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1L7F
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CRYSTAL STRUCTURE OF INFLUENZA VIRUS NEURAMINIDASE IN COMPLEX WITH BCX-1812
Descriptor:neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Smith, B.J., McKimm-Breshkin, J.L., McDonald, M., Fernley, R.T., Varghese, J.N., Colman, P.M.
Deposit date:2002-03-15
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of the resistance of influenza virus neuramindase to inhibitors.
J.Med.Chem., 45, 2002
1L7H
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CRYSTAL STRUCTURE OF R292K MUTANT INFLUENZA VIRUS NEURAMINIDASE IN COMPLEX WITH BCX-1812
Descriptor:neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Smith, B.J., McKimm-Breshkin, J.L., McDonald, M., Fernley, R.T., Varghese, J.N., Colman, P.M.
Deposit date:2002-03-15
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural studies of the resistance of influenza virus neuramindase to inhibitors.
J.Med.Chem., 45, 2002
1F8B
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NATIVE INFLUENZA VIRUS NEURAMINIDASE IN COMPLEX WITH NEU5AC2EN
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Smith, B.J., Colman, P.M., Von Itzstein, M., Danylec, B., Varghese, J.N.
Deposit date:2000-06-30
Release date:2001-04-11
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
1F8C
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NATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-NEURAMINIC ACID
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Smith, B.J., Colman, P.M., Von Itzstein, M., Danylec, B., Varghese, J.N.
Deposit date:2000-06-30
Release date:2001-04-11
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
1F8D
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NATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 9-AMINO-2-DEOXY-2,3-DEHYDRO-N-NEURAMINIC ACID
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Smith, B.J., Colman, P.M., Von Itzstein, M., Danylec, B., Varghese, J.N.
Deposit date:2000-06-30
Release date:2001-04-11
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
1F8E
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NATIVE INFLUENZA NEURAMINIDASE IN COMPLEX WITH 4,9-DIAMINO-2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Smith, B.J., Colman, P.M., Von Itzstein, M., Danylec, B., Varghese, J.N.
Deposit date:2000-06-30
Release date:2001-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
1L7G
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CRYSTAL STRUCTURE OF E119G MUTANT INFLUENZA VIRUS NEURAMINIDASE IN COMPLEX WITH BCX-1812
Descriptor:neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Smith, B.J., McKimm-Breshkin, J.L., McDonald, M., Fernley, R.T., Varghese, J.N., Colman, P.M.
Deposit date:2002-03-15
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural studies of the resistance of influenza virus neuramindase to inhibitors.
J.Med.Chem., 45, 2002
2B8H
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A/NWS/WHALE/MAINE/1/84 (H1N9) REASSORTANT INFLUENZA VIRUS NEURAMINIDASE
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Smith, B.J., Platis, D., Cox, M.M.J., Huyton, T., Joosten, R.P., McKimm-Breschkin, J.L., Zhang, J.-G., Luo, C.S., Lou, M.-Z., Garrett, T.P.J., Labrou, N.E.
Deposit date:2005-10-07
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a calcium-deficient form of influenza virus neuraminidase: implications for substrate binding.
Acta Crystallogr.,Sect.D, 62, 2006
4BPI
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MCL-1 BOUND TO ALPHA BETA PUMA BH3 PEPTIDE 2
Descriptor:FUSION PROTEIN CONSISTING OF INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 HOMOLOG, ALPHA BETA BH3PEPTIDE, CADMIUM ION
Authors:Smith, B.J., Lee, E.F., Checco, J.W., Gellman, S.H., Fairlie, W.D.
Deposit date:2013-05-27
Release date:2014-04-09
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (1.982 Å)
Cite:Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins.
Chembiochem, 14, 2013
4BPJ
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MCL-1 BOUND TO ALPHA BETA PUMA BH3 PEPTIDE 3
Descriptor:FUSION PROTEIN CONSISTING OF INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 HOMOLOG, ALPHA BETA BH3-PEPTIDE, ZINC ION, ...
Authors:Smith, B.J., Lee, E.F., Checco, J.W., Gellman, S.H., Fairlie, W.D.
Deposit date:2013-05-27
Release date:2014-04-09
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins.
Chembiochem, 14, 2013
4BPK
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BCL-XL BOUND TO ALPHA BETA PUMA BH3 PEPTIDE 5
Descriptor:BCL-2-LIKE PROTEIN 1, ALPHA BETA BH3-PEPTIDE, CADMIUM ION, ...
Authors:Smith, B.J., Lee, E.F., Checco, J.W., Gellman, S.H., Fairlie, W.D.
Deposit date:2013-05-27
Release date:2014-04-09
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.756 Å)
Cite:Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins.
Chembiochem, 14, 2013
2I54
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PHOSPHOMANNOMUTASE FROM LEISHMANIA MEXICANA
Descriptor:Phosphomannomutase, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Smith, B.J.
