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1JR1
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CRYSTAL STRUCTURE OF INOSINE MONOPHOSPHATE DEHYDROGENASE IN COMPLEX WITH MYCOPHENOLIC ACID
Descriptor:Inosine-5'-Monophosphate Dehydrogenase 2, POTASSIUM ION, INOSINIC ACID, ...
Authors:Sintchak, M.D., Fleming, M.A., Futer, O., Raybuck, S.A., Chambers, S.P., Caron, P.R., Murcko, M.A., Wilson, K.P.
Deposit date:2001-08-09
Release date:2001-09-05
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
Cell(Cambridge,Mass.), 85, 1996
1L1L
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CRYSTAL STRUCTURE OF B-12 DEPENDENT (CLASS II) RIBONUCLEOTIDE REDUCTASE
Descriptor:RIBONUCLEOSIDE TRIPHOSPHATE REDUCTASE
Authors:Sintchak, M.D., Arjara, G., Kellogg, B.A., Stubbe, J., Drennan, C.L.
Deposit date:2002-02-18
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer.
Nat.Struct.Biol., 9, 2002
3Q96
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B-RAF KINASE DOMAIN IN COMPLEX WITH A TETRAHYDRONAPHTHALENE INHIBITOR
Descriptor:Serine/threonine-protein kinase B-raf, (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
Authors:Sintchak, M.D., Aertgeerts, K., Yano, J.
Deposit date:2011-01-07
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors.
J.Med.Chem., 54, 2011
3GZN
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STRUCTURE OF NEDD8-ACTIVATING ENZYME IN COMPLEX WITH NEDD8 AND MLN4924
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ...
Authors:Sintchak, M.D.
Deposit date:2009-04-07
Release date:2010-02-02
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
Mol.Cell, 37, 2010
3MG0
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STRUCTURE OF YEAST 20S PROTEASOME WITH BORTEZOMIB
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Sintchak, M.D.
Deposit date:2010-04-05
Release date:2011-05-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Biochem.J., 430, 2010
3MG4
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STRUCTURE OF YEAST 20S PROTEASOME WITH COMPOUND 1
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Sintchak, M.D.
Deposit date:2010-04-05
Release date:2011-04-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Biochem.J., 430, 2010
3MG6
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STRUCTURE OF YEAST 20S OPEN-GATE PROTEASOME WITH COMPOUND 6
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Sintchak, M.D.
Deposit date:2010-04-05
Release date:2011-05-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Biochem.J., 430, 2010
3MG7
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STRUCTURE OF YEAST 20S OPEN-GATE PROTEASOME WITH COMPOUND 8
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Sintchak, M.D.
Deposit date:2010-04-05
Release date:2011-05-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Biochem.J., 430, 2010
3MG8
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STRUCTURE OF YEAST 20S OPEN-GATE PROTEASOME WITH COMPOUND 16
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Sintchak, M.D.
Deposit date:2010-04-05
Release date:2011-05-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Biochem.J., 430, 2010
3OEU
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STRUCTURE OF YEAST 20S OPEN-GATE PROTEASOME WITH COMPOUND 24
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Sintchak, M.D.
Deposit date:2010-08-13
Release date:2011-07-20
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Bioorg.Med.Chem.Lett., 20, 2010
3OEV
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STRUCTURE OF YEAST 20S OPEN-GATE PROTEASOME WITH COMPOUND 25
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Sintchak, M.D.
Deposit date:2010-08-13
Release date:2011-07-20
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Bioorg.Med.Chem.Lett., 20, 2010
3SDI
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STRUCTURE OF YEAST 20S OPEN-GATE PROTEASOME WITH COMPOUND 20
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Sintchak, M.D.
Deposit date:2011-06-09
Release date:2012-06-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Bioorg.Med.Chem.Lett., 20, 2010
3SDK
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STRUCTURE OF YEAST 20S OPEN-GATE PROTEASOME WITH COMPOUND 34
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Sintchak, M.D.
Deposit date:2011-06-09
Release date:2012-06-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Bioorg.Med.Chem.Lett., 20, 2010
3THB
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STRUCTURE OF PLK1 KINASE DOMAIN IN COMPLEX WITH A BENZOLACTAM-DERIVED INHIBITOR
Descriptor:Serine/threonine-protein kinase PLK1, ZINC ION, 9-chloro-2-({5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thione
Authors:Sintchak, M.D.
Deposit date:2011-08-18
Release date:2011-11-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905).
J.Med.Chem., 55, 2012
1FKJ
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ATOMIC STRUCTURE OF FKBP12-FK506, AN IMMUNOPHILIN IMMUNOSUPPRESSANT COMPLEX
Descriptor:FK506 BINDING PROTEIN, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
Authors:Wilson, K.P., Sintchak, M.D., Thomson, J.A., Navia, M.A.
