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3P1J
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CRYSTAL STRUCTURE OF HUMAN GTPASE IMAP FAMILY MEMBER 2 IN THE NUCLEOTIDE-FREE STATE
Descriptor:GTPase IMAP family member 2, UNKNOWN ATOM OR ION
Authors:Shen, L., Tempel, W., Tong, Y., Guan, X., Nedyalkova, L., Wernimont, A.K., Mackenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Andrews, D.W., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-09-30
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Crystal structure of human GTPase IMAP family member 2 in the nucleotide-free state
to be published
3PP2
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CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF ARHGAP27
Descriptor:Rho GTPase-activating protein 27, CITRIC ACID, UNKNOWN ATOM OR ION, ...
Authors:Shen, L., Tempel, W., Tong, Y., Nedyalkova, L., Li, Y., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-11-23
Release date:2010-12-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.421 Å)
Cite:Crystal structure of the pleckstrin homology domain of ArhGAP27
to be published
2IY0
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SENP1 (MUTANT) SUMO1 RANGAP
Descriptor:SENTRIN-SPECIFIC PROTEASE 1, SMALL UBIQUITIN-RELATED MODIFIER 1, RAN GTPASE-ACTIVATING PROTEIN 1
Authors:Shen, L., Dong, C., Naismith, J.H.
Deposit date:2006-07-11
Release date:2006-08-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Sumo Protease Senp1 Induces Isomerization of the Scissile Peptide Bond.
Nat.Struct.Mol.Biol., 13, 2006
2IY1
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SENP1 (MUTANT) FULL LENGTH SUMO1
Descriptor:SENTRIN-SPECIFIC PROTEASE 1, SMALL UBIQUITIN-RELATED MODIFIER 1
Authors:Shen, L., Dong, C., Naismith, J.H.
Deposit date:2006-07-11
Release date:2006-08-15
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Sumo Protease Senp1 Induces Isomerization of the Scissile Peptide Bond.
Nat.Struct.Mol.Biol., 13, 2006
3C5C
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CRYSTAL STRUCTURE OF HUMAN RAS-LIKE, FAMILY 12 PROTEIN IN COMPLEX WITH GDP
Descriptor:RAS-like protein 12, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Shen, L., Tong, Y., Tempel, W., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of human Ras-like, family 12 protein in complex with GDP.
To be Published
3C5H
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CRYSTAL STRUCTURE OF THE RAS HOMOLOG DOMAIN OF HUMAN GRLF1 (P190RHOGAP)
Descriptor:Glucocorticoid receptor DNA-binding factor 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP).
To be Published
3CXL
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CRYSTAL STRUCTURE OF HUMAN CHIMERIN 1 (CHN1)
Descriptor:N-chimerin, ZINC ION, UNKNOWN ATOM OR ION
Authors:Shen, L., Buck, M., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Wilkstrom, M., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-04-24
Release date:2008-08-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human chimerin 1 (CHN1).
To be Published
3MDB
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF FULL LENGTH CENTAURIN ALPHA-1, KIF13B FHA DOMAIN, AND IP4
Descriptor:Kinesin-like protein KIF13B, Arf-GAP with dual PH domain-containing protein 1, UNKNOWN ATOM OR ION, ...
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-03-30
Release date:2010-08-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.952 Å)
Cite:Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
to be published
3QIK
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CRYSTAL STRUCTURE OF THE FIRST PDZ DOMAIN OF PREX1
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, UNKNOWN ATOM OR ION
Authors:Shen, L., Tong, Y., Tempel, W., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-01-27
Release date:2011-02-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:Crystal structure of the first PDZ domain of PREX1
to be published
3S4Y
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CRYSTAL STRUCTURE OF HUMAN THIAMIN PYROPHOSPHOKINASE 1
Descriptor:Thiamin pyrophosphokinase 1, THIAMINE DIPHOSPHATE, SULFATE ION, ...
Authors:Shen, L., Tempel, W., Tong, Y., Li, Y., Walker, J.R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-05-20
Release date:2011-06-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human thiamin pyrophosphokinase 1
to be published
4F9O
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH 2-DEOXY-GLUCOSE 6-PHOSPHATE
Descriptor:Hexokinase-1, BETA-D-GLUCOSE, 2-deoxy-6-O-phosphono-beta-D-arabino-hexopyranose, ...
Authors:Shen, L., Honzatko, R.B.
Deposit date:2012-05-19
Release date:2013-06-12
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Inhibitor Sites of Unequal Affinity Linked by Binding Synergism in Mutant Forms of Recombinant Human Hexokinase Type-I
to be published
4FOE
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH MANNOSE 6-PHOSPHATE
Descriptor:Hexokinase-1, BETA-D-GLUCOSE, 6-O-phosphono-beta-D-mannopyranose, ...
Authors:Shen, L., Honzatko, R.B.
Deposit date:2012-06-20
Release date:2013-07-03
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Inhibitor Sites of Unequal Affinity Linked by Binding Synergism in Mutant Forms of Recombinant Human Hexokinase Type-I
to be published
4FOI
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN HEXOKINASE TYPE I MUTANT D413N WITH GLUCOSE 1,6-BISPHOSPHATE
Descriptor:Hexokinase-1, BETA-D-GLUCOSE, ALPHA-D-GLUCOSE 1,6-BISPHOSPHATE, ...
