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1UN8
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BU of 1un8 by Molmil
Crystal structure of the dihydroxyacetone kinase of C. freundii (native form)
Descriptor: (2R)-3-(PHOSPHONOOXY)-2-(TETRADECANOYLOXY)PROPYL PALMITATE, DIHYDROXYACETONE KINASE
Authors:Siebold, C, Arnold, I, Garcia-Alles, L.F, Baumann, U, Erni, B.
Deposit date:2003-09-08
Release date:2003-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Citrobacter Freundii Dihydroxyacetone Kinase Reveals an Eight-Stranded Alpha-Helical Barrel ATP-Binding Domain
J.Biol.Chem., 278, 2003
1UN9
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BU of 1un9 by Molmil
Crystal structure of the dihydroxyacetone kinase from C. freundii in complex with AMP-PNP and Mg2+
Descriptor: DIHYDROXYACETONE, DIHYDROXYACETONE KINASE, MAGNESIUM ION, ...
Authors:Siebold, C, Arnold, I, Garcia-Alles, L.F, Baumann, U, Erni, B.
Deposit date:2003-09-08
Release date:2003-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of the Citrobacter Freundii Dihydroxyacetone Kinase Reveals an Eight-Stranded Alpha-Helical Barrel ATP-Binding Domain
J.Biol.Chem., 278, 2003
1OI2
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BU of 1oi2 by Molmil
X-ray structure of the dihydroxyacetone kinase from Escherichia coli
Descriptor: GLYCEROL, HYPOTHETICAL PROTEIN YCGT, SULFATE ION
Authors:Siebold, C, Garcia-Alles, L.-F, Erni, B, Baumann, U.
Deposit date:2003-06-04
Release date:2003-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Mechanism of Covalent Substrate Binding in the X-Ray Structure of Subunit K of the Escherichia Coli Dihydroxyacetone Kinase
Proc.Natl.Acad.Sci.USA, 100, 2003
1OI3
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BU of 1oi3 by Molmil
X-ray structure of the dihydroxyacetone kinase from Escherichia coli
Descriptor: HYPOTHETICAL PROTEIN YCGT, SULFATE ION
Authors:Siebold, C, Garcia-Alles, L.-F, Erni, B, Baumann, U.
Deposit date:2003-06-04
Release date:2003-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Mechanism of Covalent Substrate Binding in the X-Ray Structure of Subunit K of the Escherichia Coli Dihydroxyacetone Kinase
Proc.Natl.Acad.Sci.USA, 100, 2003
1UVQ
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BU of 1uvq by Molmil
Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, GLYCINE, ...
Authors:Siebold, C, Hansen, B.E, Wyer, J.R, Harlos, K, Esnouf, R.E, Svejgaard, A, Bell, J.I, Strominger, J.L, Jones, E.Y, Fugger, L.
Deposit date:2004-01-22
Release date:2004-02-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Hla-Dq0602 that Protects Against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy
Proc.Natl.Acad.Sci.USA, 101, 2004
2BRY
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BU of 2bry by Molmil
Crystal structure of the native monooxygenase domain of MICAL at 1.45 A resolution
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Siebold, C, Berrow, N, Walter, T.S, Harlos, K, Owens, R.J, Terman, J.R, Stuart, D.I, Kolodkin, A.L, Pasterkamp, R.J, Jones, E.Y.
Deposit date:2005-05-13
Release date:2005-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:High-Resolution Structure of the Catalytic Region of Mical (Molecule Interacting with Casl), a Multidomain Flavoenzyme-Signaling Molecule.
Proc.Natl.Acad.Sci.USA, 102, 2005
2C4C
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BU of 2c4c by Molmil
Crystal structure of the NADPH-treated monooxygenase domain of MICAL
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, NEDD9-INTERACTING PROTEIN WITH CALPONIN HOMOLOGY AND LIM DOMAINS
Authors:Siebold, C, Berrow, N, Walter, T.S, Harlos, K, Owens, R.J, Terman, J.R, Stuart, D.I, Kolodkin, A.L, Pasterkamp, R.J, Jones, E.Y.
Deposit date:2005-10-18
Release date:2005-10-26
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:High-Resolution Structure of the Catalytic Region of Mical (Molecule Interacting with Casl), a Multidomain Flavoenzyme-Signaling Molecule.
Proc.Natl.Acad.Sci.USA, 102, 2005
2UUX
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BU of 2uux by Molmil
Structure of the tryptase inhibitor TdPI from a tick
Descriptor: SULFATE ION, TRYPTASE INHIBITOR
Authors:Siebold, C, Paesen, G.C, Harlos, K, Peacey, M.F, Nuttall, P.A, Stuart, D.I.
Deposit date:2007-03-08
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Tick Protein with a Modified Kunitz Fold Inhibits Human Tryptase.
