Author results

1DQ7
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THREE-DIMENSIONAL STRUCTURE OF A NEUROTOXIN FROM RED SCORPION (BUTHUS TAMULUS) AT 2.2A RESOLUTION.
Descriptor:NEUROTOXIN
Authors:Sharma, M., Yadav, S., Karthikeyan, S., Kumar, S., Paramasivam, M., Srinivasan, A., Singh, T.P.
Deposit date:1999-12-30
Release date:2000-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional Structure of a Neurotoxin from Red Scorpion (Buthus tamulus) at 2.2A Resolution
To be Published
2L0J
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SOLID STATE NMR STRUCTURE OF THE M2 PROTON CHANNEL FROM INFLUENZA A VIRUS IN HYDRATED LIPID BILAYER
Descriptor:Matrix protein 2
Authors:Sharma, M., Yi, M., Dong, H., Qin, H., Peterson, E., Busath, D.D., Zhou, H.X., Cross, T.A.
Deposit date:2010-07-08
Release date:2010-11-03
Last modified:2011-07-13
Method:SOLID-STATE NMR
Cite:Insight into the mechanism of the influenza a proton channel from a structure in a lipid bilayer.
Science, 330, 2010
5AQE
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COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, (4-VINYLPHENYL)METHANESULFONIC ACID, SULFATE ION, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-22
Release date:2015-10-07
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Bisubstrate Localisation by a Tailored Serine Protease Allows Creation of a Heck-Ase
To be Published
5ARB
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COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, CALCIUM ION, GLYCEROL, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-24
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase
To be Published
5ARC
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COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, CALCIUM ION, 5-methyl-2-(5-methylpyridin-2-yl)pyridine, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-24
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase
To be Published
5ARD
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COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, CALCIUM ION, GLYCEROL, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-24
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase
To be Published
6EOD
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STRUCTURE OF REDUCTIVE AMINASE FROM ASPERGILLUS TERREUS IN COMPLEX WITH NADPH
Descriptor:Reductive Aminase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sharma, M., Mangas-Sanchez, J., Turner, N.J., Grogan, G.
Deposit date:2017-10-09
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Reductive Aminase from Aspergillus terreus
To Be Published
6EOH
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REDUCTIVE AMINASE FROM ASPERGILLUS TERREUS IN COMPLEX WITH NADPH AND ETHYL LEVULINATE
Descriptor:Reductive Aminase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ethyl levulinate
Authors:Sharma, M., Grogan, G., Mangas-Sanchez, J., Turner, N.J.
Deposit date:2017-10-09
Release date:2018-10-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a Reductive Aminase from Aspergillus terreus
To Be Published
6EOI
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REDUCTIVE AMINASE FROM ASPERGILLUS TERREUS IN COMPLEX WITH NADPH AND ETHYL-5-OXOHEXANOATE
Descriptor:Reductive Aminase, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Sharma, M., Mangas-Sanchez, J., Turner, N.J., Grogan, G.
Deposit date:2017-10-09
Release date:2018-10-31
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure of Reductive Aminase from Aspergillus terreus
To Be Published
2A7T
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CRYSTAL STRUCTURE OF A NOVEL NEUROTOXIN FROM BUTHUS TAMALUS AT 2.2A RESOLUTION.
Descriptor:Neurotoxin
Authors:Ethayathulla, A.S., Sharma, M., Saravanan, K., Sharma, S., Kaur, P., Yadav, S., Srinivasan, A., Singh, T.P.
Deposit date:2005-07-06
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a highly acidic neurotoxin from scorpion Buthus tamulus at 2.2A resolution reveals novel structural features.
J.Struct.Biol., 155, 2006
5OCM
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IMINE REDUCTASE FROM STREPTOSPORANGIUM ROSEUM IN COMPLEX WITH NADP+ AND 2,2,2-TRIFLUOROACETOPHENONE HYDRATE
Descriptor:NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Sharma, M., Nestl, B., Grogan, G.