Deposit date:1995-08-18
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin.
Acta Crystallogr.,Sect.D, 51, 1995
1FKK
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ATOMIC STRUCTURE OF FKBP12, AN IMMUNOPHILIN BINDING PROTEIN
Descriptor:FK506 BINDING PROTEIN, SULFATE ION
Authors:Wilson, K.P., Sintchak, M.D., Thomson, J.A., Navia, M.A.
Deposit date:1995-08-18
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin.
Acta Crystallogr.,Sect.D, 51, 1995
1FKL
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ATOMIC STRUCTURE OF FKBP12-RAPAYMYCIN, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX
Descriptor:FK506 BINDING PROTEIN, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Wilson, K.P., Sintchak, M.D., Thomson, J.A., Navia, M.A.
Deposit date:1995-08-18
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin.
Acta Crystallogr.,Sect.D, 51, 1995
1JQK
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CRYSTAL STRUCTURE OF CARBON MONOXIDE DEHYDROGENASE FROM RHODOSPIRILLUM RUBRUM
Descriptor:carbon monoxide dehydrogenase, FE (II) ION, IRON/SULFUR CLUSTER, ...
Authors:Drennan, C.L., Heo, J., Sintchak, M.D., Schreiter, E., Ludden, P.W.
Deposit date:2001-08-07
Release date:2001-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase.
Proc.Natl.Acad.Sci.USA, 98, 2001
1Q5V
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APO-NIKR
Descriptor:Nickel responsive regulator
Authors:Schreiter, E.R., Sintchak, M.D., Guo, Y., Chivers, P.T., Sauer, R.T., Drennan, C.L.
Deposit date:2003-08-11
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Nickel-Responsive Transcription Factor NikR
Nat.Struct.Biol., 10, 2003
1Q5Y
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NICKEL-BOUND C-TERMINAL REGULATORY DOMAIN OF NIKR
Descriptor:Nickel responsive regulator, NICKEL (II) ION, 1,2-ETHANEDIOL
Authors:Schreiter, E.R., Sintchak, M.D., Guo, Y., Chivers, P.T., Sauer, R.T., Drennan, C.L.
Deposit date:2003-08-11
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of the Nickel-Responsive Transcription Factor NikR
Nat.Struct.Biol., 10, 2003
1T4A
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STRUCTURE OF B. SUBTILIS PURS C2 CRYSTAL FORM
Descriptor:PurS
Authors:Anand, R., Hoskins, A.A., Bennett, E.M., Sintchak, M.D., Stubbe, J., Ealick, S.E.
Deposit date:2004-04-28
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex.
Biochemistry, 43, 2004
1TCO
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TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
Descriptor:SERINE/THREONINE PHOSPHATASE B2, FK506-BINDING PROTEIN, ZINC ION, ...
Authors:Griffith, J.P., Kim, J.L., Kim, E.E., Sintchak, M.D., Thomson, J.A., Fitzgibbon, M.J., Fleming, M.A., Caron, P.R., Hsiao, K., Navia, M.A.
Deposit date:1996-08-21
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.
Cell(Cambridge,Mass.), 82, 1995
5TR4
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STRUCTURE OF UBIQUITIN ACTIVATING ENZYME (UBA1) IN COMPLEX WITH UBIQUITIN AND TAK-243
Descriptor:Ubiquitin-activating enzyme E1 1, Ubiquitin, [(1~{R},2~{R},3~{S},4~{R})-2,3-bis(oxidanyl)-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate
Authors:Sintchak, M.D.
Deposit date:2016-10-25
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification and Characterization of a Small Molecule Inhibitor of the Ubiquitin Activating Enzyme (TAK-243)
To be published
1TWJ
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CRYSTAL STRUCTURE OF B. SUBTILIS PURS P21 CRYSTAL FORM
Descriptor:Hypothetical UPF0062 protein yexA
Authors:Anand, R., Ealick, S.E., Hoskins, A.A., Stubbe, J.
Deposit date:2004-07-01
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Model for the Bacillus subtilis Formylglycinamide Ribonucleotide Amidotransferase Multiprotein Complex
Biochemistry, 43, 2004
2P6B
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CRYSTAL STRUCTURE OF HUMAN CALCINEURIN IN COMPLEX WITH PVIVIT PEPTIDE
Descriptor:PVIVIT 14-mer Peptide, Calmodulin-dependent calcineurin A subunit alpha isoform, Calcineurin subunit B isoform 1, ...
Authors:Li, H., Zhang, L., Rao, A., Harrison, S.C., Hogan, P.G.
Deposit date:2007-03-16
Release date:2007-06-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction
J.Mol.Biol., 369, 2007