Author results

1JSW
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NATIVE L-ASPARTATE AMMONIA LYASE
Descriptor:L-ASPARTATE AMMONIA-LYASE, BETA-D-GLUCOSE, ACETATE ION
Authors:Shi, W., Dunbar, J., Farber, G.K.
Deposit date:1997-02-19
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structure of L-aspartate ammonia-lyase from Escherichia coli.
Biochemistry, 36, 1997
4P96
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FADR, FATTY ACID RESPONSIVE TRANSCRIPTION FACTOR FROM VIBRIO CHOLERAE
Descriptor:Fatty acid metabolism regulator protein
Authors:Shi, W., Kull, F.J.
Deposit date:2014-04-02
Release date:2015-02-04
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 40-residue insertion in Vibrio cholerae FadR facilitates binding of an additional fatty acyl-CoA ligand.
Nat Commun, 6, 2015
4PDK
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FADR, FATTY ACID RESPONSIVE TRANSCRIPTION FACTOR FROM VIBRIO CHOLERAE, IN COMPLEX WITH OLEOYL-COA
Descriptor:Fatty acid metabolism regulator protein, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)
Authors:Shi, W., Kull, F.J.
Deposit date:2014-04-19
Release date:2015-02-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The 40-residue insertion in Vibrio cholerae FadR facilitates binding of an additional fatty acyl-CoA ligand.
Nat Commun, 6, 2015
1BZY
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HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR
Descriptor:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER, ...
Authors:Shi, W., Li, C., Tyler, P.C., Furneaux, R.H., Grubmeyer, C., Schramm, V.L., Almo, S.C.
Deposit date:1998-11-05
Release date:1999-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.
Nat.Struct.Biol., 6, 1999
1CI0
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PNP OXIDASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:PROTEIN (PNP OXIDASE), FLAVIN MONONUCLEOTIDE
Authors:Shi, W., Ostrov, D.A., Gerchman, S.E., Graziano, V., Kycia, H., Studier, B., Almo, S.C., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:1999-04-06
Release date:1999-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of PNP Oxidase from S. Cerevisiae
To be Published
1CJB
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MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE
Descriptor:PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, (1S)-1(9-DEAZAHYPOXANTHIN-9YL)1,4-DIDEOXY-1,4-IMINO-D-RIBITOL-5-PHOSPHATE, ...
Authors:Shi, W., Li, C.M., Tyler, P.C., Furneaux, R.H., Cahill, S.M., Girvin, M.E., Grubmeyer, C., Schramm, V.L., Almo, S.C.
Deposit date:1999-04-08
Release date:1999-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.
Biochemistry, 38, 1999
1DQN
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CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH A TRANSITION STATE ANALOGUE
Descriptor:GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER, ...
Authors:Shi, W., Munagala, N.R., Wang, C.C., Li, C.M., Tyler, P.C., Furneaux, R.H., Grubmeyer, C., Schramm, V.L., Almo, S.C.
Deposit date:2000-01-04
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
Biochemistry, 39, 2000
1DQP
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CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH IMMUCILLING
Descriptor:GUANINE PHOSPHORIBOSYLTRANSFERASE, 1,4-DIDEOXY-1,4-IMINO-1-(S)-(9-DEAZAGUANIN-9-YL)-D-RIBITOL, ISOPROPYL ALCOHOL
Authors:Shi, W., Munagala, N.R., Wang, C.C., Li, C.M., Tyler, P.C., Furneaux, R.H., Grubmeyer, C., Schramm, V.L., Almo, S.C.
Deposit date:2000-01-04
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
Biochemistry, 39, 2000
1EZR
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CRYSTAL STRUCTURE OF NUCLEOSIDE HYDROLASE FROM LEISHMANIA MAJOR
Descriptor:NUCLEOSIDE HYDROLASE, CALCIUM ION
Authors:Shi, W., Schramm, V.L., Almo, S.C.
Deposit date:2000-05-11
Release date:2000-05-24
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-a crystal structure.
J.Biol.Chem., 274, 1999
1G2O
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH A TRANSITION-STATE INHIBITOR
Descriptor:PURINE NUCLEOSIDE PHOSPHORYLASE, PHOSPHATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL
Authors:Shi, W., Basso, L.A., Tyler, P.C., Furneaux, R.H., Blanchard, J.S., Almo, S.C., Schramm, V.L.
Deposit date:2000-10-20
Release date:2001-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry, 40, 2001
1G2P
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CRYSTAL STRUCTURE OF ADENINE PHOSPHORIBOSYLTRANSFERASE
Descriptor:ADENINE PHOSPHORIBOSYLTRANSFERASE 1, SULFATE ION
Authors:Shi, W., Tanaka, K.S.E., Almo, S.C., Schramm, V.L.
Deposit date:2000-10-20
Release date:2001-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae.
Biochemistry, 40, 2001
1G2Q
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CRYSTAL STRUCTURE OF ADENINE PHOSPHORIBOSYLTRANSFERASE
Descriptor:ADENINE PHOSPHORIBOSYLTRANSFERASE 1
Authors:Shi, W., Tanaka, K.S.E., Almo, S.C., Schramm, V.L.
Deposit date:2000-10-20
Release date:2001-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae.
Biochemistry, 40, 2001
1I80
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS PNP IN COMPLEX WITH IMINORIBITOL, 9-DEAZAHYPOXANTHINE AND PHOSPHATE ION
Descriptor:PURINE NUCLEOSIDE PHOSPHORYLASE, PHOSPHATE ION, 9-DEAZAHYPOXANTHINE, ...
