Author results

1HIQ
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PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS
Descriptor:INSULIN
Authors:Hua, Q.X., Shoelson, S.E., Inouye, K., Weiss, M.A.
Deposit date:1993-03-05
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Proc.Natl.Acad.Sci.USA, 90, 1993
1IRS
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IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:IRS-1, IL-4 RECEPTOR PHOSPHOPEPTIDE
Authors:Zhou, M.-M., Huang, B., Olejniczak, E.T., Meadows, R.P., Shuker, S.B., Miyazaki, M., Trub, T., Shoelson, S.E., Feisk, S.W.
Deposit date:1996-03-22
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
1EKG
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MATURE HUMAN FRATAXIN
Descriptor:FRATAXIN
Authors:Dhe-Paganon, S., Shigeta, R., Chi, Y.I., Ristow, M., Shoelson, S.E.
Deposit date:2000-03-08
Release date:2000-11-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human frataxin.
J.Biol.Chem., 275, 2000
1IC8
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HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
Descriptor:5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3', HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Authors:Chi, Y.-I., Frantz, J.D., Oh, B.-C., Hansen, L., Dhe-Paganon, S., Shoelson, S.E.
Deposit date:2001-03-30
Release date:2002-11-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Diabetes mutations delineate an atypical POU domains in HNF1-Alpha
Mol.Cell, 10, 2002
1IFR
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STRUCTURE OF LAMIN A/C GLOBULAR DOMAIN
Descriptor:Lamin A/C, GLYCEROL
Authors:Dhe-Paganon, S., Werner, E.D., Shoelson, S.E.
Deposit date:2001-04-13
Release date:2002-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the globular tail of nuclear lamin.
J.Biol.Chem., 277, 2002
1M7W
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HNF4A LIGAND BINDING DOMAIN WITH BOUND FATTY ACID
Descriptor:Hepatocyte nuclear factor 4-alpha, LAURIC ACID
Authors:Dhe-Paganon, S., Duda, K., Iwamoto, M., Chi, Y.I., Shoelson, S.E.
Deposit date:2002-07-22
Release date:2003-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
J.Biol.Chem., 277, 2002
1Q2H
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PHENYLALANINE ZIPPER MEDIATES APS DIMERIZATION
Descriptor:adaptor protein with pleckstrin homology and src homology 2 domains
Authors:Dhe-Paganon, S., Werner, E.D., Nishi, M., Chi, Y.-I., Shoelson, S.E.
Deposit date:2003-07-24
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A phenylalanine zipper mediates APS dimerization.
Nat.Struct.Mol.Biol., 11, 2004
1QQG
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CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
Descriptor:INSULIN RECEPTOR SUBSTRATE 1
Authors:Dhe-Paganon, S., Shoelson, S.E.
Deposit date:1999-06-04
Release date:1999-08-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
2IUG
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CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
Authors:Nolte, R.T., Eck, M.J., Schlessinger, J., Shoelson, S.E., Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUH
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CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH C-KIT PHOSPHOTYROSYL PEPTIDE
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT, C-KIT PHOSPHOTYROSYL PEPTIDE
Authors:Nolte, R.T., Eck, M.J., Schlessinger, J., Shoelson, S.E., Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUI
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CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH PDGFR PHOSPHOTYROSYL PEPTIDE
Descriptor:Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta
Authors:Nolte, R.T., Eck, M.J., Schlessinger, J., Shoelson, S.E., Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2PLD
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NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE
Descriptor:PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF
Authors:Pascal, S.M., Singer, A.U., Gish, G., Yamazaki, T., Shoelson, S.E., Pawson, T., Kay, L.E., Forman-Kay, J.D.
Deposit date:1994-08-19
Release date:1995-01-26
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell(Cambridge,Mass.), 77, 1994
2PLE
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NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE
Descriptor:PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF
Authors:Pascal, S.M., Singer, A.U., Gish, G., Yamazaki, T., Shoelson, S.E., Pawson, T., Kay, L.E., Forman-Kay, J.D.
Deposit date:1994-08-19
Release date:1995-01-26
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell(Cambridge,Mass.), 77, 1994
2SHP
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TYROSINE PHOSPHATASE SHP-2
Descriptor:SHP-2, DODECANE-TRIMETHYLAMINE
Authors:Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M.J., Shoelson, S.E.
Deposit date:1997-12-01
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the tyrosine phosphatase SHP-2.
Cell(Cambridge,Mass.), 92, 1998
3QYB
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X-RAY CRYSTAL STRUCTURE OF HUMAN TBC1D4 (AS160) RABGAP DOMAIN
Descriptor:TBC1 domain family member 4
Authors:Park, S.Y., Shoelson, S.E.
Deposit date:2011-03-03
Release date:2011-03-23
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
J.Biol.Chem., 286, 2011
3QYE
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CRYSTAL STRUCTURE OF HUMAN TBC1D1 RABGAP DOMAIN
Descriptor:TBC1 domain family member 1
Authors:Park, S.Y., Shoelson, S.E.
Deposit date:2011-03-03
Release date:2011-03-23
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
J.Biol.Chem., 286, 2011
4FZ5
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CRYSTAL STRUCTURE OF HUMAN TIRAP TIR-DOMAIN
Descriptor:Toll/interleukin-1 receptor domain-containing adapter protein
Authors:Woo, J.R., Kim, S., Shoelson, S.E., Park, S.
Deposit date:2012-07-06
Release date:2013-05-29
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:X-ray Crystallographic Structure of TIR-Domain from the Human TIR-Domain Containing Adaptor Protein/MyD88 Adaptor-Like Protein (TIRAP/MAL)
Bull.Korean Chem.Soc., 33, 2013
1AYA
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CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor:PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN), PEPTIDE PDGFR-1009
Authors:Lee, C.-H., Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1AYB
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CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor:PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN), PEPTIDE IRS-1-895
Authors:Lee, C.-H., Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1AYC
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CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor:PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN), PEPTIDE PDGFR-740
Authors:Lee, C.-H., Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1AYD
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CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor:PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN)
Authors:Lee, C.-H., Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1HCS
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NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
Descriptor:ACETYL-PYEEIE-OH, HUMAN SRC
Authors:Gampe Junior, R.T., Xu, R.X.
Deposit date:1994-09-02
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
1HCT
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NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
Descriptor:ACETYL-PYEEIE-OH, HUMAN SRC
Authors:Gampe Junior, R.T., Xu, R.X.
Deposit date:1994-09-02
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
1TCE
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SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE
Descriptor:SHC, PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR
Authors:Zhou, M.-M., Meadows, R.P., Logan, T.M., Yoon, H.S., Wade, W.R., Ravichandran, K.S., Burakoff, S.J., Feisk, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Proc.Natl.Acad.Sci.USA, 92, 1995
1HIT
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RECEPTOR BINDING REDEFINED BY A STRUCTURAL SWITCH IN A MUTANT HUMAN INSULIN
Descriptor:INSULIN
Authors:Hua, Q.X., Kochoyan, M., Weiss, M.A.
Deposit date:1992-02-28
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Receptor binding redefined by a structural switch in a mutant human insulin.
Nature, 354, 1991
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