Author results

4FZ5
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CRYSTAL STRUCTURE OF HUMAN TIRAP TIR-DOMAIN
Descriptor:Toll/interleukin-1 receptor domain-containing adapter protein
Authors:Woo, J.R., Kim, S., Shoelson, S.E., Park, S.
Deposit date:2012-07-06
Release date:2013-05-29
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:X-ray Crystallographic Structure of TIR-Domain from the Human TIR-Domain Containing Adaptor Protein/MyD88 Adaptor-Like Protein (TIRAP/MAL)
Bull.Korean Chem.Soc., 33, 2013
3QYB
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X-RAY CRYSTAL STRUCTURE OF HUMAN TBC1D4 (AS160) RABGAP DOMAIN
Descriptor:TBC1 domain family member 4
Authors:Park, S.Y., Shoelson, S.E.
Deposit date:2011-03-03
Release date:2011-03-23
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
J.Biol.Chem., 286, 2011
3QYE
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CRYSTAL STRUCTURE OF HUMAN TBC1D1 RABGAP DOMAIN
Descriptor:TBC1 domain family member 1
Authors:Park, S.Y., Shoelson, S.E.
Deposit date:2011-03-03
Release date:2011-03-23
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
J.Biol.Chem., 286, 2011
3FS1
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CRYSTAL STRUCTURE OF HNF4A LBD IN COMPLEX WITH THE LIGAND AND THE COACTIVATOR PGC-1A FRAGMENT
Descriptor:Hepatocyte nuclear factor 4-alpha, PPARgamma Coactivator-1a (PGC-1a), MYRISTIC ACID
Authors:Rha, G., Wu, G., Chi, Y.
Deposit date:2009-01-08
Release date:2009-10-27
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation
J.Biol.Chem., 284, 2009
2IUG
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CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
Authors:Nolte, R.T., Eck, M.J., Schlessinger, J., Shoelson, S.E., Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUH
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CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH C-KIT PHOSPHOTYROSYL PEPTIDE
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT, C-KIT PHOSPHOTYROSYL PEPTIDE
Authors:Nolte, R.T., Eck, M.J., Schlessinger, J., Shoelson, S.E., Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUI
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CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH PDGFR PHOSPHOTYROSYL PEPTIDE
Descriptor:Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta
Authors:Nolte, R.T., Eck, M.J., Schlessinger, J., Shoelson, S.E., Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
1Q2H
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PHENYLALANINE ZIPPER MEDIATES APS DIMERIZATION
Descriptor:adaptor protein with pleckstrin homology and src homology 2 domains
Authors:Dhe-Paganon, S., Werner, E.D., Nishi, M., Chi, Y.-I., Shoelson, S.E.
Deposit date:2003-07-24
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A phenylalanine zipper mediates APS dimerization.
Nat.Struct.Mol.Biol., 11, 2004
1M7W
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HNF4A LIGAND BINDING DOMAIN WITH BOUND FATTY ACID
Descriptor:Hepatocyte nuclear factor 4-alpha, LAURIC ACID
Authors:Dhe-Paganon, S., Duda, K., Iwamoto, M., Chi, Y.I., Shoelson, S.E.
Deposit date:2002-07-22
Release date:2003-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
J.Biol.Chem., 277, 2002
1IFR
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STRUCTURE OF LAMIN A/C GLOBULAR DOMAIN
Descriptor:Lamin A/C, GLYCEROL
Authors:Dhe-Paganon, S., Werner, E.D., Shoelson, S.E.
Deposit date:2001-04-13
Release date:2002-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the globular tail of nuclear lamin.
J.Biol.Chem., 277, 2002
1IC8
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HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
Descriptor:5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3', HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Authors:Chi, Y.-I., Frantz, J.D., Oh, B.-C., Hansen, L., Dhe-Paganon, S., Shoelson, S.E.
Deposit date:2001-03-30
Release date:2002-11-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Diabetes mutations delineate an atypical POU domains in HNF1-Alpha
Mol.Cell, 10, 2002
1EKG
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MATURE HUMAN FRATAXIN
Descriptor:FRATAXIN
Authors:Dhe-Paganon, S., Shigeta, R., Chi, Y.I., Ristow, M., Shoelson, S.E.
Deposit date:2000-03-08
Release date:2000-11-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human frataxin.
J.Biol.Chem., 275, 2000
1QQG
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CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
Descriptor:INSULIN RECEPTOR SUBSTRATE 1
Authors:Dhe-Paganon, S., Shoelson, S.E.