Deposit date:2017-07-03
Release date:2018-05-16
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:New imine-reducing enzymes from beta-hydroxyacid dehydrogenases by single amino acid substitutions.
Protein Eng. Des. Sel., 31, 2018
5OJL
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IMINE REDUCTASE FROM ASPERGILLUS TERREUS IN COMPLEX WITH NADPH4 AND DIBENZ[C,E]AZEPINE
Descriptor:Imine reductase, 5-methyl-7~{H}-benzo[d][2]benzazepine, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE
Authors:Sharma, M., Grogan, G.
Deposit date:2017-07-21
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines.
Angew. Chem. Int. Ed. Engl., 56, 2017
5HGQ
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LOA LOA LYSYL-TRNA SYNTHETASE IN COMPLEX WITH CLADOSPORIN.
Descriptor:Lysine--tRNA ligase, LYSINE, cladosporin, ...
Authors:Sharma, A., Sharma, M., Yogavel, M., Sharma, A.
Deposit date:2016-01-08
Release date:2016-10-26
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3.283 Å)
Cite:Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis
PLoS Negl Trop Dis, 10, 2016
5ZH2
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CRYSTAL STRUCTURE OF PFKRS WITH INHIBITOR CLADO-5
Descriptor:Lysine-tRNA ligase, LYSINE, (3R)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ...
Authors:Babbar, P., Malhotra, N., Sharma, M., Harlos, K., Reddy, D.S., Manickam, Y., Sharma, A.
Deposit date:2018-03-11
Release date:2018-06-27
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZH3
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CRYSTAL STRUCTURE OF PFKRS WITH INHIBITOR CLADO-6
Descriptor:Lysine-tRNA ligase, LYSINE, (3S)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one
Authors:Babbar, P., Malhotra, N., Sharma, M., Harlos, K., Reddy, D.S., Manickam, Y., Sharma, A.
Deposit date:2018-03-11
Release date:2018-06-27
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZH4
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CRYSTAL STRUCTURE OF PFKRS WITH INHIBITOR CLADO-7
Descriptor:Lysine-tRNA ligase, LYSINE, (3R)-6,8-dihydroxy-3-{[(2S,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ...
Authors:Babbar, P., Malhotra, N., Sharma, M., Harlos, K., Reddy, D.S., Manickam, Y., Sharma, A.
Deposit date:2018-03-11
Release date:2018-06-27
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZH5
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CRYSTAL STRUCTURE OF PFKRS WITH INHIBITOR CLADO-2
Descriptor:Lysine--tRNA ligase, LYSINE, (3S)-6,8-dihydroxy-3-{[(2R,6S)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, ...
Authors:Babbar, P., Malhotra, N., Sharma, M., Harlos, K., Reddy, D.S., Manickam, Y., Sharma, A.
Deposit date:2018-03-11
Release date:2018-06-27
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5AQD
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CRYSTAL STRUCTURE OF PHORMIDIUM PHYCOERYTHRIN AT PH 8.5
Descriptor:PHYCOERYTHRIN ALPHA SUBUNIT, PHYCOERYTHRIN BETA SUBUNIT, PHYCOERYTHROBILIN, ...
Authors:Kumar, V., Sharma, M., Sonani, R.R., Gupta, G.D., Madamwar, D.
Deposit date:2015-09-22
Release date:2016-06-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.121 Å)
Cite:Crystal Structure Analysis of C-Phycoerythrin from Marine Cyanobacterium Phormidium Sp. A09Dm.
Photosynth.Res., 129, 2016
5FVB
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CRYSTAL STRUCTURE OF PHORMIDIUM C-PHYCOERYTHRIN AT PH 5.0
Descriptor:C-PHYCOERYTHRIN ALPHA SUBUNIT, C-PHYCOERYTHRIN BETA SUBUNIT, PHYCOERYTHROBILIN, ...
Authors:Kumar, V., Sonani, R.R., Sharma, M., Gupta, G.D., Madamwar, D.
