Author results

6ZU8
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CRYSTAL STRUCTURE OF HUMAN BRACHYURY G177D VARIANT IN COMPLEX WITH AFATINIB
Descriptor:Brachyury protein, ZINC ION, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Authors:Newman, J.A., Gavard, A.E., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2020-07-21
Release date:2020-08-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human Brachyury G177D variant in complex with Afatinib
To Be Published
6Y7F
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CRYSTAL STRUCTURE OF HUMAN ELOVL FATTY ACID ELONGASE 7 (ELOVL7)
Descriptor:Elongation of very long chain fatty acids protein 7, ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-oxidanylideneicosanethioate, Octyl Glucose Neopentyl Glycol, ...
Authors:Nie, L., Pike, A.C.W., Bushell, S.R., Chu, A., Cole, V., Speedman, D., Rodstrom, K.E.J., Kupinska, K., Shrestha, L., Mukhopadhyay, S.M.M., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2020-02-28
Release date:2020-05-13
Method:X-RAY DIFFRACTION (2.052 Å)
Cite:Crystal structure of human ELOVL fatty acid elongase 7 (ELOVL7)
TO BE PUBLISHED
6SY1
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CRYSTAL STRUCTURE OF A DEHYDROGENASE
Descriptor:Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial, THIAMINE DIPHOSPHATE, ...
Authors:Bezerra, G.A., Foster, W., Shrestha, L., Pena, I.A., Coker, J., Kolker, S., Nicola, B.B., von Delft, F., Edwards, A., Arrowsmith, C., Bountra, C., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2019-09-26
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal Structure of Dehydrogenase E1 and transketolase domain-containing protein 1 (DHTKD1)
To Be Published
5QT3
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GROUND STATE MODEL OF HUMAN ERYTHROID-SPECIFIC 5'-AMINOLEVULINATE SYNTHASE, ALAS2 - SGC DIAMOND XCHEM FRAGMENT SCREENING
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-06-28
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:PanDDA analysis group deposition of ground-state model
To Be Published
6S4L
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STRUCTURE OF HUMAN KCTD1
Descriptor:BTB/POZ domain-containing protein KCTD1, SODIUM ION, IODIDE ION
Authors:Pinkas, D.M., Bufton, J.C., Fox, A.E., Pike, A.C.W., Newman, J.A., Krojer, T., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Bullock, A.N.
Deposit date:2019-06-28
Release date:2020-07-15
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structure of human KCTD1
To be published
6S4M
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CRYSTAL STRUCTURE OF THE HUMAN ORGANIC ANION TRANSPORTER MFSD10 (TETRAN)
Descriptor:Major facilitator superfamily domain-containing protein 10, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Pascoa, T.C., Pike, A.C.W., Bushell, S.R., Quigley, A., Chu, A., Mukhopadhyay, S.M.M., Shrestha, L., Venkaya, S., Chalk, R., Burgess-Brown, N.A., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-06-28
Release date:2020-05-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human organic anion transporter TETRAN (MFSD10)
To be published
6S3Q
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STRUCTURE OF HUMAN EXCITATORY AMINO ACID TRANSPORTER 3 (EAAT3) IN COMPLEX WITH TFB-TBOA
Descriptor:Excitatory amino acid transporter 3, (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid, CHOLESTEROL HEMISUCCINATE, ...
Authors:Baronina, A., Pike, A.C.W., Yu, X., Dong, Y.Y., Shintre, C.A., Tessitore, A., Chu, A., Rotty, B., Venkaya, S., Mukhopadhyay, S., Borkowska, O., Chalk, R., Shrestha, L., Burgess-Brown, N.A., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Han, S., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-06-25
Release date:2020-07-08
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structure of human excitatory amino acid transporter 3 (EAAT3)
TO BE PUBLISHED
6RV2
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CRYSTAL STRUCTURE OF THE HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TASK-1 (K2P3.1) IN A CLOSED CONFORMATION
Descriptor:Potassium channel subfamily K member 3, POTASSIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Rodstrom, K.E.J., Pike, A.C.W., Zhang, W., Quigley, A., Speedman, D., Mukhopadhyay, S.M.M., Shrestha, L., Chalk, R., Venkaya, S., Bushell, S.R., Tessitore, A., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
6RV3
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CRYSTAL STRUCTURE OF THE HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TASK-1 (K2P3.1) IN A CLOSED CONFORMATION WITH A BOUND INHIBITOR BAY 1000493
Descriptor:Potassium channel subfamily K member 3, POTASSIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Rodstrom, K.E.J., Pike, A.C.W., Zhang, W., Quigley, A., Speedman, D., Mukhopadhyay, S.M.M., Shrestha, L., Chalk, R., Venkaya, S., Bushell, S.R., Tessitore, A., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
6RV4
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CRYSTAL STRUCTURE OF THE HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TASK-1 (K2P3.1) IN A CLOSED CONFORMATION WITH A BOUND INHIBITOR BAY 2341237
Descriptor:Potassium channel subfamily K member 3, POTASSIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Rodstrom, K.E.J., Pike, A.C.W., Zhang, W., Quigley, A., Speedman, D., Mukhopadhyay, S.M.M., Shrestha, L., Chalk, R., Venkaya, S., Bushell, S.R., Tessitore, A., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
5QQQ
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z2856434857
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QQR
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z1171217421
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QQS
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z275151340
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QQT
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z2856434834
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QQU
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z1348371854
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QQV
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z1545312521
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QQW
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z136583524
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QQX
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z373768900
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QQY
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z2856434899
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QQZ
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z1675346324
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QR0
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z730649594
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QR1
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z396380540
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QR2
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z1348371854
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QR3
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z915492990
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QR4
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF HUMAN ALAS2A IN COMPLEX WITH Z2856434826
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Deposit date:2019-05-22
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:PanDDA analysis group deposition
To Be Published
167132
数据于2020-07-29公开中