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X-ray crystal structure of 1,2,3-triazolobenzodiazepine in complex with BRD2(D2)
Descriptor:	1,2-ETHANEDIOL, 5-[7-(4-chlorophenyl)-1-methyl-6,7-dihydro-5H-[1,2,3]triazolo[1,5-d][1,4]benzodiazepin-9-yl]pyridin-2-amine, Bromodomain-containing protein 2
Authors:	Hatfaludi, T, Sharp, P.P, Garnier, J.-M, Burns, C.J, Czabotar, P.E.
Deposit date:	2016-12-09
Release date:	2017-12-13
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.775 Å)
Cite:	Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors. ACS Med Chem Lett, 8, 2017

Signal peptide mimicry primes Sec61 for client-selective inhibition
Descriptor:	Cyclic depsipeptide signal peptide mimic, Protein transport protein Sec61 subunit alpha, Protein transport protein Sec61 subunit beta, ...
Authors:	Rehan, S, Paavilainen O, V.
Deposit date:	2022-04-13
Release date:	2023-03-22
Last modified:	2023-11-15
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Signal peptide mimicry primes Sec61 for client-selective inhibition. Nat.Chem.Biol., 19, 2023

Crystal structure of mouse Bak
Descriptor:	1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, FORMIC ACID
Authors:	Brouwer, J.M, Czabotar, P.E, Colman, P.M.
Deposit date:	2018-09-03
Release date:	2019-09-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.748 Å)
Cite:	A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nat.Chem.Biol., 15, 2019