Author results

1DQ7
  • Download 1dq7
  • View 1dq7
Molmil generated image of 1dq7
THREE-DIMENSIONAL STRUCTURE OF A NEUROTOXIN FROM RED SCORPION (BUTHUS TAMULUS) AT 2.2A RESOLUTION.
Descriptor:NEUROTOXIN
Authors:Sharma, M., Yadav, S., Karthikeyan, S., Kumar, S., Paramasivam, M., Srinivasan, A., Singh, T.P.
Deposit date:1999-12-30
Release date:2000-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional Structure of a Neurotoxin from Red Scorpion (Buthus tamulus) at 2.2A Resolution
To be Published
2L0J
  • Download 2l0j
  • View 2l0j
Molmil generated image of 2l0j
SOLID STATE NMR STRUCTURE OF THE M2 PROTON CHANNEL FROM INFLUENZA A VIRUS IN HYDRATED LIPID BILAYER
Descriptor:Matrix protein 2
Authors:Sharma, M., Yi, M., Dong, H., Qin, H., Peterson, E., Busath, D.D., Zhou, H.X., Cross, T.A.
Deposit date:2010-07-08
Release date:2010-11-03
Last modified:2011-07-13
Method:SOLID-STATE NMR
Cite:Insight into the mechanism of the influenza a proton channel from a structure in a lipid bilayer.
Science, 330, 2010
5AQE
  • Download 5aqe
  • View 5aqe
Molmil generated image of 5aqe
COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, (4-VINYLPHENYL)METHANESULFONIC ACID, SULFATE ION, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-22
Release date:2015-10-07
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Bisubstrate Localisation by a Tailored Serine Protease Allows Creation of a Heck-Ase
To be Published
5ARB
  • Download 5arb
  • View 5arb
Molmil generated image of 5arb
COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, CALCIUM ION, GLYCEROL, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-24
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase
To be Published
5ARC
  • Download 5arc
  • View 5arc
Molmil generated image of 5arc
COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, CALCIUM ION, 5-methyl-2-(5-methylpyridin-2-yl)pyridine, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-24
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase
To be Published
5ARD
  • Download 5ard
  • View 5ard
Molmil generated image of 5ard
COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, CALCIUM ION, GLYCEROL, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-24
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase
To be Published
6EOD
  • Download 6eod
  • View 6eod
Molmil generated image of 6eod
STRUCTURE OF REDUCTIVE AMINASE FROM ASPERGILLUS TERREUS IN COMPLEX WITH NADPH
Descriptor:Reductive Aminase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sharma, M., Mangas-Sanchez, J., Turner, N.J., Grogan, G.
Deposit date:2017-10-09
Release date:2018-10-31
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases
Acs Catalysis, 2018
6EOH
  • Download 6eoh
  • View 6eoh
Molmil generated image of 6eoh
REDUCTIVE AMINASE FROM ASPERGILLUS TERREUS IN COMPLEX WITH NADPH AND ETHYL LEVULINATE
Descriptor:Reductive Aminase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ethyl levulinate
Authors:Sharma, M., Grogan, G., Mangas-Sanchez, J., Turner, N.J.
Deposit date:2017-10-09
Release date:2018-10-31
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases
Acs Catalysis, 2018
6EOI
  • Download 6eoi
  • View 6eoi
Molmil generated image of 6eoi
REDUCTIVE AMINASE FROM ASPERGILLUS TERREUS IN COMPLEX WITH NADPH AND ETHYL-5-OXOHEXANOATE
Descriptor:Reductive Aminase, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Sharma, M., Mangas-Sanchez, J., Turner, N.J., Grogan, G.
Deposit date:2017-10-09
Release date:2018-10-31
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases
Acs Catalysis, 2018
6H7P
  • Download 6h7p
  • View 6h7p
Molmil generated image of 6h7p
REDUCTIVE AMINASE FROM ASPERGILLUS TERREUS IN COMPLEX WITH NADPH4, CYCLOHEXANONE AND ALLYL AMINE
Descriptor:Reductive Aminase, [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate, prop-2-en-1-amine, ...
Authors:Sharma, M., Grogan, G., Mangas-Sanchez, J., Turner, N.J.
