ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
登録日2009-11-17
公開日2010-02-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
登録日2011-04-26
公開日2012-05-02
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, PHENOL, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published