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1A3E
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BU of 1a3e by Molmil
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG2
Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BOROLOG2, ...
Authors:Skordalakes, E, Elgendy, S, Goodwin, C.A, Green, D, Scullly, M.F, Kakkar, V.V, Freyssinet, J.M, Dodson, G, Deadman, J.
Deposit date:1998-01-21
Release date:1998-06-03
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Biochemistry, 37, 1998
1A3B
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BU of 1a3b by Molmil
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1
Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), Hirudin, ...
Authors:Skordalakes, E, Elgendy, S, Dodson, G, Goodwin, C.A, Green, D, Scully, M.F, Freyssinet, J.H, Kakkar, V.V, Deadman, J.
Deposit date:1998-01-20
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Biochemistry, 37, 1998
1H8D
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BU of 1h8d by Molmil
X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor.
Descriptor: HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-{(1S,3E)-1-[dihydroxy(diphenoxy)-lambda~5~-phosphanyl]-4-methoxybut-3-en-1-yl}-L-prolinamide, THROMBIN
Authors:Skordalakes, E, Dodson, G.G, Green, D, Deadman, J.
Deposit date:2001-02-01
Release date:2001-02-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate
J.Mol.Biol., 311, 2001
1H8I
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BU of 1h8i by Molmil
X-ray crystal structure of human alpha-thrombin with a tripeptide phosphonate inhibitor.
Descriptor: HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-[(1S)-4-methoxy-1-phosphonobutyl]-L-prolinamide, THROMBIN
Authors:Skordalakes, E, Dodson, G.G, Green, D, Deadman, J.
Deposit date:2001-02-08
Release date:2001-03-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate
J.Mol.Biol., 311, 2001
2HT1
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BU of 2ht1 by Molmil
The closed ring structure of the Rho transcription termination factor in complex with nucleic acid in the motor domains
Descriptor: 5'-R(*UP*C)-3', 5'-R(*UP*CP*UP*CP*U)-3', SULFATE ION, ...
Authors:Skordalakes, E, Berger, J.M.
Deposit date:2006-07-24
Release date:2006-11-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Structural Insights into RNA-Dependent Ring Closure and ATPase Activation by the Rho Termination Factor.
Cell(Cambridge,Mass.), 127, 2006
7SBE
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BU of 7sbe by Molmil
Structure of the K. lactis telomerase RNA binding domain
Descriptor: Telomerase reverse transcriptase
Authors:Skordalakes, E, Tzfati, Y.
Deposit date:2021-09-24
Release date:2022-09-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the K. lactis telomerase RNA binding domain
Int J Mol Sci, 2022
1XPR
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BU of 1xpr by Molmil
Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic 5a-formylbicyclomycin (FB)
Descriptor: 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3', 5A-FORMYLBICYCLOMYCIN, MAGNESIUM ION, ...
Authors:Skordalakes, E, Brogan, A.P, Park, B.S, Kohn, H, Berger, J.M.
Deposit date:2004-10-09
Release date:2004-11-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin
Structure, 13, 2005
1XPU
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BU of 1xpu by Molmil
Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic 5a-(3-formylphenylsulfanyl)-dihydrobicyclomycin (FPDB)
Descriptor: 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3', 5A-(3-FORMYLPHENYLSULFANYL)-DIHYDROBICYCLOMYCIN, MAGNESIUM ION, ...
Authors:Skordalakes, E, Brogan, A.P, Park, B.S, Kohn, H, Berger, J.M.
Deposit date:2004-10-09
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin
Structure, 13, 2005
1XPO
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BU of 1xpo by Molmil
Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin
Descriptor: 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3', BICYCLOMYCIN, MAGNESIUM ION, ...
Authors:Skordalakes, E, Brogan, A.P, Park, B.S, Kohn, H, Berger, J.M.
Deposit date:2004-10-09
Release date:2005-02-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin
Structure, 13, 2005
1PV4
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BU of 1pv4 by Molmil
X-ray crystal structure of the Rho transcription termination factor in complex with single stranded DNA
Descriptor: 5'-D(P*CP*C)-3', Transcription termination factor rho
Authors:Skordalakes, E, Berger, J.M.
Deposit date:2003-06-26
Release date:2003-07-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading
Cell(Cambridge,Mass.), 114, 2003
1PVO
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BU of 1pvo by Molmil
X-ray crystal structure of Rho transcription termination factor in complex with ssRNA substrate and ANPPNP
Descriptor: 5'-R(P*UP*C)-3', PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transcription termination factor rho
Authors:Skordalakes, E, Berger, J.M.
Deposit date:2003-06-27
Release date:2003-07-22
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading
Cell(Cambridge,Mass.), 114, 2003
5UGW
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BU of 5ugw by Molmil
STRUCTURE OF THE HUMAN TELOMERASE THUMB DOMAIN
Descriptor: GLUTATHIONE, Telomerase reverse transcriptase
Authors:Skordalakes, E, Hoffman, H.
Deposit date:2017-01-10
Release date:2017-02-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes.