Deposit date:2006-08-24
Release date:2007-04-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms
J.Mol.Biol., 363, 2006
2I55
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COMPLEX OF GLUCOSE-1,6-BISPHOSPHATE WITH PHOSPHOMANNOMUTASE FROM LEISHMANIA MEXICANA
Descriptor:Phosphomannomutase, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Smith, B.J.
Deposit date:2006-08-24
Release date:2007-04-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms
J.Mol.Biol., 363, 2006
2WBF
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CRYSTAL STRUCTURE ANALYSIS OF SERA5E FROM PLASMODIUM FALCIPARUM WITH LOOP 690-700 ORDERED
Descriptor:SERINE-REPEAT ANTIGEN PROTEIN, DIMETHYL SULFOXIDE, CALCIUM ION, ...
Authors:Smith, B.J., Malby, R.L., Colman, P.M., Clarke, O.B.
Deposit date:2009-02-27
Release date:2009-03-31
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.
J. Mol. Biol., 392, 2009
2YQ6
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STRUCTURE OF BCL-XL BOUND TO BIMSAHB
Descriptor:BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL
Authors:Smith, B.J., Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
2YQ7
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STRUCTURE OF BCL-XL BOUND TO BIMLOCK
Descriptor:BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL
Authors:Smith, B.J., Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
3CH2
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CRYSTAL STRUCTURE ANALYSIS OF SERA5E FROM PLASMODIUM FALCIPARUM
Descriptor:Serine-repeat antigen protein, CALCIUM ION
Authors:Smith, B.J., Malby, R.L., Colman, P.M., Clarke, O.B.
Deposit date:2008-03-07
Release date:2008-03-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine
J.Mol.Biol., 392, 2009
3CH3
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CRYSTAL STRUCTURE ANALYSIS OF SERA5E FROM PLASMODIUM FALCIPARUM
Descriptor:Serine-repeat antigen protein, POTASSIUM ION, DIHYDROGENPHOSPHATE ION
Authors:Smith, B.J., Malby, R.L., Colman, P.M., Clarke, O.B.
Deposit date:2008-03-07
Release date:2008-03-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine
J.Mol.Biol., 392, 2009
5AGW
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BCL-2 ALPHA BETA-1 COMPLEX
Descriptor:APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11
Authors:Smith, B.J., F Lee, E., Checco, J.W., Gellman, S.H., Fairlie, W.D.
Deposit date:2015-02-04
Release date:2015-09-09
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:Alpha Beta Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity on Living Cells
J.Am.Chem.Soc., 137, 2015
5AGX
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BCL-2 ALPHA BETA-1 LINEAR COMPLEX
Descriptor:APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11
Authors:Smith, B.J., F Lee, E., Checco, J.W., Gellman, S.H., Fairlie, W.D.
Deposit date:2015-02-04
Release date:2015-09-09
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Alpha Beta Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity on Living Cells
J.Am.Chem.Soc., 137, 2015
1F5Z
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CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM I
Descriptor:N-ACETYLNEURAMINATE LYASE
Authors:Barbosa, J.A.R.G., Smith, B.J., DeGori, R., Lawrence, M.C.
Deposit date:2000-06-18
Release date:2000-12-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
J.Mol.Biol., 303, 2000
1F6P
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CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III
Descriptor:N-ACETYL NEURAMINATE LYASE
Authors:Barbosa, J.A.R.G., Smith, B.J., DeGori, R., Lawrence, M.C.
Deposit date:2000-06-22
Release date:2000-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
J.Mol.Biol., 303, 2000
6DCN
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BCL-XL COMPLEX WITH BECLIN 1 BH3 DOMAIN T108PTHR
Descriptor:BCL-xl protein, Beclin-1
Authors:Lee, E.F., Smith, B.J., Smith, N.A., Yao, S., Fairlie, W.D.
Deposit date:2018-05-07
Release date:2018-05-23
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.444 Å)
Cite:Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Autophagy, 2019
6DCO
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BCL-XL COMPLEX WITH BECLIN 1 BH3 DOMAIN T108D
Descriptor:Bcl-2-like protein 1,Bcl-2-like protein 1, Beclin-1, CHLORIDE ION
Authors:Lee, E.F., Smith, B.J., Smith, N.A., Yao, S., Fairlie, W.D.
Deposit date:2018-05-07
Release date:2018-05-30
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Autophagy, 2019
1F6K
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CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM II
Descriptor:N-ACETYLNEURAMINATE LYASE, SULFATE ION, GLYCEROL
Authors:Barbosa, J.A.R.G., Smith, B.J., DeGori, R., Lawrence, M.C.
Deposit date:2000-06-21
Release date:2000-12-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
J.Mol.Biol., 303, 2000