Author results

1A3B
  • Download 1a3b
  • View 1a3b
Molmil generated image of 1a3b
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Hirudin, ...
Authors:Skordalakes, E., Elgendy, S., Dodson, G., Goodwin, C.A., Green, D., Scully, M.F., Freyssinet, J.H., Kakkar, V.V., Deadman, J.
Deposit date:1998-01-20
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Biochemistry, 37, 1998
1A3E
  • Download 1a3e
  • View 1a3e
Molmil generated image of 1a3e
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG2
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Hirudin, ...
Authors:Skordalakes, E., Elgendy, S., Goodwin, C.A., Green, D., Scullly, M.F., Kakkar, V.V., Freyssinet, J.M., Dodson, G., Deadman, J.
Deposit date:1998-01-21
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Biochemistry, 37, 1998
1H8D
  • Download 1h8d
  • View 1h8d
Molmil generated image of 1h8d
X-RAY STRUCTURE OF THE HUMAN ALPHA-THROMBIN COMPLEX WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.
Descriptor:THROMBIN, HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-{(1S,3E)-1-[dihydroxy(diphenoxy)-lambda~5~-phosphanyl]-4-methoxybut-3-en-1-yl}-L-prolinamide
Authors:Skordalakes, E., Dodson, G.G., Green, D., Deadman, J.
Deposit date:2001-02-01
Release date:2001-02-26
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate
J.Mol.Biol., 311, 2001
1H8I
  • Download 1h8i
  • View 1h8i
Molmil generated image of 1h8i
X-RAY CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.
Descriptor:THROMBIN, HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-[(1S)-4-methoxy-1-phosphonobutyl]-L-prolinamide
Authors:Skordalakes, E., Dodson, G.G., Green, D., Deadman, J.
Deposit date:2001-02-08
Release date:2001-03-02
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate
J.Mol.Biol., 311, 2001
1PV4
  • Download 1pv4
  • View 1pv4
Molmil generated image of 1pv4
X-RAY CRYSTAL STRUCTURE OF THE RHO TRANSCRIPTION TERMINATION FACTOR IN COMPLEX WITH SINGLE STRANDED DNA
Descriptor:5'-D(P*CP*C)-3', Transcription termination factor rho
Authors:Skordalakes, E., Berger, J.M.
Deposit date:2003-06-26
Release date:2003-07-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading
Cell(Cambridge,Mass.), 114, 2003
1PVO
  • Download 1pvo
  • View 1pvo
Molmil generated image of 1pvo
X-RAY CRYSTAL STRUCTURE OF RHO TRANSCRIPTION TERMINATION FACTOR IN COMPLEX WITH SSRNA SUBSTRATE AND ANPPNP
Descriptor:5'-R(P*UP*C)-3', Transcription termination factor rho, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Skordalakes, E., Berger, J.M.
Deposit date:2003-06-27
Release date:2003-07-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading
Cell(Cambridge,Mass.), 114, 2003
1XPO
  • Download 1xpo
  • View 1xpo
Molmil generated image of 1xpo
STRUCTURAL MECHANISM OF INHIBITION OF THE RHO TRANSCRIPTION TERMINATION FACTOR BY THE ANTIBIOTIC BICYCLOMYCIN
Descriptor:5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3', Rho transcription termination factor, MAGNESIUM ION, ...
Authors:Skordalakes, E., Brogan, A.P., Park, B.S., Kohn, H., Berger, J.M.
Deposit date:2004-10-09
Release date:2005-02-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin
Structure, 13, 2005
1XPR
  • Download 1xpr
  • View 1xpr
Molmil generated image of 1xpr
STRUCTURAL MECHANISM OF INHIBITION OF THE RHO TRANSCRIPTION TERMINATION FACTOR BY THE ANTIBIOTIC 5A-FORMYLBICYCLOMYCIN (FB)
Descriptor:5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3', Rho transcription termination factor, MAGNESIUM ION, ...
Authors:Skordalakes, E., Brogan, A.P., Park, B.S., Kohn, H., Berger, J.M.
