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1F8X
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BU of 1f8x by Molmil
CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE
Descriptor: NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE
Authors:Armstrong, S.R, Cook, W.J, Short, S.A, Ealick, S.E.
Deposit date:2000-07-05
Release date:2000-07-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site.
Structure, 4, 1996
1SQN
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BU of 1sqn by Molmil
Progesterone Receptor Ligand Binding Domain with bound Norethindrone
Descriptor: (14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one, progesterone receptor
Authors:Williams, S.P, Madauss, K.P, Deng, J.-S, Austin, R.J.H, Lambert, M.H, McLay, I, Pritchard, J, Short, S.A, Stewart, E.L, Uings, I.J.
Deposit date:2004-03-19
Release date:2004-07-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes
J.Med.Chem., 47, 2004
1CTU
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BU of 1ctu by Molmil
TRANSITION-STATE SELECTIVITY FOR A SINGLE OH GROUP DURING CATALYSIS BY CYTIDINE DEAMINASE
Descriptor: 4-HYDROXY-3,4-DIHYDRO-ZEBULARINE, CYTIDINE DEAMINASE, ZINC ION
Authors:Xiang, S, Short, S.A, Wolfenden, R, Carter, C.W.
Deposit date:1995-02-11
Release date:1995-05-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Transition-state selectivity for a single hydroxyl group during catalysis by cytidine deaminase.
Biochemistry, 34, 1995
1CTT
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BU of 1ctt by Molmil
TRANSITION-STATE SELECTIVITY FOR A SINGLE OH GROUP DURING CATALYSIS BY CYTIDINE DEAMINASE
Descriptor: 3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE NUCLEOSIDE, CYTIDINE DEAMINASE, ZINC ION
Authors:Xiang, S, Short, S.A, Wolfenden, R, Carter, C.W.
Deposit date:1995-02-11
Release date:1995-05-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Transition-state selectivity for a single hydroxyl group during catalysis by cytidine deaminase.
Biochemistry, 34, 1995
1DQW
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BU of 1dqw by Molmil
CRYSTAL STRUCTURE OF OROTIDINE 5'-PHOSPHATE DECARBOXYLASE
Descriptor: OROTIDINE 5'-PHOSPHATE DECARBOXYLASE
Authors:Milburn, M.V, Miller, B.G, Hassell, A.M, Wolfenden, R, Short, S.A.
Deposit date:2000-01-05
Release date:2000-03-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog.
Proc.Natl.Acad.Sci.USA, 97, 2000
1DQX
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CRYSTAL STRUCTURE OF OROTIDINE 5'-PHOSPHATE DECARBOXYLASE COMPLEXED TO 6-HYDROXYURIDINE 5'-PHOSPHATE (BMP)
Descriptor: 6-HYDROXYURIDINE-5'-PHOSPHATE, OROTIDINE 5'-PHOSPHATE DECARBOXYLASE
Authors:Milburn, M.V, Miller, B.G, Hassell, A.M, Wolfenden, R, Short, S.A.
Deposit date:2000-01-05
Release date:2000-03-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog.
Proc.Natl.Acad.Sci.USA, 97, 2000
1TPT
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BU of 1tpt by Molmil
THREE-DIMENSIONAL STRUCTURE OF THYMIDINE PHOSPHORYLASE FROM ESCHERICHIA COLI AT 2.8 ANGSTROMS RESOLUTION
Descriptor: SULFATE ION, THYMIDINE PHOSPHORYLASE, THYMINE
Authors:Walter, M.R, Cook, W.J, Cole, L.B, Short, S.A, Koszalka, G.W, Krenitsky, T.A, Ealick, S.E.
Deposit date:1990-06-14
Release date:1991-07-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution.
J.Biol.Chem., 265, 1990
1F8Y
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CRYSTAL STRUCTURE ANALYSIS OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE COMPLEXED WITH 5-METHYL-2'-DEOXYPSEUDOURIDINE
Descriptor: 2'-deoxy-1-methyl-pseudouridine, NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE
Authors:Armstrong, S.R, Cook, W.J, Short, S.A, Ealick, S.E.
Deposit date:2000-07-05
Release date:2000-08-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site.
Structure, 4, 1996
1FKO
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CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Descriptor: (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, HIV-1 RT, A-CHAIN, ...
Authors:Ren, J, Milton, J, Weaver, K.L, Short, S.A, Stuart, D.I, Stammers, D.K.
Deposit date:2000-08-10
Release date:2000-11-03
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Structure Fold.Des., 8, 2000
1FK9
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BU of 1fk9 by Molmil
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Descriptor: (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, HIV-1 RT, A-CHAIN, ...
Authors:Ren, J, Milton, J, Weaver, K.L, Short, S.A, Stuart, D.I, Stammers, D.K.
Deposit date:2000-08-09
Release date:2000-11-03
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
STRUCTURE FOLD.DES., 8, 2000
1FKP
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BU of 1fkp by Molmil
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 RT, A-CHAIN, ...
