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1EA5
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NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA AT 1.8A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE
Authors:Harel, M., Weik, M., Silman, I., Sussman, J.L.
Deposit date:2000-11-06
Release date:2000-11-08
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Structures of Torpedo Californica Acetylcholinesterase Complexed with (+)-Huperzine a and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement
Biochemistry, 41, 2002
2ACE
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NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA
Descriptor:ACETYLCHOLINESTERASE, ACETYLCHOLINE
Authors:Harel, M., Raves, M.L., Silman, I., Sussman, J.L.
Deposit date:1996-06-23
Release date:1996-11-08
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nat.Struct.Biol., 4, 1997
1AX9
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ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, LAUE DATA
Descriptor:ACETYLCHOLINESTERASE, EDROPHONIUM ION
Authors:Raves, M.L., Ravelli, R.B.G., Sussman, J.L., Harel, M., Silman, I.
Deposit date:1997-11-03
Release date:1998-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Static Laue diffraction studies on acetylcholinesterase.
Acta Crystallogr.,Sect.D, 54, 1998
1ODC
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-4'-QUINOLYL-N'-9"-(1",2",3",4"-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.2A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N-QUINOLIN-4-YL-N'-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)OCTANE-1,8-DIAMINE
Authors:Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.-F., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2003-02-15
Release date:2005-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
1UT6
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.4 ANGSTROMS RESOLUTION.
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE
Authors:Brumshtein, B., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2003-12-04
Release date:2005-04-21
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge.
J.Med.Chem., 49, 2006
1ZGB
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CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (R)-TACRINE(10)-HUPYRIDONE INHIBITOR.
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, (5R)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE
Authors:Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-04-21
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
1ZGC
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CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (RS)-TACRINE(10)-HUPYRIDONE INHIBITOR.
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, (5S)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE
Authors:Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-04-21
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
2ACK
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ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA
Descriptor:ACETYLCHOLINESTERASE, EDROPHONIUM ION
Authors:Raves, M.L., Sussman, J.L., Harel, M., Silman, I.
Deposit date:1997-10-29
Release date:1998-02-11
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Static Laue diffraction studies on acetylcholinesterase.
Acta Crystallogr.,Sect.D, 54, 1998
1E3Q
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH BW284C51
Descriptor:ACETYLCHOLINESTERASE, 4-(5-{4-[DIMETHYL(PROP-2-ENYL)AMMONIO]PHENYL}-3-OXOPENTYL)-N,N-DIMETHYL-N-PROP-2-ENYLBENZENAMINIUM, SULFATE ION, ...
Authors:Felder, C.E., Harel, M., Silman, I., Sussman, J.L.
Deposit date:2000-06-21
Release date:2000-07-03
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of a Complex of the Potent and Specific Inhibitor Bw284C51 with Torpedo Californica Acetylcholinesterase
Acta Crystallogr.,Sect.D, 58, 2002
1H22
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(10)-HUPYRIDONE AT 2.15A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,10-DIAMINODECANE DIHYDROCHLORIDE, N-ACETYL-D-GLUCOSAMINE
Authors:Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.-F., Pang, Y.-P., Silman, I., Sussman, J.L.
Deposit date:2002-07-30
Release date:2002-12-23
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J.Am.Chem.Soc., 125, 2003
1H23
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STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(12)-HUPYRIDONE AT 2.15A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,12-DIAMINODODECANE DIHYDROCHLORIDE, N-ACETYL-D-GLUCOSAMINE
Authors:Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.F., Pang, Y.P., Silman, I., Sussman, J.L.
Deposit date:2002-07-30
Release date:2002-12-23
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J.Am.Chem.Soc., 125, 2003
1ACJ
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QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE
Descriptor:ACETYLCHOLINESTERASE, TACRINE
Authors:Sussman, J.L., Harel, M., Silman, I.
Deposit date:1993-08-18
Release date:1994-08-31
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
Proc.Natl.Acad.Sci.USA, 90, 1993
1ACL
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QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE
Descriptor:ACETYLCHOLINESTERASE, DECAMETHONIUM ION
Authors:Sussman, J.L., Harel, M., Silman, I.
Deposit date:1993-08-18
Release date:1994-08-31
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
Proc.Natl.Acad.Sci.USA, 90, 1993
1AMN
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TRANSITION STATE ANALOG: ACETYLCHOLINESTERASE COMPLEXED WITH M-(N,N,N-TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE
Descriptor:ACETYLCHOLINESTERASE, SULFATE ION, M-(N,N,N-TRIMETHYLAMMONIO)-2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYLBENZENE
Authors:Harel, M., Silman, I., Sussman, J.L.
