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1IK9
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CRYSTAL STRUCTURE OF A XRCC4-DNA LIGASE IV COMPLEX
Descriptor:DNA REPAIR PROTEIN XRCC4, DNA LIGASE IV
Authors:Sibanda, B.L., Critchlow, S.E., Begun, J., Pei, X.Y., Jackson, S.P., Blundell, T.L., Pellegrini, L.
Deposit date:2001-05-03
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of an Xrcc4-DNA ligase IV complex.
Nat.Struct.Biol., 8, 2001
3KGV
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CRYSTAL STRUCTURE OF HUMAN DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (DNA-PKCS)
Descriptor:DNA-dependent Protein Kinase Catalytic Subunit
Authors:Sibanda, B.L., Chirgadze, D.Y., Blundell, T.L.
Deposit date:2009-10-29
Release date:2009-12-22
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (6.6 Å)
Cite:Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
Nature, 463, 2010
5LUQ
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CRYSTAL STRUCTURE OF HUMAN DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (DNA-PKCS)
Descriptor:DNA-dependent protein kinase catalytic subunit,DNA-dependent Protein Kinase Catalytic Subunit,DNA-dependent protein kinase catalytic subunit, C-terminal fragment of KU80 (KU80ct194)
Authors:Sibanda, B.L., Chirgadze, D.Y., Ascher, D.B., Blundell, T.L.
Deposit date:2016-09-09
Release date:2017-02-15
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.
Science, 355, 2017
1Z56
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CO-CRYSTAL STRUCTURE OF LIF1P-LIG4P
Descriptor:Ligase interacting factor 1, DNA ligase IV
Authors:Dore, A.S., Furnham, N., Davies, O.R., Sibanda, B.L., Chirgadze, D.Y., Jackson, S.P., Pellegrini, L., Blundell, T.L.
Deposit date:2005-03-17
Release date:2006-01-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA REPAIR, 5, 2006
2QM4
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CRYSTAL STRUCTURE OF HUMAN XLF/CERNUNNOS, A NON-HOMOLOGOUS END-JOINING FACTOR
Descriptor:Non-homologous end-joining factor 1
Authors:Li, Y., Chirgadze, D.Y., Sibanda, B.L., Bolanos-Garcia, V.M., Davies, O.R., Blundell, T.L.
Deposit date:2007-07-14
Release date:2007-12-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ.
Embo J., 27, 2008
1AW8
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PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE
Descriptor:L-ASPARTATE-ALPHA-DECARBOXYLASE
Authors:Albert, A., Dhanaraj, V., Genschel, U., Khan, G., Ramjee, M.K., Pulido, R., Sybanda, B.L., von Delf, F., Witty, M., Blundell, T.L., Smith, A.G., Abell, C.
Deposit date:1997-10-12
Release date:1998-04-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing.
Nat.Struct.Biol., 5, 1998
1BBS
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X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS
Descriptor:RENIN
Authors:Dhanaraj, V., Blundell, T.L.
Deposit date:1992-05-21
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.
Nature, 357, 1992
1SMR
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THE 3-D STRUCTURE OF MOUSE SUBMAXILLARY RENIN COMPLEXED WITH A DECAPEPTIDE INHIBITOR CH-66 BASED ON THE 4-16 FRAGMENT OF RAT ANGIOTENSINOGEN
Descriptor:RENIN, INHIBITOR CH-66
Authors:Dealwis, C.G., Blundell, T.L.
Deposit date:1992-03-11
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
J.Mol.Biol., 236, 1994
4ER4
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HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES
Descriptor:ENDOTHIAPEPSIN, H-142
Authors:Foundling, S.I., Watson, F.E., Szelke, M., Blundell, T.L.
Deposit date:1991-01-05
Release date:1991-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes.
Nature, 327, 1987
1PPY
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NATIVE PRECURSOR OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE
Descriptor:Aspartate 1-decarboxylase precursor, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-17
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PQE
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S25A MUTANT OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE
Descriptor:Aspartate 1-decarboxylase
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-18
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PQF
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GLYCINE 24 TO SERINE MUTATION OF ASPARTATE DECARBOXYLASE
Descriptor:Aspartate 1-decarboxylase, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-18
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PQH
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SERINE 25 TO THREONINE MUTATION OF ASPARTATE DECARBOXYLASE
Descriptor:Aspartate 1-decarboxylase, SODIUM ION, MALONIC ACID
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-18
Release date:2003-11-18
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PT0
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UNPROCESSED PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE WITH AN ALANINE INSERTION AT POSITION 26
Descriptor:Aspartate 1-decarboxylase, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-22
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PT1
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UNPROCESSED PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE WITH HISTIDINE 11 MUTATED TO ALANINE
Descriptor:Aspartate 1-decarboxylase, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-22
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PYQ
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UNPROCESSED ASPARTATE DECARBOXYLASE MUTANT, WITH ALANINE INSERTED AT POSITION 24
Descriptor:Aspartate 1-decarboxylase, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-07-09
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PYU
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PROCESSED ASPARTATE DECARBOXYLASE MUTANT WITH SER25 MUTATED TO CYS
Descriptor:Aspartate 1-decarboxylase beta chain, Aspartate 1-decarboxylase alfa chain, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-07-09
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
2C45
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NATIVE PRECURSOR OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE
Descriptor:Aspartate 1-decarboxylase
Authors:Gopalan, G., Chopra, S., Ranganathan, A., Swaminathan, K.
Deposit date:2005-10-15
Release date:2007-03-06
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Crystal structure of uncleaved L-aspartate-alpha-decarboxylase from Mycobacterium tuberculosis.
Proteins, 65, 2006