Author results

4ATO
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NEW INSIGHTS INTO THE MECHANISM OF BACTERIAL TYPE III TOXIN-ANTITOXIN SYSTEMS: SELECTIVE TOXIN INHIBITION BY A NON-CODING RNA PSEUDOKNOT
Descriptor:TOXN, TOXI, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Short, F.L., Pei, X.Y., Blower, T.R., Ong, S.L., Luisi, B.F., Salmond, G.P.C.
Deposit date:2012-05-09
Release date:2012-12-26
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selectivity and Self-Assembly in the Control of a Bacterial Toxin by an Antitoxic Noncoding RNA Pseudoknot.
Proc.Natl.Acad.Sci.USA, 110, 2013
2XD0
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A PROCESSED NON-CODING RNA REGULATES A BACTERIAL ANTIVIRAL SYSTEM
Descriptor:TOXN, TOXI
Authors:Blower, T.R., Pei, X.Y., Short, F.L., Fineran, P.C., Humphreys, D.P., Luisi, B.F., Salmond, G.P.C.
Deposit date:2010-04-28
Release date:2011-01-12
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:A processed noncoding RNA regulates an altruistic bacterial antiviral system.
Nat. Struct. Mol. Biol., 18, 2011
2XDB
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A PROCESSED NON-CODING RNA REGULATES A BACTERIAL ANTIVIRAL SYSTEM
Descriptor:TOXN, TOXI, SULFATE ION, ...
Authors:Blower, T.R., Pei, X.Y., Short, F.L., Fineran, P.C., Humphreys, D.P., Luisi, B.F., Salmond, G.P.C.
Deposit date:2010-04-30
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A Processed Noncoding RNA Regulates an Altruistic Bacterial Antiviral System.
Nat.Struct.Mol.Biol., 18, 2011
3QQS
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS172)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-16
Release date:2012-08-22
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QR9
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (APO STRUCTURE)
Descriptor:Anthranilate phosphoribosyltransferase, GLYCEROL
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-17
Release date:2011-06-15
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QS8
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS174)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-20
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3R6C
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS179)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-03-21
Release date:2012-09-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3R88
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS145)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S.
Deposit date:2011-03-23
Release date:2012-09-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3TWP
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS TRPD IN COMPLEX WITH AN INHIBITOR
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S.
Deposit date:2011-09-22
Release date:2012-09-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3UU1
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS142)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S.
Deposit date:2011-11-27
Release date:2012-12-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
4N93
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ALTERNATIVE SUBSTRATES OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, 2-amino-6-methylbenzoic acid, ...
Authors:Castell, A., Short, F.L., Lott, J.S.
Deposit date:2013-10-19
Release date:2014-04-23
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWM
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ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 3-FLUOROANTHRANILATE, PRPP AND MAGNESIUM
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
Authors:Castell, A., Cookson, T.V.M., Short, F.L., Lott, J.S.
Deposit date:2014-02-02
Release date:2014-04-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWN
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ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 5-FLUOROANTHRANILATE, PRPP AND MAGNESIUM
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Castell, A., Cookson, T.V.M., Short, F.L., Lott, J.S.
Deposit date:2014-02-02
Release date:2014-04-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWO
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ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 6-FLUOROANTHRANILATE, PRPP AND MAGNESIUM
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
Authors:Castell, A., Cookson, T.V.M., Short, F.L., Lott, J.S.
Deposit date:2014-02-02
Release date:2014-04-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWQ
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ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 3-METHYLANTHRANILATE, PRPP AND MAGNESIUM
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
Authors:Castell, A., Cookson, T.V.M., Short, F.L., Lott, J.S.
Deposit date:2014-02-03
Release date:2014-04-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWS
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ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 4-METHYLANTHRANILATE, PRPP AND MAGNESIUM
Descriptor:Anthranilate phosphoribosyltransferase, PYROPHOSPHATE 2-, 2-azanyl-4-methyl-benzoic acid, ...
Authors:Castell, A., Cookson, T.V.M., Short, F.L., Lott, J.S.
Deposit date:2014-02-03
Release date:2014-04-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWU
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ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 5-METHYLANTHRANILATE, PRPP AND MAGNESIUM
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
Authors:Castell, A., Cookson, T.V.M., Short, F.L., Lott, J.S.
Deposit date:2014-02-03
Release date:2014-04-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWV
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ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ANTHRANILATE
Descriptor:Anthranilate phosphoribosyltransferase, 2-AMINOBENZOIC ACID, GLYCEROL, ...
Authors:Castell, A., Cookson, T.V.M., Short, F.L., Lott, J.S.
Deposit date:2014-02-04
Release date:2014-04-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4RMO
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CRYSTAL STRUCTURE OF THE CPTIN TYPE III TOXIN-ANTITOXIN SYSTEM FROM EUBACTERIUM RECTALE
Descriptor:CptN Toxin, RNA (45-MER), CALCIUM ION
Authors:Rao, F., Voss, J.E., Short, F.L., Luisi, B.F.
Deposit date:2014-10-21
Release date:2015-09-30
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Co-evolution of quaternary organization and novel RNA tertiary interactions revealed in the crystal structure of a bacterial protein-RNA toxin-antitoxin system.
Nucleic Acids Res., 43, 2015
3QSA
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR TAMU-A7)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-20
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel.
To be Published
2XDD
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A PROCESSED NON-CODING RNA REGULATES A BACTERIAL ANTIVIRAL SYSTEM
Descriptor:TOXN, TOXI, ZINC ION
Authors:Blower, T.R., Pei, X.Y., Short, F.L., Fineran, P.C., Humphreys, D.P., Luisi, B.F., Salmond, G.P.C.
Deposit date:2010-04-30
Release date:2011-01-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Phage Abortive Infection System, Toxin, Functions as a Protein-RNA Toxin-Antitoxin Pair.
Proc.Natl.Acad.Sci.USA, 106, 2009
4N5V
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ALTERNATIVE SUBSTRATES OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Cookson, T.V.M., Parker, E.J., Baker, E.N., Lott, J.S.
Deposit date:2013-10-10
Release date:2014-04-23
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4N8Q
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ALTERNATIVE SUBSTRATES OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE
Descriptor:Anthranilate phosphoribosyltransferase, 2-amino-4-fluorobenzoic acid
Authors:Castell, A., Cookson, T.V.M., Bulloch, E., Evans, G.L., Baker, E.N., Lott, J.S., Parker, E.J.
Deposit date:2013-10-17
Release date:2014-04-23
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4ZTV
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NON-ANTHRANILATE-LIKE INHIBITOR (TAMU-A7) COMPLEXED WITH ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS IN ABSENCE OF PRPP
Descriptor:Anthranilate phosphoribosyltransferase, 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione
Authors:Evans, G.L., Eom, J., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-15
Release date:2016-05-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis.
To be Published
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