Authors:Shi, W., Basso, L.A., Tyler, P.C., Furneaux, R.H., Blanchard, J.S., Almo, S.C., Schramm, V.L.
Deposit date:2001-03-12
Release date:2001-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry, 40, 2001
1L1Q
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CRYSTAL STRUCTURE OF APRTASE FROM GIARDIA LAMBLIA COMPLEXED WITH 9-DEAZAADENINE
Descriptor:Adenine phosphoribosyltransferase, SULFATE ION, 9-DEAZAADENINE
Authors:Shi, W., Sarver, A.E., Wang, C.C., Tanaka, K.S., Almo, S.C., Schramm, V.L.
Deposit date:2002-02-19
Release date:2002-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Closed Site Complexes of Adenine Phosphoribosyltransferase from Giardia lamblia Reveal a Mechanism of Ribosyl Migration.
J.Biol.Chem., 277, 2002
1L1R
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CRYSTAL STRUCTURE OF APRTASE FROM GIARDIA LAMBLIA COMPLEXED WITH 9-DEAZAADENINE, MG2+ AND PRPP
Descriptor:Adenine phosphoribosyltransferase, MAGNESIUM ION, 9-DEAZAADENINE, ...
Authors:Shi, W., Sarver, A.E., Wang, C.C., Tanaka, K.S., Almo, S.C., Schramm, V.L.
Deposit date:2002-02-19
Release date:2002-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Closed Site Complexes of Adenine Phosphoribosyltransferase from Giardia lamblia Reveal a Mechanism of Ribosyl Migration.
J.Biol.Chem., 277, 2002
1NW4
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH IMMH AND SULFATE
Descriptor:uridine phosphorylase, putative, SULFATE ION, ...
Authors:Shi, W., Ting, L.M., Kicska, G.A., Lewandowicz, A., Tyler, P.C., Evans, G.B., Furneaux, R.H., Kim, K., Almo, S.C., Schramm, V.L.
Deposit date:2003-02-05
Release date:2004-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION.
J.Biol.Chem., 279, 2004
1Q1G
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM PNP WITH 5'-METHYLTHIO-IMMUCILLIN-H
Descriptor:Uridine phosphorylase putative, SULFATE ION, 3,4-DIHYDROXY-2-[(METHYLSULFANYL)METHYL]-5-(4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)PYRROLIDINIUM, ...
Authors:Shi, W., Ting, L.M., Kicska, G.A., Lewandowicz, A., Tyler, P.C., Evans, G.B., Furneaux, R.H., Kim, K., Almo, S.C., Schramm, V.L.
Deposit date:2003-07-19
Release date:2004-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION.
J.Biol.Chem., 279, 2004
1RR6
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STRUCTURE OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH IMMUCILLIN-H AND PHOSPHATE
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL
Authors:Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
Deposit date:2003-12-08
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.
J.Biol.Chem., 279, 2004
1RSZ
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STRUCTURE OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH DADME-IMMUCILLIN-H AND SULFATE
Descriptor:Purine nucleoside phosphorylase, SULFATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
Authors:Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
Deposit date:2003-12-10
Release date:2005-02-22
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
1RT9
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STRUCTURE OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH IMMUCILLIN-H AND SULFATE
Descriptor:Purine nucleoside phosphorylase, SULFATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL
Authors:Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
Deposit date:2003-12-10
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
1ZVM
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CRYSTAL STRUCTURE OF HUMAN CD38: CYCLIC-ADP-RIBOSYL SYNTHETASE/NAD+ GLYCOHYDROLASE
Descriptor:ADP-ribosyl cyclase 1, SULFATE ION
Authors:Shi, W., Yang, T., Almo, S.C., Schramm, V.L., Sauve, A.
Deposit date:2005-06-02
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human CD38: Cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase
To be Published
3K9A
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CRYSTAL STRUCTURE OF HIV GP41 WITH MPER
Descriptor:HIV glycoprotein gp41
Authors:Shi, W., Han, D., Habte, H., Cho, M., Chance, M.R.
Deposit date:2009-10-15
Release date:2010-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of HIV gp41 with the membrane-proximal external region
J.Biol.Chem., 285, 2010
4P9U
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FADR, FATTY ACID RESPONSIVE TRANSCRIPTION FACTOR FROM VIBRIO CHOLERAE, IN COMPLEX WITH DNA
Descriptor:Fatty acid metabolism regulator protein, DNA (31-MER)
Authors:Kull, F.J., Shi, W.
Deposit date:2014-04-05
Release date:2015-02-04
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.208 Å)
Cite:The 40-residue insertion in Vibrio cholerae FadR facilitates binding of an additional fatty acyl-CoA ligand.
Nat Commun, 6, 2015
1K27
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CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE IN COMPLEX WITH A TRANSITION STATE ANALOGUE
Descriptor:5'-Deoxy-5'-Methylthioadenosine Phosphorylase, PHOSPHATE ION, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL
Authors:Shi, W., Singh, V., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
Deposit date:2001-09-26
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
Biochemistry, 43, 2004
1ZOS
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STRUCTURE OF 5'-METHYLTHIONADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE FROM S. PNEUMONIAE WITH A TRANSITION-STATE INHIBITOR MT-IMMA
Descriptor:5'-methylthioadenosine / S-adenosylhomocysteine nucleosidase, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL
Authors:Shi, W., Singh, V., Zhen, R., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
Deposit date:2005-05-13
Release date:2006-04-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.
Biochemistry, 45, 2006