Author results

1TZH
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CRYSTAL STRUCTURE OF THE FAB YADS1 COMPLEXED WITH H-VEGF
Descriptor:Vascular endothelial growth factor A, Fab YADS1 Light Chain, Fab YADS1 Heavy Chain
Authors:Fellouse, F.A., Wiesmann, C., Sidhu, S.S.
Deposit date:2004-07-09
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
1TZI
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CRYSTAL STRUCTURE OF THE FAB YADS2 COMPLEXED WITH H-VEGF
Descriptor:Fab YADS2 Light Chain, Fab YADS2 Heavy Chain, Vascular endothelial growth factor A
Authors:Fellouse, F.A., Wiesmann, C., Sidhu, S.S.
Deposit date:2004-07-10
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
2H2B
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CRYSTAL STRUCTURE OF ZO-1 PDZ1 BOUND TO A PHAGE-DERIVED LIGAND (WRRTTYL)
Descriptor:Tight junction protein ZO-1, ACETIC ACID
Authors:Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.
Deposit date:2006-05-18
Release date:2006-06-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H2C
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CRYSTAL STRUCTURE OF ZO-1 PDZ1 BOUND TO A PHAGE-DERIVED LIGAND (WRRTTWV)
Descriptor:Tight junction protein ZO-1
Authors:Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.
Deposit date:2006-05-18
Release date:2006-06-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H3L
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CRYSTAL STRUCTURE OF ERBIN PDZ
Descriptor:LAP2 protein
Authors:Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.
Deposit date:2006-05-22
Release date:2006-06-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H3M
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CRYSTAL STRUCTURE OF ZO-1 PDZ1
Descriptor:Tight junction protein ZO-1, SULFATE ION
Authors:Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.
Deposit date:2006-05-22
Release date:2006-06-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
4F59
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TRIPLE MUTANT SRC SH2 DOMAIN
Descriptor:Proto-oncogene tyrosine-protein kinase Src
Authors:Kaneko, T., Huang, H., Cao, X., Li, C., Voss, C., Sidhu, S.S., Li, S.S.
Deposit date:2012-05-12
Release date:2012-10-03
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
4F5A
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TRIPLE MUTANT SRC SH2 DOMAIN BOUND TO PHOSPHATE ION
Descriptor:Proto-oncogene tyrosine-protein kinase Src, PHOSPHATE ION
Authors:Kaneko, T., Huang, H., Cao, X., Li, C., Voss, C., Sidhu, S.S., Li, S.S.
Deposit date:2012-05-12
Release date:2012-10-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
4F5B
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TRIPLE MUTANT SRC SH2 DOMAIN BOUND TO PHOSPHOTYROSINE
Descriptor:Proto-oncogene tyrosine-protein kinase Src, O-PHOSPHOTYROSINE
Authors:Kaneko, T., Huang, H., Cao, X., Li, C., Voss, C., Sidhu, S.S., Li, S.S.
Deposit date:2012-05-12
Release date:2012-10-03
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
1L7I
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CRYSTAL STRUCTURE OF THE ANTI-ERBB2 FAB2C4
Descriptor:chimera of Fab2C4: "humanized" murine monoclonal antibody, SULFATE ION
Authors:Vajdos, F.F., Adams, C.W., Breece, T.N., Presta, L.G., de Vos, A.M., Sidhu, S.S.
Deposit date:2002-03-15
Release date:2002-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis.
J.Mol.Biol., 320, 2002
1LB7
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IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1
Descriptor:IGF-1 ANTAGONIST F1-1
Authors:Deshayes, K., Schaffer, M.L., Skelton, N.J., Nakamura, G.R., Kadkhodayan, S., Sidhu, S.S.
Deposit date:2002-04-02
Release date:2002-06-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function.
Chem.Biol., 9, 2002
1N7T
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ERBIN PDZ DOMAIN BOUND TO A PHAGE-DERIVED PEPTIDE
Descriptor:99-mer peptide of densin-180-like protein, phage-derived peptide
Authors:Skelton, N.J., Koehler, M.F.T., Zobel, K., Wong, W.L., Yeh, S., Pisabarro, M.T., Yin, J.P., Lasky, L.A., Sidhu, S.S.
Deposit date:2002-11-16
Release date:2003-01-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain.
J.Biol.Chem., 278, 2003
1SHM
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CONVERGENT SOLUTIONS TO VHH DOMAIN STABILIZATION FROM NATURAL AND IN VITRO EVOLUTION
Descriptor:ANTIBODY RIG
Authors:Bond, C.J., Wiesmann, C., Marsters, J.C., Sidhu, S.S.
Deposit date:2004-02-26
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A structure-based database of antibody variable domain diversity.
