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2Y1M
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STRUCTURE OF NATIVE C-CBL
分子名称:E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION, CALCIUM ION
著者Dou, H., Sibbet, G.J., Huang, D.T.
登録日2010-12-08
公開日2012-01-18
最終更新日2012-02-15
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
2Y1N
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STRUCTURE OF C-CBL-ZAP-70 PEPTIDE COMPLEX
分子名称:E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, SYK-RELATED TYROSINE KINASE, ...
著者Dou, H., Sibbet, G.J., Huang, D.T.
登録日2010-12-08
公開日2012-01-18
最終更新日2012-02-15
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
3ZNI
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STRUCTURE OF PHOSPHOTYR363-CBL-B - UBCH5B-UB - ZAP-70 PEPTIDE COMPLEX
分子名称:E3 UBIQUITIN-PROTEIN LIGASE CBL-B, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
著者Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T.
登録日2013-02-14
公開日2013-07-10
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3.
Nat.Struct.Mol.Biol., 20, 2013
4A49
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STRUCTURE OF PHOSPHOTYR371-C-CBL-UBCH5B COMPLEX
分子名称:E3 ubiquitin-protein ligase CBL, Ubiquitin-conjugating enzyme E2 D2, ZINC ION, ...
著者Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
登録日2011-10-07
公開日2012-01-25
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.214 Å)
主引用文献Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Nat. Struct. Mol. Biol., 19, 2012
4A4B
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STRUCTURE OF MODIFIED PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX
分子名称:E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
著者Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
登録日2011-10-08
公開日2012-01-25
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (2.789 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
4A4C
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STRUCTURE OF PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX
分子名称:E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
著者Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
登録日2011-10-08
公開日2012-01-25
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.704 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
4AUQ
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STRUCTURE OF BIRC7-UBCH5B-UB COMPLEX.
分子名称:UBIQUITIN-CONJUGATING ENZYME E2 D2, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7, POLYUBIQUITIN-C, ...
著者Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T.
登録日2012-05-21
公開日2012-08-15
最終更新日2012-09-26
実験手法X-RAY DIFFRACTION (2.176 Å)
主引用文献Birc7-E2 Ubiquitin Conjugate Structure Reveals the Mechanism of Ubiquitin Transfer by a Ring Dimer.
Nat.Struct.Mol.Biol., 19, 2012
4V3K
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RNF38-UBCH5B-UB COMPLEX
分子名称:UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
著者Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T.
登録日2014-10-20
公開日2015-04-08
最終更新日2015-04-29
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
4V3L
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RNF38-UB-UBCH5B-UB COMPLEX
分子名称:UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
著者Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T.
登録日2014-10-20
公開日2015-04-08
最終更新日2015-04-29
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
5J3X
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STRUCTURE OF C-CBL Y371F
分子名称:E3 ubiquitin-protein ligase CBL, ZINC ION, CALCIUM ION
著者Huang, D.T., Buetow, L., Dou, H.
登録日2016-03-31
公開日2016-09-21
実験手法X-RAY DIFFRACTION (2.822 Å)
主引用文献Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
Bmc Biol., 14, 2016
5MNJ
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STRUCTURE OF MDM2-MDMX-UBCH5B-UBIQUITIN COMPLEX
分子名称:Ubiquitin-conjugating enzyme E2 D2, Polyubiquitin-B, E3 ubiquitin-protein ligase Mdm2, ...
著者Klejnot, M., Huang, D.T.
登録日2016-12-13
公開日2017-05-31
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Nat. Struct. Mol. Biol., 24, 2017
5O6S
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UBV.B4R, A DIMERIC UBIQUITIN VARIANT BINDING TO BIRC4 RING
分子名称:Polyubiquitin-B
著者Gabrielsen, M., Buetow, L., Huang, D.T.
登録日2017-06-07
公開日2017-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O6T
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BIRC4 RING IN COMPLEX WITH DIMERIC UBIQUITIN VARIANT
分子名称:E3 ubiquitin-protein ligase XIAP, Polyubiquitin-B, ZINC ION, ...
著者Gabrielsen, M., Buetow, L., Huang, D.T.
登録日2017-06-07
公開日2017-11-01
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O75
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UBE4B U-BOX DOMAIN
分子名称:Ubiquitin conjugation factor E4 B, SULFATE ION
著者Gabrielsen, M., Buetow, L., Nakasone, M.A., Huang, D.T.
登録日2017-06-08
公開日2017-11-01
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.483 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O76
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STRUCTURE OF PHOSPHOY371 C-CBL IN COMPLEX WITH ZAP70-PEPTIDE AND UBV.PCBL UBIQUITIN VARIANT
分子名称:E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, UbV.pCBL ubiquitin variant, ...
著者Gabrielsen, M., Buetow, L., Huang, D.T.
登録日2017-06-08
公開日2017-11-01
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.473 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
6HPR
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CRYSTAL STRUCTURE OF CIAP1 RING DOMAIN BOUND TO UBCH5B-UB AND A NON-COVALENT UB
分子名称:Baculoviral IAP repeat-containing protein 2, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ...
著者Patel, A., Huang, D.T.
登録日2018-09-21
公開日2018-12-12
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex.
J. Biol. Chem., 294, 2019