3RA3
 
 | | Crystal structure of a section of a de novo design gigaDalton protein fibre | | Descriptor: | SODIUM ION, p1c, p2f | | Authors: | Zaccai, N.R, Sharp, T.H, Bruning, M, Woolfson, D.N, Brady, R.L. | | Deposit date: | 2011-03-27 | | Release date: | 2012-08-08 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design
Proc.Natl.Acad.Sci.USA, 109, 2012
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7ZL1
 | | PTX3 Pentraxin Domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Pentraxin-related protein PTX3 | | Authors: | Noone, D.P, Sharp, T.H. | | Deposit date: | 2022-04-13 | | Release date: | 2022-08-03 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8BTB
 | | Hexameric human IgG3 Fc complex | | Descriptor: | FLJ00385 protein (Fragment) | | Authors: | Abendstein, L, Sharp, T.H. | | Deposit date: | 2022-11-28 | | Release date: | 2023-06-21 | | Last modified: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains.
Nat Commun, 14, 2023
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8CPU
 | | Human apoferritin after 561 nm laser exposure | | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | | Deposit date: | 2023-03-03 | | Release date: | 2023-03-15 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (1.76 Å) | | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM.
J.Struct.Biol., 215, 2023
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8CPV
 | | Human apoferritin | | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | | Deposit date: | 2023-03-03 | | Release date: | 2023-03-15 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (1.76 Å) | | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM.
J.Struct.Biol., 215, 2023
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8CPT
 | | Human apoferritin after 488 nm laser exposure | | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | | Deposit date: | 2023-03-03 | | Release date: | 2023-03-15 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (1.79 Å) | | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM.
J.Struct.Biol., 215, 2023
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8CPX
 | | Human apoferritin after 488 nm laser exposure in presence of rsEGFP2 | | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | | Deposit date: | 2023-03-03 | | Release date: | 2023-03-15 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (1.76 Å) | | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM.
J.Struct.Biol., 215, 2023
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8CPS
 | | Human apoferritin | | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | | Deposit date: | 2023-03-03 | | Release date: | 2023-03-15 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (1.82 Å) | | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM.
J.Struct.Biol., 215, 2023
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8CPM
 | | Human apoferritin after 405 nm laser exposure | | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | | Deposit date: | 2023-03-03 | | Release date: | 2023-03-15 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (1.81 Å) | | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM.
J.Struct.Biol., 215, 2023
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8CPW
 | | Human apoferritin after 405 nm + 488 nm laser exposure in presence of rsEGFP2 | | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | | Deposit date: | 2023-03-03 | | Release date: | 2023-03-15 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (1.79 Å) | | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM.
J.Struct.Biol., 215, 2023
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7PKE
 | | C-reactive protein pentamer at pH 7.5 with phosphocholine ligand | | Descriptor: | C-reactive protein, CALCIUM ION, PHOSPHOCHOLINE | | Authors: | Noone, D.P, Sharp, T.H. | | Deposit date: | 2021-08-25 | | Release date: | 2021-12-22 | | Last modified: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein.
Front Immunol, 12, 2021
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7PKF
 | | C-reactive protein decamer at pH 5 | | Descriptor: | C-reactive protein, CALCIUM ION | | Authors: | Noone, D.P, Sharp, T.H. | | Deposit date: | 2021-08-25 | | Release date: | 2021-12-22 | | Last modified: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein.
Front Immunol, 12, 2021
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7PKH
 | | C-reactive protein decamer at pH 5 with phosphocholine ligand | | Descriptor: | C-reactive protein, CALCIUM ION, PHOSPHOCHOLINE | | Authors: | Noone, D.P, Sharp, T.H. | | Deposit date: | 2021-08-25 | | Release date: | 2021-12-22 | | Last modified: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein.
Front Immunol, 12, 2021
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7PK9
 | | C-reactive protein decamer at pH 7.5 | | Descriptor: | C-reactive protein, CALCIUM ION | | Authors: | Noone, D.P, Sharp, T.H. | | Deposit date: | 2021-08-25 | | Release date: | 2021-12-22 | | Last modified: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein.
Front Immunol, 12, 2021
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7PKB
 | | C-reactive protein pentamer at pH 7.5 | | Descriptor: | C-reactive protein, CALCIUM ION | | Authors: | Noone, D.P, Sharp, T.H. | | Deposit date: | 2021-08-25 | | Release date: | 2021-12-22 | | Last modified: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein.
Front Immunol, 12, 2021
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7PKG
 | | C-reactive protein pentamer at pH 5 | | Descriptor: | C-reactive protein, CALCIUM ION | | Authors: | Noone, D.P, Sharp, T.H. | | Deposit date: | 2021-08-25 | | Release date: | 2021-12-22 | | Last modified: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein.
Front Immunol, 12, 2021
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7PKD
 | | C-reactive protein decamer at pH 7.5 with phosphocholine ligand | | Descriptor: | C-reactive protein, CALCIUM ION, PHOSPHOCHOLINE | | Authors: | Noone, D.P, Sharp, T.H. | | Deposit date: | 2021-08-25 | | Release date: | 2021-12-22 | | Last modified: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein.
Front Immunol, 12, 2021
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6FCZ
 | | Model of gC1q-Fc complex based on 7A EM map | | Descriptor: | Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, ... | | Authors: | Ugurlar, D, Howes, S.C, de Kreuk, B.J.K, de Jong, R.N, Beurskens, F.J, Koster, A.J, Parren, P.W.H.I, Sharp, T.H, Gros, P, Koning, R.I. | | Deposit date: | 2017-12-21 | | Release date: | 2018-02-28 | | Last modified: | 2018-10-24 | | Method: | ELECTRON MICROSCOPY (10 Å) | | Cite: | Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.
Science, 359, 2018
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5AMO
 | | Structure of a mouse Olfactomedin-1 disulfide-linked dimer of the Olfactomedin domain and part of the coiled coil | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Pronker, M.F, Bos, T.G.A.A, Sharp, T.H, Thies-Weesie, D.M, Janssen, B.J.C. | | Deposit date: | 2015-03-11 | | Release date: | 2015-04-29 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Olfactomedin-1 Has a V-Shaped Disulfide-Linked Tetrameric Structure.
J.Biol.Chem., 290, 2015
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7Y0J
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7Y09
 | | Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... | | Authors: | Shen, H, Ji, C, Xiao, J. | | Deposit date: | 2022-06-03 | | Release date: | 2023-03-29 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M
Nat Commun, 14, 2023
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7Y0H
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7YG2
 | | Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DBLMSP2, ... | | Authors: | Shen, H, Ji, C, Xiao, J. | | Deposit date: | 2022-07-09 | | Release date: | 2023-03-29 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M
Nat Commun, 14, 2023
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5O35
 | | Structure of complement proteins complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H | | Authors: | Xue, X, Wu, J, Forneris, F, Gros, P. | | Deposit date: | 2017-05-23 | | Release date: | 2017-06-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
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5O32
 | | The structure of complement complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Xue, X, Wu, J, Forneris, F, Gros, P. | | Deposit date: | 2017-05-23 | | Release date: | 2017-06-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (4.206209 Å) | | Cite: | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
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