Authors:Ren, J, Milton, J, Weaver, K.L, Short, S.A, Stuart, D.I, Stammers, D.K.
Deposit date:2000-08-10
Release date:2000-11-03
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Structure Fold.Des., 8, 2000
2OPR
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BU of 2opr by Molmil
Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Descriptor: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, Reverse transcriptase/ribonuclease H, p51 RT
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K.
Deposit date:2007-01-30
Release date:2007-05-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
2OPS
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BU of 2ops by Molmil
Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Descriptor: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ...
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K.
Deposit date:2007-01-30
Release date:2007-05-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
2OVM
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Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor NCoR
Descriptor: 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, NCoR, Progesterone receptor
Authors:Madauss, K.P, Deng, S.-J, Short, S.A, Stewart, E.L, Williams, S.P.
Deposit date:2007-02-14
Release date:2007-03-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.
Mol.Endocrinol., 21, 2007
2OPQ
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BU of 2opq by Molmil
Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Descriptor: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ...
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K.
Deposit date:2007-01-30
Release date:2007-05-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
2OVH
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Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT
Descriptor: 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, Progesterone receptor, SMRT peptide
Authors:Madauss, K.P, Deng, S.-J, Short, S.A, Stewart, E.L, Williams, S.P.
Deposit date:2007-02-13
Release date:2007-03-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.
Mol.Endocrinol., 21, 2007
1SR7
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Progesterone Receptor Hormone Binding Domain with Bound Mometasone Furoate
Descriptor: GLYCEROL, MOMETASONE FUROATE, Progesterone receptor, ...
Authors:Madauss, K.P, Deng, S.-J, Austin, R.J, Lambert, M.H, McLay, I, Pritchard, J, Short, S.A, Stewart, E.L, Uings, I.J, Williams, S.P.
Deposit date:2004-03-22
Release date:2004-06-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes
J.Med.Chem., 47, 2004
1ALN
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BU of 1aln by Molmil
CRYSTAL STRUCTURE OF CYTIDINE DEAMINASE COMPLEXED WITH 3-DEAZACYTIDINE
Descriptor: 3-DEAZACYTIDINE, CYTIDINE DEAMINASE, ZINC ION
Authors:Xiang, S, Carter, C.W.
Deposit date:1997-06-02
Release date:1997-09-17
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cytidine deaminase complexed to 3-deazacytidine: a "valence buffer" in zinc enzyme catalysis.
Biochemistry, 35, 1996
1AF2
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BU of 1af2 by Molmil
CRYSTAL STRUCTURE OF CYTIDINE DEAMINASE COMPLEXED WITH URIDINE
Descriptor: CYTIDINE DEAMINASE, URIDINE-5'-MONOPHOSPHATE, ZINC ION
Authors:Xiang, S, Carter, C.W.
Deposit date:1997-03-20
Release date:1997-07-07
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the cytidine deaminase-product complex provides evidence for efficient proton transfer and ground-state destabilization.
Biochemistry, 36, 1997
1TKX
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745
Descriptor: 4-[(CYCLOPROPYLETHYNYL)OXY]-6-FLUORO-3-ISOPROPYLQUINOLIN-2(1H)-ONE, Pol polyprotein, Reverse transcriptase, ...
Authors:Ren, J, Hopkins, A.L, Stuart, D.I, Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
J.Med.Chem., 47, 2004
1TL3
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BU of 1tl3 by Molmil
Crystal structure of hiv-1 reverse transcriptase in complex with gw450557
Descriptor: 6-CHLORO-4-(CYCLOHEXYLOXY)-3-ISOPROPYLQUINOLIN-2(1H)-ONE, PHOSPHATE ION, Pol polyprotein, ...
Authors:Hopkins, A.L, Ren, J, Stuart, D.I, Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J.Med.Chem., 47, 2004
1TKT
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318
Descriptor: 6-CHLORO-4-(CYCLOHEXYLOXY)-3-PROPYLQUINOLIN-2(1H)-ONE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Hopkins, A.L, Ren, J, Stuart, D.I, Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J.Med.Chem., 47, 2004
1TL1
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW451211
Descriptor: 6-CHLORO-4-(CYCLOHEXYLSULFINYL)-3-PROPYLQUINOLIN-2(1H)-ONE, PHOSPHATE ION, Pol polyprotein, ...
Authors:Hopkins, A.L, Ren, J, Stuart, D.I, Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J.Med.Chem., 47, 2004
1TKZ
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW429576
Descriptor: 6-CHLORO-4-(CYCLOHEXYLSULFANYL)-3-PROPYLQUINOLIN-2(1H)-ONE, PHOSPHATE ION, Pol polyprotein, ...
Authors:Hopkins, A.L, Ren, J, Stuart, D.I, Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2020-01-15
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J.Med.Chem., 47, 2004
1S1T
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BU of 1s1t by Molmil
Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781
Descriptor: 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE, PHOSPHATE ION, Reverse transcriptase
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004

 

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