Author results

2F2K
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ALDOSE REDUCTASE TERTIARY COMPLEX WITH NADPH AND DEG
分子名称:Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GAMMA-GLUTAMYL-S-(1,2-DICARBOXYETHYL)CYSTEINYLGLYCINE
著者Singh, R., White, M.A., Ramana, K.V., Petrash, J.M., Watowich, S.J., Bhatnagar, A., Srivastava, S.K.
登録日2005-11-17
公開日2006-05-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Structure of a glutathione conjugate bound to the active site of aldose reductase.
Proteins, 64, 2006
5X49
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CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL X-PROLYL AMINOPEPTIDASE (XPNPEP3)
分子名称:Probable Xaa-Pro aminopeptidase 3, MANGANESE (II) ION, DODECAETHYLENE GLYCOL, ...
著者Singh, R., Kumar, A., Ghosh, B., Jamdar, S., Makde, R.D.
登録日2017-02-10
公開日2017-05-17
最終更新日2017-12-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.
J. Biol. Chem., 292, 2017
6A9T
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CRYSTAL STRUCTURE OF ICP55 FROM SACCHAROMYCES CEREVISIAE (N-TERMINAL 58 RESIDUES DELETION)
分子名称:Intermediate cleaving peptidase 55, MANGANESE (II) ION, GLYCINE, ...
著者Singh, R., Kumar, A., Goyal, V.D., Makde, R.D.
登録日2018-07-16
公開日2019-01-16
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structures and biochemical analyses of intermediate cleavage peptidase: role of dynamics in enzymatic function.
FEBS Lett., 593, 2019
6A9U
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CRYSTAL STRCTURE OF ICP55 FROM SACCHAROMYCES CEREVISIAE BOUND TO APSTATIN INHIBITOR
分子名称:Intermediate cleaving peptidase 55, apstatin, MANGANESE (II) ION
著者Singh, R., Kumar, A., Goyal, V.D., Makde, R.D.
登録日2018-07-16
公開日2019-01-16
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structures and biochemical analyses of intermediate cleavage peptidase: role of dynamics in enzymatic function.
FEBS Lett., 593, 2019
6A9V
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CRYSTAL STRUCTURE OF ICP55 FROM SACCHAROMYCES CEREVISIAE (N-TERMINAL 42 RESIDUES DELETION)
分子名称:Intermediate cleaving peptidase 55, MANGANESE (II) ION, TRIETHYLENE GLYCOL, ...
著者Singh, R., Kumar, A., Goyal, V.D., Makde, R.D.
登録日2018-07-16
公開日2019-01-16
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structures and biochemical analyses of intermediate cleavage peptidase: role of dynamics in enzymatic function.
FEBS Lett., 593, 2019
3QNR
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DYPB FROM RHODOCOCCUS JOSTII RHA1, CRYSTAL FORM 1
分子名称:DyP Peroxidase, PROTOPORPHYRIN IX CONTAINING FE, FORMIC ACID, ...
著者Singh, R., Roberts, J.N., Grigg, J.C., Eltis, L.D., Murphy, M.E.P.
登録日2011-02-09
公開日2011-04-27
最終更新日2012-08-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Characterization of dye-decolorizing peroxidases from Rhodococcus jostii RHA1.
Biochemistry, 50, 2011
3VEC
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RHODOCOCCUS JOSTII RHA1 DYPB D153A VARIANT IN COMPLEX WITH HEME
分子名称:DypB, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
著者Grigg, J.C., Singh, R., Armstrong, Z., Eltis, L.D., Murphy, M.E.P.
登録日2012-01-07
公開日2012-01-18
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Distal heme pocket residues of B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity.
J.Biol.Chem., 287, 2012
3VED
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RHODOCOCCUS JOSTII RHA1 DYPB D153H VARIANT IN COMPLEX WITH HEME
分子名称:DypB, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
著者Grigg, J.C., Singh, R., Armstrong, Z., Eltis, L.D., Murphy, M.E.P.
登録日2012-01-07
公開日2012-01-18
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Distal heme pocket residues of B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity.
J.Biol.Chem., 287, 2012
3VEE
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RHODOCOCCUS JOSTII RHA1 DYPB N246A VARIANT IN COMPLEX WITH HEME
分子名称:DypB, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
著者Grigg, J.C., Singh, R., Armstrong, Z., Eltis, L.D., Murphy, M.E.P.