Deposit date:1996-02-13
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.
J.Am.Chem.Soc., 118, 1996
1B41
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HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN
Descriptor:ACETYLCHOLINESTERASE, FASCICULIN-2, ALPHA-L-FUCOSE, ...
Authors:Kryger, G., Harel, M., Shafferman, A., Silman, I., Sussman, J.L.
Deposit date:1999-01-05
Release date:2001-01-17
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta Crystallogr.,Sect.D, 56, 2000
1CFJ
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METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ISOPROPYLMETHYLPHOSPHONOFLUORIDATE (GB, SARIN)
Descriptor:PROTEIN (ACETYLCHOLINESTERASE), N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Millard, C.B., Silman, I., Sussman, J.L.
Deposit date:1999-03-19
Release date:1999-06-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry, 38, 1999
1EEA
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ACETYLCHOLINESTERASE
Descriptor:PROTEIN (ACETYLCHOLINESTERASE)
Authors:Raves, M.L., Giles, K., Schrag, J.D., Schmid, M.F., Phillips Jr., G.N., Wah, C., Howard, A.J., Silman, I., Sussman, J.L.
Deposit date:1999-01-26
Release date:1999-02-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Quaternary Structure of Tetrameric Acetylcholinesterase
Structure and Function of Cholinesterases and Related Proteins, 1998
1EVE
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THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE
Authors:Kryger, G., Silman, I., Sussman, J.L.
Deposit date:1998-03-04
Release date:1999-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Structure Fold.Des., 7, 1999
1FSS
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ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II
Descriptor:ACETYLCHOLINESTERASE, FASCICULIN II, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Harel, M., Kleywegt, G.J., Silman, I., Sussman, J.L.
Deposit date:1995-10-25
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target.
Structure, 3, 1995
1GCD
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REFINED CRYSTAL STRUCTURE OF "AGED" AND "NON-AGED" ORGANOPHOSPHORYL CONJUGATES OF GAMMA-CHYMOTRYPSIN
Descriptor:GAMMA-CHYMOTRYPSIN, SULFATE ION, DIETHYL PHOSPHONATE
Authors:Harel, M., Sussman, J.L., Silman, I.
Deposit date:1994-05-05
Release date:1994-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.
J.Mol.Biol., 221, 1991
1GMH
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REFINED CRYSTAL STRUCTURE OF "AGED" AND "NON-AGED" ORGANOPHOSPHORYL CONJUGATES OF GAMMA-CHYMOTRYPSIN
Descriptor:GAMMA-CHYMOTRYPSIN A, SULFATE ION, PHOSPHORYLISOPROPANE
Authors:Harel, M., Sussman, J.L., Silman, I.
Deposit date:1994-07-01
Release date:1994-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.
J.Mol.Biol., 221, 1991
1GQR
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ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH RIVASTIGMINE
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, 3-[(1S)-1-(DIMETHYLAMINO)ETHYL]PHENOL, ...
Authors:Raves, M.L., Harel, M., Silman, I., Sussman, J.L.
Deposit date:2001-12-04
Release date:2002-03-15
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine
Biochemistry, 41, 2002
1GQS
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ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH NAP
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, 3-[(1S)-1-(DIMETHYLAMINO)ETHYL]PHENOL
Authors:Bar-on, P., Millard, C.B., Harel, M., Dvir, H., Enz, A., Sussman, J.L., Silman, I.
Deposit date:2001-12-04
Release date:2002-03-15
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine
Biochemistry, 41, 2002
1SOM
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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE INHIBITED BY NERVE AGENT GD (SOMAN).
Descriptor:PROTEIN (ACETYLCHOLINESTERASE), N-ACETYL-D-GLUCOSAMINE, UNKNOWN ATOM OR ION, ...
Authors:Greenblatt, H.M., Millard, C.B., Sussman, J.L., Silman, I.
Deposit date:1999-03-17
Release date:1999-06-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry, 38, 1999
1VOT
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ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A
Descriptor:ACETYLCHOLINESTERASE, Huperzine A
Authors:Raves, M.L., Harel, M., Silman, I., Sussman, J.L.
Deposit date:1996-06-23
Release date:1997-06-16
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nat.Struct.Biol., 4, 1997