Deposit date:2018-07-31
Release date:2019-04-03
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure of Reductive Aminase from Aspergillus terreus
Acs Catalysis, 2018
2A7T
  • Download 2a7t
  • View 2a7t
Molmil generated image of 2a7t
CRYSTAL STRUCTURE OF A NOVEL NEUROTOXIN FROM BUTHUS TAMALUS AT 2.2A RESOLUTION.
Descriptor:Neurotoxin
Authors:Ethayathulla, A.S., Sharma, M., Saravanan, K., Sharma, S., Kaur, P., Yadav, S., Srinivasan, A., Singh, T.P.
Deposit date:2005-07-06
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a highly acidic neurotoxin from scorpion Buthus tamulus at 2.2A resolution reveals novel structural features.
J.Struct.Biol., 155, 2006
6K5P
  • Download 6k5p
  • View 6k5p
Molmil generated image of 6k5p
STRUCTURE OF MOSQUITO-LARVICIDAL BINARY TOXIN RECEPTOR, CQM1
Descriptor:Binary toxin receptor protein, MAGNESIUM ION, CADMIUM ION, ...
Authors:Kumar, V., Sharma, M.
Deposit date:2019-05-30
Release date:2019-09-11
Method:X-RAY DIFFRACTION (1.805 Å)
Cite:Crystal structure of BinAB toxin receptor (Cqm1) protein and molecular dynamics simulations reveal the role of unique Ca(II) ion.
Int.J.Biol.Macromol., 2019
5OCM
  • Download 5ocm
  • View 5ocm
Molmil generated image of 5ocm
IMINE REDUCTASE FROM STREPTOSPORANGIUM ROSEUM IN COMPLEX WITH NADP+ AND 2,2,2-TRIFLUOROACETOPHENONE HYDRATE
Descriptor:NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Sharma, M., Nestl, B., Grogan, G.
Deposit date:2017-07-03
Release date:2018-05-16
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:New imine-reducing enzymes from beta-hydroxyacid dehydrogenases by single amino acid substitutions.
Protein Eng. Des. Sel., 31, 2018
5OJL
  • Download 5ojl
  • View 5ojl
Molmil generated image of 5ojl
IMINE REDUCTASE FROM ASPERGILLUS TERREUS IN COMPLEX WITH NADPH4 AND DIBENZ[C,E]AZEPINE
Descriptor:Imine reductase, 5-methyl-7~{H}-benzo[d][2]benzazepine, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE
Authors:Sharma, M., Grogan, G.
Deposit date:2017-07-21
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines.
Angew. Chem. Int. Ed. Engl., 56, 2017
5HGQ
  • Download 5hgq
  • View 5hgq
Molmil generated image of 5hgq
LOA LOA LYSYL-TRNA SYNTHETASE IN COMPLEX WITH CLADOSPORIN.
Descriptor:Lysine--tRNA ligase, LYSINE, cladosporin, ...
Authors:Sharma, A., Sharma, M., Yogavel, M., Sharma, A.
Deposit date:2016-01-08
Release date:2016-10-26
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3.283 Å)
Cite:Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis
PLoS Negl Trop Dis, 10, 2016
5ZH2
  • Download 5zh2
  • View 5zh2
Molmil generated image of 5zh2
CRYSTAL STRUCTURE OF PFKRS WITH INHIBITOR CLADO-5
Descriptor:Lysine-tRNA ligase, LYSINE, (3R)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ...
Authors:Babbar, P., Malhotra, N., Sharma, M., Harlos, K., Reddy, D.S., Manickam, Y., Sharma, A.
Deposit date:2018-03-11
Release date:2018-06-27
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZH3
  • Download 5zh3
  • View 5zh3
Molmil generated image of 5zh3
CRYSTAL STRUCTURE OF PFKRS WITH INHIBITOR CLADO-6
Descriptor:Lysine-tRNA ligase, LYSINE, (3S)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one
Authors:Babbar, P., Malhotra, N., Sharma, M., Harlos, K., Reddy, D.S., Manickam, Y., Sharma, A.
Deposit date:2018-03-11
Release date:2018-06-27
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZH4
  • Download 5zh4
  • View 5zh4
Molmil generated image of 5zh4
CRYSTAL STRUCTURE OF PFKRS WITH INHIBITOR CLADO-7
Descriptor:Lysine-tRNA ligase, LYSINE, (3R)-6,8-dihydroxy-3-{[(2S,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ...
Authors:Babbar, P., Malhotra, N., Sharma, M., Harlos, K., Reddy, D.S., Manickam, Y., Sharma, A.
