Author results

6R7X
  • Download 6r7x
  • View 6r7x
Molmil generated image of 6r7x
CRYOEM STRUCTURE OF CALCIUM-BOUND HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (2MM CA2+, CLOSED FORM)
Descriptor:Anoctamin-10, CALCIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Baronina, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
6R7Y
  • Download 6r7y
  • View 6r7y
Molmil generated image of 6r7y
CRYOEM STRUCTURE OF CALCIUM-BOUND HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (LOW CA2+, CLOSED FORM)
Descriptor:Anoctamin-10, CALCIUM ION
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
6R7Z
  • Download 6r7z
  • View 6r7z
Molmil generated image of 6r7z
CRYOEM STRUCTURE OF CALCIUM-FREE HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (CLOSED FORM)
Descriptor:Anoctamin-10
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Last modified:2019-05-15
Method:ELECTRON MICROSCOPY (5.14 Å)
Cite:CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
6R65
  • Download 6r65
  • View 6r65
Molmil generated image of 6r65
CRYSTAL STRUCTURE OF HUMAN TMEM16K / ANOCTAMIN 10 (FORM 2)
Descriptor:Anoctamin-10, CALCIUM ION
Authors:Bushell, S.R., Pike, A.C.W., Chu, A., Tessitore, A., Rotty, B., Mukhopadhyay, S., Kupinska, K., Shrestha, L., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-26
Release date:2019-05-01
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal Structure of human TMEM16K / Anoctamin 10 (Form 2)
TO BE PUBLISHED
6QNV
  • Download 6qnv
  • View 6qnv
Molmil generated image of 6qnv
FIBRINOGEN-LIKE GLOBE DOMAIN OF HUMAN TENASCIN-C
Descriptor:Tenascin
Authors:Coker, J.A., Bezerra, G.A., Bradshaw, W.J., Zhang, M., Yosaatmadja, Y., Fernandez-Cid, A., Shrestha, L., Burgess-Brown, N., Gileadi, O., Arrowsmith, C.H., Bountra, C., Midwood, K.S., Yue, W.W., Marsden, B.D., Structural Genomics Consortium (SGC)
Deposit date:2019-02-12
Release date:2019-02-27
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Fibrinogen-like globe domain of Human Tenascin-C
To Be Published
6QD5
  • Download 6qd5
  • View 6qd5
Molmil generated image of 6qd5
X-RAY STRUCTURE OF THE HUMAN UREA CHANNEL SLC14A1/UT1
Descriptor:Urea transporter 1, B-OCTYLGLUCOSIDE, CHOLESTEROL HEMISUCCINATE, ...
Authors:Dietz, L., Chi, G., Pike, A.C.W., Moreau, C., Man, H., Snee, M., Scacioc, A., Shrestha, L., Mukhopadhyay, S.M.M., Mckinley, G., Ellis, K., Kliszcak, M., Chalk, R., Borkowska, O., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Durr, K.L., Structural Genomics Consortium (SGC)
Deposit date:2018-12-31
Release date:2019-01-09
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:X-ray Structure of the Human Urea Channel SLC14A1/UT1
To Be Published
6I8Y
  • Download 6i8y
  • View 6i8y
Molmil generated image of 6i8y
CRYSTAL STRUCTURE OF SPINDLIN1 IN COMPLEX WITH THE METHYLTRANSFERASE INHIBITOR A366
Descriptor:Spindlin-1, 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine, 1,2-ETHANEDIOL, ...
Authors:Srikannathasan, V., Johansson, C., Gileadi, C., Shrestha, L., Sorrell, F.J., Krojer, T., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.C.T.
Deposit date:2018-11-21
Release date:2018-12-26
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal structure of Spindlin1 in complex with the Methyltransferase inhibitor A366
To Be Published
6HRH
  • Download 6hrh
  • View 6hrh
Molmil generated image of 6hrh
STRUCTURE OF HUMAN ERYTHROID-SPECIFIC 5'-AMINOLEVULINATE SYNTHASE, ALAS2
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bailey, H.J., Shrestha, L., Rembeza, E., Newman, J., Kupinska, K., Diaz-saez, L., Kennedy, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2018-09-27
Release date:2018-11-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human erythroid-specific 5'-aminolevulinate synthase, ALAS2
To Be Published
6HRL
  • Download 6hrl
  • View 6hrl
Molmil generated image of 6hrl
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL17
Descriptor:Kelch-like protein 17, SULFATE ION, CHLORIDE ION, ...
Authors:Chen, Z., Williams, E., Sorrell, F.J., Newman, J.A., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, F., Edwards, C.H., Bountra, C., Bullock, A.N.
