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2YCB
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STRUCTURE OF THE ARCHAEAL BETA-CASP PROTEIN WITH N-TERMINAL KH DOMAINS FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS
Descriptor:CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR, ZINC ION, PHOSPHATE ION, ...
Authors:Silva, A.P.G., Chechik, M., Byrne, R.T., Waterman, D.G., Ng, C.L., Dodson, E.J., Koonin, E.V., Antson, A.A., Smits, C.
Deposit date:2011-03-13
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure and Activity of a Novel Archaeal Beta-Casp Protein with N-Terminal Kh Domains.
Structure, 19, 2011
2WWF
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH TMP AND ADP
Descriptor:THYMIDILATE KINASE, PUTATIVE, THYMIDINE-5'-PHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2WWH
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH AP5DT
Descriptor:THYMIDILATE KINASE, PUTATIVE, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2WWI
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH AZTMP AND ADP
Descriptor:THYMIDILATE KINASE, PUTATIVE, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2YOF
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A (THIO)UREA- BETA-DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea, ACETATE ION, ...
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
2YOG
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A (THIO)UREA- ALPHA-DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
2YOH
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A UREA-ALPHA- DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[[(2R,3S,5S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]-3-(4-nitrophenyl)urea
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
6BGG
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SOLUTION NMR STRUCTURES OF THE BRD3 ET DOMAIN IN COMPLEX WITH A CHD4 PEPTIDE
Descriptor:CHD4, Bromodomain-containing protein 3
Authors:Wai, D.C.C., Szyszka, T.N., Campbell, A.E., Kwong, C., Wilkinson-White, L., Silva, A.P.G., Low, J.K.K., Kwan, A.H., Gamsjaeger, R., Lu, B., Vakoc, C.R., Blobel, G.A., Mackay, J.P.
Deposit date:2017-10-28
Release date:2018-03-21
Last modified:2018-05-23
Method:SOLUTION NMR
Cite:The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.
J. Biol. Chem., 293, 2018
2N5N
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STRUCTURE OF AN N-TERMINAL DOMAIN OF CHD4
Descriptor:Chromodomain-helicase-DNA-binding protein 4
Authors:Silva, A.P.G., Mackay, J.P.
Deposit date:2015-07-22
Release date:2015-11-18
Last modified:2016-01-27
Method:SOLUTION NMR
Cite:The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).
J.Biol.Chem., 291, 2016
2N39
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NMR SOLUTION STRUCTURE OF A C-TERMINAL DOMAIN OF THE CHROMODOMAIN HELICASE DNA-BINDING PROTEIN 1
Descriptor:Chromodomain-helicase-DNA-binding protein 1
Authors:Mohanty, B., Silva, A.P.G., Mackay, J.P., Ryan, D.P.
Deposit date:2015-05-26
Release date:2016-06-01
Last modified:2017-05-10
Method:SOLUTION NMR
Cite:The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain.
J. Mol. Biol., 428, 2016
4PBY
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STRUCTURE OF THE HUMAN RBAP48-MTA1(656-686) COMPLEX
Descriptor:Histone-binding protein RBBP4, Metastasis-associated protein MTA1, ISOPROPYL ALCOHOL
Authors:Murthy, A., Lejon, S., Alqarni, S.S.M., Silva, A.P.G., Watson, A.A., Mackay, J.P., Laue, E.D.
Deposit date:2014-04-14
Release date:2014-06-11
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex.
J.Biol.Chem., 289, 2014
4PBZ
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STRUCTURE OF THE HUMAN RBAP48-MTA1(670-695) COMPLEX
Descriptor:Histone-binding protein RBBP4, Metastasis-associated protein MTA1
Authors:Murthy, A., Pei, X.Y., Watson, A.A., Silva, A.P.G., Mackay, J.P., Laue, E.D.
Deposit date:2014-04-14
Release date:2014-06-11
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex.
J.Biol.Chem., 289, 2014
4PC0
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STRUCTURE OF THE HUMAN RBAP48-MTA1(670-711) COMPLEX
Descriptor:Histone-binding protein RBBP4, Metastasis-associated protein MTA1, GLYCEROL, ...
Authors:Alqarni, S.S.M., Silva, A.P.G., Mackay, J.P., Laue, E.D.
Deposit date:2014-04-14
Release date:2014-06-11
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex.
J.Biol.Chem., 289, 2014
6CME
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STRUCTURE OF WILD-TYPE ISL2-LID IN COMPLEX WITH LHX4-LIM1+2
Descriptor:LIM/homeobox protein Lhx4,Insulin gene enhancer protein ISL-2, ZINC ION
Authors:Stokes, P.H., Silva, A., Guss, J.M., Matthews, J.M.
Deposit date:2018-03-04
Release date:2019-04-10
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Mutation in a flexible linker modulates binding affinity for modular complexes.
Proteins, 87, 2019