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2QYQ
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BU of 2qyq by Molmil
Human raf kinase inhibitor protein (rkip) in complex with o-phosphotyrosine
Descriptor: O-PHOSPHOTYROSINE, Phosphatidylethanolamine-binding protein 1
Authors:Simister, P.C, Brady, R.L.
Deposit date:2007-08-15
Release date:2008-07-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Phosphotyrosine recognition by the Raf Kinase Inhibitor Protein
Forum Immunopath.Dis.Ther., 2, 2011
7QPJ
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BU of 7qpj by Molmil
Crystal structure of engineered TCR (756) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
Descriptor: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ...
Authors:Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J.
Deposit date:2022-01-04
Release date:2022-08-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
J Immunother Cancer, 10, 2022
1KN3
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BU of 1kn3 by Molmil
Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)
Descriptor: Phosphatidylethanolamine Binding Protein-2
Authors:Simister, P.C, Banfield, M.J, Brady, R.L.
Deposit date:2001-12-18
Release date:2002-06-12
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family.
Acta Crystallogr.,Sect.D, 58, 2002
3RNJ
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BU of 3rnj by Molmil
Crystal structure of the SH3 domain from IRSp53 (BAIAP2)
Descriptor: 1,2-ETHANEDIOL, Brain-specific angiogenesis inhibitor 1-associated protein 2, ISOPROPYL ALCOHOL, ...
Authors:Simister, P.C, Barilari, M, Muniz, J.R.C, Dente, L, Knapp, S, von Delft, F, Filippakopoulos, P, Vollmar, M, Chaikuad, A, Raynor, J, Tregubova, A, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Feller, S.M, Structural Genomics Consortium (SGC)
Deposit date:2011-04-22
Release date:2011-05-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the SH3 domain from IRSp53 (BAIAP2)
To be Published
7PDW
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BU of 7pdw by Molmil
Crystal structure of parent TCR (728) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
Descriptor: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ...
Authors:Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J.
Deposit date:2021-08-09
Release date:2022-08-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
J Immunother Cancer, 10, 2022
7PBC
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BU of 7pbc by Molmil
Crystal structure of engineered TCR (796) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
Descriptor: Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ...
Authors:Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J.
Deposit date:2021-08-02
Release date:2022-08-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
J Immunother Cancer, 10, 2022
7PDX
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BU of 7pdx by Molmil
Crystal structure of parent MAGE-A10 TCR (728)
Descriptor: CHLORIDE ION, PHOSPHATE ION, T-cell receptor alpha chain (TRAV/TRAC), ...
Authors:Simister, P.C, Border, E.C, Vieira, J.F, Pumphrey, N.J.
Deposit date:2021-08-09
Release date:2022-08-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
J Immunother Cancer, 10, 2022
3U23
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BU of 3u23 by Molmil
Atomic resolution crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide from human RIN3
Descriptor: 1,2-ETHANEDIOL, CD2-associated protein, Ras and Rab interactor 3
Authors:Simister, P.C, Rouka, E, Janning, M, Muniz, J.R.C, Kirsch, K.H, Knapp, S, von Delft, F, Filippakopoulos, P, Arrowsmith, C.H, Krojer, T, Edwards, A.M, Weigelt, J, Bountra, C, Feller, S.M, Structural Genomics Consortium (SGC)
Deposit date:2011-09-30
Release date:2011-12-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
J.Biol.Chem., 290, 2015
3LTL
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BU of 3ltl by Molmil
Crystal structure of human BIG1 Sec7 domain
Descriptor: ACETIC ACID, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, CALCIUM ION
Authors:Simister, P.C, Joubert, A, Cherfils, J, Biou, V.
Deposit date:2010-02-16
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Sec7 domain structures of human BIG1 and Cytohesin1 Arf nucleotide exchange factors
To be Published
2XYM
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BU of 2xym by Molmil
HCV-JFH1 NS5B T385A mutant
Descriptor: PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE
Authors:Simister, P.C, Caillet-Saguy, C, Bressanelli, S.
Deposit date:2010-11-18
Release date:2011-01-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.774 Å)
Cite:A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strains Jfh1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture Across Genotypes.
J.Virol., 85, 2011
4WCI
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BU of 4wci by Molmil
Crystal structure of the 1st SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 378-393) from human RIN3
Descriptor: CD2-associated protein, Ras and Rab interactor 3, SULFATE ION
Authors:Rouka, E, Simister, P.C, Janning, M, Kirsch, K.H, Krojer, T, Knapp, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Feller, S.M, Structural Genomics Consortium (SGC)
Deposit date:2014-09-04
Release date:2015-08-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
J.Biol.Chem., 290, 2015
4X1V
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BU of 4x1v by Molmil
Crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 76-91) from human ARAP1
Descriptor: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, CD2-associated protein
Authors:Rouka, E, Krojer, T, von Delft, F, Knapp, S, Kirsch, K.H, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Feller, S.M, Simister, P.C.