Deposit date:2016-02-05
Release date:2016-06-29
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal Structure Analysis of C-Phycoerythrin from Marine Cyanobacterium Phormidium Sp. A09Dm.
Photosynth.Res., 129, 2016
2KSP
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MECHANISM FOR THE SELECTIVE INTERACTION OF C-TERMINAL EH-DOMAIN PROTEINS WITH SPECIFIC NPF-CONTAINING PARTNERS
Descriptor:EH domain-containing protein 1, MICAL L1 like peptide, CALCIUM ION
Authors:Kieken, F., Sharma, M., Jovic, M., Giridharan, S.S., Naslavsky, N., Caplan, S., Sorgen, P.L.
Deposit date:2010-01-11
Release date:2010-01-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mechanism for the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners.
J.Biol.Chem., 285, 2010
4UN2
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CRYSTAL STRUCTURE OF THE UBA DOMAIN OF DSK2 IN COMPLEX WITH UBIQUITIN
Descriptor:UBIQUITIN, UBIQUITIN DOMAIN-CONTAINING PROTEIN DSK2
Authors:Michielssens, S., Peters, J.H., Ban, D., Pratihar, S., Seeliger, D., Sharma, M., Giller, K., Sabo, T.M., Becker, S., Lee, D., Griesinger, C., de Groot, B.L.
Deposit date:2014-05-23
Release date:2014-08-27
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:A Designed Conformational Shift to Control Protein Binding Specificity.
Angew.Chem.Int.Ed.Engl., 53, 2014
5A3G
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STRUCTURE OF HERPESVIRUS NUCLEAR EGRESS COMPLEX SUBUNIT M50
Descriptor:M50
Authors:Leigh, K.E., Boeszoermenyi, A., Mansueto, M.S., Sharma, M., Filman, D.J., Coen, D.M., Wagner, G., Hogle, J.M., Arthanari, H.
Deposit date:2015-06-01
Release date:2015-07-15
Last modified:2015-08-05
Method:SOLUTION NMR
Cite:Structure of a Herpesvirus Nuclear Egress Complex Subunit Reveals an Interaction Groove that is Essential for Viral Replication
Proc.Natl.Acad.Sci.USA, 112, 2015
5Z79
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CRYSTAL STRUCTURE ANALYSIS OF THE HPPK-DHPS IN COMPLEX WITH SUBSTRATES
Descriptor:Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, ...
Authors:Manickam, Y., Karl, H., Sharma, A.
Deposit date:2018-01-27
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance
J. Biol. Chem., 293, 2018
2MCU
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SOLID-STATE NMR STRUCTURE OF PISCIDIN 1 IN ALIGNED 3:1 PHOSPHATIDYLCHOLINE/PHOSPHOGLYCEROL LIPID BILAYERS
Descriptor:Moronecidin
Authors:Fu, R., Tian, Y., Perrin Jr., B.S., Grant, C.V., Pastor, R.W., Cotten, M.L.
Deposit date:2013-08-27
Release date:2014-01-22
Last modified:2014-03-19
Method:SOLID-STATE NMR
Cite:High-resolution structures and orientations of antimicrobial peptides piscidin 1 and piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion.
J.Am.Chem.Soc., 136, 2014
2MCV
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SOLID-STATE NMR STRUCTURE OF PISCIDIN 1 IN ALIGNED 1:1 PHOSPHATIDYLETHANOLAMINE/PHOSPHOGLYCEROL LIPID BILAYERS
Descriptor:Moronecidin
Authors:Fu, R., Tian, Y., Perrin Jr., B.S., Grant, C.V., Hayden, R.M., Pastor, R.W., Cotten, M.L.
Deposit date:2013-08-27
Release date:2014-01-22
Last modified:2014-03-19
Method:SOLID-STATE NMR
Cite:High-resolution structures and orientations of antimicrobial peptides piscidin 1 and piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion.
J.Am.Chem.Soc., 136, 2014
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