J. Biol. Chem., 292, 2017
3KYL
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BU of 3kyl by Molmil
Structure of the catalytic subunit of telomerase bound to its RNA template and telomeric DNA
Descriptor: DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*TP*TP*CP*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*G)-3'), MAGNESIUM ION, Telomerase reverse transcriptase
Authors:Skordalakes, E.
Deposit date:2009-12-06
Release date:2010-03-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA.
Nat.Struct.Mol.Biol., 17, 2010
3DU5
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BU of 3du5 by Molmil
Structure of the catalytic subunit of telomerase, TERT
Descriptor: Telomerase reverse transcriptase
Authors:Skordalakes, E.
Deposit date:2008-07-16
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Nature, 455, 2008
3DU6
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BU of 3du6 by Molmil
Structure of the catalytic subunit of telomerase, TERT
Descriptor: Telomerase reverse transcriptase
Authors:Skordalakes, E.
Deposit date:2008-07-16
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Nature, 455, 2008
4LMO
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BU of 4lmo by Molmil
Structure of a vertebrate RNA binding domain of telomerase (TRBD)
Descriptor: Telomerase reverse transcriptase
Authors:Harkisheimer, M, Mason, M, Shuvaeva, E, Skordalakes, E.
Deposit date:2013-07-10
Release date:2013-10-09
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:A Motif in the Vertebrate Telomerase N-Terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and Processivity.
Structure, 21, 2013
6E53
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BU of 6e53 by Molmil
Structure of TERT in complex with a novel telomerase inhibitor
Descriptor: MAGNESIUM ION, RNA/DNA hairpin, Telomerase reverse transcriptase, ...
Authors:Hernandez-Sanchez, W, Huang, W, Plucinsky, B, Garcia-Vazquez, N, Berdis, A.J, Skordalakes, E, Taylor, D.J.
Deposit date:2018-07-19
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.
Plos Biol., 17, 2019
5CQG
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BU of 5cqg by Molmil
Structure of Tribolium telomerase in complex with the highly specific inhibitor BIBR1532
Descriptor: 2-{[(2E)-3-(naphthalen-2-yl)but-2-enoyl]amino}benzoic acid, Telomerase reverse transcriptase
Authors:Bryan, C, Rice, C, Hoffman, H, Harkisheimer, M, Sweeney, M, Skordalakes, E.
Deposit date:2015-07-21
Release date:2015-09-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532.
Structure, 23, 2015
5UN7
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BU of 5un7 by Molmil
Structure of the human POT1-TPP1 telomeric complex
Descriptor: Adrenocortical dysplasia protein homolog, POTASSIUM ION, Protection of telomeres protein 1, ...
Authors:Rice, C, Doukov, T, Skordalakes, E.
Deposit date:2017-01-30
Release date:2017-04-12
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional analysis of the human POT1-TPP1 telomeric complex.
Nat Commun, 8, 2017
5W2L
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BU of 5w2l by Molmil
Structure of a central domain of human Ctc1
Descriptor: CST complex subunit CTC1, MERCURY (II) ION
Authors:Rice, C, Skordalakes, E.
Deposit date:2017-06-06
Release date:2017-11-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes.
Nucleic Acids Res., 46, 2018
3NWT
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BU of 3nwt by Molmil
Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13
Descriptor: Cell division control protein 13
Authors:Mitchell, M.T, Smith, J.S, Mason, M, Harper, S, Speicher, D.W, Johnson, F.B, Skordalakes, E.
Deposit date:2010-07-10
Release date:2010-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation.
Mol.Cell.Biol., 30, 2010
3NWS
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BU of 3nws by Molmil
Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13
Descriptor: Cell division control protein 13
Authors:Mitchell, M.T, Smith, J.S, Mason, M, Harper, S, Speicher, D.W, Johnson, F.B, Skordalakes, E.
Deposit date:2010-07-10
Release date:2010-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation.
Mol.Cell.Biol., 30, 2010
3LAW
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BU of 3law by Molmil
Structure of GTP-bound L129F mutant Rab7
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-7a
Authors:McCray, B.A, Skordalakes, E, Taylor, J.P.
Deposit date:2010-01-07
Release date:2010-01-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.
Hum.Mol.Genet., 19, 2010
2Q17
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BU of 2q17 by Molmil
Formylglycine Generating Enzyme from Streptomyces coelicolor
Descriptor: CALCIUM ION, formylglycine generating enzyme
Authors:Carlson, B.L, Ballister, E.R, Skordalakes, E, King, D.S, Breidenbach, M.A, Gilmore, S.A, Berger, J.M, Bertozzi, C.R.
Deposit date:2007-05-23
Release date:2008-04-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Function and structure of a prokaryotic formylglycine-generating enzyme.
J.Biol.Chem., 283, 2008
2R4G
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BU of 2r4g by Molmil
The high resolution structure of the RNA-binding domain of telomerase
Descriptor: BROMIDE ION, Telomerase reverse transcriptase
Authors:Rouda, S, Skordalakes, E.
Deposit date:2007-08-31
Release date:2007-11-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding.
Structure, 15, 2007

 

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