J.Mol.Biol., 348, 2005
1ZA3
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THE CRYSTAL STRUCTURE OF THE YSD1 FAB BOUND TO DR5
Descriptor:Fab-YSd1 light chain, Fab-YSd1 heavy chain, Tumor necrosis factor receptor superfamily member 10B
Authors:Fellouse, F.A., Li, B., Compaan, D.M., Peden, A.A., Hymowitz, S.G., Sidhu, S.S.
Deposit date:2005-04-05
Release date:2005-06-14
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Molecular recognition by a binary code.
J.Mol.Biol., 348, 2005
2JOA
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HTRA1 BOUND TO AN OPTIMIZED PEPTIDE: NMR ASSIGNMENT OF PDZ DOMAIN AND LIGAND RESONANCES
Descriptor:Serine protease HTRA1, Peptide H1-C1
Authors:Runyon, S.T., Zhang, Y., Appleton, B.A., Sazinksy, S.L., Wu, P., Pan, B., Wiesmann, C., Skelton, N.J., Sidhu, S.S.
Deposit date:2007-03-01
Release date:2007-11-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3
Protein Sci., 16, 2007
2R8S
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HIGH RESOLUTION STRUCTURE OF A SPECIFIC SYNTHETIC FAB BOUND TO P4-P6 RNA RIBOZYME DOMAIN
Descriptor:P4-P6 RNA RIBOZYME DOMAIN, Fab light chain, Fab heavy chain, ...
Authors:Ye, J.D., Tereshko, V., Sidhu, S.S., Koide, S., Kossiakoff, A.A., Piccirilli, J.A.
Deposit date:2007-09-11
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Synthetic antibodies for specific recognition and crystallization of structured RNA
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EFD
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THE CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF KCSA
Descriptor:FabL, FabH, KcsA
Authors:Uysal, S., Vasquez, V., Tereshko, V., Esaki, K., Fellouse, F.A., Sidhu, S.S., Koide, S., Perozo, E., Kossiakoff, A.
Deposit date:2008-09-08
Release date:2009-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of full-length KcsA in its closed conformation.
Proc.Natl.Acad.Sci.USA, 106, 2009
3EFF
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THE CRYSTAL STRUCTURE OF FULL-LENGTH KCSA IN ITS CLOSED CONFORMATION
Descriptor:FAB, Voltage-gated potassium channel
Authors:Uysal, S., Vasquez, V., Tereshko, T., Esaki, K., Fellouse, F.A., Sidhu, S.S., Koide, S., Perozo, E., Kossiakoff, A.
Deposit date:2008-09-08
Release date:2009-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of full-length KcsA in its closed conformation.
Proc.Natl.Acad.Sci.USA, 106, 2009
3PNW
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CRYSTAL STRUCTURE OF THE TUDOR DOMAIN OF HUMAN TDRD3 IN COMPLEX WITH AN ANTI-TDRD3 FAB
Descriptor:FAB light chain, FAB heavy chain, Tudor domain-containing protein 3, ...
Authors:Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC)
Deposit date:2010-11-19
Release date:2010-12-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies.
J.Mol.Biol., 425, 2013
5JG6
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APC11-UBV SHOWS ROLE OF NONCOVALENT RING-UBIQUITIN INTERACTIONS IN PROCESSIVE MULTIUBIQUITINATION AND UBIQUITIN CHAIN ELONGATION BY APC/C
Descriptor:Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION
Authors:Brown, N.G., Zhang, W., Yu, S., Miller, D.J., Sidhu, S.S., Schulman, B.A.
Deposit date:2016-04-19
Release date:2016-06-15
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.0013 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5VEI
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN OF HUMAN SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 2
Descriptor:Sorbin and SH3 domain-containing protein 2, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Huang, H., Gu, J., Liu, K., Sidhu, S.S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-04-04
Release date:2017-08-02
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2
To be Published
6CPM
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STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH A THIRD-GENERATION INHIBITORY UBV
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.1d, CALCIUM ION, ...
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-03-13
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6CRN
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STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH A HIGH-AFFINITY FIRST-GENERATION UBV
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-03-19
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6DJ9
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STRUCTURE OF THE USP15 DUSP DOMAIN IN COMPLEX WITH A HIGH-AFFINITY UBIQUITIN VARIANT (UBV)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin Variant UbV 15.D
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-05-24
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6EDF
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FRAGMENT OF A TYROSINE-PROTEIN KINASE
Descriptor:FYN, GLYCEROL, UNKNOWN ATOM OR ION
Authors:Tempel, W., Huang, H., Sochirca, I., Liu, K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Sidhu, S.S., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-08-09
Release date:2018-08-29
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Fragment of a tyrosine-protein kinase
To be Published