Deposit date:1999-06-04
Release date:1999-08-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
2SHP
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TYROSINE PHOSPHATASE SHP-2
Descriptor:SHP-2, DODECANE-TRIMETHYLAMINE
Authors:Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M.J., Shoelson, S.E.
Deposit date:1997-12-01
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the tyrosine phosphatase SHP-2.
Cell(Cambridge,Mass.), 92, 1998
1SKJ
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COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX
Descriptor:PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN, 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID
Authors:Holland, D.R., Rubin, J.R.
Deposit date:1997-09-18
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand.
J.Med.Chem., 40, 1997
1BKL
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SELF-ASSOCIATED APO SRC SH2 DOMAIN
Descriptor:PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN
Authors:Holland, D.R., Rubin, J.R.
Deposit date:1997-05-02
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel Pp60Src Sh2 Domain Crystal Structures: A 2.0 Angstrom Co-Crystal Structure of a D-Amino Acid Substituted Phosphopeptide Complex and a 2.1 Angstrom Apo Structure Displaying Self-Association
To be Published
1BKM
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COCRYSTAL STRUCTURE OF D-AMINO ACID SUBSTITUTED PHOSPHOPEPTIDE COMPLEX
Descriptor:PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN, [[O-PHOSPHONO-N-ACETYL-TYROSINYL]-GLUTAMYL-3[CYCLOHEXYLMETHYL]ALANINYL]-AMINE
Authors:Holland, D.R., Rubin, J.R.
Deposit date:1997-05-02
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Design of a Novel Series of Nonpeptide Ligands that Bind to the Pp60Src Sh2 Domain
J.Am.Chem.Soc., 119, 1997
1XGL
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HUMAN INSULIN DISULFIDE ISOMER, NMR, 10 STRUCTURES
Descriptor:INSULIN
Authors:Hua, Q.X., Gozani, S.N., Chance, R.E., Hoffmann, J.A., Frank, B.H., Weiss, M.A.
Deposit date:1996-10-10
Release date:1997-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a protein in a kinetic trap.
Nat.Struct.Biol., 2, 1995
2HIU
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NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES
Descriptor:INSULIN
Authors:Hua, Q.X., Gozani, S.N., Chance, R.E., Hoffmann, J.A., Frank, B.H., Weiss, M.A.
Deposit date:1996-10-08
Release date:1997-04-01
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structure of a protein in a kinetic trap.
Nat.Struct.Biol., 2, 1995
1SHC
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SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:SHC, TRKA RECEPTOR PHOSPHOPEPTIDE
Authors:Zhou, M.-M., Ravichandran, K.S., Olejniczak, E.T., Petros, A.M., Meadows, R.P., Sattler, M., Harlan, J.E., Wade, W.S., Burakoff, S.J., Fesik, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature, 378, 1995
1TCE
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SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE
Descriptor:SHC, PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR
Authors:Zhou, M.-M., Meadows, R.P., Logan, T.M., Yoon, H.S., Wade, W.R., Ravichandran, K.S., Burakoff, S.J., Feisk, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Proc.Natl.Acad.Sci.USA, 92, 1995
1IRS
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IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:IRS-1, IL-4 RECEPTOR PHOSPHOPEPTIDE
Authors:Zhou, M.-M., Huang, B., Olejniczak, E.T., Meadows, R.P., Shuker, S.B., Miyazaki, M., Trub, T., Shoelson, S.E., Feisk, S.W.
Deposit date:1996-03-22
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
1LCJ
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SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL
Descriptor:P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL
Authors:Eck, M., Harrison, S.
Deposit date:1994-12-12
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck.
Nature, 362, 1993
1LCK
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SH3-SH2 DOMAIN FRAGMENT OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 10 RESIDUE SYNTHETIC PHOSPHOTYROSYL PEPTIDE TEGQPYQPQPA
Descriptor:P56==LCK== TYROSINE KINASE, TAIL PHOSPHOPEPTIDE TEGQ(PHOSPHO)YQPQPA
Authors:Eck, M., Harrison, S.
Deposit date:1994-12-12
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the regulatory domains of the Src-family tyrosine kinase Lck.
Nature, 368, 1994
1HCS
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NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
Descriptor:ACETYL-PYEEIE-OH, HUMAN SRC
Authors:Gampe Junior, R.T., Xu, R.X.
Deposit date:1994-09-02
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
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