Deposit date:2014-11-25
Release date:2016-02-17
Last modified:2016-02-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 76-91) from human ARAP1
to be published
2XHV
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BU of 2xhv by Molmil
HCV-J4 NS5B Polymerase Point Mutant Orthorhombic Crystal Form
Descriptor: MAGNESIUM ION, RNA-directed RNA polymerase, SULFATE ION
Authors:Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
Deposit date:2010-06-21
Release date:2010-08-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010
2XI3
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BU of 2xi3 by Molmil
HCV-H77 NS5B Polymerase Complexed With GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA-directed RNA polymerase
Authors:Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
Deposit date:2010-06-25
Release date:2010-08-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010
2XHU
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BU of 2xhu by Molmil
HCV-J4 NS5B Polymerase Orthorhombic Crystal Form
Descriptor: RNA-directed RNA polymerase, SULFATE ION
Authors:Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
Deposit date:2010-06-21
Release date:2010-08-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.287 Å)
Cite:Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010
2XI2
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BU of 2xi2 by Molmil
HCV-H77 NS5B Apo Polymerase
Descriptor: RNA-directed RNA polymerase, SULFATE ION
Authors:Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
Deposit date:2010-06-25
Release date:2010-08-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010
2XHW
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BU of 2xhw by Molmil
HCV-J4 NS5B Polymerase Trigonal Crystal Form
Descriptor: RNA-directed RNA polymerase
Authors:Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S.
Deposit date:2010-06-21
Release date:2010-08-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
J.Biol.Chem., 285, 2010
3I5K
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BU of 3i5k by Molmil
Crystal structure of the NS5B polymerase from Hepatitis C Virus (HCV) strain JFH1
Descriptor: PHOSPHATE ION, RNA-directed RNA polymerase
Authors:Simister, P.C, Schmitt, M, Lohmann, V, Bressanelli, S.
Deposit date:2009-07-05
Release date:2009-09-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional analysis of hepatitis C virus strain JFH1 polymerase
J.Virol., 83, 2009
2W10
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BU of 2w10 by Molmil
Mona SH3C in complex
Descriptor: GRB2-RELATED ADAPTOR PROTEIN 2, PHOSPHATE ION, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23
Authors:Harkiolaki, M, Feller, S.M.
Deposit date:2008-10-13
Release date:2009-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the Sh3C Domain of Grb2.
Structure, 17, 2009
2VWF
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BU of 2vwf by Molmil
Grb2 SH3C (2)
Descriptor: GRB2-ASSOCIATED-BINDING PROTEIN 2, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
Authors:Harkiolaki, M, Tsirka, T, Feller, S.M.
Deposit date:2008-06-24
Release date:2009-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the Sh3C Domain of Grb2.
Structure, 17, 2009
2VVK
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BU of 2vvk by Molmil
Grb2 SH3C (1)
Descriptor: GLYCEROL, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
Authors:Harkiolaki, M, Tsirka, T, Feller, S.M.
Deposit date:2008-06-09
Release date:2009-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the Sh3C Domain of Grb2.
Structure, 17, 2009
2W0Z
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BU of 2w0z by Molmil
Grb2 SH3C (3)
Descriptor: GRB2-ASSOCIATED-BINDING PROTEIN 2, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
Authors:Harkiolaki, M, Tsirka, T, Feller, S.M.
Deposit date:2008-10-13
Release date:2009-05-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the Sh3C Domain of Grb2.
Structure, 17, 2009
2XXD
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BU of 2xxd by Molmil
HCV-JFH1 NS5B polymerase structure at 1.9 angstrom
Descriptor: PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE
Authors:Caillet-Saguy, C, Bressanelli, S.
Deposit date:2010-11-10
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.881 Å)
Cite:A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strains Jfh1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture Across Genotypes.
J.Virol., 85, 2011
2XWH
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BU of 2xwh by Molmil
HCV-J6 NS5B polymerase structure at 1.8 Angstrom
Descriptor: DI(HYDROXYETHYL)ETHER, POLYETHYLENE GLYCOL (N=34), RNA DEPENDENT RNA POLYMERASE
Authors:Scrima, N, Bressanelli, S.
Deposit date:2010-11-03
Release date:2011-01-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strains Jfh1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture Across Genotypes.
J.Virol., 85, 2011

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PDB entries from 2024-03-27

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