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2VIJ
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HUMAN BACE-1 IN COMPLEX WITH 3-(1,1-DIOXIDOTETRAHYDRO-2H-1,2-THIAZIN- 2-YL)-5-(ETHYLAMINO)-N-((1S,2R)-2-HYDROXY-1-(PHENYLMETHYL)-3-(1,2,3,4- TETRAHYDRO-1-NAPHTHALENYLAMINO)PROPYL)BENZAMIDE
Descriptor:BETA-SECRETASE 1, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}-3-(1,1-dioxido-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide
Authors:Beswick, P., Charrier, N., Clarke, B., Demont, E., Dingwall, C., Dunsdon, R., Faller, A., Gleave, R., Hawkins, J., Hussain, I., Johnson, C.N., Macpherson, D., Maile, G., Matico, R., Milner, P., Mosley, J., Naylor, A., O'Brien, A., Redshaw, S., Riddell, D., Rowland, P., Skidmore, J., Soleil, V., Smith, K.J., Stanway, S., Stemp, G., Stuart, A., Sweitzer, S., Theobald, P., Vesey, D., Walter, D.S., Ward, J., Wayne, G.
Deposit date:2007-12-04
Release date:2008-01-29
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Bace-1 Inhibitors Part 3: Identification of Hydroxy Ethylamines (Heas) with Nanomolar Potency in Cells.
Bioorg.Med.Chem.Lett., 18, 2008
5J4H
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STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22F IN COMPLEX WITH INDOLE-6-CARBOXYLIC ACID
Descriptor:DNA repair and recombination protein RadA, 1H-indole-6-carboxylic acid, SODIUM ION, ...
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-01
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.374 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5J4K
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STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22F IN COMPLEX WITH 1-INDANE-6-CARBOXYLIC ACID
Descriptor:DNA repair and recombination protein RadA, SODIUM ION, CALCIUM ION, ...
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-01
Release date:2016-10-26
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.346 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5J4L
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22F
Descriptor:DNA repair and recombination protein RadA, CHLORIDE ION
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-01
Release date:2016-10-19
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5JEC
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA33F
Descriptor:DNA repair and recombination protein RadA, CHLORIDE ION, SULFATE ION
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-18
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5JED
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA28
Descriptor:DNA repair and recombination protein RadA, SULFATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-18
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.332 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5JEE
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA26F
Descriptor:DNA repair and recombination protein RadA, CALCIUM ION
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-18
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5KDD
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22
Descriptor:DNA repair and recombination protein RadA, SULFATE ION
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-06-08
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5L8V
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA4
Descriptor:DNA repair and recombination protein RadA, PHOSPHATE ION
Authors:Marsh, M., Fischer, G., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-06-08
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5LB2
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA2
Descriptor:DNA repair and recombination protein RadA
Authors:Marsh, M., Fischer, G., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-06-15
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5LB4
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA14
Descriptor:DNA repair and recombination protein RadA
Authors:Marsh, M., Fischer, G., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-06-15
Release date:2016-10-19
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5LBI
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APO-STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA3
Descriptor:DNA repair and recombination protein RadA, CALCIUM ION
Authors:Marsh, M., Fischer, G., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-06-16
Release date:2016-10-26
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5FOS
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HUMANISED MONOMERIC RADA IN COMPLEX WITH OLIGOMERISATION PEPTIDE
Descriptor:DNA REPAIR AND RECOMBINATION PROTEIN RADA, PHOSPHATE ION, GLYCEROL
Authors:Sharpe, T., Moschetti, T., Fischer, G., Marsh, M., Blundell, T.L., Abell, C., Hyvonen, M.
Deposit date:2015-11-26
Release date:2016-10-19
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors Against Human Rad51.
J.Mol.Biol., 428, 2016
5JFG
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STRUCTURE OF HUMANISED RADA-MUTANT HUMRADA22F IN COMPLEX WITH PEPTIDE FHTA
Descriptor:DNA repair and recombination protein RadA, PEPTIDE FHTA, DIMETHYL SULFOXIDE, ...
Authors:Fischer, G., Marsh, M., Moschetti, T., Sharpe, T., Scott, D., Morgan, M., Ng, H., Skidmore, J., Venkitaraman, A., Abell, C., Blundell, T.L., Hyvonen, M.
Deposit date:2016-04-19
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Humanisation of RadA from Pyrococcus furiosus
To Be Published
167327
數據於2020-08-05公開中