登録日2012-01-07
公開日2012-01-18
最終更新日2012-08-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Distal heme pocket residues of B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity.
J.Biol.Chem., 287, 2012
3VEF
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RHODOCOCCUS JOSTII RHA1 DYPB N246H VARIANT IN COMPLEX WITH HEME
分子名称:DypB, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION
著者Grigg, J.C., Singh, R., Armstrong, Z., Eltis, L.D., Murphy, M.E.P.
登録日2012-01-07
公開日2012-01-18
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Distal heme pocket residues of B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity.
J.Biol.Chem., 287, 2012
3VEG
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RHODOCOCCUS JOSTII RHA1 DYPB R244L VARIANT IN COMPLEX WITH HEME
分子名称:DypB, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION
著者Grigg, J.C., Singh, R., Armstrong, Z., Eltis, L.D., Murphy, M.E.P.
登録日2012-01-07
公開日2012-01-18
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Distal heme pocket residues of B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity.
J.Biol.Chem., 287, 2012
4FP7
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2.2A RESOLUTION STRUCTURE OF PROTEASOME ASSEMBLY CHAPERONE HSM3
分子名称:DNA mismatch repair protein HSM3
著者Lovell, S., Battaile, K.P., Singh, R., Zolkiewski, M., Roelofs, J.
登録日2012-06-21
公開日2013-04-10
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献2.2A resolution structure of Proteasome Assembly Chaperone Hsm3
To be Published
4HOV
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DYPB N246A IN COMPLEX WITH MANGANESE
分子名称:DypB, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
著者Grigg, J.C., Singh, R., Eltis, L.D., Murphy, M.E.P.
登録日2012-10-22
公開日2013-01-16
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Improved Manganese-Oxidizing Activity of DypB, a Peroxidase from a Lignolytic Bacterium.
Acs Chem.Biol., 8, 2013
1EE1
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CRYSTAL STRUCTURE OF NH3-DEPENDENT NAD+ SYNTHETASE FROM BACILLUS SUBTILIS COMPLEXED WITH ONE MOLECULE ATP, TWO MOLECULES DEAMIDO-NAD+ AND ONE MG2+ ION
分子名称:NH(3)-DEPENDENT NAD(+) SYNTHETASE, MAGNESIUM ION, NICOTINIC ACID ADENINE DINUCLEOTIDE, ...
著者Devedjiev, Y., Symersky, J., Singh, R., Jedrzejas, M., Brouillette, C., Brouillette, W., Muccio, D., Chattopadhyay, D., Delucas, L.
登録日2000-01-28
公開日2001-06-06
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis.
Acta Crystallogr.,Sect.D, 57, 2001
2BV3
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CRYSTAL STRUCTURE OF A MUTANT ELONGATION FACTOR G TRAPPED WITH A GTP ANALOGUE
分子名称:ELONGATION FACTOR G, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION
著者Hansson, S., Singh, R., Gudkov, A.T., Liljas, A., Logan, D.T.
登録日2005-06-22
公開日2005-08-10
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of a Mutant Elongation Factor G Trapped with a GTP Analogue.
FEBS Lett., 579, 2005
3ZJT
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TERNARY COMPLEX OF E.COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU)574 AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJV
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3213 IN THE EDITING CONFORMATION
分子名称:LEUCINE--TRNA LIGASE, TRNALEU5 UAA ISOACCEPTOR
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
1FYD
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CRYSTAL STRUCTURE OF NH3-DEPENDENT NAD+ SYNTHETASE FROM BACILLUS SUBTILIS COMPLEXED WITH ONE MOLECULE AMP, ONE PYROPHOSPHATE ION AND ONE MG2+ ION
分子名称:NH(3)-DEPENDENT NAD(+) SYNTHETASE, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ...
著者Devedjiev, Y., Symersky, J., Singh, R., Brouillette, W., Muccio, D., Jedrzejas, M., Brouillette, C., DeLucas, L.
登録日2000-09-28
公開日2001-06-06
最終更新日2015-12-30
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis.
Acta Crystallogr.,Sect.D, 57, 2001
1IFX
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CRYSTAL STRUCTURE OF NH3-DEPENDENT NAD+ SYNTHETASE FROM BACILLUS SUBTILIS COMPLEXED WITH TWO MOLECULES DEAMIDO-NAD
分子名称:NH(3)-DEPENDENT NAD(+) SYNTHETASE, NICOTINIC ACID ADENINE DINUCLEOTIDE
著者Devedjiev, Y., Symersky, J., Singh, R., Brouillette, W., Muccio, D., Jedrzejas, M., Brouillette, C., DeLucas, L.