Deposit date:2018-09-27
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the Kelch domain of human KLHL17
To Be Published
6H00
  • Download 6h00
  • View 6h00
Molmil generated image of 6h00
CRYSTAL STRUCTURE OF HUMAN PYRIDOXINE 5-PHOPHATE OXIDASE, R116Q VARIANT
Descriptor:Pyridoxine-5'-phosphate oxidase, SULFATE ION, FLAVIN MONONUCLEOTIDE, ...
Authors:Mackinnon, S., Wilson, M.P., Shrestha, L., Bezerra, G.A., Newman, J., Fox, N., Sorrell, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Clayton, P.T., Mills, P.B., Yue, W.W.
Deposit date:2018-07-05
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal structure of human pyridoxine 5-phophate oxidase, R116Q variant
To Be Published
6GY4
  • Download 6gy4
  • View 6gy4
Molmil generated image of 6gy4
CRYSTAL STRUCTURE OF THE N-TERMINAL KH DOMAIN OF HUMAN BICC1
Descriptor:Protein bicaudal C homolog 1, SULFATE ION, 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, ...
Authors:Newman, J.A., Katis, V.L., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2018-06-28
Release date:2018-07-18
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:Crystal structure of the N-terminal KH domain of human BICC1
To Be Published
6G4Q
  • Download 6g4q
  • View 6g4q
Molmil generated image of 6g4q
STRUCTURE OF HUMAN ADP-FORMING SUCCINYL-COA LIGASE COMPLEX SUCLG1-SUCLA2
Descriptor:Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial, Succinate--CoA ligase [ADP-forming] subunit beta, ...
Authors:Bailey, H.J., Shrestha, L., Rembeza, E., Sorrell, F.J., Newman, J., Strain-Damerell, C., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2018-03-28
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2
To Be Published
6F58
  • Download 6f58
  • View 6f58
Molmil generated image of 6f58
CRYSTAL STRUCTURE OF HUMAN BRACHYURY (T) IN COMPLEX WITH DNA
Descriptor:DNA (5'-D(*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP*AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*TP*T)-3'), Brachyury protein, SODIUM ION
Authors:Newman, J.A., Gavard, A.E., Krojer, T., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-12-01
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.253 Å)
Cite:Crystal structure of human Brachyury (T) in complex with DNA
To Be Published
6F59
  • Download 6f59
  • View 6f59
Molmil generated image of 6f59
CRYSTAL STRUCTURE OF HUMAN BRACHYURY (T) G177D VARIANT IN COMPLEX WITH DNA
Descriptor:DNA (26-MER), Brachyury protein, SODIUM ION, ...
Authors:Newman, J.A., Gavard, A.E., Krojer, T., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-12-01
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Crystal structure of human Brachyury (T) G177D variant in complex with DNA
To Be Published
5OCH
  • Download 5och
  • View 5och
Molmil generated image of 5och
THE CRYSTAL STRUCTURE OF HUMAN ABCB8 IN AN OUTWARD-FACING STATE
Descriptor:ATP-binding cassette sub-family B member 8, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Faust, B., Pike, A.C.W., Shintre, C.A., Quiqley, A.M., Chu, A., Barr, A., Shrestha, L., Mukhopadhyay, S., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The crystal structure of human ABCB8 in an outward-facing state
To Be Published
5OC9
  • Download 5oc9
  • View 5oc9
Molmil generated image of 5oc9
CRYSTAL STRUCTURE OF HUMAN TMEM16K / ANOCTAMIN 10
Descriptor:Anoctamin-10, CALCIUM ION, (2R)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate
Authors:Bushell, S.R., Pike, A.C.W., Chu, A., Tessitore, A., Rotty, B., Mukhopadhyay, S., Kupinska, K., Shrestha, L., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-29
Release date:2018-07-25
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of human TMEM16K / Anoctamin 10
TO BE PUBLISHED
5NFJ
  • Download 5nfj
  • View 5nfj
Molmil generated image of 5nfj
CRYSTAL STRUCTURE OF THE METHYLTRANSFERASE SUBUNIT OF HUMAN MITOCHONDRIAL RIBONUCLEASE P (MRPP1) BOUND TO S-ADENOSYL-METHIONINE (SAM)
Descriptor:Mitochondrial ribonuclease P protein 1, S-ADENOSYLMETHIONINE, GLYCEROL, ...
