Author results

1DIF
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HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285
Descriptor:HIV-1 PROTEASE, BETA-MERCAPTOETHANOL, N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Silva, A.M., Cachau, R.E., Sham, H.L., Erickson, J.W.
Deposit date:1995-10-09
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition and catalytic mechanism of HIV-1 aspartic protease.
J.Mol.Biol., 255, 1996
1SME
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PLASMEPSIN II, A HEMOGLOBIN-DEGRADING ENZYME FROM PLASMODIUM FALCIPARUM, IN COMPLEX WITH PEPSTATIN A
Descriptor:PLASMEPSIN II, Pepstatin
Authors:Silva, A.M., Lee, A.Y., Gulnik, S.V., Goldberg, D.E., Erickson, J.W.
Deposit date:1996-06-11
Release date:1997-01-11
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.
Proc.Natl.Acad.Sci.USA, 93, 1996
4FE6
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH AN ENAMINO-OXINDOLE INHIBITOR
Descriptor:HIV protease, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-3-hydroxy-4-[({(3Z)-3-[1-(methylamino)ethylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl}sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate
Authors:Silva, A.M., Eissenstat, M., Guerassina, T., Gulnik, S., Afonina, E., Yu, B., Erickson, J., Ludke, D., Yokoe, H.
Deposit date:2012-05-29
Release date:2012-07-18
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enamino-oxindole HIV protease inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
1LEE
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CRYSTAL STRUCTURE OF PLASMEPSIN FROM P. FALCIPARUM IN COMPLEX WITH INHIBITOR RS367
Descriptor:Plasmepsin 2, 4-AMINO-N-{4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-1-ISOBUTYL-5-PHENYL-PENTYL}-BENZAMIDE
Authors:Asojo, O.A., Afonina, E., Gulnik, S.V., Yu, B., Erickson, J.W., Randad, R., Mehadjed, D., Silva, A.M.
Deposit date:2002-04-09
Release date:2002-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.
Acta Crystallogr.,Sect.D, 58, 2002
1LF2
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CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR RS370
Descriptor:Plasmepsin 2, 3-AMINO-N-{4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-1-ISOBUTYL-5-PHENYL-PENTYL}-BENZAMIDE
Authors:Asojo, O.A., Afonina, E., Gulnik, S.V., Yu, B., Erickson, J.W., Randad, R., Mehadjed, D., Silva, A.M.
Deposit date:2002-04-10
Release date:2002-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.
Acta Crystallogr.,Sect.D, 58, 2002
1LF3
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CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR EH58
Descriptor:plasmepsin 2, N-(1-BENZYL-3-{[3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONYL]-[2-(HEXAHYDRO-BENZO[1,3]DIOXOL-5-YL)-ETHYL]-AMINO}-2-HYDROXY-PROPYL)-4-BENZYLOXY-3,5-DIMETHOXY-BENZAMIDE
Authors:Asojo, O.A., Gulnik, S.V., Afonina, E., Yu, B., Ellman, J.A., Haque, T.S., Silva, A.M.
Deposit date:2002-04-10
Release date:2002-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
J.Mol.Biol., 327, 2003
1LF4
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STRUCTURE OF PLASMEPSIN II
Descriptor:Plasmepsin 2
Authors:Asojo, O.A., Gulnik, S.V., Afonina, E., Yu, B., Ellman, J.A., Haque, T.S., Silva, A.M.
Deposit date:2002-04-10
Release date:2002-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
J.Mol.Biol., 327, 2003
1LS5
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CRYSTAL STRUCTURE OF PLASMEPSIN IV FROM P. FALCIPARUM IN COMPLEX WITH PEPSTATIN A
Descriptor:plasmepsin IV, Pepstatin
Authors:Asojo, O.A., Gulnik, S.V., Afonina, E., Yu, B., Ellman, J.A., Haque, T.S., Silva, A.M.
Deposit date:2002-05-16
Release date:2002-06-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
J.Mol.Biol., 327, 2003
1M43
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CRYSTAL STRUCTURE OF PMII IN COMPLEX WITH PEPSTATIN A TO 2.4 A
Descriptor:plasmepsin II, Pepstatin
Authors:Asojo, O.A., Silva, A.M., Gulnik, S.