Deposit date:2004-10-09
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin
Structure, 13, 2005
1XPU
  • Download 1xpu
  • View 1xpu
Molmil generated image of 1xpu
STRUCTURAL MECHANISM OF INHIBITION OF THE RHO TRANSCRIPTION TERMINATION FACTOR BY THE ANTIBIOTIC 5A-(3-FORMYLPHENYLSULFANYL)-DIHYDROBICYCLOMYCIN (FPDB)
Descriptor:5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3', Rho transcription termination factor, MAGNESIUM ION, ...
Authors:Skordalakes, E., Brogan, A.P., Park, B.S., Kohn, H., Berger, J.M.
Deposit date:2004-10-09
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin
Structure, 13, 2005
2HT1
  • Download 2ht1
  • View 2ht1
Molmil generated image of 2ht1
THE CLOSED RING STRUCTURE OF THE RHO TRANSCRIPTION TERMINATION FACTOR IN COMPLEX WITH NUCLEIC ACID IN THE MOTOR DOMAINS
Descriptor:5'-R(*UP*C)-3', 5'-R(*UP*CP*UP*CP*U)-3', Transcription termination factor rho, ...
Authors:Skordalakes, E., Berger, J.M.
Deposit date:2006-07-24
Release date:2006-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Structural Insights into RNA-Dependent Ring Closure and ATPase Activation by the Rho Termination Factor.
Cell(Cambridge,Mass.), 127, 2006
3DU5
  • Download 3du5
  • View 3du5
Molmil generated image of 3du5
STRUCTURE OF THE CATALYTIC SUBUNIT OF TELOMERASE, TERT
Descriptor:Telomerase reverse transcriptase
Authors:Skordalakes, E.
Deposit date:2008-07-16
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Nature, 455, 2008
3DU6
  • Download 3du6
  • View 3du6
Molmil generated image of 3du6
STRUCTURE OF THE CATALYTIC SUBUNIT OF TELOMERASE, TERT
Descriptor:Telomerase reverse transcriptase
Authors:Skordalakes, E.
Deposit date:2008-07-16
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Nature, 455, 2008
3KYL
  • Download 3kyl
  • View 3kyl
Molmil generated image of 3kyl
STRUCTURE OF THE CATALYTIC SUBUNIT OF TELOMERASE BOUND TO ITS RNA TEMPLATE AND TELOMERIC DNA
Descriptor:Telomerase reverse transcriptase, DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*TP*TP*CP*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*G)-3'), MAGNESIUM ION
Authors:Skordalakes, E.
Deposit date:2009-12-06
Release date:2010-03-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA.
Nat.Struct.Mol.Biol., 17, 2010
5UGW
  • Download 5ugw
  • View 5ugw
Molmil generated image of 5ugw
STRUCTURE OF THE HUMAN TELOMERASE THUMB DOMAIN
Descriptor:Telomerase reverse transcriptase, GLUTATHIONE
Authors:Skordalakes, E., Hoffman, H.
Deposit date:2017-01-10
Release date:2017-02-08
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes.
J. Biol. Chem., 292, 2017
4LMO
  • Download 4lmo
  • View 4lmo
Molmil generated image of 4lmo
STRUCTURE OF A VERTEBRATE RNA BINDING DOMAIN OF TELOMERASE (TRBD)
Descriptor:Telomerase reverse transcriptase
Authors:Harkisheimer, M., Mason, M., Shuvaeva, E., Skordalakes, E.
Deposit date:2013-07-10
Release date:2013-10-09
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:A Motif in the Vertebrate Telomerase N-Terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and Processivity.
Structure, 21, 2013
1ROC
  • Download 1roc
  • View 1roc
Molmil generated image of 1roc
CRYSTAL STRUCTURE OF THE HISTONE DEPOSITION PROTEIN ASF1
Descriptor:Anti-silencing protein 1, BROMIDE ION
Authors:Daganzo, S.M., Erzberger, J.P., Lam, W.M., Skordalakes, E., Zhang, R., Franco, A.A., Brill, S.J., Adams, P.D., Berger, J.M., Kaufman, P.D.
Deposit date:2003-12-02
Release date:2003-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and function of the conserved core of histone deposition protein Asf1.