Authors:Oerum, S., Kopec, J., Fitzpatrick, F., Newman, J.A., Chalk, R., Shrestha, L., Fairhead, M., Talon, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, C., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2017-03-14
Release date:2018-05-16
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of the methyltransferase subunit of human mitochondrial Ribonuclease P (MRPP1) bound to S-adenosyl-methionine (SAM)
To Be Published
5LZK
  • Download 5lzk
  • View 5lzk
Molmil generated image of 5lzk
STRUCTURE OF THE DOMAIN OF UNKNOWN FUNCTION DUF1669 FROM HUMAN FAM83B
Descriptor:Protein FAM83B, IODIDE ION, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Bufton, J.C., Williams, E.P., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2016-09-29
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.575 Å)
Cite:Structure of the domain of unknown function DUF1669 from human FAM83B
To Be Published
5LUG
  • Download 5lug
  • View 5lug
Molmil generated image of 5lug
CRYSTAL STRUCTURE OF HUMAN SPINDLIN-2B PROTEIN IN COMPLEX WITH ART(M3L)QTA(2MR)KS PEPTIDE
Descriptor:Spindlin-like protein 2, isoform CRA_a, ALA-ARG-THR-M3L-GLN-THR-ALA-2MR-LYS-SER, ...
Authors:Srikannathasan, V., Gileadi, C., Talon, R., Shrestha, L., Kopec, J., Szykowska, A., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Oppermann, U., Huber, K.
Deposit date:2016-09-08
Release date:2017-09-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human Spindlin-2B protein in complex with ART(M3L)QTA(2MR)KS peptide
To be published
5LF9
  • Download 5lf9
  • View 5lf9
Molmil generated image of 5lf9
CRYSTAL STRUCTURE OF HUMAN NUDT22
Descriptor:Nucleoside diphosphate-linked moiety X motif 22
Authors:Tallant, C., Siejka, P., Mathea, S., Shrestha, L., Krojer, T., Srikannathasan, V., Elkins, J.M., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Huber, K., Structural Genomics Consortium (SGC)
Deposit date:2016-06-30
Release date:2017-08-02
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of human NUDT22
To Be Published
5K47
  • Download 5k47
  • View 5k47
Molmil generated image of 5k47
CRYOEM STRUCTURE OF THE HUMAN POLYCYSTIN-2/PKD2 TRP CHANNEL
Descriptor:Polycystin-2, N-ACETYL-D-GLUCOSAMINE
Authors:Pike, A.C.W., Grieben, M., Shintre, C.A., Tessitore, A., Shrestha, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Burgess-Brown, N.A., Huiskonen, J.T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2016-05-20
Release date:2016-08-24
Last modified:2018-10-10
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Nat. Struct. Mol. Biol., 24, 2017
5IN3
  • Download 5in3
  • View 5in3
Molmil generated image of 5in3
CRYSTAL STRUCTURE OF GLUCOSE-1-PHOSPHATE BOUND NUCLEOTIDYLATED HUMAN GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
Descriptor:Galactose-1-phosphate uridylyltransferase, ZINC ION, 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE, ...
Authors:Kopec, J., McCorvie, T., Tallant, C., Velupillai, S., Shrestha, L., Fitzpatrick, F., Patel, D., Chalk, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2016-03-07
Release date:2016-03-30
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
Hum.Mol.Genet., 25, 2016
5FWJ
  • Download 5fwj
  • View 5fwj
Molmil generated image of 5fwj
CRYSTAL STRUCTURE OF HUMAN JARID1C IN COMPLEX WITH KDM5-C49
Descriptor:HISTONE DEMETHYLASE JARID1C, MAGNESIUM ION, ZINC ION, ...
Authors:Srikannathasan, V., Szykowska, A., Strain-Damerell, C., Kopec, J., Nowak, R., Gileadi, C., Johansson, C., Kupinska, K., Burgess-Brown, N.A., Shrestha, L., Dong, W., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Huber, K., Oppermann, U.
Deposit date:2016-02-17
Release date:2016-04-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5HES
  • Download 5hes
  • View 5hes
Molmil generated image of 5hes
HUMAN LEUCINE ZIPPER- AND STERILE ALPHA MOTIF-CONTAINING KINASE (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) IN COMPLEX WITH VEMURAFENIB
Descriptor:Mitogen-activated protein kinase kinase kinase MLT, N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide, 1,2-ETHANEDIOL
Authors:Mathea, S., Salah, E., Abdul Azeez, K.R., Tallant, C., Szklarz, M., Chaikuad, A., Shrestha, B., Sorrell, F.J., Elkins, J.M., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2016-01-06
Release date:2016-03-30
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.
Acs Chem.Biol., 11, 2016
5FII
  • Download 5fii
  • View 5fii
Molmil generated image of 5fii
STRUCTURE OF A HUMAN ASPARTATE KINASE, CHORISMATE MUTASE AND TYRA DOMAIN.
Descriptor:PHENYLALANINE-4-HYDROXYLASE, PHENYLALANINE
Authors:Patel, D., Kopec, J., Shrestha, L., Fitzpatrick, F., Pinkas, D., Chaikuad, A., Dixon-Clarke, S., McCorvie, T.J., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2015-09-25
Release date:2016-03-30
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Ligand-Dependent Dimerization of Phenylalanine Hydroxylase Regulatory Domain.
Sci.Rep., 6, 2016