Deposit date:2002-07-02
Release date:2002-07-24
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Novel uncomplexed and complex structures of PM II, an aspartic protease from P. falciparum
To be Published
2CW2
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CRYSTAL STRUCTURE OF SUPEROXIDE DISMUTASE FROM P. MARINUS
Descriptor:superoxide dismutase 1, FE (III) ION
Authors:Asojo, O.A., Schott, E.J., Vasta, G.R., Silva, A.M.
Deposit date:2005-06-16
Release date:2006-07-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus
ACTA CRYSTALLOGR.,SECT.F, 62, 2006
2CW3
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X-RAY STRUCTURE OF PMSOD2, SUPEROXIDE DISMUTASE FROM PERKINSUS MARINUS
Descriptor:iron superoxide dismutase, FE (III) ION
Authors:Asojo, O.A., Schott, E.J., Vasta, G.R., Silva, A.M.
Deposit date:2005-06-16
Release date:2006-07-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus
ACTA CRYSTALLOGR.,SECT.F, 62, 2006
3J6S
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 3 AT 28 DEGREES C
Descriptor:envelope protein, membrane protein
Authors:Fibriansah, G., Tan, J.L., Smith, S.A., de Alwis, R., Ng, T.-S., Kostyuchenko, V.A., Kukkaro, P., de Silva, A.M., Crowe Jr., J.E., Lok, S.-M.
Deposit date:2014-03-24
Release date:2015-03-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6 Å)
Cite:A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
3J6T
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 3 AT 37 DEGREES C
Descriptor:envelope protein, membrane protein
Authors:Fibriansah, G., Tan, J.L., Smith, S.A., de Alwis, R., Ng, T.-S., Kostyuchenko, V.A., Kukkaro, P., de Silva, A.M., Crowe Jr., J.E., Lok, S.-M.
Deposit date:2014-03-25
Release date:2015-03-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7 Å)
Cite:A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
3J6U
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 3 IN COMPLEX WITH HUMAN ANTIBODY 5J7 FAB
Descriptor:envelope protein, membrane protein, Fab 5J7 heavy chain, ...
Authors:Fibriansah, G., Tan, J.L., Smith, S.A., de Alwis, R., Ng, T.-S., Kostyuchenko, V.A., Kukkaro, P., de Silva, A.M., Crowe Jr., J.E., Lok, S.-M.
Deposit date:2014-03-26
Release date:2015-03-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9 Å)
Cite:A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
4AGS
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LEISHMANIA TDR1 - A UNIQUE TRIMERIC GLUTATHIONE TRANSFERASE
Descriptor:THIOL-DEPENDENT REDUCTASE 1, GLUTATHIONE, 1,2-ETHANEDIOL
Authors:Fyfe, P.K., Westrop, G.D., Silva, A.M., Coombs, G.H., Hunter, W.N.
Deposit date:2012-01-31
Release date:2012-07-04
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Leishmania Tdr1 Structure, a Unique Trimeric Glutathione Transferase Capable of Deglutathionylation and Antimonial Prodrug Activation.
Proc.Natl.Acad.Sci.USA, 109, 2012
4UIF
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 IN COMPLEX WITH ANTIGEN-BINDING FRAGMENTS OF HUMAN ANTIBODY 2D22
Descriptor:DENGUE VIRUS SEROTYPE 2 STRAIN PVP94 07 - ENVELOPE PROTEIN, DENGUE VIRUS SEROTYPE 2 STRAIN STRAIN PVP94 07 - MEMBRANE PROTEIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ...
Authors:Fibriansah, G., Ibarra, K.D., Ng, T.-S., Smith, S.A., Tan, J.L., Lim, X.-N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Junior, J.E., Lok, S.-M.
Deposit date:2015-03-30
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
4UIH
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA-C COMPLEXED WITH HUMAN ANTIBODY 2D22 FAB AT 37 DEGREE C. THE FAB MOLECULES WERE ADDED TO THE VIRUS BEFORE 37 DEGREE C INCUBATION.