J.Mol.Biol., 368, 2007
2UUY
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BU of 2uuy by Molmil
Structure of a tick tryptase inhibitor in complex with bovine trypsin
Descriptor: CALCIUM ION, CATIONIC TRYPSIN, CHLORIDE ION, ...
Authors:Siebold, C, Paesen, G.C, Harlos, K, Peacey, M.F, Nuttall, P.A, Stuart, D.I.
Deposit date:2007-03-08
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:A Tick Protein with a Modified Kunitz Fold Inhibits Human Tryptase.
J.Mol.Biol., 368, 2007
1UOD
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BU of 1uod by Molmil
Crystal structure of the dihydroxyacetone kinase from E. coli in complex with dihydroxyacetone-phosphate
Descriptor: DIHYDROXYACETONE KINASE, GLYCERALDEHYDE-3-PHOSPHATE, SULFATE ION
Authors:Siebold, C, Garcia-Alles, L.F, Luthi-Nyffeler, T, Flukiger-Bruhwiler, K, Burgi, H.-B, Baumann, U, Erni, B.
Deposit date:2003-09-16
Release date:2004-09-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phosphoenolpyruvate- and ATP-Dependent Dihydroxyacetone Kinases: Covalent Substrate-Binding and Kinetic Mechanism
Biochemistry, 43, 2004
1UOE
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BU of 1uoe by Molmil
Crystal structure of the dihydroxyacetone kinase from E. coli in complex with glyceraldehyde
Descriptor: DIHYDROXYACETONE KINASE, GLYCEROL, SULFATE ION
Authors:Siebold, C, Garcia-Alles, L.F, Luthi-Nyffeler, T, Flukiger-Bruhwiler, K, Burgi, H.-B, Baumann, U, Erni, B.
Deposit date:2003-09-16
Release date:2004-09-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Phosphoenolpyruvate- and ATP-Dependent Dihydroxyacetone Kinases: Covalent Substrate-Binding and Kinetic Mechanism
Biochemistry, 43, 2004
6RVD
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BU of 6rvd by Molmil
Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:El Omari, K, Rudolf, A.F, Kowatsch, C, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-31
Release date:2019-10-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
7ZI0
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BU of 7zi0 by Molmil
Structure of human Smoothened in complex with cholesterol and SAG
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, ...
Authors:Byrne, E.F.X, Woolley, R.E, Ansell, B, Sansom, M.S.P, Newstead, S, Siebold, C.
Deposit date:2022-04-07
Release date:2022-06-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Sci Adv, 8, 2022
6Z3J
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BU of 6z3j by Molmil
Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 1)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C.
Deposit date:2020-05-20
Release date:2020-07-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
7Q6Z
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BU of 7q6z by Molmil
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575
Descriptor: 2-(2-methylpropylamino)-1-[(4R)-4-(6-methylpyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone, CHOLESTEROL, Megabody 177, ...
Authors:Coupland, C, Carrique, L, Siebold, C.
Deposit date:2021-11-09
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Mol.Cell, 81, 2021
7Q1U
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BU of 7q1u by Molmil
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map)
Descriptor: CHOLESTEROL, MAGNESIUM ION, Megabody 177, ...
Authors:Coupland, C, Carrique, L, Siebold, C.
Deposit date:2021-10-21
Release date:2022-06-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Mol.Cell, 81, 2021
2V5P
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BU of 2v5p by Molmil
COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, INSULIN-LIKE GROWTH FACTOR II, ...
Authors:Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y.
Deposit date:2007-07-06
Release date:2007-12-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structure and Functional Analysis of the Igf-II/Igf2R Interaction
Embo J., 27, 2008
3SUA
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BU of 3sua by Molmil
Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ...
Authors:Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C.
Deposit date:2011-07-11
Release date:2011-09-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.39 Å)
Cite:A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
3SU8
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BU of 3su8 by Molmil
Crystal structure of a truncated intracellular domain of Plexin-B1 in complex with Rac1
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ...
Authors:Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C.
Deposit date:2011-07-11
Release date:2011-09-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
7NDG
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BU of 7ndg by Molmil
Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neogenin, ...
Authors:Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C.
Deposit date:2021-02-01
Release date:2021-03-31
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (5.98 Å)
Cite:Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
7NE0
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BU of 7ne0 by Molmil
Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin
Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C.
Deposit date:2021-02-02
Release date:2021-03-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
7NE1
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BU of 7ne1 by Molmil
Structure of the complex between Netrin-1 and its receptor Neogenin
Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C.
Deposit date:2021-02-02
Release date:2021-03-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
4GZA
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BU of 4gza by Molmil
Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1
Descriptor: CALCIUM ION, Neuropilin-1, Plexin-A2, ...
Authors:Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (7 Å)
Cite:Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
4GZ8
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BU of 4gz8 by Molmil
Mouse Semaphorin 3A, domains Sema-PSI-IG
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
4GZ9
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BU of 4gz9 by Molmil
Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012

217705

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