5THZ
 
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6MFD
 | | GphF GNAT-like decarboxylase in complex with isobutyryl-CoA | | Descriptor: | ACETATE ION, GLYCEROL, GphF, ... | | Authors: | Skiba, M.A, Tran, C.L, Smith, J.L. | | Deposit date: | 2018-09-10 | | Release date: | 2019-09-18 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.794 Å) | | Cite: | Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis.
Structure, 28, 2020
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6MFC
 | | GphF GNAT-like decarboxylase | | Descriptor: | GLYCEROL, GphF, PENTAETHYLENE GLYCOL | | Authors: | Skiba, M.A, Tran, C.L, Smith, J.L. | | Deposit date: | 2018-09-10 | | Release date: | 2019-09-18 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.589 Å) | | Cite: | Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis.
Structure, 28, 2020
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6B3A
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6B3B
 | | AprA Methyltransferase 1 - GNAT in complex with Mn2+ , SAM, and Malonate | | Descriptor: | AprA Methyltransferase 1, GLYCEROL, MALONATE ION, ... | | Authors: | Skiba, M.A, Smith, J.L. | | Deposit date: | 2017-09-21 | | Release date: | 2017-11-15 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.
ACS Chem. Biol., 12, 2017
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6B39
 | | AprA Methyltransferase 1 - GNAT in complex with SAH | | Descriptor: | AprA Methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION | | Authors: | Skiba, M.A, Smith, J.L. | | Deposit date: | 2017-09-21 | | Release date: | 2017-11-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.392 Å) | | Cite: | A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.
ACS Chem. Biol., 12, 2017
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6ECW
 | | StiD O-MT residues 956-1266 | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, StiD protein | | Authors: | Skiba, M.A, Bivins, M.M, Smith, J.L. | | Deposit date: | 2018-08-08 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Basis of Polyketide Synthase O-Methylation.
ACS Chem. Biol., 13, 2018
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6ECX
 | | StiE O-MT residues 942-1257 | | Descriptor: | GLYCEROL, S-ADENOSYLMETHIONINE, StiE protein | | Authors: | Skiba, M.A, Bivins, M.B, Smith, J.L. | | Deposit date: | 2018-08-08 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis of Polyketide Synthase O-Methylation.
ACS Chem. Biol., 13, 2018
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6ECV
 | | StiD O-MT residues 976-1266 | | Descriptor: | CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE, StiD protein | | Authors: | Skiba, M.A, Bivins, M.M, Smith, J.L. | | Deposit date: | 2018-08-08 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | Structural Basis of Polyketide Synthase O-Methylation.
ACS Chem. Biol., 13, 2018
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6ECT
 | | StiE O-MT residues 961-1257 | | Descriptor: | S-ADENOSYLMETHIONINE, StiE protein | | Authors: | Skiba, M.A, Bivins, M.M, Smith, J.L. | | Deposit date: | 2018-08-08 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Structural Basis of Polyketide Synthase O-Methylation.
ACS Chem. Biol., 13, 2018
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6ECU
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5THY
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7UCH
 | | AprA Methyltransferase 1 - GNAT in complex with Mn2+ , SAM, and Di-methyl-malonate | | Descriptor: | AprA Methyltransferase 1, GLYCEROL, MANGANESE (II) ION, ... | | Authors: | Skiba, M.A, Lao, Y, Smith, J.L. | | Deposit date: | 2022-03-16 | | Release date: | 2022-06-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Structural Basis for Control of Methylation Extent in Polyketide Synthase Metal-Dependent C -Methyltransferases.