Descriptor:DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA-C E PROTEIN ECTODOMAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -LIGHT CHAIN
Authors:Fibriansah, G., Ibarra, K.D., Ng, T.-S., Smith, S.A., Tan, J.L., Lim, X.N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe, J.E., Lok, S.-M.
Deposit date:2015-03-30
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
5A1Z
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CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 STRAIN PVP94-07 COMPLEXED WITH HUMAN ANTIBODY 2D22 FAB AT 37 DEGREES C
Descriptor:ENVELOPE PROTEIN, MEMBRANE GLYCOPROTEIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ...
Authors:Fibriansah, G., Ibarra, K.D., Ng, T.S., Smith, S.A., Tan, J.L., Lim, X.N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Jr, J.E., Lok, S.M.
Deposit date:2015-05-06
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
4SBV
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THE REFINEMENT OF SOUTHERN BEAN MOSAIC VIRUS IN RECIPROCAL SPACE
Descriptor:SOUTHERN BEAN MOSAIC VIRUS COAT PROTEIN, CALCIUM ION
Authors:Rossmann, M.G.
Deposit date:1985-04-01
Release date:1985-07-17
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Refinement of Southern Bean Mosaic Virus in Reciprocal Space
Acta Crystallogr.,Sect.B, 41, 1985
1LYA
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CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN
Descriptor:CATHEPSIN D, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Baldwin, E.T., Bhat, T.N., Gulnik, S., Erickson, J.W.
Deposit date:1993-04-22
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Proc.Natl.Acad.Sci.USA, 90, 1993
1LYB
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CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN
Descriptor:CATHEPSIN D, PEPSTATIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Baldwin, E.T., Bhat, T.N., Gulnik, S., Erickson, J.W.
Deposit date:1993-04-22
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Proc.Natl.Acad.Sci.USA, 90, 1993
3DSL
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THE THREE-DIMENSIONAL STRUCTURE OF BOTHROPASIN, THE MAIN HEMORRHAGIC FACTOR FROM BOTHROPS JARARACA VENOM.
Descriptor:Zinc metalloproteinase-disintegrin bothropasin, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Muniz, J.R.C., Ambrosio, A., Selistre-de-Araujo, H.S., Oliva, G., Garratt, R.C., Souza, D.H.F.
Deposit date:2008-07-13
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The three-dimensional structure of bothropasin, the main hemorrhagic factor from Bothrops jararaca venom: Insights for a new classification of snake venom metalloprotease subgroups.
Toxicon, 52, 2008
1CF9
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STRUCTURE OF THE MUTANT VAL169CYS OF CATALASE HPII FROM ESCHERICHIA COLI
Descriptor:PROTEIN (CATALASE HPII), PROTOPORPHYRIN IX CONTAINING FE
Authors:Mate, M.J., Loewen, P.C., Fita, I.
Deposit date:1999-03-24
Release date:1999-04-06
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutants that alter the covalent structure of catalase hydroperoxidase II from Escherichia coli.
J.Biol.Chem., 274, 1999
1E93
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HIGH RESOLUTION STRUCTURE AND BIOCHEMICAL PROPERTIES OF A RECOMBINANT CATALASE DEPLETED IN IRON
Descriptor:CATALASE, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Andreoletti, P., Sainz, G., Jaquinod, M., Gagnon, J., Jouve, H.M.
Deposit date:2000-10-05
Release date:2000-10-13
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-Resolution Structure and Biochemical Properties of a Recombinant Proteus Mirabilis Catalase Depleted in Iron.
Proteins: Struct.,Funct., Genet., 50, 2003
1H6N
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FORMATION OF A TYROSYL RADICAL INTERMEDIATE IN PROTEUS MIRABILIS CATALASE BY DIRECTED MUTAGENESIS AND CONSEQUENCES FOR NUCLEOTIDE REACTIVITY
Descriptor:CATALASE, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Andreoletti, P., Sainz, G., Jaquinod, M., Gagnon, J., Jouve, H.M.
Deposit date:2001-06-20
Release date:2003-10-03
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:High Resolution Structure and Biochemical Properties of a Recombinant Proteus Mirabilis Catalase Depleted in Iron.
Proteins: Struct.,Funct., Genet., 50, 2003
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