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8CX9
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BU of 8cx9 by Molmil
Structure of the SARS-COV2 PLpro (C111S) in complex with a dimeric Ubv that inhibits activity by an unusual allosteric mechanism
Descriptor: BROMIDE ION, CHLORIDE ION, Papain-like protease nsp3, ...
Authors:Singer, A.U, Slater, C.L, Patel, A, Russel, R, Mark, B.L, Sidhu, S.S.
Deposit date:2022-05-20
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site.
Plos Pathog., 18, 2022
6UBH
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BU of 6ubh by Molmil
Structure of the MM7 Erbin PDZ variant in complex with a high-affinity peptide
Descriptor: Erbin, SODIUM ION, peptide
Authors:Singer, A.U, Teyra, J, McLaughlin, M, Ernst, A, Sicheri, F, Sidhu, S.S.
Deposit date:2019-09-11
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comprehensive Assessment of the Relationship Between Site -2 Specificity and Helix alpha 2 in the Erbin PDZ Domain.
J.Mol.Biol., 433, 2021
1TZH
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BU of 1tzh by Molmil
Crystal Structure of the Fab YADS1 Complexed with h-VEGF
Descriptor: Fab YADS1 Heavy Chain, Fab YADS1 Light Chain, Vascular endothelial growth factor A
Authors:Fellouse, F.A, Wiesmann, C, Sidhu, S.S.
Deposit date:2004-07-09
Release date:2004-08-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
1TZI
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BU of 1tzi by Molmil
Crystal Structure of the Fab YADS2 Complexed with h-VEGF
Descriptor: Fab YADS2 Heavy Chain, Fab YADS2 Light Chain, Vascular endothelial growth factor A
Authors:Fellouse, F.A, Wiesmann, C, Sidhu, S.S.
Deposit date:2004-07-10
Release date:2004-08-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
8TS5
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BU of 8ts5 by Molmil
Structure of the apo FabS1C_C1
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
Authors:Singer, A.U, Bruce, H.A, Blazer, L.L, Adams, J.J, Sicheri, F, Sidhu, S.S.
Deposit date:2023-08-10
Release date:2023-11-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
8TRT
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BU of 8trt by Molmil
Structure of the EphA2 CRD bound to FabS1CE_C1, monoclinic form
Descriptor: CHLORIDE ION, Ephrin type-A receptor 2, S1CE variant of Fab C1 heavy chain, ...
Authors:Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S.
Deposit date:2023-08-10
Release date:2023-11-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
8TRS
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BU of 8trs by Molmil
Structure of the EphA2 CRD bound to FabS1CE_C1, trigonal form
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S.
Deposit date:2023-08-10
Release date:2023-11-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
8T7I
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BU of 8t7i by Molmil
Structure of the S1CE variant of Fab F1 (FabS1CE-F1)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, S1CE variant of Fab F1 heavy chain, ...
Authors:Singer, A.U, Bruce, H.A, Enderle, L, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S.
Deposit date:2023-06-20
Release date:2023-11-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
8T7G
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BU of 8t7g by Molmil
Structure of the CK variant of Fab F1 (FabC-F1)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CK variant of Fab F1 heavy chain, ...
Authors:Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S.
Deposit date:2023-06-20
Release date:2023-11-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
8T7F
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BU of 8t7f by Molmil
Structure of the S1 variant of Fab F1
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, S1 variant of Fab F1 heavy chain, S1 variant of Fab F1 light chain, ...
Authors:Singer, A.U, Bruce, H.A, Enderle, L, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S.
Deposit date:2023-06-20
Release date:2023-11-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
7T1K
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BU of 7t1k by Molmil
Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ...
Authors:Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S.
Deposit date:2021-12-02
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
7T1L
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BU of 7t1l by Molmil
Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide
Descriptor: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ...
Authors:Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S.
Deposit date:2021-12-02
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
7T1U
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BU of 7t1u by Molmil
Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide
Descriptor: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION
Authors:Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S.
Deposit date:2021-12-02
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
2H3L
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BU of 2h3l by Molmil
Crystal Structure of ERBIN PDZ
Descriptor: LAP2 protein
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-22
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H2C
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BU of 2h2c by Molmil
Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV)
Descriptor: Tight junction protein ZO-1
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-18
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H2B
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BU of 2h2b by Molmil
Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTYL)
Descriptor: ACETIC ACID, Tight junction protein ZO-1
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-18
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H3M
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BU of 2h3m by Molmil
Crystal Structure of ZO-1 PDZ1
Descriptor: SULFATE ION, Tight junction protein ZO-1
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-22
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
6Q0M
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BU of 6q0m by Molmil
Structure of Erbin PDZ derivative E-14 with a high-affinity peptide
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ...
Authors:Singer, A.U, Teyra, J, Ernst, A, Sicheri, F, Sidhu, S.S.
Deposit date:2019-08-02
Release date:2019-11-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.
Protein Sci., 29, 2020
6Q0N
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BU of 6q0n by Molmil
Structure of the Erbin PDB domain in complex with a high-affinity peptide
Descriptor: Erbin, peptide
Authors:Singer, A.U, Teyra, J, Ernst, A, Sicheri, F, Sidhu, S.S.
Deposit date:2019-08-02
Release date:2019-11-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.
Protein Sci., 29, 2020
6Q0U
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BU of 6q0u by Molmil
Structure of the Erbin PDZ variant E-6a with a high-affinity C-terminal peptide
Descriptor: 1,2-ETHANEDIOL, Erbin, peptide
Authors:Singer, A.U, Teyra, J, Ernst, A, Sicheri, F, Sidhu, S.S.
Deposit date:2019-08-02
Release date:2019-11-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.
Protein Sci., 29, 2020
1ZA3
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BU of 1za3 by Molmil
The crystal structure of the YSd1 Fab bound to DR5
Descriptor: Fab-YSd1 heavy chain, Fab-YSd1 light chain, Tumor necrosis factor receptor superfamily member 10B
Authors:Fellouse, F.A, Li, B, Compaan, D.M, Peden, A.A, Hymowitz, S.G, Sidhu, S.S.
Deposit date:2005-04-05
Release date:2005-06-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Molecular recognition by a binary code.
J.Mol.Biol., 348, 2005
1SHM
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BU of 1shm by Molmil
Convergent solutions to VHH domain stabilization from natural and in vitro evolution
Descriptor: ANTIBODY RIG
Authors:Bond, C.J, Wiesmann, C, Marsters, J.C, Sidhu, S.S.
Deposit date:2004-02-26
Release date:2005-03-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A structure-based database of antibody variable domain diversity.
J.Mol.Biol., 348, 2005
4F59
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BU of 4f59 by Molmil
Triple mutant Src SH2 domain
Descriptor: Proto-oncogene tyrosine-protein kinase Src
Authors:Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S.
Deposit date:2012-05-12
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
4F5A
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BU of 4f5a by Molmil
Triple mutant Src SH2 domain bound to phosphate ion
Descriptor: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src
Authors:Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S.
Deposit date:2012-05-12
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
4F5B
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BU of 4f5b by Molmil
Triple mutant Src SH2 domain bound to phosphotyrosine
Descriptor: O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src
Authors:Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S.
Deposit date:2012-05-12
Release date:2012-10-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012

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PDB entries from 2024-03-27

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