Deposit date:2018-03-11
Release date:2018-06-27
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZH5
  • Download 5zh5
  • View 5zh5
Molmil generated image of 5zh5
CRYSTAL STRUCTURE OF PFKRS WITH INHIBITOR CLADO-2
Descriptor:Lysine--tRNA ligase, LYSINE, (3S)-6,8-dihydroxy-3-{[(2R,6S)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ...
Authors:Babbar, P., Malhotra, N., Sharma, M., Harlos, K., Reddy, D.S., Manickam, Y., Sharma, A.
Deposit date:2018-03-11
Release date:2018-06-27
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZKE
  • Download 5zke
  • View 5zke
Molmil generated image of 5zke
CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF PLASMODIUM VIVAX P43 IN SPACE GROUP P212121
Descriptor:Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein p43
Authors:Gupta, S., Sharma, M., Harlos, K., Manickam, Y., Sharma, A.
Deposit date:2018-03-23
Release date:2019-04-24
Method:X-RAY DIFFRACTION (1.492 Å)
Cite:Structural analysis of aminoacyl-tRNA synthetase-interacting multifunctional proteins from plasmodium species
To Be Published
5ZKF
  • Download 5zkf
  • View 5zkf
Molmil generated image of 5zkf
CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF PLASMODIUM VIVAX P43 IN SPACE GROUP P21
Descriptor:Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein p43
Authors:Gupta, S., Sharma, M., Harlos, K., Manickam, Y., Sharma, A.
Deposit date:2018-03-23
Release date:2019-04-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural analysis of aminoacyl-tRNA synthetase-interacting multifunctional proteins from plasmodium species
To Be Published
5ZKG
  • Download 5zkg
  • View 5zkg
Molmil generated image of 5zkg
CRYSTAL STRUCTURE OF C-TERMINAL DOMAIN OF PLASMODIUM VIVAX P43
Descriptor:Aminoacyl-tRna synthetase-interacting multifunctional protein P43
Authors:Gupta, S., Sharma, M., Manickam, Y., Sharma, A.
Deposit date:2018-03-23
Release date:2019-04-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural analysis of aminoacyl-tRNA synthetase-interacting multifunctional proteins from plasmodium species
To Be Published
5AQD
  • Download 5aqd
  • View 5aqd
Molmil generated image of 5aqd
CRYSTAL STRUCTURE OF PHORMIDIUM PHYCOERYTHRIN AT PH 8.5
Descriptor:PHYCOERYTHRIN ALPHA SUBUNIT, PHYCOERYTHRIN BETA SUBUNIT, PHYCOERYTHROBILIN, ...
Authors:Kumar, V., Sharma, M., Sonani, R.R., Gupta, G.D., Madamwar, D.
Deposit date:2015-09-22
Release date:2016-06-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.121 Å)
Cite:Crystal Structure Analysis of C-Phycoerythrin from Marine Cyanobacterium Phormidium Sp. A09Dm.
Photosynth.Res., 129, 2016
5FVB
  • Download 5fvb
  • View 5fvb
Molmil generated image of 5fvb
CRYSTAL STRUCTURE OF PHORMIDIUM C-PHYCOERYTHRIN AT PH 5.0
Descriptor:C-PHYCOERYTHRIN ALPHA SUBUNIT, C-PHYCOERYTHRIN BETA SUBUNIT, PHYCOERYTHROBILIN, ...
Authors:Kumar, V., Sonani, R.R., Sharma, M., Gupta, G.D., Madamwar, D.
Deposit date:2016-02-05
Release date:2016-06-29
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal Structure Analysis of C-Phycoerythrin from Marine Cyanobacterium Phormidium Sp. A09Dm.
Photosynth.Res., 129, 2016
2KSP
  • Download 2ksp
  • View 2ksp
Molmil generated image of 2ksp
MECHANISM FOR THE SELECTIVE INTERACTION OF C-TERMINAL EH-DOMAIN PROTEINS WITH SPECIFIC NPF-CONTAINING PARTNERS
Descriptor:EH domain-containing protein 1, MICAL L1 like peptide, CALCIUM ION
Authors:Kieken, F., Sharma, M., Jovic, M., Giridharan, S.S., Naslavsky, N., Caplan, S., Sorgen, P.L.
Deposit date:2010-01-11
Release date:2010-01-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mechanism for the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners.
J.Biol.Chem., 285, 2010
<123>