登録日2001-04-13
公開日2001-06-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis.
Acta Crystallogr.,Sect.D, 57, 2001
1IH8
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NH3-DEPENDENT NAD+ SYNTHETASE FROM BACILLUS SUBTILIS COMPLEXED WITH AMP-CPP AND MG2+ IONS.
分子名称:NH(3)-DEPENDENT NAD(+) synthetase, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
著者Devedjiev, Y., Symersky, J., Singh, R., Jedrzejas, M., Brouillette, C., Brouillette, W., Muccio, D., Chattopadhyay, D., DeLucas, L.
登録日2001-04-18
公開日2001-06-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis.
Acta Crystallogr.,Sect.D, 57, 2001
1MU6
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CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH L-378,622
分子名称:THROMBIN, HIRUDIN IIB, 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDE
著者Burgey, C.S., Robinson, K.A., Lyle, T.A., Sanderson, P.E., Lewis, S.D., Lucas, B.J., Krueger, J.A., Singh, R., Miller-Stein, C., White, R.B., Wong, B., Lyle, E.A., Williams, P.D., Coburn, C.A., Dorsey, B.D., Barrow, J.C., Stranieri, M.T., Holahan, M.A., Sitko, G.R., Cook, J.J., McMasters, D.R., McDonough, C.M., Sanders, W.M., Wallace, A.A., Clayton, F.C., Bohn, D., Leonard, Y.M., Detwiler Jr., T.J., Lynch Jr., J.J., Yan, Y., Chen, Z., Kuo, L., Gardell, S.J., Shafer, J.A., Vacca, J.P.J.
登録日2002-09-23
公開日2004-04-06
最終更新日2013-03-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
J.Med.Chem., 46, 2003
1MU8
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THROMBIN-HIRUGEN_L-378,650
分子名称:THROMBIN, HIRUDIN IIB, 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDE
著者Burgey, C.S., Robinson, K.A., Lyle, T.A., Sanderson, P.E., Lewis, S.D., Lucas, B.J., Krueger, J.A., Singh, R., Miller-Stein, C., White, R.B., Wong, B., Lyle, E.A., Williams, P.D., Coburn, C.A., Dorsey, B.D., Barrow, J.C., Stranieri, M.T., Holahan, M.A., Sitko, G.R., Cook, J.J., McMasters, D.R., McDonough, C.M., Sanders, W.M., Wallace, A.A., Clayton, F.C., Bohn, D., Leonard, Y.M., Detwiler Jr., T.J., Lynch Jr., J.J., Yan, Y., Chen, Z., Kuo, L., Gardell, S.J., Shafer, J.A., Vacca, J.P.J.
登録日2002-09-23
公開日2004-04-06
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
J.Med.Chem., 46, 2003
1MUE
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THROMBIN-HIRUGEN-L405,426
分子名称:THROMBIN, HIRUDIN IIB, 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE
著者Burgey, C.S., Robinson, K.A., Lyle, T.A., Nantermet, P.G., Selnick, H.G., Isaacs, R.C., Lewis, S.D., Lucas, B.J., Krueger, J.A., Singh, R., Miller-Stein, C., White, R.B., Wong, B., Lyle, E.A., Stranieri, M.T., Cook, J.J., McMasters, D.R., Pellicore, J.M., Pal, S., Wallace, A.A., Clayton, F.C., Bohn, D., Welsh, D.C., Lynch, J.J., Yan, Y., Chen, Z., Kuo, L., Gardell, S.J., Shafer, J.A., Vacca, J.P.
登録日2002-09-23
公開日2004-04-06
最終更新日2013-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.
Bioorg.Med.Chem.Lett., 13, 2003
1XRZ
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NMR STRUCTURE OF A ZINC FINGER WITH CYCLOHEXANYLALANINE SUBSTITUTED FOR THE CENTRAL AROMATIC RESIDUE
分子名称:Zinc finger Y-chromosomal protein, ZINC ION
著者Lachenmann, M.J., Ladbury, J.E., Qian, X., Huang, K., Singh, R., Weiss, M.A.
登録日2004-10-17
公開日2004-11-30
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice
Protein Sci., 13, 2004
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