Authors:Shen, L., Honzatko, R.B.
Deposit date:2012-06-20
Release date:2013-07-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:DETERMINATION of SITE AFFINITY CONSTANTS FOR PRODUCT INHIBITION OF WILD-TYPE AND MUTANT FORMS OF RECOMBINANT HUMAN HEXOKINASE TYPE I
To be Published
4FPA
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN HEXOKINASE TYPE I MUTANT D413N GLUCOSE 6-PHOSPHATE
Descriptor:Hexokinase-1, BETA-D-GLUCOSE, BETA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Shen, L., Honzatko, R.B.
Deposit date:2012-06-21
Release date:2013-07-03
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:DETERMINATION OF SITE AFFINITY CONSTANTS FOR PRODUCT INHIBITION of WILD-TYPE AND MUTANT FORMS OF RECOMBINANT HUMAN HEXOKINASE TYPE I
To be Published
4FPB
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH 1,5-ANHYDROGLUCITOL 6-PHOSPHATE
Descriptor:Hexokinase-1, BETA-D-GLUCOSE, 1,5-anhydro-6-O-phosphono-D-glucitol, ...
Authors:Shen, L., Honzatko, R.B.
Deposit date:2012-06-21
Release date:2013-07-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibitor Sites of Unequal Affinity Linked by Binding Synergism in Mutant Forms of Recombinant Human Hexokinase Type-I
to be published
3FEH
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CRYSTAL STRUCTURE OF FULL LENGTH CENTAURIN ALPHA-1
Descriptor:Centaurin-alpha-1, ZINC ION, UNKNOWN ATOM OR ION
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-11-29
Release date:2008-12-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin {alpha}1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3FM8
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CRYSTAL STRUCTURE OF FULL LENGTH CENTAURIN ALPHA-1 BOUND WITH THE FHA DOMAIN OF KIF13B (CAPRI TARGET)
Descriptor:Kinesin-like protein KIF13B, Centaurin-alpha-1, UNKNOWN ATOM OR ION, ...
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-12-19
Release date:2009-08-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LJU
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CRYSTAL STRUCTURE OF FULL LENGTH CENTAURIN ALPHA-1 BOUND WITH THE HEAD GROUP OF PIP3
Descriptor:Arf-GAP with dual PH domain-containing protein 1, ZINC ION, (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane-1,2-diyl dioctanoate
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-01-26
Release date:2010-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
4RXX
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN UBIQUITIN SPECIFIC PROTEASE 38
Descriptor:Ubiquitin carboxyl-terminal hydrolase 38, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Dong, A., Shen, L., Hu, J., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2014-12-12
Release date:2015-01-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal Structure of the N-terminal Domain of Human Ubiquitin Specific Protease 38
to be published
5JRH
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CRYSTAL STRUCTURE OF SALMONELLA ENTERICA ACETYL-COA SYNTHETASE (ACS) IN COMPLEX WITH CAMP AND COENZYME A
Descriptor:Acetyl-coenzyme A synthetase, COENZYME A, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ...
Authors:Shen, L., Zhang, Y.
Deposit date:2016-05-06
Release date:2016-12-21
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.644 Å)
Cite:Cyclic AMP Inhibits the Activity and Promotes the Acetylation of Acetyl-CoA Synthetase through Competitive Binding to the ATP/AMP Pocket.
J. Biol. Chem., 292, 2017
3NF1
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CRYSTAL STRUCTURE OF THE TPR DOMAIN OF KINESIN LIGHT CHAIN 1
Descriptor:Kinesin light chain 1
Authors:Tong, Y., Tempel, W., Shen, L., Shen, Y., Nedyalkova, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-06-09
Release date:2011-05-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the TPR domain of kinesin light chain 1
to be published
2FOL
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CRYSTAL STRUCTURE OF HUMAN RAB1A IN COMPLEX WITH GDP
Descriptor:Ras-related protein Rab-1A, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Wang, J., Tempel, W., Shen, Y., Shen, L., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-01-13
Release date:2006-01-31
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:Crystal structure of human RAB1A in complex with GDP
To be Published
2G1L
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CRYSTAL STRUCTURE OF THE FHA DOMAIN OF HUMAN KINESIN FAMILY MEMBER C
Descriptor:Kinesin-like protein KIF1C, CHLORIDE ION, NICKEL (II) ION, ...
Authors:Wang, J., Tempel, W., Shen, Y., Shen, L., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-02-14
Release date:2006-02-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Crystal structure of the FHA domain of human kinesin family member C
to be published
2G6B
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CRYSTAL STRUCTURE OF HUMAN RAB26 IN COMPLEX WITH A GTP ANALOGUE
Descriptor:Ras-related protein Rab-26, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Wang, J., Tempel, W., Shen, Y., Shen, L., Yaniw, D., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-02-24
Release date:2006-03-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human RAB26 in complex with a GTP analogue
To be Published
3EAP
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CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF ARHGAP11A
Descriptor:Rho GTPase-activating protein 11A, UNKNOWN ATOM OR ION
Authors:Shen, Y., Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2008-08-26
Release date:2008-09-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the RhoGAP domain of ARHGAP11A
To be Published