Acs Chem.Biol., 17, 2022
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7T83
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6OS0
 | | Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to angiotensin II | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensinogen, CHLORIDE ION, ... | | Authors: | Wingler, L.M, Staus, D.P, Skiba, M.A, McMahon, C, Kleinhenz, A.L.W, Lefkowitz, R.J, Kruse, A.C. | | Deposit date: | 2019-05-01 | | Release date: | 2020-02-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
Science, 367, 2020
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6OS2
 | | Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV026 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Wingler, L.M, Staus, D.P, Skiba, M.A, McMahon, C, Kleinhenz, A.L.W, Lefkowitz, R.J, Kruse, A.C. | | Deposit date: | 2019-05-01 | | Release date: | 2020-02-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
Science, 367, 2020
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6OS1
 | | Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV023 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Nanobody Nb.AT110i1_le, ... | | Authors: | Wingler, L.M, Staus, D.P, Skiba, M.A, McMahon, C, Kleinhenz, A.L.W, Lefkowitz, R.J, Kruse, A.C. | | Deposit date: | 2019-05-01 | | Release date: | 2020-02-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.794 Å) | | Cite: | Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
Science, 367, 2020
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7TJ4
 | | Structure of the S. aureus amidase LytH and activator ActH extracellular domains | | Descriptor: | ActH, LytH, ZINC ION | | Authors: | Page, J.E, Skiba, M.A, Kruse, A.C, Walker, S. | | Deposit date: | 2022-01-14 | | Release date: | 2022-07-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7T84
 | | Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant | | Descriptor: | CITRIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Nemeth, G.R, Skiba, M.A, Kruse, A.C. | | Deposit date: | 2021-12-15 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | An in silico method to assess antibody fragment polyreactivity.
Nat Commun, 13, 2022
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7UCI
 | | SxtA Methyltransferase and decarboxylase didomain in complex with Mn2+ and SAH | | Descriptor: | GLYCEROL, MANGANESE (II) ION, Polyketide synthase-related protein, ... | | Authors: | Lao, Y, Skiba, M.A, Smith, J.L. | | Deposit date: | 2022-03-16 | | Release date: | 2022-06-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Basis for Control of Methylation Extent in Polyketide Synthase Metal-Dependent C -Methyltransferases.
Acs Chem.Biol., 17, 2022
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5VE4
 | | Crystal structure of persulfide dioxygenase-rhodanese fusion protein with rhodanese domain inactivating mutation (C314S) from Burkholderia phytofirmans | | Descriptor: | BpPRF, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Motl, N, Skiba, M.A, Smith, J.L, Banerjee, R. | | Deposit date: | 2017-04-03 | | Release date: | 2017-07-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation.
J. Biol. Chem., 292, 2017
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5VE5
 | | Crystal structure of persulfide dioxygenase rhodanese fusion protein with rhodanese domain inactivating mutation (C314S) from Burkholderia phytofirmans in complex with glutathione | | Descriptor: | BpPRF, CHLORIDE ION, FE (III) ION, ... | | Authors: | Motl, N, Skiba, M.A, Smith, J.L, Banerjee, R. | | Deposit date: | 2017-04-03 | | Release date: | 2017-07-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation.
J. Biol. Chem., 292, 2017
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5VE3
 | | Crystal structure of wild-type persulfide dioxygenase-rhodanese fusion protein from Burkholderia phytofirmans | | Descriptor: | BpPRF, FE (III) ION | | Authors: | Motl, N, Skiba, M.A, Smith, J.L, Banerjee, R. | | Deposit date: | 2017-04-03 | | Release date: | 2017-07-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.793 Å) | | Cite: | Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation.
J. Biol. Chem., 292, 2017
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6D6Y
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5KCI
 | | Crystal Structure of HTC1 | | Descriptor: | GLYCEROL, SULFATE ION, Uncharacterized protein YPL067C, ... | | Authors: | Martin, R.M, Horowitz, S, Koepnick, B, Cooper, S, Flatten, J, Rogawski, D.S, Koropatkin, N.M, Beinlich, F.R.M, Players, F, Students, U.M, Popovic, Z, Baker, D, Khatib, F, Bardwell, J.C.A. | | Deposit date: | 2016-06-06 | | Release date: | 2016-09-21 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.833 Å) | | Cite: | Determining crystal structures through crowdsourcing and coursework.
Nat Commun, 7, 2016
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