Curr.Biol., 13, 2003
2Q17
  • Download 2q17
  • View 2q17
Molmil generated image of 2q17
FORMYLGLYCINE GENERATING ENZYME FROM STREPTOMYCES COELICOLOR
Descriptor:formylglycine generating enzyme, CALCIUM ION
Authors:Carlson, B.L., Ballister, E.R., Skordalakes, E., King, D.S., Breidenbach, M.A., Gilmore, S.A., Berger, J.M., Bertozzi, C.R.
Deposit date:2007-05-23
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Function and structure of a prokaryotic formylglycine-generating enzyme.
J.Biol.Chem., 283, 2008
2R4G
  • Download 2r4g
  • View 2r4g
Molmil generated image of 2r4g
THE HIGH RESOLUTION STRUCTURE OF THE RNA-BINDING DOMAIN OF TELOMERASE
Descriptor:Telomerase reverse transcriptase, BROMIDE ION
Authors:Rouda, S., Skordalakes, E.
Deposit date:2007-08-31
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding.
Structure, 15, 2007
3FK3
  • Download 3fk3
  • View 3fk3
Molmil generated image of 3fk3
STRUCTURE OF THE YEATS DOMAIN, YAF9
Descriptor:Protein AF-9 homolog
Authors:Wang, A.Y., Schulze, J.M., Skordalakes, E., Berger, J.M., Rine, J., Kobor, M.S.
Deposit date:2008-12-15
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation
Proc.Natl.Acad.Sci.USA, 106, 2009
3LAW
  • Download 3law
  • View 3law
Molmil generated image of 3law
STRUCTURE OF GTP-BOUND L129F MUTANT RAB7
Descriptor:Ras-related protein Rab-7a, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:McCray, B.A., Skordalakes, E., Taylor, J.P.
Deposit date:2010-01-07
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.
Hum.Mol.Genet., 19, 2010
3NWS
  • Download 3nws
  • View 3nws
Molmil generated image of 3nws
CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST TELOMERE-BINDING AND TELOMERASE REGULATORY PROTEIN CDC13
Descriptor:Cell division control protein 13
Authors:Mitchell, M.T., Smith, J.S., Mason, M., Harper, S., Speicher, D.W., Johnson, F.B., Skordalakes, E.
Deposit date:2010-07-10
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation.
Mol.Cell.Biol., 30, 2010
3NWT
  • Download 3nwt
  • View 3nwt
Molmil generated image of 3nwt
CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST TELOMERE-BINDING AND TELOMERASE REGULATORY PROTEIN CDC13
Descriptor:Cell division control protein 13
Authors:Mitchell, M.T., Smith, J.S., Mason, M., Harper, S., Speicher, D.W., Johnson, F.B., Skordalakes, E.
Deposit date:2010-07-10
Release date:2010-09-22
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation.
Mol.Cell.Biol., 30, 2010
4HCE
  • Download 4hce
  • View 4hce
Molmil generated image of 4hce
CRYSTAL STRUCTURE OF THE TELOMERIC SACCHAROMYCES CEREVISIAE CDC13 OB2 DOMAIN
Descriptor:Cell division control protein 13
Authors:Mason, M., Wannat, J.J., Harper, S., Schultz, D.C., Speicher, D.W., Johnson, F.B., Skordalakes, E.
Deposit date:2012-09-29
Release date:2012-11-28
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance.
Structure, 21, 2013
4JOI
  • Download 4joi
  • View 4joi
Molmil generated image of 4joi
CRYSTAL STRUCTURE OF THE HUMAN TELOMERIC STN1-TEN1 COMPLEX
Descriptor:CST complex subunit STN1, CST complex subunit TEN1
Authors:Bryan, C., Rice, C., Harkisheimer, M., Schultz, D., Skordalakes, E.
Deposit date:2013-03-18
Release date:2013-05-29
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the human telomeric stn1-ten1 capping complex.
Plos One, 8, 2013
4JQF
  • Download 4jqf
  • View 4jqf
Molmil generated image of 4jqf
STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN TELOMERIC STN1
Descriptor:CST complex subunit STN1
Authors:Bryan, C.F., Rice, C.T., Harkisheimer, M., Schultz, D., Skordalakes, E.
Deposit date:2013-03-20
Release date:2013-06-05
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the human telomeric stn1-ten1 capping complex.
Plos One, 8, 2013
<12>